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Dimethylamine, N - nitroso -

RTECS #: IQ0525000

CAS #: 62-75-9


UPDATE: May 2009 MW: 74.10 MF: C2H6N2O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. DMN
  2. DMNA
  3. Dimethylnitrosamin (German)
  4. Dimethylnitrosamine
  5. Dimethylnitrosoamine
  6. Dimethylnitrosoamine (OSHA)
  7. Methanamine, N - methyl - N - nitroso - (9CI)
  8. N,N - Dimethylnitrosamine
  1. N - Methyl - N - nitrosomethanamine
  2. N - Nitroso - N,N - dimethylamine
  3. N - Nitrosodimethylamine
  4. N - Nitrosodimethylamine (ACGIH:OSHA)
  5. NDMA
  6. Nitrosodimethylamine
  7. RCRA waste number P082


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
body fluid assay rat
ovary
320 mg/kg MUREAV 143,263,1985
cytogenetic analysis cattle lymphocyte 60 mol/L MUREAV 290,311,1993
cytogenetic analysis hamster embryo 100 mmol/L PJABDW 56,41,1980
cytogenetic analysis intraperitoneal
hamster
20 mg/kg CGCYDF 10,23,1983
cytogenetic analysis hamster lung 500 mg/L GMCRDC 27,95,1981
cytogenetic analysis hamster fibroblast 40 mmol/L MUREAV 51,397,1978
cytogenetic analysis hamster ovary 1,110 mol/L MOTOEX 1,217,1987
cytogenetic analysis hamster lung 1,000 mg/L/6 hour (+enzymatic activation step) FCTOD7 40,599,2002
cytogenetic analysis human HeLa cell 10 mol/L TXCYAC 9,21,1978
cytogenetic analysis human lymphocyte 50 mmol/L ARTODN 39,159,1977
cytogenetic analysis mouse other cell types 2 mg/L (+enzymatic activation step) TCMUD8 23(Suppl 1),137,2003
cytogenetic analysis subcutaneous
rat
40 mg/kg NULSAK 23,121,1980
cytogenetic analysis rat liver 45 mol/L CRNGDP 8,1077,1987
cytogenetic analysis oral
rat
20 mg/kg MUREAV 251,59,1991
cytogenetic analysis inhalation
rat
10 mg/kg/10 day MUREAV 577S,1,2005
dominant lethal test oral
Drosophila melanogaster
10 mmol/L RPZHAW 33,215,1982
dominant lethal test intraperitoneal
mouse
4,400 g/kg MGGEAE 117,197,1972
dominant lethal test subcutaneous
mouse
45 mg/kg ATXKA8 28,135,1971
DNA adduct human lung 27,600 nmol/L CNREA8 37,2309,1977
DNA adduct human other cell types 1,300 nmol PAACA3 24,65,1983
DNA adduct human other cell types 4,100 nmol PAACA3 24,65,1983
DNA adduct mouse other cell types 5 mol PAACA3 24,65,1983
DNA adduct mouse other cell types 72 mol PAACA3 24,65,1983
DNA adduct rat other cell types 175 mol PAACA3 24,65,1983
DNA adduct rat other cell types 6,300 nmol PAACA3 24,65,1983
DNA damage intraperitoneal
gerbil
100 g/kg CNREA8 43,1306,1983
DNA damage intraperitoneal
hamster
10 g/kg CNREA8 39,50,1979
DNA damage hamster lung 3 mmol/L MUREAV 187,181,1987
DNA damage hamster ovary 5 mmol/L MUREAV 77,259,1980
DNA damage hamster liver 50 mol/L EMMUEG 15,24,1990
DNA damage hamster lung 2 mg/L/3 hour (+enzymatic activation step) MUREAV 536,27,2003
DNA damage human kidney 32 mmol/L MUREAV 368,41,1996
DNA damage human other cell types 90 mmol/L MUREAV 441,215,1999
DNA damage human liver 5 mmol/L TOSCF2 53,71,2000
DNA damage human liver 1 mmol/L/4 hour TXAPA9 182,219,2002
DNA damage human ovary 2 mmol/L MUREAV 575,17,2005
DNA damage human lung 2.5 mmol/L/20 hour MUREAV 605,94,2006
DNA damage human liver 100 mol/L/24 hour MUREAV 657,133,2008
DNA damage mammal (species unspecified) kidney 1 mmol/L JTEHD6 6,333,1980
DNA damage mammal (species unspecified) lymphocyte 430 mol/L MUREAV 135,87,1984
DNA damage mouse other cell types 1 mol/L MUREAV 213,185,1989
DNA damage multiple
mouse
57,400 g/kg/6 week- continuous CBINA8 4,321,1971/1972
DNA damage intraperitoneal
mouse
5,700 g/kg MUREAV 54,39,1978
DNA damage oral
mouse
15 mg/kg IJCNAW 17,765,1976
DNA damage intraperitoneal
mouse
5 mg/kg CRNGDP 19,731,1998
DNA damage oral
mouse
0.135 mmol/kg MUREAV 539,65,2003
DNA damage oral
other insects
0.25 mol/tube MUREAV 480-481,139,2001
DNA damage unreported route
rat
5 mg/kg CBINA8 15,101,1976
DNA damage intravenous
rat
1 g/kg CNREA8 41,3128,1981
DNA damage intraperitoneal
rat
5 mg/kg CALEDQ 40,203,1988
DNA damage oral
rat
22 g/kg CNREA8 47,3485,1987
DNA damage parenteral
rat
2 mg/kg NATUAS 248,153,1974
DNA damage rat other cell types 1 mmol/L CRNGDP 5,1453,1984
DNA damage rat kidney 32 mmol/L MUREAV 368,41,1996
DNA damage rat liver 5 mmol/L TOSCF2 53,71,2000
DNA damage rat liver 1 mmol/L/4 hour TXAPA9 182,219,2002
DNA damage rat other cell types 10 mmol/L/16 hour BCPCA6 68,523,2004
DNA damage rat lung 2.5 mmol/L/20 hour MUREAV 605,94,2006
DNA damage rat liver 100 mol/L/3 hour MUREAV 629,49,2007
DNA damage rat liver 1 mmol/L/20 hour MUREAV 564,21,2004
DNA inhibition human HeLa cell 100 mmol/L/1 hour- continuous JEPTDQ 2(1),65,1978
DNA inhibition intraperitoneal
mouse
20 gm/kg ARGEAR 51,605,1981
DNA inhibition parenteral
mouse
20 mg/kg RCOCB8 21,281,1978
DNA inhibition intraperitoneal
rat
9 mg/kg CBINA8 27,81,1979
DNA inhibition subcutaneous
rat
12,500 g/kg BIMDB3 20,119,1974
DNA repair Bacillus subtilis 25 gm/L EVSRBT 24,19,1981
DNA repair Escherichia coli 50 ng/well MUREAV 46,53,1977
DNA repair human liver 5 mmol/L/20 hour MUREAV 536,69,2003
DNA repair rat liver 5 mmol/L/20 hour MUREAV 536,69,2003
unscheduled DNA synthesis hamster liver 100 mol/L ENMUDM 6,1,1984
