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Volume 25, Number 11—November 2019
Research Letter

Drug-Susceptible and Multidrug-Resistant Mycobacterium tuberculosis in a Single Patient

Anthony Baffoe-Bonnie, Eric R. Houpt, Lauren Turner, Denise Dodge, and Scott K. HeysellComments to Author 
Author affiliations: Virginia Polytechnic Institute and State University Carilion School of Medicine, Roanoke, Virginia, USA (A. Baffoe-Bonnie); University of Virginia, Charlottesville, Virginia, USA (E.R. Houpt, S.K. Heysell); Division of Consolidated Laboratory Services, Richmond, Virginia, USA (L. Turner); Virginia Department of Health, Richmond (D. Dodge)

Main Article

Table

Characteristics of cases of treatment failure resulting from concurrent infection with mixed strains of drug-resistant Mycobacterium tuberculosis*

Patient age, y/sex Immune status Site(s) of infection Time to recurrence Platform for strain identification Patient country of origin Country of diagnosis Reference
24/M
 Immunocompetent
 Lymph node, gastric aspirate
 100 d
 Mixed-linker fingerprint PCR
 Nepal
 Germany
 (1)
23/M
 HIV negative
 Pulmonary
 150 d
 Spoligotyping and MIRU
 Somalia
 USA
 (4)
24/M
 HIV negative
 Pulmonary, gastric aspirate
 90 d
 IS6110 RFLP and spoligotyping
 Kazakhstan
 Germany
 (2)
62/M
 HIV negative
 Pulmonary
 120 d
 MIRU-VNTR
 Portugal
 UK
 (3)
28/M HIV positive Lymph node, trachea 84 d Spoligotyping and WGS Philippines USA This study

*IS, insertion sequence; MIRU-VNTR, mycobacterial interspersed repetitive unit–variable number tandem repeat; RFLP, restriction fragment length polymorphism; WGS, whole genome sequencing.

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Page updated: October 15, 2019
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