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Volume 30, Number 2—February 2024
Dispatch

Identification of Large Adenovirus Infection Outbreak at University by Multipathogen Testing, South Carolina, USA, 2022

Marco E. ToriComments to Author , Judith Chontos-Komorowski, Jason Stacy, Daryl M. Lamson, Kirsten St. George, Avril T. Lail, Heather A. Stewart-Grant, Linda J. Bell, Hannah L. Kirking, and Christopher H. Hsu
Author affiliations: South Carolina Department of Health and Environmental Control, Columbia, South Carolina, USA (M.E. Tori, L.J. Bell); Centers for Disease Control and Prevention, Atlanta, Georgia, USA (M.E. Tori, H.L. Kirking, C.H. Hsu); University of South Carolina Student Health Services, Columbia (J. Chontos-Komorowski, J. Stacy, A.T. Lail, H.A. Stewart-Grant); New York State Department of Health, Albany, NY, USA (D.M. Lamson, K. St. George)

Main Article

Table 2

Comparison of university students with HAdV infection only and those with respiratory virus co-detections in study identifying a large adenovirus infection outbreak by multipathogen testing, South Carolina, USA, 2022*

Characteristics
 HAdV infection only
 HAdV + co-detected respiratory virus†
 p value
No. students
 152
 43
 NA
Sex
F 70 (46) 28 (65) 0.002
M
 82 (54)
 15 (35)
 0.03
Median age, y (range)
 19 (18–24)
 19 (18–22)
 NA
Residence
On campus dormitory 85 (56) 30 (66) 0.09
Off campus
 59 (39)
 11 (25)
 0.09
Symptoms
Cough 113 (74) 36 (84) 0.16
Sore throat 124 (82) 42 (98) 0.001
Fever 116 (76) 30 (70) 0.41
Headache 90 (59) 30 (70) 0.19
Nausea or vomiting 44 (29) 8 (19) 0.14
Conjunctivitis
 19 (13)
 1 (2)
 0.001
Severe infection
 6 (4)
 1 (2)
 0.07
Smoking or vaping 15 (11) 5 (12) 0.75

*Values are no. (%) except as indicated. p values were obtained from 2-sided t-tests. HAdV, human adenovirus; NA, not applicable. †One student was HAdV positive in March, then had recurrent symptoms in early May and was found to be both HAdV and parainfluenza 3 positive. The student was included in the HAdV infection only column and not in the co-detection column. This student’s clinical course and timeline were more consistent with a new parainfluenza infection; the detection of adenovirus was likely attributable to prolonged virus DNA shedding, not a new infection. This group does not include students with Epstein-Barr virus or group A Streptococcus infections.

Main Article

Page created: December 06, 2023
Page updated: January 24, 2024
Page reviewed: January 24, 2024
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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