unscheduled DNA synthesis hamster lung 10 mol/L ENMUDM 6,454,1984
unscheduled DNA synthesis human other cell types 1,300 mol/L MUREAV 235,81,1990
unscheduled DNA synthesis human fibroblast 1 mmol/L/1 hour IJCNAW 16,284,1975
unscheduled DNA synthesis human HeLa cell 100 mol/L CNREA8 38,2621,1978
unscheduled DNA synthesis human other cell types 1 mmol/L JJIND8 69,557,1982
unscheduled DNA synthesis human liver 1 mmol/L BANRDU 13,101,1982
unscheduled DNA synthesis human other cell types 30 mg/L MUREAV 271,201,1992
unscheduled DNA synthesis human liver 10 mmol/L/44 hour MUREAV 559,211,2004
unscheduled DNA synthesis monkey liver 5 mmol/L MUREAV 206,91,1988
unscheduled DNA synthesis oral
mouse
1,200 g/kg BBRCA9 58,242,1974
unscheduled DNA synthesis mouse liver 10 mol/L TOPADD 12,119,1984
unscheduled DNA synthesis intraperitoneal
mouse
3 mg/kg TXAPA9 53,357,1980
unscheduled DNA synthesis subcutaneous
mouse
150 mg/kg PSEBAA 145,1339,1974
unscheduled DNA synthesis other fish liver 100 mol/L NCIMAV 65,163,1984
unscheduled DNA synthesis subcutaneous
rat
1,560 g/kg BIMDB3 20,119,1974
unscheduled DNA synthesis rat liver 30 mg/L MUREAV 124,299,1983
unscheduled DNA synthesis oral
rat
625 g/kg MUREAV 344,109,1995
unscheduled DNA synthesis intraperitoneal
rat
1 mg/kg CRNGDP 3,1071,1982
unscheduled DNA synthesis rat other cell types 1 mmol/L CRNGDP 5,773,1984
unscheduled DNA synthesis rat other cell types 5 mmol/L PAACA3 25,106,1984
unscheduled DNA synthesis inhalation
rat
500 ppm/4 hour PAACA3 25,106,1984
unscheduled DNA synthesis rat other cell types 5 mmol/L CRNGDP 5,1453,1984
unscheduled DNA synthesis intravenous
rat
10 mg/kg TCMUD8 23(Suppl 1),137,2003
host-mediated assay mammal (species unspecified)
Escherichia coli
100 mg/kg ARZNAD 24,1422,1974
host-mediated assay mouse
leukocyte
2,500 g/kg CNREA8 34,3073,1974
host-mediated assay mouse
Schizosaccharomyces pombe
1 mg/kg MUREAV 85,57,1981
host-mediated assay mouse
Salmonella typhimurium
24,200 g/kg MGGEAE 117,197,1972
host-mediated assay mouse
Serratia marcescens
12 mg/kg/2 hour MGGEAE 117,197,1972
host-mediated assay mouse
Saccharomyes cerevisiae
10 mol/kg AGACBH 3,99,1973
host-mediated assay mouse
Escherichia coli
15 mg/kg MUREAV 25,187,1974
host-mediated assay mouse
other cell types
2 mg/kg MUREAV 207,57,1988
host-mediated assay rat
Saccharomyes cerevisiae
3,705 mg/kg MUREAV 31,381,1975
host-mediated assay rat
Salmonella typhimurium
600 g/kg ENMUDM 1,277,1979
mutation in microorganisms Aspergillus nidulans 20,096 g/plate (-enzymatic activation step) MUREAV 80,265,1981
mutation in microorganisms Escherichia coli 140 nmol/plate (+enzymatic activation step) MUREAV 135,87,1984
mutation in microorganisms hamster lung 100 mol/L (+enzymatic activation step) CRNGDP 6,1403,1985
mutation in microorganisms hamster ovary 150 mol/L (+enzymatic activation step) MOTOEX 1,217,1987
mutation in microorganisms mouse mammary gland 10 mmol/L (+enzymatic activation step) MUREAV 30,249,1975
mutation in microorganisms mouse lymphocyte 100 g/L (+enzymatic activation step) ENMUDM 9,331,1987
mutation in microorganisms Neurospora crassa 100 nmol/L (-enzymatic activation step) MUREAV 3,537,1966
mutation in microorganisms Neurospora crassa 90 mmol/L (+enzymatic activation step) MUREAV 31,195,1975
mutation in microorganisms other microorganisms 1 pph/72 hour- continuous (-enzymatic activation step) SOGEBZ 10,522,1974
mutation in microorganisms Salmonella typhimurium 50 L/plate (+enzymatic activation step) MUREAV 54,101,1978
mutation in microorganisms Salmonella typhimurium 10 mmol/L (-enzymatic activation step) CALEDQ 47,63,1989
mutation in microorganisms Salmonella typhimurium 0.2 mol/plate/48 hour (-enzymatic activation step) MUREAV 484,61,2001
mutation in microorganisms Salmonella typhimurium 20 g/plate/48 hour (+enzymatic activation step) MUTAEX 16,523,2001
mutation in microorganisms Salmonella typhimurium 135 nmol/plate/48 hour (+enzymatic activation step) MUREAV 541,123,2003
mutation in microorganisms Salmonella typhimurium 1 mg/plate (+enzymatic activation step) MUTAEX 16,479,2001
mutation in microorganisms Salmonella typhimurium 360 mg/L/2 hour (+enzymatic activation step) MUREAV 578,210,2005
mutation in microorganisms Saccharomyes cerevisiae 450 mmol/L (-enzymatic activation step) BBRCA9 83,14,1978
mutation in microorganisms Saccharomyes cerevisiae 350 mmol/L (+enzymatic activation step) MUREAV 45,309,1977
mutation in microorganisms Saccharomyes cerevisiae 50 mg/L/18 hour (+enzymatic activation step) MUREAV 653,63,2008
mutation in microorganisms Saccharomyes cerevisiae 50 mg/L/18 hour (+enzymatic activation step) MUREAV 653,63,2008
micronucleus test intraperitoneal
hamster
10 mg/kg MUREAV 43,255,1977
micronucleus test human liver 5 mmol/L MUREAV 414,37,1998
micronucleus test human liver 10 mmol/L/4 hour MUREAV 536,79,2003
micronucleus test inhalation
mouse
1,030 mg/m3 NEZAAQ 40,280,1985
micronucleus test intraperitoneal
mouse
10 mg/kg MUREAV 278,103,1992
micronucleus test oral
mouse
12,500 g/kg MUREAV 97,43,1982
micronucleus test parenteral
rat
