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Ethane, bromo -

RTECS #: KH6475000

CAS #: 74-96-4


UPDATE: May 2009 MW: 108.98 MF: C2H5Br


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. Bromic ether
  2. Bromoethane
  3. Bromure d'ethyle
  4. Ethyl bromide
  5. Ethyl bromide (ACGIH:OSHA)
  1. Etylu bromek (Polish)
  2. Halon 2001
  3. Hydrobromic ether
  4. Monobromoethane
  5. NCI - C55481


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
DNA damage Saccharomyes cerevisiae 7,300 mg/L/17 hour MUREAV 633,80,2007
mutation in microorganisms Salmonella typhimurium 75 ng/plate (+enzymatic activation step) NTPTR* NTP-TR-363,1989
sister chromatid exchange hamster ovary 100 mg/L EMMUEG 13,60,1989


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lowest published toxic concentration: 200 ppm/6 hour/2 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Reproductive: Tumorigenic effects: Uterine tumors
NTPTR* NTP-TR-363,1989
inhalation
rat
lowest published toxic concentration: 100 ppm/6 hour/2 year- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Brain and Coverings: Tumors
NTPTR* NTP-TR-363,1989


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
cat
lethal concentration (50 percent kill): 550,000 mg/m3/40 minute N/R VCVGH* -,584,1990
inhalation
dog
lowest published lethal concentration: 80,000 mg/m3/1 hour Brain and Coverings: Other degenerative changes

Behavioral: Ataxia
VCVGH* -,584,1990
inhalation
guinea pig
lowest published lethal concentration: 44,000 mg/m3 Behavioral: General anesthetic VCVGH* -,584,1990
inhalation
mouse
lethal concentration (50 percent kill): 16,230 ppm/1 hour Behavioral: Somnolence (general depressed activity)

Gastrointestinal: Hypermotility, diarrhea
AMRL** TR-72-62,1972
inhalation
mouse
lowest published toxic concentration: 85,000 mg/m3/15 minute Behavioral: General anesthetic VCVGH* -,584,1990
inhalation
mouse
lowest published lethal concentration: 15,000 mg/m3/6 hour Cardiac: Other changes

Liver: Fatty liver degeneration

Kidney, Ureter, and Bladder: Other changes
VCVGH* -,584,1990
inhalation
mouse
lethal concentration (50 percent kill): 36,000 mg/m3/2 hour N/R VCVGH* -,572,1990
inhalation
rat
lethal concentration (50 percent kill): 26,980 ppm/1 hour N/R AMRL** TR-72-62,1972
inhalation
rat
lethal concentration (50 percent kill): 534,000 mg/m3/4 hour N/R VCVGH* -,572,1990
inhalation
rabbit
lowest published lethal concentration: 40,000 mg/m3 N/R VCVGH* -,584,1990
intraperitoneal
mouse
lethal dose (50 percent kill): 573 mg/kg N/R VCVGH* -,572,1990
intraperitoneal
rat
lethal dose (50 percent kill): 1,750 mg/kg N/R JPCEAO 320,133,1978
oral
rat
lethal dose (50 percent kill): 1,350 mg/kg N/R 85GMAT -,65,1982


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lowest published toxic concentration: 1 pph/6 hour/14 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTPTR* NTP-TR-363,1989
inhalation
rat
lowest published toxic concentration: 2 pph/6 hour/14 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTPTR* NTP-TR-363,1989
inhalation
rat
lowest published toxic concentration: 1,600 ppm/6 hour/14 week- intermittent Blood: Changes in spleen

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTPTR* NTP-TR-363,1989
inhalation
rat
lowest published toxic concentration: 47 mg/m3/4 hour/20 week- intermittent Liver: Other changes VCVGH* -,585,1990
inhalation
rabbit
lowest published toxic concentration: 47 mg/m3/4 hour/20 week- intermittent Liver: Other changes VCVGH* -,585,1990
subcutaneous
mouse
lowest published toxic dose: 1,500 mg/kg/3 day- intermittent Reproductive: Maternal effects: Uterus, cervix, vagina

