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Oxalic acid

RTECS #: RO2450000

CAS #: 144-62-7


UPDATE: May 2009 MW: 90.04 MF: C2H2O4


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. Acide oxalique (French)
  2. Acido ossalico (Italian)
  3. Aktisal
  4. Aquisal
  5. Ethanedioic acid
  6. Ethanedionic acid
  1. Kyselina stavelova (Czech)
  2. NCI - C55209
  3. Oxaalzuur (Dutch)
  4. Oxalic acid (ACGIH:OSHA)
  5. Oxalsaeure (German)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
250 g/24 hour severe 85JCAE -,311,1986
eye
rabbit
100 mg/4S rinse severe FCTOD7 20,573,1982
skin
rabbit
500 mg/24 hour mild 85JCAE -,311,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 8,400 mg/kg (7 day male/7 day prior to copulation-21 day pregnant) Reproductive: Effects on fertility: Other measures of fertility

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
NTIS** PB86-167053
oral
mouse
lowest published toxic dose: 9.63 gm/kg (7 day male/7 day prior to copulation/21 day pregnant) Reproductive: Effects on fertility: Other measures of fertility

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
NTIS** #PB86167053
oral
mouse
lowest published toxic dose: 275 mg/kg (multigenerations) Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)
NTIS** #PB86167053


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
mouse
lethal dose (50 percent kill): 270 mg/kg N/R TXCYAC 62,203,1990
oral
dog
lowest published lethal dose: 1 gm/kg N/R HBAMAK 4,1377,1935
oral
woman
lowest published lethal dose: 600 mg/kg Gastrointestinal: Changes in structure or function of esophagus

Gastrointestinal: Hypermotility, diarrhea

Gastrointestinal: Other changes
YKYUA6 31,959,1980
subcutaneous
cat
lowest published lethal dose: 112 mg/kg N/R HBAMAK 4,1377,1935
subcutaneous
frog
lowest published lethal dose: 757 mg/kg N/R HBAMAK 4,1377,1935
unreported route
rat
lethal dose (50 percent kill): 382 mg/kg N/R HBPTO* 1,824,2001


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
rat
lowest published toxic dose: 225 mg/kg/5 day- intermittent Liver: Other changes

Blood: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport
ARTODN 76,269,2002
oral
mouse
lowest published toxic dose: 2,268 mg/kg/14 day- continuous Behavioral: Fluid intake NTIS** #PB86167053
oral
mouse
lowest published toxic dose: 40,425 mg/kg/21 week- continuous Related to Chronic Data: Changes in prostate weight NTIS** #PB86167053
oral
rat
lowest published toxic dose: 175 gm/kg/70 day- continuous Endocrine: Changes in thyroid weight

Musculoskeletal: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TXAPA9 48,409,1979


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 1 mg/m3;short term exposure limit 2 mg/m3 DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
FNSCA6 2,67,1973
TOXICOLOGY REVIEW
AINCM* 7,63,2006
TOXICOLOGY REVIEW
ENTOX* -,320,2005
TOXICOLOGY REVIEW
EMCNA* 25,375,2007
TOXICOLOGY REVIEW
HUTOX* -,683,1996


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: RED Completed RBREV* -,329,1998
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 1 mg/m3 DTLVS* 3,193,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 1 mg/m3 CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 1 mg/m3 CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 1 mg/m3 CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 1 mg/m3 CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 1 mg/m3, JAN1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 1 mg/m3, short term exposure limit 2 mg/m3, JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 1 mg/m3, short term exposure limit 2 mg/m3, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 1 mg/m3, OCT 2002
Occupational Exposure Limit - EC time-weighted average 1 mg/m3, FEB 2006
Occupational Exposure Limit - FINLAND time-weighted average 1 mg/m3, short term exposure limit 3 mg/m3, JAN1999
Occupational Exposure Limit - FRANCE VME 1 mg/m3, FEB2006
Occupational Exposure Limit - HUNGARY time-weighted average 1 mg/m3, SEP2000
Occupational Exposure Limit - KOREA time-weighted average 1 mg/m3, short term exposure limit 2 mg/m3, 2006
Occupational Exposure Limit - MEXICO time-weighted average 1 mg/m3;
short term exposure limit 2 mg/m3, 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 1 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 1 mg/m3, short term exposure limit 2 ppm, JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 0.01 mg(Ag)/m3, JAN1999
Occupational Exposure Limit - POLAND MAC(time-weighted average) 1 mg/m3, MAC(short term exposure limit) 2 mg/m3, JAN1999
Occupational Exposure Limit - SWEDEN time-weighted average 1 mg/m3;
short term exposure limit 2 mg/m3, JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 1 mg/m3, DEC2006
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 1 mg/m3;
short term exposure limit 2 mg/m3, 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 1 mg/m3;
short term exposure limit 2 mg/m3
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 1 mg/m3;
short term exposure limit 2 mg/m3


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO OXALIC ACID-air 10 hour time-weighted average 1 mg/m3;
short term exposure limit 2 mg/m3
NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 52480;
Number of Industries 109;
Total Number of Facilities 11,395;
Number of Occupations 66;
Total Number of Employees Exposed 180,732
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 52480;
Number of Industries 75;
Total Number of Facilities 6,866;
Number of Occupations 84;
Total Number of Employees Exposed 142,000;
Total Number of Female Employees Exposed 58,727


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in textile finishing, stripping, metal and equipment cleaning and as an intermediate
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AINCM* Anaesthesia and Intensive Care Medicine (Abingdon: Medicine Pub. Co.) V.1- 2000-
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EMCNA*
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
FNSCA6 Forensic Science. (Lausanne, Switzerland) V.1-11, 1972-78. For pub lisher information, see FSINDR.
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.)
HBPTO* Handbook of pesticide toxicology. Robert Krieger ed, Academic press, 2001
HUTOX*
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950-

Used in textile finishing, stripping, metal and equipment cleaning and as an intermediate

NIOSH PROFILE (GLASS and CERAMICS MANUFACTURE), SRC, 6/80

NIOSH PROFILE (OXALIC ACID), SRC, 10/77

RTECS Compound Description:
   Agricultural Chemical
   Reproductive Effector
   Human Data
   Primary Irritant

Click Here for Additional Information about RTECS

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