30 mg/kg ZKKOBW 84,135,1975
micronucleus test rat liver 5 mmol/L TOSCF2 53,71,2000
micronucleus test intraperitoneal
rat
5 mg/kg MUREAV 583,133,2005
micronucleus test oral
rat
5 mg/kg MUREAV 583,133,2005
gene conversion and mitotic recombination Aspergillus nidulans 20,096 g/plate MUREAV 80,265,1981
gene conversion and mitotic recombination Chlamydomonas reinhardi 68 mol/L CUGED5 10,393,1986
gene conversion and mitotic recombination Drosophila melanogaster 0.1 mmol/L MUREAV 514,193,2002
gene conversion and mitotic recombination oral
Drosophila melanogaster
1 mmol/L/48 hour MUTAEX 19,187,2004
gene conversion and mitotic recombination Saccharomyes cerevisiae 5 mmol/L MUREAV 108,161,1983
gene conversion and mitotic recombination Saccharomyes cerevisiae 200 mmol/L/3 hour (-enzymatic activation step) EMMUEG 36,97,2000
gene conversion and mitotic recombination Saccharomyes cerevisiae 200 mmol/L/3 hour (+enzymatic activation step) EMMUEG 36,97,2000
mutation in mammalian somatic cells intraperitoneal
hamster
200 mg/kg TOLED5 2,277,1978
mutation in mammalian somatic cells hamster lung 100 mol/L ENMUDM 6,454,1984
mutation in mammalian somatic cells hamster ovary 100 mg/L ENMUDM 6,539,1984
mutation in mammalian somatic cells hamster ovary 200 mg/L/5 hour (-enzymatic activation step) JAPTO* 21,449,2001
mutation in mammalian somatic cells hamster ovary 200 mg/L/5 hour (+enzymatic activation step) JAPTO* 21,449,2001
mutation in mammalian somatic cells human lymphocyte 14 mmol/L MUREAV 128,221,1984
mutation in mammalian somatic cells intraperitoneal
mouse
4 mg/kg/4 day- continuous MUREAV 412,161,1998
mutation in mammalian somatic cells mouse lymphocyte 3,700 mg/L JEPTDQ 4(2-3),327,1980
mutation in mammalian somatic cells rat embryo 100 g/L JTEHD6 4,79,1978
morphological transform hamster kidney 80 g/L BJCAAI 37,873,1978
morphological transform hamster embryo 100 mg/L IJCNAW 19,642,1977
morphological transform oral
hamster
200 mg/kg EVHPAZ 45,119,1982
morphological transform human other cell types 200 g/L CANCAR 47,1543,1981
morphological transform human fibroblast 1 g/L BANRDU 12,3,1982
morphological transform mouse fibroblast 500 g/L JJIND8 67,1303,1981
morphological transform intraperitoneal
rat
60 mg/kg ONCOBS 34,16,1977
morphological transform oral
rat
100 mol/kg CBINA8 43,313,1983
morphological transform rat liver 100 mg/L BJCAAI 28,215,1973
morphological transform rat embryo 1,300 mg/L JJIND8 67,1303,1981
morphological transform oral
rat
16 mg/kg/14 day- intermittent MUREAV 575,61,2005
other mutation test systems Escherichia coli 40 nmol/tube PNASA6 79,5971,1982
other mutation test systems intravenous
mouse
25 mg/kg ARTODN 54,215,1983
other mutation test systems oral
mouse
35 mg/kg CBINA8 21,45,1978
other mutation test systems intraperitoneal
mouse
40 mg/kg CNREA8 44,5110,1984
other mutation test systems intraperitoneal
rat
30 mg/kg BBACAQ 654,31,1981
other mutation test systems intraperitoneal
rat
4 mg/kg BBACAQ 697,336,1982
other mutation test systems Salmonella typhimurium 1,500 mg/L MUREAV 192,239,1987
sister chromatid exchange cattle lymphocyte 6 mol/L MUREAV 290,311,1993
sister chromatid exchange intraperitoneal
hamster
15 mg/kg PSEBAA 158,269,1978
sister chromatid exchange hamster fibroblast 40 mmol/L MUREAV 51,397,1978
sister chromatid exchange hamster ovary 500 g/L ENMUDM 7,1,1985
sister chromatid exchange hamster other cell types 40 mmol/L/30 minute ARTODN 46,61,1980
sister chromatid exchange hamster lung 10 mol/L ENMUDM 6,454,1984
sister chromatid exchange oral
hamster
50 mg/kg MUREAV 113,33,1983
sister chromatid exchange hamster ovary 0.2 gm/L/4 hour (+enzymatic activation step) JAPTO* 22,45,2001
sister chromatid exchange hamster ovary 300 mg/L/2 hour (+enzymatic activation step) JAPTO* 21,449,2001
sister chromatid exchange hamster lung 0.1 mol/L/32 hour MUREAV 580,41,2005
sister chromatid exchange human fibroblast 3 mmol/L ENMUDM 4,203,1982
sister chromatid exchange human lymphocyte 29 mg/L CNREA8 40,4775,1980
sister chromatid exchange intraperitoneal
mouse
120 mol/kg TCMUD8 9,219,1989
sister chromatid exchange mouse lung 15 mg/kg PSEBAA 158,269,1978
sister chromatid exchange intraperitoneal
rat
10 mg/kg MUREAV 107,131,1983
sister chromatid exchange rat liver 100 nmol/L CRNGDP 8,1077,1987
sister chromatid exchange oral
rat
10 mg/kg MUREAV 251,59,1991
sex chromosome loss and nondisjunction parenteral
Drosophila melanogaster
2 mmol/L CBINA8 14,21,1976
sex chromosome loss and nondisjunction oral
Drosophila melanogaster
2,500 mol/L ENMUDM 2,187,1980
specific locus test oral
Drosophila melanogaster
100 mol/L ENMUDM 5,455,1983
specific locus test parenteral
Drosophila melanogaster
1 mmol/L CNREA8 35,3780,1975
specific locus test hamster ovary 700 mg/L PMRSDJ 1,594,1981
specific locus test hamster ovary 0.2 gm/L/24 hour (+enzymatic activation step) JAPTO* 22,45,2001
specific locus test intraperitoneal
mouse
7,500 g/kg ARTODN 38,87,1977
specific locus test mouse other cell types 10 mg/L (+enzymatic activation step) MUREAV 577S,1,2005
sperm morphology intraperitoneal
mouse
2 mg/kg TXCYAC 12,183,1979


