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Volume 28, Number 3—March 2022
Research

Effectiveness of 3 COVID-19 Vaccines in Preventing SARS-CoV-2 Infections, January–May 2021, Aragon, Spain

Alicia del Cura-BilbaoComments to Author , Héctor López-Mendoza, Armando Chaure-Pardos, Alberto Vergara-Ugarriza, and Joaquín Guimbao-Bescós
Author affiliations: Miguel Servet University Hospital, Zaragoza, Spain (A. del Cura-Bilbao); Aragon Department of Health, Zaragoza (A. del Cura-Bilbao, H. López-Mendoza, A. Chaure-Pardos, A. Vergara-Ugarriza, J. Guimbao-Bescós); University of Zaragoza CASSETEM Research Group, Zaragoza (H. López-Mendoza); Lozano Blesa University Hospital, Zaragoza (H. López-Mendoza, A. Chaure-Pardos); GRISSA Research Group, Zaragoza (A. Chaure-Pardos); Aragon Health Research Institute Foundation (IIS Aragon), Zaragoza (A. Chaure-Pardos)

Main Article

Figure 2

Cumulative risk curves (1 minus the Kaplan-Meier risk) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection for 3 coronavirus disease vaccines, Aragon, Spain, January–May 2021. A) BioNTech-Pfizer BNT162b2 mRNA, B) Moderna mRNA-1273, and C) Oxford-AstraZeneca ChAdOx1-S-AZD1222. Shadows across lines represent 95% CI. For unvaccinated participants, 95% CI at day 90 of follow-up was 2.6%–2.8%. For participants who went on to receive the BioNTech-Pfizer vaccine, 95% CI at day 90 of follow-up was 0.5%–1.4% (1 dose) and 0.3%–0.4% (2 doses). For the Moderna vaccine, 95% CI at day 90 of follow-up was 0.1%–0.2% (1 dose), and 0.2%–0.8% (2 doses). For Oxford-AstraZeneca, 95% CI at day 90 of follow-up was 0.7%–1.0% (1 dose). Cumulative risk curves of SARS-CoV-2 infection start from the day after vaccination when full protection against SARS-CoV-2 infection is thought to begin, according to previous studies (1–3). The hairs on both sides of the lines represent participants lost to follow-up; gaps represent periods of time between losses.

Figure 2. Cumulative risk curves (1 minus the Kaplan-Meier risk) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection for 3 coronavirus disease vaccines, Aragon, Spain, January–May 2021. A) BioNTech-Pfizer BNT162b2 mRNA, B) Moderna mRNA-1273, and C) Oxford-AstraZeneca ChAdOx1-S-AZD1222. Shadows across lines represent 95% CI. For unvaccinated participants, 95% CI at day 90 of follow-up was 2.6%–2.8%. For participants who went on to receive the BioNTech-Pfizer vaccine, 95% CI at day 90 of follow-up was 0.5%–1.4% (1 dose) and 0.3%–0.4% (2 doses). For the Moderna vaccine, 95% CI at day 90 of follow-up was 0.1%–0.2% (1 dose), and 0.2%–0.8% (2 doses). For Oxford-AstraZeneca, 95% CI at day 90 of follow-up was 0.7%–1.0% (1 dose). Cumulative risk curves of SARS-CoV-2 infection start from the day after vaccination when full protection against SARS-CoV-2 infection is thought to begin, according to previous studies (1–3). The hairs on both sides of the lines represent participants lost to follow-up; gaps represent periods of time between losses.

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Page created: December 14, 2021
Page updated: February 21, 2022
Page reviewed: February 21, 2022
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