CDC logo, Safer Healthier People  CDC HomeCDC SearchCDC Health Topics A-Z
NIOSH - National Institute for Occupational Safety and Health

Search NIOSH  |  NIOSH Home  |  NIOSH Topics  |  Site Index  |  Databases and Information Resources  |  NIOSH Products  |  Contact Us






Triethylamine

RTECS #: YE0175000

CAS #: 121-44-8


UPDATE: May 2009 MW: 101.22 MF: C6H15N


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. (Diethylamino) ethane
  2. Ethanamine, N,N - diethyl -
  3. N,N - Diethylethanamine
  4. TEN
  1. Triaethylamin (German)
  2. Triethylamine (ACGIH:OSHA)
  3. Trietilamina (Italian)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
skin
rabbit
365 mg open irritation test mild UCDS** 3/23/1970


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis inhalation
rat
1 mg/m3 GISAAA 36(11),9,1971


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
guinea pig
lowest published lethal concentration: 1,000 ppm/4 hour N/R JIHTAB 30,2,1948
inhalation
human
lowest published toxic concentration: 12 mg/m3/11 week- continuous Eye: Visual field changes IAEHDW 57,297,1986
inhalation
human
lowest published toxic concentration: 6,500 g/m3/4 hour Eye: Visual field changes

Eye: Corneal damage

Eye: Other eye effects
OEMEEM 56,1,1999
inhalation
human
lowest published toxic concentration: 20 mg/m3/8 hour Eye: Corneal damage WDZAEK 4,45,1990
inhalation
mammal (species unspecified)
lethal concentration (50 percent kill): 6 gm/m3 N/R TPKVAL 14,80,1975
inhalation
mammal (species unspecified)
lowest published toxic concentration: 0.1 gm/m3 Eye: Lacrimation

Eye: Conjunctiva irritation
TPKVAL 7,56,1965
inhalation
mouse
lethal concentration (50 percent kill): 6 gm/m3 Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Other changes

Liver: Fatty liver degeneration
TPKVAL 7,56,1965
inhalation
mouse
lowest published toxic concentration: 0.5 gm/m3 Eye: Corneal damage TPKVAL 7,56,1965
inhalation
mouse
lowest published lethal concentration: 5 gm/m3 Lung, Thorax, or Respiration: Respiratory depression

Liver: Fatty liver degeneration

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)
TPKVAL 7,56,1965
inhalation
rat
lowest published lethal concentration: 1,000 ppm/4 hour N/R AMIHBC 4,119,1951
inhalation
rat
lowest published toxic concentration: 0.2 gm/m3 Skin: After systemic exposure: Dermatitis, other TPKVAL 7,56,1965
inhalation
rat
lowest published lethal concentration: 6 gm/m3 Vascular: Other changes

Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Respiratory depression
TPKVAL 7,56,1965
intraperitoneal
mouse
lethal dose (50 percent kill): 405 mg/kg N/R YKKZAJ 97,1117,1977
intraperitoneal
rat
lowest published lethal dose: 75 mg/kg N/R FATOAO 31,238,1968
ocular
rabbit
lowest published toxic dose: 100 pph Eye: Lacrimation

Eye: Conjunctiva irritation
TPKVAL 7,56,1965
oral
mouse
lethal dose (50 percent kill): 546 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Excitement

Behavioral: Muscle weakness
HYSAAV 30(7-9),351,1965
oral
rat
lethal dose (50 percent kill): 460 mg/kg N/R AMIHBC 4,119,1951
skin
mouse
lowest published toxic dose: 100 pph/10 minute Skin: After topical application: Corrosive TPKVAL 7,56,1965
skin
rabbit
lethal dose (50 percent kill): 570 L/kg N/R AMIHBC 4,119,1951


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lowest published toxic concentration: 3 mg/m3/3 hour/26 week- intermittent Lung, Thorax, or Respiration: Other changes WDZAEK 4,45,1990
inhalation
rat
lowest published toxic concentration: 1 gm/m3/2 week- intermittent Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi
TPKVAL 7,56,1965
inhalation
rat
lowest published toxic concentration: 0.5 gm/m3/0.5 year- intermittent Liver: Other changes

Blood: Changes in spleen

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TPKVAL 7,56,1965
inhalation
rat
lowest published toxic concentration: 0.5 gm/m3/30 day- intermittent Peripheral Nerve and Sensation: Recording from peripheral motor nerve

Blood: Other changes
TPKVAL 7,56,1965
inhalation
rat
lowest published toxic concentration: 0.5 gm/m3/20 day- intermittent Behavioral: Alteration of classical conditioning TPKVAL 7,56,1965
inhalation
rabbit
lowest published toxic concentration: 420 mg/m3/7 hour/6 week- intermittent Cardiac: Other changes