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraplacental
rat
lowest published toxic dose: 500 g/kg (13 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death BEXBAN 78,1308,1974
intraperitoneal
mouse
lowest published toxic dose: 10 mg/kg (18 day pregnant) Reproductive: Effects on newborn: Biochemical and metabolic TXCYAC 24,251,1982
intraperitoneal
rat
lowest published toxic dose: 5 mg/kg (12 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death CNREA8 33,2231,1973
intravenous
rat
lowest published toxic dose: 20 mg/kg (10 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death ZEKBAI 71,32,1968
oral
mouse
lowest published toxic dose: 1,940 g/kg (75 day prior to copulation/1-22 day pregnant) Reproductive: Effects on newborn: Stillbirth

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)
RCOCB8 19,311,1978
oral
rat
lowest published toxic dose: 20 mg/kg (20 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) FCTOD7 21,453,1983
oral
rat
lowest published toxic dose: 30 mg/kg (10 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death ZEKBAI 71,32,1968
oral
rat
lowest published toxic dose: 35 mg/kg (8-14 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Other developmental abnormalities
VOONAW 13(5),87,1967
oral
rat
lowest published toxic dose: 30 mg/kg (10 day pregnant) Reproductive: Effects on fertility: Abortion VOONAW 13(5),87,1967
oral
rat
lowest published toxic dose: 35 mg/kg (1-7 day pregnant) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) VOONAW 13(5),87,1967
unreported route
rat
lowest published toxic dose: 7 mg/kg (1-7 day pregnant) Reproductive: Other effects to embryo or fetus IARCCD 4,1,1973


