Volume 24, Number 10—October 2018
CME ACTIVITY - Synopsis
Human Pegivirus in Patients with Encephalitis of Unclear Etiology, Poland
Iwona Bukowska-Ośko, Karol Perlejewski
, Agnieszka Pawełczyk, Małgorzata Rydzanicz, Agnieszka Pollak, Marta Popiel, Kamila Caraballo Cortés, Marcin Paciorek, Andrzej Horban, Tomasz Dzieciątkowski, Marek Radkowski, and Tomasz Laskus
, Agnieszka Pawełczyk, Małgorzata Rydzanicz, Agnieszka Pollak, Marta Popiel, Kamila Caraballo Cortés, Marcin Paciorek, Andrzej Horban, Tomasz Dzieciątkowski, Marek Radkowski, and Tomasz Laskus
Table 2
5 Human pegivirus variants in serum and cerebrospinal fluid in 3 patients with encephalitis of unknown origin, Poland, 2012–2015*
| RNA region |
Patient 1 |
Patient 2 |
Patient 3 |
|||||
|---|---|---|---|---|---|---|---|---|
| Serum |
CSF |
Serum |
CSF |
Serum |
CSF |
|||
| 5′ untranslated region | ||||||||
| No. reads before error cutoff | 124,987 | 110,331 | 108,002 | 183,046 | 101,240 | 145,411 | ||
| No. reads after error cutoff | 61,783 | 57,668 | 49,075 | 109,061 | 55,328 | 75,998 | ||
| No. nucleotide variants† | 3 | 7 | 3 | 3 | 2 | 3 | ||
| No. unique nucleotide variants in CSF† | – | 5 (29.32) | – | 1 (2.28) | – | 1 (2.49) | ||
| No. nucleotide substitutions | 2 | 7 | 2 | 2 | 1 | 2 | ||
| Nucleotide diversity per site |
0.004 |
0.007 |
0.004 |
0.004 |
0.003 |
0.004 |
||
| E2 region | ||||||||
| No. reads before error cutoff | 70,460 | 38,025 | 77,656 | 76,918 | 2,706 | 82,738 | ||
| No. reads after error cutoff | 26,720 | 20,619 | 26,558 | 42,609 | 453 | 34,887 | ||
| No. nucleotide variants† | 8 | 4 | 8 | 9 | 4 | 7 | ||
| No. unique nucleotide variants in CSF† | – | 0 | – | 5 (41.78) | – | 3 (27.28) | ||
| No. nucleotide substitutions | 4 | 2 | 5 | 5 | 2 | 3 | ||
| Nucleotide diversity per site | 0.007 | 0.004 | 0.006 | 0.007 | 0.004 | 0.005 | ||
| No. amino acid variants† | 2 | 2 | 2 | 5 | 2 | 4 | ||
| No. unique amino acid variants in CSF† | – | 0 | – | 3 (27.28) | – | 2 (27.28) | ||
*Numbers in parentheses are percentages. CSF, cerebrospinal fluid
†After applying the 1.22% sequencing error cutoff.
Page created: September 14, 2018
Page updated: September 14, 2018
Page reviewed: September 14, 2018
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