Biochemical: Metabolism (intermediary): Other proteins
TXAPA9 209,226,2005
subcutaneous
mouse
lowest published toxic dose: 1,500 mg/kg/3 day- intermittent Reproductive: Maternal effects: Uterus, cervix, vagina TXAPA9 209,226,2005


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 5 ppm (skin) DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Confirmed animal carcinogen DTLVS* TLV/BEI,2007
International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMEMDT 52,299,1991
International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMEMDT 71,1305,1999
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 71,1305,1999
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMEMDT 71,1305,1999
TOXICOLOGY REVIEW
MUREAV 543,201,2003
TOXICOLOGY REVIEW
ENTOX* -,283,2005
TOXICOLOGY REVIEW
MUREAV 584,1,2005
TOXICOLOGY REVIEW
HETOEA 25,413,2006
TOXICOLOGY REVIEW
HTOPA* 1,501,2002


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 200 ppm (890 mg/m3) DTLVS* 3,105,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 200 ppm (890 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 200 ppm (890 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 200 ppm (890 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 200 ppm (890 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 5 ppm (22 mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 5 ppm (22 mg/m3), Skin, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 5 ppm (22 mg/m3), OCT 2002
Occupational Exposure Limit - FINLAND time-weighted average 200 ppm (890 mg/m3), short term exposure limit 250 ppm (1115 mg/m3), JAN1999
Occupational Exposure Limit - FRANCE VME 200 ppm (890 mg/m3), continuous3 Carcinogen, FEB2006
Occupational Exposure Limit - HUNGARY time-weighted average 50 mg/m3, short term exposure limit 50 mg/m3, SEP2000
Occupational Exposure Limit - KOREA time-weighted average 200 ppm (890 mg/m3), short term exposure limit 250 ppm (1110 mg/m3), 2006
Occupational Exposure Limit - MEXICO time-weighted average 200 ppm (890 mg/m3);
short term exposure limit 250 ppm (skin), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 22 mg/m3, Skin, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 5 ppm (22 mg/m3), skin, JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 5 ppm (22 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 300 ppm (890 mg/m3), JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 50 mg/m3, MAC(short term exposure limit) 400 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 5 mg/m3, JUN2003
Occupational Exposure Limit - SWITZERLAND MAK- week 5 ppm (22 mg/m3), Skin, Carcinogen, DEC2006
Occupational Exposure Limit - TURKEY time-weighted average 200 ppm (890 mg/m3), JAN1993
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Confirmed animal carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Confirmed animal carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 31900;
Number of Industries 1;
Total Number of Facilities 14;
Number of Occupations 1;
Total Number of Employees Exposed 196
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 31900;
Number of Industries 15;
Total Number of Facilities 1,452;
Number of Occupations 13;
Total Number of Employees Exposed 12,285;
Total Number of Female Employees Exposed 1,535


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as an industrial chemical, pharmaceutical and veterinary drug
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Ethyl bromide, 1011
NCI Carcinogenesis Studies (inhal);clear evidence:mouse
NTP Carcinogenesis Studies (inhalation);some evidence:rat NTPTR* NTP-TR-363,1989
NCI Carcinogenesis Studies (inhal);equivocal evidence:rat


REFERENCES:

CODEN
REFERENCE

85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
AMRL** Aerospace Medical Research Laboratory Report. (Aerospace Technical Div., Air Force Systems Command, Wright-Patterson Air Force Base, OH 45433)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
HETOEA Human & Experimental Toxicology. (Macmillan Press Ltd., Brunel Road, Houndmills, Basingstoke, Hampshire, RG21 2XS, UK) V.9- 1990-
HTOPA*
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
JPCEAO Journal fuer Praktische Chemie. (Johann Ambrosius Barth Verlag, Postfach 109, Leipzig DDR-7010, Ger. Dem. Rep.) V.1- 1834-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VCVGH* "Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances: Galogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990.

Used as an industrial chemical, pharmaceutical and veterinary drug

NIOSH PROFILE (ALIPHATICS, BROMINATED), SRI, 2/77

RTECS Compound Description:
   Tumorigen
   Mutagen

Click Here for Additional Information about RTECS

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