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lowest published toxic concentration: 200 g/m3/45 week- continuous Tumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Liver: Tumors
VOONAW 21(6),107,1975
inhalation
rat
lowest published toxic concentration: 200 g/m3/45 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Kidney, Ureter, and Bladder: Kidney tumors
VOONAW 21(6),107,1975
intramuscular
rat
lowest published toxic dose: 18 mg/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Kidney, Ureter, and Bladder: Kidney tumors
INURAQ 4,39,1966
intraperitoneal
hamster
lowest published toxic dose: 20 mg/kg Tumorigenic: Neoplastic by RTECS criteria

Liver: Tumors
CRNGDP 1,91,1980
intraperitoneal
mouse
lowest published toxic dose: 7 mg/kg Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors
IJCNAW 28,199,1981
intraperitoneal
mouse
toxic dose : 7 mg/kg Tumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Liver: Tumors
CBINA8 1,395,1969/1970
intraperitoneal
mouse
lowest published toxic dose: 1 mg/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors
MUREAV 477,41,2001
intraperitoneal
mouse
lowest published toxic dose: 2.400 mg/kg/7 day- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
CALEDQ 143,81,1999
intraperitoneal
mouse
lowest published toxic dose: 10 mg/kg Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Tumorigenic: Increased incidence of tumors in susceptible strains
TXAPA9 179,21,2002
intraperitoneal
rat
lowest published toxic dose: 30 mg/kg Tumorigenic: Carcinogenic by RTECS criteria

Kidney, Ureter, and Bladder: Kidney tumors
CNREA8 30,2796,1970
intraperitoneal
rat
toxic dose : 40 mg/kg Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Consolidation

Kidney, Ureter, and Bladder: Kidney tumors
BJEPA5 51,587,1970
intraperitoneal
rat
toxic dose : 30 mg/kg Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Kidney, Ureter, and Bladder: Bladder tumors
CRNGDP 5,1003,1984
intraperitoneal
rat
toxic dose : 20 mg/kg Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Kidney, Ureter, and Bladder: Kidney tumors
JSONAU 8,539,1976
intrarenal
rat
lowest published toxic dose: 20 mg/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Kidney, Ureter, and Bladder: Kidney tumors
JJIND8 71,787,1983
intratracheal
hamster
lowest published toxic dose: 12 mg/kg/8 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors
CRNGDP 9,947,1988
intratracheal
hamster
lowest published toxic dose: 12 mg/kg/15 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors
FCTOD7 26,847,1988
intravenous
rat
lowest published toxic dose: 18 mg/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Kidney, Ureter, and Bladder: Kidney tumors
INURAQ 4,39,1966
multiple
rat
lowest published toxic dose: 420 mg/kg/2 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Kidney, Ureter, and Bladder: Kidney tumors
APJAAG 23,87,1973
oral
frog
lowest published toxic dose: 3,076 mg/kg/29 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
BEXBAN 92,1084,1981
oral
hamster
lowest published toxic dose: 13 mg/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors
BJCAAI 46,985,1982
oral
mammal (species unspecified)
lowest published toxic dose: 49 mg/kg/71 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors
IARCCD 14,443,1976
oral
mouse
lowest published toxic dose: 140 g/kg (4 week prior to copulation-3 week after birth) Tumorigenic: Neoplastic by RTECS criteria

Reproductive: Tumorigenic effects: Transplacental tumorigenesis

Lung, Thorax, or Respiration: Tumors
JJIND8 62,1553,1979
oral
mouse
lowest published toxic dose: 80 mg/kg/8 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors
IJCNAW 28,199,1981
oral
mouse
toxic dose : 370 mg/kg/56 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Liver: Tumors
JNCIAM 41,1213,1968
oral
mouse
toxic dose : 11 mg/kg/16 week- continuous Tumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors
PAACA3 25,98,1984
oral
rat
lowest published toxic dose: 30 mg/kg (21 day pregnant) Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Reproductive: Tumorigenic effects: Transplacental tumorigenesis

