Volume 30, Number 1—January 2024
Research
Disease-Associated Streptococcus pneumoniae Genetic Variation
Table 3
Association analysis between k-mers and disease status used in study of disease-associated Streptococcus pneumoniae genetic variation*
| k-mer | Genes | Infection isolates, no. (%), n = 349 |
Carriage isolates, no. (%), n = 434 | p value | OR (95%CI) |
|---|---|---|---|---|---|
| Kmer_9823 | srtG1 | 264 (75.6) | 75 (17.3) | 8.55 × 10–45 | 1.88 (1.79–1.96) |
| Kmer_10633 | pbp2b | 218 (62.5) | 78 (18.0) | 2.68 × 10–37 | 1.77 (1.71–1.84) |
| Kmer_10039 | pitA | 194 (55.6) | 69 (15.9) | 1.47 × 10–31 | 1.65 (1.51–1.79) |
| Kmer_7775 | cpsC | 290 (83.1) | 132 (30.4) | 6.59 × 10–49 | 1.75 (1.66–1.83) |
| Kmer_1319 | pbp3 | 219 (62.8) | 96 (22.1) | 9.95 × 10–31 | 1.79 (1.70–1.87) |
| Kmer_7075 | pspA | 276 (79.1) | 126 (29.0) | 4.31 × 10–44 | 1.64 (1.55–1.72) |
| Kmer_10431 | cbpE | 146 (41.8) | 7 (1.6) | 3.38 × 10–45 | 1.69 (1.62–1.76) |
| Kmer_8201 | nanA | 292 (83.7) | 241 (55.5) | 4.68 × 10–17 | 1.66 (1.55–1.76) |
*OR, odds ratio.
1These authors contributed equally to this article.
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