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Volume 28, Number 8—August 2022
Dispatch

Zoonotic Threat of G4 Genotype Eurasian Avian-Like Swine Influenza A(H1N1) Viruses, China, 2020

Min Gu1, Kaibiao Chen1, Zhichuang Ge, Jun Jiao, Tianyu Cai, Suhan Liu, Xiaoquan Wang, Xinan Jiao, Daxin Peng, and Xiufan LiuComments to Author 
Author affiliations: Yangzhou University, Yangzhou, China (M. Gu, K. Chen, Z. Ge, J. Jiao, T. Cai, S. Liu, X. Wang, X. Jiao, D. Peng, X. Liu); Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou (M. Gu, X. Wang, X. Jiao, D. Peng, X. Liu)

Main Article

Table 1

Comparison of 2 G4 Eurasian avian-like H1N1 swine isolates from pigs in China with similar influenza viruses retrieved from the GISAID and GenBank databases*

Gene and
isolate		 Most homologous sequence in GISAID
 Most homologous sequence in GenBank
Virus strain % Similarity
 Virus strain % Similarity
nt aa nt aa
PB2
HD11 A/Sichuan/01208/2021(H1N1) 99.25 99.47 A/swine/Liaoning/PJ89/2014(H1N1) 97.72 98.69
HD21
 A/Sichuan/01208/2021(H1N1)
 97.11
 98.03
A/swine/Liaoning/PJ89/2014(H1N1)
 97.54
 98.29
PB1
HD11 A/Shandong/00204/2021(H1N1) 99.60 100.00 A/swine/Liaoning/CY102/2014(H1N1) 97.98 98.42
HD21
 A/Hubei-Wujiagang/1324/2020(H1N1)
 97.58
 98.68
A/swine/Liaoning/CY102/2014(H1N1)
 97.71
 98.68
PA
HD11 A/Tianjin/00030/2020(H1N1) 99.67 99.86 A/swine/Liaoning/PJ43/2014(H1N1) 97.44 99.30
HD21
 A/swine/China/Qingdao/2018(H1N1)
 97.49
 99.02
A/swine/China/Qingdao/2018(H1N1)
 97.49
 99.02
HA
HD11 A/Tianjin/00030/2020(H1N1) 99.47 99.47 A/swine/Liaoning/CY102/2014(H1N1) 97.47 97.18
HD21
 A/Tianjin/00030/2020(H1N1)
 98.71
 98.59
A/swine/Liaoning/CY102/2014(H1N1)
 97.30
 97.35
NP
HD11 A/Tianjin/00030/2020(H1N1) 99.73 100.00 A/swine/Guangxi/NS1402/2012(H3N2) 97.80 98.20
HD21
 A/Tianjin/00030/2020(H1N1)
 98.00
 98.60
A/swine/Guangdong/NS2883/2012(H3N2)
 97.80
 99.00
NA
HD11 A/Shandong/00204/2021(H1N1) 99.57 99.36 A/swine/Ningjin/03/2014(H1N1) 97.02 95.96
HD21
 A/Sichuan/01208/2021(H1N1)
 97.02
 97.45
A/swine/Liaoning/PJ43/2014(H1N1)
 96.67
 95.74
M
HD11 A/Tianjin/00030/2020(H1N1) 99.69 99.70 A/swine/Shandong/LY142/2017(H1N1) 98.78 98.78
A/Sichuan/01208/2021(H1N1)
HD21 A/Tianjin/00030/2020(H1N1) 98.47 98.48 A/swine/Shandong/LY142/2017(H1N1) 98.57 99.39
A/Sichuan/01208/2021(H1N1)
 98.47
 98.48
NS
HD11 A/Shandong/00204/2021(H1N1) 100.00 100.00 A/swine/Guangxi/1874/2012(H3N2) 97.97 96.43
A/Sichuan/01208/2021(H1N1) 100.00 100.00
HD21 A/Hubei-Wujiagang/1324/2020(H1N1) 97.49 95.00 A/swine/China/Qingdao/2018(H1N1) 97.14 95.00

*HD11 is the isolate A/swine/Jiangsu/HD11/2020(H1N1); HD21 is the isolate A/swine/Anhui/HD21/2020(H1N1). GISAID, https://www.gisaid.org. HA, hemagglutinin; M, matrix; NA, neuraminidase; NP, nucleoprotein; NS, nonstructural protein; PA, polymerase acid; PB, polymerase basic.

Main Article

1These authors contributed equally to this article.

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Page updated: July 20, 2022
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