Kidney, Ureter, and Bladder: Kidney tumors
BEXBAN 78,1308,1974
oral
rat
lowest published toxic dose: 23 mg/kg/2 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors

Liver: Tumors
CNREA8 41,4997,1981
oral
rat
toxic dose : 42 mg/kg/30 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors

Liver: Tumors
CNREA8 41,4997,1981
oral
rat
toxic dose : 114 mg/kg/81 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Liver: Tumors
GISAAA 48(3),19,1983
oral
rat
toxic dose : 336 mg/kg/2 week- continuous Tumorigenic: Neoplastic by RTECS criteria

Kidney, Ureter, and Bladder: Kidney tumors
TOLED5 18(Suppl 1),115,1983
oral
rabbit
lowest published toxic dose: 325 mg/kg/37 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Liver: Tumors
BJCAAI 23,125,1969
subcutaneous
hamster
lowest published toxic dose: 62 mg/kg/44 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
JNCIAM 51,1295,1973
subcutaneous
hamster
lowest published toxic dose: 12 mg/kg (14 day pregnant) Tumorigenic: Neoplastic by RTECS criteria

Reproductive: Tumorigenic effects: Transplacental tumorigenesis

Endocrine: Tumors
ZKKOBW 90,79,1977
subcutaneous
hamster
toxic dose : 74,200 g/kg/53 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
CALEDQ 31,181,1986
subcutaneous
mouse
lowest published toxic dose: 38 mg/kg (17-19 day pregnant) Tumorigenic: Carcinogenic by RTECS criteria

Reproductive: Tumorigenic effects: Transplacental tumorigenesis

Lung, Thorax, or Respiration: Tumors
VOONAW 17(8),75,1971
subcutaneous
mouse
lowest published toxic dose: 70 mg/kg/1 week- continuous Tumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Kidney, Ureter, and Bladder: Kidney tumors
BJCAAI 20,871,1966
subcutaneous
rat
lowest published toxic dose: 24,466 g/kg/20 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors
CNREA8 46,498,1986
skin
mouse
lowest published toxic dose: 800 mg/kg/20 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Bronchogenic carcinoma

Tumorigenic: Increased incidence of tumors in susceptible strains
EJCAAH 16,695,1980
unreported route
rat
lowest published toxic dose: 7 mg/kg (15-21 day pregnant) Tumorigenic: Neoplastic by RTECS criteria

Reproductive: Tumorigenic effects: Transplacental tumorigenesis

Kidney, Ureter, and Bladder: Kidney tumors
IARCCD 4,1,1973


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
dog
lowest published lethal concentration: 16 ppm/4 hour Behavioral: Food intake (animal)

Gastrointestinal: Nausea or vomiting

Nutritional and Gross Metabolic: Body temperature increase
AMIHAB 12,617,1955
inhalation
mouse
lethal concentration (50 percent kill): 57 ppm/4 hour Eye: Other eye effects

Behavioral: Somnolence (general depressed activity)

Blood: Hemorrhage
AMIHAB 12,617,1955
inhalation
rat
lethal concentration (50 percent kill): 78 ppm/4 hour Eye: Other eye effects

Behavioral: Somnolence (general depressed activity)

Blood: Hemorrhage
AMIHAB 12,617,1955
inhalation
rat
lethal concentration (50 percent kill): 78 ppm/4 hour N/R ENTOX* -,255,2005
intraperitoneal
guinea pig
lethal dose (50 percent kill): 13,700 g/kg N/R CRNGDP 5,533,1984
intraperitoneal
hamster
lowest published lethal dose: 30 mg/kg N/R CRNGDP 1,91,1980
intraperitoneal
mouse
lethal dose (50 percent kill): 19 mg/kg N/R EXPEAM 32,495,1976
intraperitoneal
mouse
lowest published toxic dose: 5 mg/kg Liver: Other changes MUREAV 577S,1,2005
intraperitoneal
rat
lethal dose (50 percent kill): 26,500 g/kg Behavioral: Somnolence (general depressed activity)

Gastrointestinal: Other changes

Skin and Appendages: Other: Hair
BJIMAG 11,167,1954
intraperitoneal
rat
lowest published toxic dose: 50 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Food intake (animal)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
FATOAO 46,111,1983
intraperitoneal
rat
lowest published toxic dose: 20 mg/kg Liver: Hepatitis (hepatocellular necrosis), zonal

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases

Biochemical: Metabolism (intermediary): Lipids including transport
FCTOD7 46,1279,2008
intravenous
rat
lowest published lethal dose: 40 mg/kg Behavioral: Somnolence (general depressed activity)

Gastrointestinal: Other changes

Skin and Appendages: Other: Hair
BJIMAG 11,167,1954
oral
dog
lowest published lethal dose: 20 mg/kg Behavioral: Muscle weakness

