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Volume 28, Number 11—November 2022
Research

Differences in SARS-CoV-2 Clinical Manifestations and Disease Severity in Children and Adolescents by Infecting Variant

Ana Maria Quintero, Mariah Eisner, Rouba Sayegh, Tori Wright, Octavio Ramilo, Amy L. Leber, Huanyu Wang1Comments to Author , and Asuncion Mejias1Comments to Author 
Author affiliations: Nationwide Children’s Hospital, Columbus, Ohio, USA (A.M. Quintero, R. Sayegh, T. Wright, O. Ramilo, A.L. Leber, H. Wang, A. Mejias); Biostatistics Resource at Nationwide Children’s Hospital, Columbus (M. Eisner); The Ohio State University, Columbus (M. Eisner, O. Ramilo, H. Wang, A. Mejias)

Main Article

Figure 4

SARS-CoV-2 viral loads and viral co-infections among children and adolescents with COVID-19 at Nationwide Children’s Hospital, Columbus, Ohio, USA, by the infecting SARS-CoV-2 variant, January 1, 2021–January 15, 2022. A) Nasopharyngeal SARS-CoV-2 viral loads expressed as Ct values according to the infecting SARS-CoV-2 variant in the clinical cohort (n = 676). Percentage of total infections for each variant is below each bar. B) Viral co-infections by SARS-CoV-2 variant during the study period in patients that underwent multiplex viral testing. Twelve patients with other variants tested negative for viral co-infections (not shown). Percentage of total co-infections is above each bar. p value was determined by χ2 test. C) Nasopharyngeal SARS-CoV-2 Ct values by infecting SARS-CoV-2 variant among inpatients with acute COVID-19, excluding patients with MIS-C, SARS-CoV-2 detected by screening in inpatients, and those infected with uncommon SARS-CoV-2 strains. p value at bottom right represents the overall Kruskal-Wallis p value; values above bars indicate ad hoc pairwise comparisons by Dunn multiple test correction. For box plots in panels A and C, horizontal lines within boxes indicate medians; box tops and bottoms indicate interquartile ranges; error bars indicate 95% CIs. AdV, adenovirus; HCoV, human coronavirus; hPMV, human metapneumovirus; MIS-C, multisystem inflammatory syndrome in children; NS, not significant. PIV, parainfluenza virus; RSV, respiratory syncytial virus; RV, rhinovirus.

Figure 4. SARS-CoV-2 viral loads and viral co-infections among children and adolescents with COVID-19 at Nationwide Children’s Hospital, Columbus, Ohio, USA, by the infecting SARS-CoV-2 variant, January 1, 2021–January 15, 2022. A) Nasopharyngeal SARS-CoV-2 viral loads expressed as Ct values according to the infecting SARS-CoV-2 variant in the clinical cohort (n = 676). Percentage of total infections for each variant is below each bar. B) Viral co-infections by SARS-CoV-2 variant during the study period in patients that underwent multiplex viral testing. Twelve patients with other variants tested negative for viral co-infections (not shown). Percentage of total co-infections is above each bar. p value was determined by χ2 test. C) Nasopharyngeal SARS-CoV-2 Ct values by infecting SARS-CoV-2 variant among inpatients with acute COVID-19, excluding patients with MIS-C, SARS-CoV-2 detected by screening in inpatients, and those infected with uncommon SARS-CoV-2 strains. p value at bottom right represents the overall Kruskal-Wallis p value; values above bars indicate ad hoc pairwise comparisons by Dunn multiple test correction. For box plots in panels A and C, horizontal lines within boxes indicate medians; box tops and bottoms indicate interquartile ranges; error bars indicate 95% CIs. AdV, adenovirus; HCoV, human coronavirus; hPMV, human metapneumovirus; MIS-C, multisystem inflammatory syndrome in children; NS, not significant. PIV, parainfluenza virus; RSV, respiratory syncytial virus; RV, rhinovirus.

Main Article

1These authors contributed equally to and co-directed this work.

Page created: October 06, 2022
Page updated: October 21, 2022
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