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Volume 30, Number 6—June 2024
Synopsis

Deciphering Unexpected Vascular Locations of Scedosporium spp. and Lomentospora prolificans Fungal Infections, France

Carole VignalsComments to Author , Joseph Emmerich, Hugues Begueret, Dea Garcia-Hermoso, Guillaume Martin-Blondel, Adela Angoulvant, Damien Blez, Patrick Bruneval, Sophie Cassaing, Emilie Catherinot, Pierre Cahen, Cécile Moluçon-Chabrot, Carole Chevenet, Laurence Delhaes, Lélia Escaut, Marie Faruch, Frédéric Grenouillet, Fabrice Larosa, Lucie Limousin, Elisabeth Longchampt, François Mellot, Céline Nourrisson, Marie-Elisabeth Bougnoux, Olivier Lortholary, Antoine Roux, Laura Rozenblum, Mathilde Puges, Fanny Lanternier, and Didier Bronnimann
Author affiliations: Centre Hospitalier Universitaire de Bordeaux, Bordeaux, France (C. Vignals, H. Begueret, L. Delhaes, M. Puges, D. Bronnimann); Hôpital Saint-Joseph, Paris, France (J. Emmerich); Institut Pasteur, Paris (D. Garcia-Hermoso, M.-E. Bougnoux, O. Lortholary, F. Lanternier); Centre Hospitalier Universitaire de Toulouse, Toulouse, France (G. Martin-Blondel, S. Cassaing, M. Faruch); Hôpital Bicêtre, Le Kremlin-Bicêtre, France (A. Angoulvant, L. Escaut); Hôpital Européen Georges Pompidou, Paris (D. Blez, P. Bruneval); Hôpital Foch, Suresnes, France (E. Catherinot, P. Cahen, L. Limousin, E. Longchampt, F. Mellot, A. Roux); Centre hospitalier universitaire de Clermont-Ferrand, Clermont-Ferrand, France (C. Moluçon-Chabrot, C. Chevenet, C. Nourrisson); Centre hospitalier universitaire de Besançon, Besançon, France (F. Grenouillet); Centre Hospitalier Universitaire de Dijon, Dijon, France (F. Larosa); Hôpital Necker-enfants malades AP-HP, Paris (M.-E. Bougnoux, O. Lortholary, F. Lanternier); Hôpital Pitié-Salpêtrière AP-HP, Paris (L. Rozenblum)

Main Article

Table 2

Clinical and radiologic characteristics of patients in study of unexpected vascular locations of Scedosporium spp. and Lomentospora prolificans fungal infections, France*

Variables
 SOS, n = 7 Literature, n = 13 Total, n = 20
Clinical manifestations at diagnosis
Fever 6/7 (86) 3/8 (38) 9/15 (60)
Sepsis 1/7 (14) 2/13 (15) 3/20 (15)
Thoracic or abdominal pain among aortitis 2/5 (40) 5/9 (56) 7/14 (50)
Local inflammatory sign among peripheral arteritis
 0
 2/4 (50)
 2/10 (20)
Vascular involvement at scedosporiosis/lomentosporiosis diagnosis
 5/7 (71)
 5/13 (39)
 10/20 (50)
Other infection locations
Pulmonary 4/7 (57) 5/13 (39) 9/20 (45)
Central nervous system 2/7 (29) 3/13 (23) 5/20 (25)
Cutaneous 2/7 (29) 2/13 (15) 4/20 (20)
Osteoarticular 3/7 (43) 7/13 (54) 10/20 (50)
Including spondylodiscitis 1/3 (33) 4/7 (57) 5/10 (50)
Including contiguous localizations 1/3 (33) 6/7 (86) 7/10 (70)
Endocarditis
 2/7 (29)
 2/13 (15)
 4/20 (20)
Localization of vascular infection
Aortitis 5/7 (71) 9/13 (69) 14/20 (70)
Including thoracic aortitis 1/5 (20) 4/8 (50) 5/13 (39)
Including abdominal aortitis 4/5 (80) 4/8 (50) 8/13 (62)
Peripheral arteritis 6/7 (86) 4/13 (31) 10/20 (50)
Including iliac or femoral arteritis
 3/6 (50)
 1/4 (25)
 4/10 (40)
Type of aortitis vascular impairment
Aneurysm 1/4 (25) 7/7 (100) 8/11 (73)
With rupture 1/1 (100) 2/7 (29) 3/8 (38)
Perivascular abscess 1/4 (25) 0 1/11 (9)
Isolated vascular thickening
 2/4 (50)
 0
 2/11 (18)
Type of peripheral arteritis vascular impairment
Aneurysm 3/6 (50) 3/4 (75) 6/10 (60)
With rupture 0 1/3 (33) 1/6 (17)
Perivascular abscess 1/6 (17) 0 1/10 (10)
Septic thrombosis 2/6 (33) 1/4 (25) 3/10 (30)
Isolated vascular thickening
 1/6 (17)
 0
 1/10 (10)
Vascular hypermetabolism on PET/CT
 3/3 (100) 3/3 (100) 6/6 (100)

*Values are no./total no. analyzed (%). Denominators are different in some cases because of missing data. Patients had non–central nervous system vascular infections caused by Scedosporium spp. or Lomentospora prolificans; cases were obtained from the SOS and published literature. PET/CT, positron emission tomography/computed tomography; SOS, Scedosporiosis/lomentosporiosis Observational Study.

Main Article

Page created: March 28, 2024
Page updated: May 22, 2024
Page reviewed: May 22, 2024
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