Gastrointestinal: Nausea or vomiting

Blood: Hemorrhage
BJIMAG 11,167,1954
oral
guinea pig
lowest published lethal dose: 25 mg/kg Liver: Liver function tests impaired

Kidney, Ureter, and Bladder: Changes primarily in glomeruli

Blood: Thrombocytopenia
STGNBT -,183,1999
oral
hamster
lethal dose (50 percent kill): 28 mg/kg Gastrointestinal: Ulceration or bleeding from stomach

Liver: Hepatitis (hepatocellular necrosis), diffuse

Liver: Fatty liver degeneration
JNCIAM 33,341,1964
oral
rat
lethal dose (50 percent kill): 37 mg/kg N/R GISAAA 50(8),81,1985
oral
rat
lowest published toxic dose: 50 mg/kg Liver: Other changes

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
BCPCA6 67,2141,2004
oral
rat
lethal dose (50 percent kill): 26 mg/kg Lung, Thorax, or Respiration: Other changes

Liver: Multiple effects

Blood: Hemorrhage
ENTOX* -,255,2005
oral
rabbit
lowest published lethal dose: 10 mg/kg Liver: Liver function tests impaired

Kidney, Ureter, and Bladder: Changes primarily in glomeruli

Blood: Thrombocytopenia
STGNBT -,183,1999
oral
woman
lowest published lethal dose: 20 mg/kg/2.5 year Gastrointestinal: Ulceration or bleeding from small intestine

Gastrointestinal: Nausea or vomiting

Nutritional and Gross Metabolic: Body temperature increase
ONCOBS 37,273,1980
subcutaneous
hamster
lethal dose (50 percent kill): 17,700 g/kg Lung, Thorax, or Respiration: Other changes

Liver: Other changes

Blood: Other changes
BJCAAI 33,411,1976
subcutaneous
mammal (species unspecified)
lethal dose (50 percent kill): 10 mg/kg Liver: Other changes

Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
AVSCA7 22,501,1981
subcutaneous
rat
lethal dose (50 percent kill): 15 mg/kg Liver: Liver function tests impaired

Kidney, Ureter, and Bladder: Changes primarily in glomeruli

Blood: Thrombocytopenia
STGNBT -,183,1999
unreported route
guinea pig
lowest published lethal dose: 25 mg/kg Blood: Hemorrhage BJIMAG 11,167,1954
unreported route
mouse
lowest published lethal dose: 20 mg/kg Liver: Other changes BJIMAG 11,167,1954
unreported route
rat
lethal dose (50 percent kill): 36 mg/kg N/R GISAAA 45(8),11,1980
unreported route
rat
lowest published toxic dose: 30 mg/kg Liver: Multiple effects FATOAO 48,103,1985
unreported route
rabbit
lowest published lethal dose: 10 mg/kg Liver: Other changes BJIMAG 11,167,1954


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
mouse
lowest published toxic dose: 60 mg/kg/24 day- intermittent Liver: Hepatitis, fibrous (cirrhosis, post- necrotic scarring)

Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
BPBLEO 31,309,2008
intraperitoneal
rat
lowest published toxic dose: 160 mg/kg/4 week- intermittent Liver: Hepatitis, fibrous (cirrhosis, post- necrotic scarring) TOXID9 72,345,2003
intraperitoneal
rat
lowest published toxic dose: 120 mg/kg/4 week- intermittent Liver: Hepatitis, fibrous (cirrhosis, post- necrotic scarring)

Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
CEXPB9 28,522,2001
intraperitoneal
rat
lowest published toxic dose: 90 L/kg/3 week- intermittent Liver: Hepatitis, fibrous (cirrhosis, post- necrotic scarring)

Liver: Changes in liver weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
CBINA8 147,9,2004
intraperitoneal
rat
lowest published toxic dose: 90 L/kg/3 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
CBINA8 147,9,2004
intraperitoneal
rat
lowest published toxic dose: 120 L/kg/4 week- intermittent Liver: Hepatitis, fibrous (cirrhosis, post- necrotic scarring)

Liver: Liver function tests impaired

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
TOXID9 66,365,2002
intraperitoneal
rat
lowest published toxic dose: 150 L/kg/5 week- intermittent Liver: Hepatitis, fibrous (cirrhosis, post- necrotic scarring) TOXID9 60,345,2001
intraperitoneal
rat
: 120 mg/kg/4 week- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Liver: Changes in liver weight
BPBLEO 27,72,2004
intraperitoneal
rat
lowest published toxic dose: 30 mg/kg/3 week- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases JTPAE7 17,205,2004
intraperitoneal
rat
lowest published toxic dose: 120 mg/kg/4 week- intermittent Liver: Hepatitis, fibrous (cirrhosis, post- necrotic scarring)

Liver: Jaundice (or hyperbilirubinemia) hepatocellular

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
CHMED* 3,1,2008
oral
mouse
lowest published toxic dose: 23,800 g/kg/17 week- continuous Immunological Including Allergic: Decrease in cellular immune response

