Volume 29, Number 10—October 2023
CME ACTIVITY - Synopsis
Spike in Congenital Syphilis, Mississippi, USA, 2016–2022
Table 2
Delivery subcohort: clinical characteristic for infants with and without congenital syphilis, Mississippi, USA, 2016–2022
| Infant characteristics | Congenital syphilis, no. (%) | No congenital syphilis, no. (%) | p value | Crude odds ratio (95% CI) | Adjusted odds ratio (95% CI)* |
|---|---|---|---|---|---|
| Maternal substance use | 340 | 233,529 | <0.001 | ||
| Y | 73 (21.5) | 5,597 (2.4) | 11.14 (8.53–14.36) | 9.39 (7.16–12.16) | |
| N |
267 (78.5) |
227,932 (97.6) |
Referent |
Referent |
|
| Birthweight† | |||||
| Very low birthweight | 28 (8.5) | 4,430 (1.9) | <0.001 | 5.38 (3.55–7.81) | 4.05 (2.67–5.90) |
| Low birthweight | 59 (17.9) | 22,556 (9.7) | 2.23 (1.66–2.94) | 1.81 (1.35–2.40) | |
| Normal birthweight |
242 (73.6) |
205,901 (88.3) |
Referent |
Referent |
|
| Preterm | |||||
| Y | 92 (27.1) | 29,544 (12.7) | <0.001 | 2.56 (2.01–3.24) | 2.26 (1.77–2.86) |
| N |
248 (72.9) |
203,985 (87.3) |
Referent |
Referent |
|
| Newborn respiratory distress | |||||
| Y | 72 (21.2) | 21,204 (9.1) | <0.001 | 2.69 (2.06–3.47) | 2.54 (1.94–3.28) |
| N | 268 (78.8) | 212,325 (90.9) | Referent | Referent |
*Each of the models was adjusted for demographic characteristics, including race, sex, residence, and payer. We excluded newborns of undetermined/unknown sex from this analysis. †Not all newborn records had recorded birthweight; therefore, we excluded newborns with unknown birthweight from this analysis (11 records for the congenital syphilis cohort and 642 records for the cohort without congenital syphilis). Very low birthweight, <1,500 g; low birthweight, 1,500-2,500 g; normal birthweight, >2,500 g.
Page created: July 13, 2023
Page updated: September 20, 2023
Page reviewed: September 20, 2023
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