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Volume 30, Number 2—February 2024
Research

Evidence of Zika Virus Reinfection by Genome Diversity and Antibody Response Analysis, Brazil

Marcia da Costa Castilho, Ana Maria Bispo de Filippis, Lais Ceschini Machado, Thaise Yasmine Vasconcelos de Lima Calvanti, Morganna Costa Lima, Vagner Fonseca, Marta Giovanetti, Cassia Docena, Armando Menezes Neto, Camila Helena Aguiar Bôtto-Menezes, Edna Oliveira Kara, Rafael de La Barrera, Kayvon Modjarrad, Silvana Pereira Giozza, Gerson Fernando Pereira, Luiz Carlos Junior Alcantara, Nathalie Jeanne Nicole Broutet, Guilherme Amaral Calvet1, Gabriel Luz Wallau1, and Rafael Freitas Oliveira Franca1Comments to Author 
Author affiliations: Tropical Medicine Foundation Doctor Heitor Vieira Dourado, Manaus, Brazil (M. da Costa Castilho, C.H.A. Bôtto-Menezes); Oswaldo Cruz Foundation, Rio de Janeiro, Brazil (A.M.B. de Filippis, M. Giovanetti, L.C.J. Alcantara); Oswaldo Cruz Foundation, Recife, Brazil (L.C. Machado, T.Y.V. de L. Calvanti, M.C. Lima, C. Docena, A.M. Neto, G.A. Calvet, G.L. Wallau, R.F.O. Franca); Organização Pan-Americana da Saúde/Organização Mundial da Saúde, Brasília, Brazil (V. Fonseca); University of Campus Bio-Medico di Roma, Rome, Italy (M. Giovanetti); World Health Organization, Geneva, Switzerland (E.O. Kara, N.J.N. Broutet); Walter Reed Army Institute of Research, Silver Spring, Maryland, USA (R. de La Barrera, K. Modjarrad); Department of Chronic Condition Diseases and Sexually Transmitted Infections, Brasília, Brazil (S.P. Giozza, G.F. Pereira); National Reference Center for Tropical Infectious Diseases, Hamburg, Germany (G.L. Wallau)

Main Article

Figure 1

Genomic epidemiology of Zika virus strains obtained from study participants in northern Brazil and reference sequences. A) Time-scaled maximum clade credibility tree of Zika virus Asian lineage in Brazil, including the 238 new genomes generated in this study (dark blue) plus 481 reference strains sampled worldwide. Tips are colored according to the sample source location. Values at nodes represent posterior probability support of the tree nodes inferred under Bayesian evolutionary analysis using a relaxed molecular clock approach. B) Root-to-tip regression of sequence sampling date against genetic divergence from the root of the outbreak clade.

Figure 1. Genomic epidemiology of Zika virus strains obtained from study participants in northern Brazil and reference sequences. A) Time-scaled maximum clade credibility tree of Zika virus Asian lineage in Brazil, including the 238 new genomes generated in this study (dark blue) plus 481 reference strains sampled worldwide. Tips are colored according to the sample source location. Values at nodes represent posterior probability support of the tree nodes inferred under Bayesian evolutionary analysis using a relaxed molecular clock approach. B) Root-to-tip regression of sequence sampling date against genetic divergence from the root of the outbreak clade.

Main Article

1These authors contributed equally to this article.

Page created: January 09, 2024
Page updated: January 24, 2024
Page reviewed: January 24, 2024
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