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Phenol, o - sec - butyl -

RTECS #: SJ8920000

CAS #: 89-72-5


UPDATE: May 2009 MW: 150.24 MF: C10H14O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. REVIEWS:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. 2 - (1 - Methylpropyl) phenol
  2. 2 - (2 - Butyl) phenol
  3. 2 - sec - Butylphenol
  4. 2 - sec.Butylfenol (Czech)
  1. Phenol, 2 - (1 - methylpropyl) - (9CI)
  2. o - sec - Butylphenol
  3. o - sec - Butylphenol (ACGIH)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
50 g/24 hour severe 85JCAE -,224,1986
skin
rabbit
2 mg/24 hour severe 85JCAE -,224,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lethal concentration (50 percent kill): >290 ppm/4 hour N/R NTIS** OTS0572448
intraperitoneal
mouse
lethal dose (50 percent kill): 63 mg/kg N/R JMCMAR 18,868,1975
intravenous
mouse
lethal dose (50 percent kill): 60 mg/kg Behavioral: Sleep JMCMAR 23,1350,1980
oral
guinea pig
lethal dose (50 percent kill): 600 mg/kg N/R 85INA8 5,84,1986
oral
rat
lethal dose (50 percent kill): 320 mg/kg Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Respiratory depression
NTIS** OTS0572448
skin
guinea pig
lethal dose (50 percent kill): 600 mg/kg N/R 85INA8 5,84,1986
skin
rabbit
lethal dose (50 percent kill): 5,560 mg/kg Skin: After systemic exposure: Dermatitis, other NTIS** OTS0572448


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 5 ppm (skin) DTLVS* TLV/BEI,2007


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - AUSTRALIA time-weighted average 5 ppm (31 mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 5 ppm (31 mg/m3), Skin, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 5 ppm (30 mg/m3), OCT 2002
Occupational Exposure Limit - FRANCE VME 5 ppm (30 mg/m3), Skin, FEB2006
Occupational Exposure Limit - KOREA time-weighted average 5 ppm (30 mg/m3), skin, 2006
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 30 mg/m3, Skin, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 5 ppm (31 mg/m3), skin, JAN2002
Occupational Exposure Limit - SWITZERLAND MAK- week 5 ppm (30 mg/m3), Skin, DEC2006
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 5 ppm (31 mg/m3) (skin), 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 5 ppm (skin)
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 5 ppm (skin)


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO o-sec-BUTYLPHENOL-air 10 hour time-weighted average 5 ppm (Sk) NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 83612;
Number of Industries 2;
Total Number of Facilities 41;
Number of Occupations 2;
Total Number of Employees Exposed 316


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

85INA8 "Documentation of the Threshold Limit Values and Biological Exposure Indices," 5th ed., Cincinnati, OH, American Conference of Governmental Industrial Hygienists, Inc., 1986
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.

RTECS Compound Description:
   Primary Irritant

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