Lung, Thorax, or Respiration: Other changes

Liver: Other changes
WDZAEK 4,45,1990
oral
rat
lowest published toxic dose: 4,223 mg/kg/11 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain GISAAA 30(9),28,1965
oral
rat
lowest published toxic dose: 210 mg/kg/30 week- intermittent Brain and Coverings: Other degenerative changes WDZAEK 4,45,1990


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 1 ppm;short term exposure limit 3 ppm (skin) DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not classifiable as human carcinogen DTLVS* TLV/BEI,2007


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 25 ppm (100 mg/m3) DTLVS* 3,268,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 25 ppm (100 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 25 ppm (100 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 25 ppm (100 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 25 ppm (100 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 2 ppm (8 mg/m3), short term exposure limit 4 ppm (17 mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 1 ppm (4.2 mg/m3), MAR2002
Occupational Exposure Limit - BELGIUM short term exposure limit 3 ppm (12.6 mg/m3), Skin, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 1 ppm (4.1 mg/m3), OCT 2002
Occupational Exposure Limit - EC time-weighted average 8.4 mg/m3 (2 ppm);
short term exposure limit 12.6 mg/m3 (skin), FEB 2006
Occupational Exposure Limit - FINLAND time-weighted average 10 mg/m3, short term exposure limit 20 mg/m3, Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 2 ppm (8.4 mg/m3), VLE 3 ppm (12.6 mg/m3), Skin, FEB2006
Occupational Exposure Limit - GERMANY MAK 4.2 mg/m3 (1 mL/m3), 2005
Occupational Exposure Limit - HUNGARY time-weighted average 8.4 mg/m3, short term exposure limit 12.6 mg/m3, Skin, SEP2000
Occupational Exposure Limit - KOREA time-weighted average 10 ppm (40 mg/m3), short term exposure limit 15 ppm (60 mg/m3), 2006
Occupational Exposure Limit - MEXICO time-weighted average 25 ppm (100 mg/m3);
short term exposure limit 40 ppm (160 mg/m3), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 20 mg/m3, Skin, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 3 ppm (12 mg/m3), short term exposure limit 5 ppm (20 mg/m3), skin, JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 10 ppm (40 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 25 ppm (100 mg/m3), JAN1993
Occupational Exposure Limit - RUSSIA short term exposure limit 10 mg/m3, Skin, JUN2003
Occupational Exposure Limit - SWITZERLAND MAK- week 1 ppm (4.2 mg/m3),KZG- week 2 ppm (8.4 mg/m3), DEC2006
Occupational Exposure Limit - TURKEY time-weighted average 25 ppm (100 mg/m3), JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 2 ppm (8 mg/m3);
short term exposure limit 4 ppm (skin), 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not classifiable as human carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not classifiable as human carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 74175;
Number of Industries 15;
Total Number of Facilities 959;
Number of Occupations 21;
Total Number of Employees Exposed 10,558
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X6415;
Number of Industries 1;
Total Number of Facilities 5;
Number of Occupations 1;
Total Number of Employees Exposed 622;
Total Number of Female Employees Exposed 55
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 74175;
Number of Industries 74;
Total Number of Facilities 3,153;
Number of Occupations 52;
Total Number of Employees Exposed 68,091;
Total Number of Female Employees Exposed 9,701


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a solvent, corrosion inhibitor, in chemical synthesis and accelerator activators
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP Carcinogenesis studies; selected, October 2000


REFERENCES:

CODEN
REFERENCE

AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
HYSAAV Hygiene and Sanitation (USSR). English translation of GISAAA. (Springfield, VA) 1964-71. Discontinued.
IAEHDW International Archives of Occupational and Environmental Health. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.35- 1975-
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
OEMEEM Occupational and Environmental Medicine. (BMJ Publishing Group, POB 299, London WC1H 9TD, United Kingdom) V.51- 1994-
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)
WDZAEK Weisheng Dulixue Zazhi. Journal of Health Toxicology. (Weisheng Dulixue Zazhi Bianjibu, Dongdaqiao, Chaoyang Menwai, Beijing, Peop. Rep. China) V.1- 1987
YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881-

Used as a solvent, corrosion inhibitor, in chemical synthesis and accelerator activators

NIOSH PROFILE (AMINES, TERTIARY ALIPHATIC), SRI, 2/77

RTECS Compound Description:
   Tumorigen
   Mutagen
   Human Data
   Primary Irritant

Click Here for Additional Information about RTECS

NIOSH Home |  NIOSH Search  |  Site Index  |  Topic List |  Contact Us