Tuberculosis Epidemiologic Studies Consortium (TBESC)
TBESC-II
Study Sites
- California Department of Public Health
- Denver Health and Hospital Authority, Colorado
- Duke University, North Carolina and Tennessee
- Emory University, Georgia
- Hawaii Department of Health
- Public Health-Seattle and King County, Washington
- Maricopa County Department of Public Health, Arizona
- Maryland Department of Health and Mental Hygiene
- University of Florida
- University of North Texas Health Science Center
Study 1: Evaluating tests for TB infection
This first TBESC-II study was a head-to-head comparison of the three tests for TB infection in populations at high risk of latent TB infection and/or progression to TB disease.
Sub studies
- Repeatability and reproducibility of two interferon-gamma release assay (IGRA) blood tests– the QuantiFERON®-TB Gold In-Tube (QFT-GIT), and T-SPOT®.TB test (T-SPOT)
- Feasibility and cost of testing for prediabetes and diabetes in high-risk persons tested for TB infection
- Cost-effectiveness of TB infection testing in high-risk populations
Study 2: The latent TB infection care cascade
The second study focused on describing and quantifying the steps in the TB prevention cascade of care within health department clinics. This included better understanding the proportions of patients with latent TB infection who are identified, offered treatment, accept treatment, and complete treatment.
Sub studies
- Developed algorithms to estimate latent TB infection prevalence at any county or state level.
- Developed tools for local TB programs to identify local clinicians who treat underserved populations at high risk, so they can partner with these groups to increase latent TB infection treatment.
- Used insurance billing codes to estimate the extent and magnitude of latent TB infection testing and treatment in commercial and community health sectors.
Study 3: Closing the gaps in the TB care cascade
The third study focused on identifying barriers and facilitators to latent TB infection diagnosis and treatment at community health clinics (CHCs). Researchers collected and analyzed quantitative and qualitative data that can be used to inform development of interventions to improve targeted TB testing and latent TB infection treatment at CHCs.
TBESC-I
Tuberculosis Epidemiologic Studies Consortium Research Projects | ||
---|---|---|
Task Order | Task Order Title | Principal Investigator |
32 | The Current Cost of TB within urban United States | Jenny Pang Thad Miller Dolly Katz |
31 | Evaluation of Interferon Gamma Release Assays in Overseas Immigration Examination of Children in Moderate- and High-burden Countries | Denise Garrett John Painter Drew Posey Domestic: Randall Reves |
30 | Quantifying the risk of premature death in TB survivors | Suzanne Beavers Thad Miller Jenny Pang |
29** | Improving testing for TB and latent TB infection for Persons with HIV Infection at HRSA-funded HIV/AIDS Clinics | Suzanne Marks |
28 | Treatment Practices, Outcomes and Cost of Multidrug-resistant (MDR TB) and Extensively Drug Resistant Tuberculosis (XDR TB) in the United States | Suzanne Marks Lori Armstrong |
27 | Use of Nucleic Acid Amplification Test to Determine the Relative Infectiousness of Pulmonary TB Patients | Suzanne Marks |
26 | Improving the Utilization and Integration of TB Genotyping into Routine TB Program Practice: Analyzing the Impact Through Public Health Interventions | Roque Miramontes Wendy Cronin |
25 | Tuberculosis Mortality in the United States: Epidemiology and Prevention Opportunities | Suzanne Beavers Jenny Flood |
24 | Perceptions of TB among the Karen-Burmese: An Ethnographic Study | Robin Shrestha-Kuwahara |
23 | National Study of Determinants of Early Diagnosis, Prevention, and Treatment of TB in the African-American Community | Rachel Royce Dolly Katz |
21 | Acquired Rifamycin-resistant TB among HIV infected patients | Sundari Mase |
20 | Assessing QFT as an initial screening tool for U.S. bound applicants for immigration and feasibility of follow-up in U.S. immigrants | Randall Reves John Painter Lilia Manangan |
19 | Effectiveness of Quantiferon- TB Gold (QFT-G) in contact tracing | Lauren Lambert Sharon Welbel |
18 | Evaluation of New Interferon-y Release Assays in the Diagnosis of Latent TB Infection in Health Care Workers | Denise Garrett Charles Daley Susan Dorman |
16* | African Refugee Women’s Health Improvement Project | Sue Etkind Jennifer Cochran |
15 | Enhancing TB Programs’ Capacity for Self-Evaluation: Testing New Tools and Developing an Evaluation Toolkit | Maureen Wilce |
14 | Culturally Appropriate TB Educational Materials for Leaders and Staff of Hispanic Service Organizations | Wanda Walton |
13 | Factors Associated with Acceptance of, Adherence to and Toxicity From Treatment for Latent TB Infection and Pilot Study of Treatment for Latent TB Infection Effectiveness | Robin Shrestha-Kuwahara Stefan Goldberg Paul Colson, Yael Hirsch-Moverman |
12 | Assessing the TB Knowledge, Attitudes, Beliefs, and Practices Among Private Providers Serving Foreign-born Populations at Risk for TB | Wanda Walton Jenny Pang |
11 | Addressing TB Among African Americans in the Southeast: Identifying and Overcoming Barriers to Treatment Adherence for Latent TB Infection and TB Disease | Wanda Walton Rachel Royce |
10 | New Model for Assessing TB Surveillance and Action Performance and Cost | Scott McNabb |
9 | Missed Opportunities for TB Prevention in Foreign-Born Population in the United States and Canada | Dolly Katz Randall Reves Amy Davidow |
8 | An Analysis of Molecular Epidemiology of Multi-Drug Resistant M. tuberculosis in the United States | Edward Graviss Patrick Moonan Jenny Flood |
7 | Use of Network Analysis Methods to Characterize M. tuberculosis Transmission Patterns Among Women and Other High-Risk Populations | Peter McElroy Maureen Wilce |
6 | Regional Capacity-Building in Low-Incidence Areas | Paul Tribble |
5 | Prevalence of Latent TB Infection Among High Risk Populations in the United States | Rachel Albalak |
4 | Models for Incorporating HIV Counseling, Testing, and Referral into Tuberculosis Contact Investigations | Suzanne Marks |
3 | Zero Tolerance for Pediatric TB | Mark Lobato |
2 | Prospective Evaluation of Immunogenetic and Immunologic Markers for Susceptibility to Tuberculosis Infection and Progression from M. Tuberculosis infection to active TB | Mary Reichler Tim Sterling |
1 | TBES Consortium: Core Requirements | |
*Alternate Track Task Order: Local initiative not reviewed and monitored by Research Committee **Outside Funding Task Order: Project funded from outside of CDC Division of TB Elimination. Reviewed and monitored by Research Committee |