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Volume 30, Number 6—June 2024
Dispatch

Concurrent Infection with Clade 2.3.4.4b Highly Pathogenic Avian Influenza H5N6 and H5N1 Viruses, South Korea, 2023

Gyeong-Beom Heo, Yong-Myung Kang, Se-Hee An, Yeongbu Kim, Ra Mi Cha, Yunyueng Jang, Eun-Kyoung Lee, Youn-Jeong Lee, and Kwang-Nyeong LeeComments to Author 
Author affiliations: Seoul National University, Seoul, South Korea (G.-B. Heo); Animal and Plant Quarantine Agency, Gimcheon, South Korea (G.-B. Heo, Y.-M. Kang, S.-H. An, Y. Kim, R.M. Cha, Y. Jang, E.-K. Lee, Y.-J. Lee, K.-N. Lee)

Main Article

Table 1

Nucleotide sequence identities of gene segments between reassortant clade 2.3.4.4b HPAI H5N6 virus from a duck farm in South Korea, 2023, compared with A/duck/Korea/D448-N6/2023(H5N6) virus and the closest referent in the GISAID database*

Gene Virus GISAID accession no. % Identity Sample date LPIAI or HPAI H5 clade
PB2 A/mallard/South_Korea/20X-20/2021(H7N9) EPI_ISL_6781375 98.73 2021 Jan 6 LPAI
PB1 A/large billed_crow/Kanagawa/1403C006/2023(H5N1) EPI_ISL_17949961 99.69 2023 Mar 10 2.3.4.4b
PA A/common_teal/Amur_region/92b/2020(H6N2) EPI_ISL_1184535 99.58 2020 Sep 6 LPAI
HA A/Mandarin_duck/Korea/WA496/2022(H5N1) EPI_ISL_15647836 99.53 2022 Oct 10 2.3.4.4b
NP A/gadwall/Novosibirsk_region/3407k/2020(H4N6) EPI_ISL_1184520 98.8 2020 Aug 29 LPAI
NA A/duck/Hunan/S40199/2021(H5N6)† EPI_ISL_11208196 98.62 2021 Dec 1 2.3.4.4b
M A/Mandarin_duck/Korea/WA496/2022(H5N1) EPI_ISL_15647836 99.8 2022 Oct 10 2.3.4.4b
NS A/Falcated_duck/South_Korea/JB42–30/2020(H9N2) EPI_ISL_4072076 99.64 2020 Feb 19 LPAI

*One A/duck/Korea/D448-N6/2023(H5N6) isolate from a wild bird (WA875) and 2 isolates from poultry (D448-N6, D449) had high nucleotide identities among them in all 8 genes: PB2, >99.82%; PB1, >99.78%; PA, >99.86%; HA, >99.82%; NP, >99.87%; NA, >99.86%; M, >99.90%; NS, >99.88%. GISAID, https://www.gisaid.org; HA, hemagglutinin; HPAI, highly pathogenic avian influenza; LPAI, low pathogenicity avian influenza; M, matrix; N, nucleocapsid; NA, neuraminidase; NP, nucleoprotein; NS, nonstructural; PA, polymerase acidic; PB, polymerase basic. †This virus was isolated from bird in poultry market, and all the other viruses compared were from wild birds.

Main Article

Page created: May 02, 2024
Page updated: May 22, 2024
Page reviewed: May 22, 2024
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