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2 - Propenoic acid, butyl ester

RTECS #: UD3150000

CAS #: 141-32-2


UPDATE: May 2009 MW: 128.19 MF: C7H12O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. Acrylic acid n - butyl ester
  2. Acrylic acid, butyl ester
  3. Butyl 2 - propenoate
  4. Butyl acrylate
  1. Butylester kyseliny akrylove (Czech)
  2. n - Butyl acrylate
  3. n - Butyl acrylate (ACGIH)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
50 mg mild UCDS** 4/5/1973
eye
rabbit
500 mg/24 hour mild 85JCAE -,370,1986
skin
rabbit
10 mg/24 hour open irritation test mild AMIHBC 4,119,1951
skin
rabbit
500 mg open irritation test mild UCDS** 4/5/1973


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 135 ppm/6 hour (6-15 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) FAATDF 3,443,1983
inhalation
rat
lowest published toxic concentration: 135 ppm/6 hour (6-15 day pregnant) Reproductive: Other effects on female

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)
NTIS** OTS0534614
inhalation
rat
lowest published toxic concentration: 200 ppm/6 hour (6-20 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) TOSCF2 48,240,1999
inhalation
rat
lowest published toxic concentration: 200 ppm (6-20 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Other effects on female
TOSCF2 48,240,1999


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mammal (species unspecified)
lethal concentration (50 percent kill): 7,800 mg/m3 N/R GISAAA 51(5),61,1986
inhalation
mouse
lethal concentration (50 percent kill): 7,800 mg/m3/2 hour N/R 85GMAT -,28,1982
inhalation
rat
lethal concentration (50 percent kill): 2,730 ppm/4 hour Olfaction: Other olfaction effects

Eye: Other eye effects

Lung, Thorax, or Respiration: Dyspnea
JTEHD6 16,811,1985
inhalation
rat
lowest published toxic concentration: 5.05 gm/m3/6 hour Liver: Other changes

Endocrine: Hyperglycemia

Biochemical: Metabolism (intermediary): Other
TXCYAC 65,209,1990
intraperitoneal
mouse
lethal dose (50 percent kill): 200 mL/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory stimulation
NTIS** OTS05220809
intraperitoneal
rat
lethal dose (50 percent kill): 550 mg/kg N/R AMPMAR 36,58,1975
oral
mouse
lethal dose (50 percent kill): 5,880 mg/kg Lung, Thorax, or Respiration: Other changes GTPZAB 25(11),57,1981
oral
rat
lethal dose (50 percent kill): 900 mg/kg N/R 85GMAT -,28,1982
oral
rabbit
lowest published lethal dose: 2 mL/kg N/R NTIS** OTS0520808
skin
rat
lowest published lethal dose: 1,700 mg/kg N/R PJPPAA 32,223,1980
skin
rabbit
lethal dose (50 percent kill): 2 mL/kg N/R TXAPA9 28,313,1974


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 211 ppm/6 hour/13 week- intermittent Liver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** OTS0555423
oral
rat
lowest published toxic dose: 13,650 mg/kg/13 week- intermittent Liver: Changes in liver weight TOXID9 2,33,1982
skin
guinea pig
lowest published toxic dose: 5 pph/12 week- intermittent Skin: After topical application: Cutaneous sensitization (experimental) CODEDG 9,55,1983


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 2 ppm (sen) DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not classifiable as human carcinogen DTLVS* TLV/BEI,2007
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 39,67,1986
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 71,359,1999
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 39,67,1986
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Evidence IMEMDT 71,359,1999
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMEMDT 71,359,1999
TOXICOLOGY REVIEW
EVHPAZ 11,141,1975


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - AUSTRALIA time-weighted average 1 ppm (5 mg/m3), short term exposure limit 5 ppm (26 mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 2 ppm (11 mg/m3), short term exposure limit 10 ppm (53 mg/m3), MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 2 ppm (11 mg/m3), OCT 2002
Occupational Exposure Limit - EC time-weighted average 11 mg/m3 (2 ppm);
short term exposure limit 53 mg/m3 (10 ppm), FEB 2006
Occupational Exposure Limit - FINLAND time-weighted average 10 ppm (55 mg/m3), short term exposure limit 20 ppm (110 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 2 ppm (11 mg/m3), VLE 10 ppm (53 mg/m3), FEB2006
Occupational Exposure Limit - GERMANY MAK 11 mg/m3 (2 mL/m3) (skin, sen), 2005
Occupational Exposure Limit - HUNGARY time-weighted average 11 mg/m3, short term exposure limit 53 mg/m3, SEP2000
Occupational Exposure Limit - KOREA time-weighted average 10 ppm (55 mg/m3), 2006
Occupational Exposure Limit - MEXICO time-weighted average 10 ppm (55 mg/m3), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 1 1 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 10 ppm (52 mg/m3), sen, JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 10 ppm (55 mg/m3), JAN1999
Occupational Exposure Limit - POLAND time-weighted average 20 mg/m3, short term exposure limit 70 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA time-weighted average 10 mg/m3, short term exposure limit 30 mg/m3, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 10 ppm (50 mg/m3);
short term exposure limit 15 ppm (80 mg/m3), Sen, JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 2 ppm (11 mg/m3);
KZG- week 4 ppm (22 mg/m3), DEC2006
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 1 ppm (5 mg/m3);
short term exposure limit 5 ppm (26 mg/m3), 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not classifiable as human carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not classifiable as human carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO BUTYL ACRYLATE-air 10 hour time-weighted average 10 ppm NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 84295;
Number of Industries 28;
Total Number of Facilities 2,222;
Number of Occupations 33;
Total Number of Employees Exposed 16,374
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84295;
Number of Industries 33;
Total Number of Facilities 2,948;
Number of Occupations 40;
Total Number of Employees Exposed 39,848;
Total Number of Female Employees Exposed 6,688


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE FEREAC 47,26992,82
Used in emulsion polymers for paints, textiles, adhesives, coatings and binders
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
AMPMAR Archives des Maladies Professionnelles de Medecine du Travail et de Securite Sociale. (SPPIF, B.P.22, F-41353 Vineuil, France) V.7- 1946-
CODEDG Contact Dermatitis. Environmental and Occupational Dermatitis. (Munksgaard International Pub., c/o Publications Expediting Inc., 200 Meacham Ave., Elmont, NY 11003) V.1- 1975-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
PJPPAA Polish Journal of Pharmacology and Pharmacy. (ARS Polona, POB 1001, 00-068 Warsaw 1, Poland) V.25-44, 1973-92. For publisher information, see PJPAE3
TOSCF2 Toxicological Sciences (Oxford University Press, 6277 Sea Harbor Drive, Orlando, FL 32887 ) V. 41, Jan. 1998-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)

Used in emulsion polymers for paints, textiles, adhesives, coatings and binders

NIOSH PROFILE (ACRYLIC ACID and ESTERS), SRC, 12/79

RTECS Compound Description:
   Tumorigen
   Reproductive Effector
   Primary Irritant

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