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Volume 26, Number 3—March 2020
Research

Acquisition of Plasmid with Carbapenem-Resistance Gene blaKPC2 in Hypervirulent Klebsiella pneumoniae, Singapore

Yahua Chen, Kalisvar Marimuthu, Jeanette Teo, Indumathi Venkatachalam, Benjamin Pei Zhi Cherng, Liang De Wang, Sai Rama Sridatta Prakki, Weizhen Xu, Yi Han Tan, Lan Chi Nguyen, Tse Hsien Koh, Oon Tek Ng, and Yunn-Hwen GanComments to Author 
Author affiliations: National University of Singapore, Singapore (Y. Chen, Y.H. Tan, L.C. Nguyen, Y.-H. Gan); National Centre for Infectious Diseases, Singapore (K. Marimuthu, L.D. Wang, S.R.S. Prakki, W. Xu, O.T. Ng); Tan Tock Seng Hospital, Singapore (K. Marimuthu, O.T. Ng); National University Hospital, Singapore (J. Teo); Singapore General Hospital, Singapore (I. Venkatachalam, B.P.Z. Cherng, T.H. Koh); Nanyang Technological University, Singapore (O.T. Ng)

Main Article

Table 3

MICs of antimicrobial drugs against 3 carbapenem-resistant hypervirulent Klebsiella pneumoniae isolates from patient A2, Singapore, 2013–2014, compared with reference strain SGH10*

Antimicrobial drug group and drug SGH10 ENT494 ENT646 ENT1734
Penicillins
Ampicillin >64 >64 >64 >64
Piperacillin
 32
 >64
 >64
 >64
Cephems
Ceftriaxone
 <1
 >64
 >64
 >64
Carbapenems
Imipenem <1 >64 >64 >64
Meropenem
 <1
 8
 16
 8–16
Aminoglycosides
Amikacin <1 <1 2–4 4–8
Gentamicin <1 <1 <1 <1
Kanamycin
 2
 4
 16
 32
Tetracyclines
Doxycycline
 <1
 2
 2
 2
Fluoroquinolones
Ciprofloxacin <1 <1 8 <1
Levofloxacin
 <1
 <1
 <1
 <1
Folate pathway antagonists
Sulfamethoxazole 128 512 512 >512
Trimethoprim
 <1
 <1
 >64
 <1
Phenicols
Chloramphenicol
 4
 4–8
 4–8
 4
Fosfomycins
Fosfomycin
 >64
 >64
 >64
 >64
Lipopeptides
Colistin 4 2 2–4 2–4
Polymyxin B 4 4 4 4

*Bold numbers indicate resistance as interpreted by Clinical and Laboratory Standards Institute interpretative criteria for MICs (38).

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