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Volume 29, Number 7—July 2023
Research

Sensitivity to Neutralizing Antibodies and Resistance to Type I Interferons in SARS-CoV-2 R.1 Lineage Variants, Canada

Rajesh Abraham Jacob, Ali Zhang1, Hannah O. Ajoge1, Michael R. D'Agostino1, Kuganya Nirmalarajah, Altynay Shigayeva, Wael L. Demian, Sheridan J.C. Baker, Hooman Derakhshani, Laura Rossi, Jalees A. Nasir, Emily M. Panousis, Ahmed N. Draia, Christie Vermeiren, Jodi Gilchrist, Nicole Smieja, David Bulir, Marek Smieja, Michael G. Surette, Andrew G. McArthur, Allison J. McGeer, Samira Mubareka, Arinjay Banerjee, Matthew S. Miller, and Karen MossmanComments to Author 
Author affiliations: McMaster University, Hamilton, Ontario, Canada (R.A. Jacob, A. Zhang, H.O. Ajoge, M.R. D'Agostino, W.L. Demian, S.J.C. Baker, L. Rossi, J.A. Nasir, E.M. Panousis, A.N. Draia, D. Bulir, M. Smieja, M.G. Surette, A.G. McArthur, M.S. Miller, K. Mossman); Sunnybrook Research Institute, Toronto, Ontario, Canada (K. Nirmalarajah, S. Mubareka); University of Toronto, Toronto (A. Shigayeva, C. Vermeiren, A.J. McGeer, S. Mubareka, A. Banerjee); University of Manitoba, Winnipeg, Manitoba, Canada (H. Derakhshani); Research Institute of St. Joe’s Hamilton, Hamilton (J. Gilchrist, N. Smieja, D. Bulir); Vaccine and Infectious Disease Organization, Saskatoon, Saskatchewan, Canada (A. Banerjee); University of Saskatchewan, Saskatoon (A. Banerjee); University of Waterloo, Waterloo, Ontario, Canada (A. Banerjee); University of British Columbia, Vancouver, British Columbia, Canada (A. Banerjee)

Main Article

Figure 1

Phylogenetic confirmation that SARS-CoV-2 isolates belong to R.1 lineage in study of sensitivity to neutralizing antibodies and resistance to type I interferons in SARS-CoV-2 R.1 lineage variants, Canada. Tree constructed by using maximum-likelihood estimations by executing 1,000 rapid bootstrap inferences and a thorough search with the general time reversible model of nucleotide substitution. Blue indicates R1 isolates (R.1 645, R.1 646) and red SB3 isolate. Variants are highlighted in magenta (Alpha), green (Beta), brown (Delta), mocha (Gamma), and orange (Omicron). The tree was visualized using FigTree version 1.4.2 (http://tree.bio.ed.ac.uk/software/figtree).

Figure 1. Phylogenetic confirmation that SARS-CoV-2 isolates belong to R.1 lineage in study of sensitivity to neutralizing antibodies and resistance to type I interferons in SARS-CoV-2 R.1 lineage variants, Canada. Tree constructed by using maximum-likelihood estimations by executing 1,000 rapid bootstrap inferences and a thorough search with the general time reversible model of nucleotide substitution. Blue indicates R1 isolates (R.1 645, R.1 646) and red SB3 isolate. Variants are highlighted in magenta (Alpha), green (Beta), brown (Delta), mocha (Gamma), and orange (Omicron). The tree was visualized using FigTree version 1.4.2 (http://tree.bio.ed.ac.uk/software/figtree).

Main Article

1These authors contributed equally to this article.

Page created: May 08, 2023
Page updated: June 20, 2023
Page reviewed: June 20, 2023
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