Immunological Including Allergic: Decrease in humoral immune response

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
JTEHD6 37,351,1992
oral
rat
lowest published toxic dose: 156 mg/kg/7 day- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other hydrolases
TXAPA9 16,626,1970
oral
rat
lowest published toxic dose: 412 mg/kg/16 week- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain BJIMAG 11,167,1954
oral
rat
lowest published toxic dose: 28 mg/kg/7 day- intermittent Liver: Hepatitis (hepatocellular necrosis), zonal

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TOSCF2 77,19,2004
oral
rat
lowest published toxic dose: 56 mg/kg/14 day- intermittent Liver: Hepatitis (hepatocellular necrosis), zonal

Biochemical: Metabolism (intermediary): Other proteins

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TOSCF2 77,19,2004
subcutaneous
rat
lowest published toxic dose: 63 mg/kg/3 week- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Metabolism (intermediary): Lipids including transport
GISAAA 50(8),81,1985


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Control as low as possible (skin) DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Confirmed animal carcinogen DTLVS* TLV/BEI,2007
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 17,125,1978
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 17,125,1978
International Agency for Research on Cancer (IARC) Cancer Review Group 2A IMSUDL 7,56,1987
TOXICOLOGY REVIEW
RREVAH 64,77,1976
TOXICOLOGY REVIEW
GMCRDC 17,107,1975
TOXICOLOGY REVIEW
TXAPA9 41,157,1977
TOXICOLOGY REVIEW
85CVA2 5,257,1970
TOXICOLOGY REVIEW
ATXKA8 28,135,1971
TOXICOLOGY REVIEW
APLMAS 107,54,1983
TOXICOLOGY REVIEW
BLFSBY 24,129,1983
TOXICOLOGY REVIEW
MUTAEX 14,141,1999
TOXICOLOGY REVIEW
ONCOBS 37,259,1980
TOXICOLOGY REVIEW
MUREAV 588,88,2005
TOXICOLOGY REVIEW
EMMUEG 44,44,2004
TOXICOLOGY REVIEW
MUTAEX 19,251,2004
TOXICOLOGY REVIEW
DIMON* 39,678,1993
TOXICOLOGY REVIEW
MUREAV 628,31,2007
TOXICOLOGY REVIEW
FCTOD7 44,1699,2006
TOXICOLOGY REVIEW
MUREAV 627,10,2007
TOXICOLOGY REVIEW
MUREAV 627,59,2007
TOXICOLOGY REVIEW
MUREAV 627,59,2007
TOXICOLOGY REVIEW
MUREAV 635,90,2007
TOXICOLOGY REVIEW
MUREAV 635,90,2007
TOXICOLOGY REVIEW
ENTOX* -,249,2005
TOXICOLOGY REVIEW
ENTOX* -,255,2005
TOXICOLOGY REVIEW
MUREAV 584,1,2005
TOXICOLOGY REVIEW
MUREAV 566,183,2004
TOXICOLOGY REVIEW
MUREAV 636,178,2007
TOXICOLOGY REVIEW
MUREAV 635,52,2007
TOXICOLOGY REVIEW
MUREAV 658,124,2008
TOXICOLOGY REVIEW
MUTAEX 19,169,2004
TOXICOLOGY REVIEW
MUTAEX 19,251,2004
TOXICOLOGY REVIEW
MUREAV 659,202,2008
TOXICOLOGY REVIEW
MUTAEX 19,251,2004
TOXICOLOGY REVIEW
MUREAV 659,202,2008
TOXICOLOGY REVIEW
JTPAE7 19,1,2006
TOXICOLOGY REVIEW
MUREAV 657,84,2008
TOXICOLOGY REVIEW
MUREAV 608,136,2006
TOXICOLOGY REVIEW
TXAPA9 231,197,2008


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD skin-SUSPECTED CARCINOGEN DTLWS* 3,25,1973
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) see Code of Federal Regulations (CFR) 29,1910.1016 CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) see Code of Federal Regulations (CFR) 29,1926.1116 CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) see Code of Federal Regulations (CFR) 29,1915.1016 CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) see Appendix A3 (skin) CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) cancer suspect agent CFRGBR 29,1910.1016,1987
Occupational Exposure Limit - AUSTRALIA Carcinogen, JUL2008
Occupational Exposure Limit - AUSTRIA TRK 0.001 mg/m3, JAN 2006
Occupational Exposure Limit - AUSTRIA TRK 0.0025 mg/m3 (production), JAN 2006
Occupational Exposure Limit - BELGIUM Skin, MAR2002
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.001 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND skin, JAN2002
Occupational Exposure Limit - SWEDEN Group B Carcinogen, JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 0.001 mg/m3, Skin, DEC2006
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Confirmed animal carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Confirmed animal carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO N-NITROSODIMETHYLAMINE-air Carcinogen use 29 Code of Federal Regulations (CFR) 1910.1016 NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 51110;
Number of Industries 1;
Total Number of Facilities 75;
Number of Occupations 1;
Total Number of Employees Exposed 747;
Total Number of Female Employees Exposed 299


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

ATSDR TOXICOLOGY PROFILE (NTIS** PB/90/182130/AS)
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Positive: D melanogaster-reciprocal translocation
EPA GENETOX PROGRAM 1988, Positive: Host-mediated assay; L5178Y cells in vitro-TK test
EPA GENETOX PROGRAM 1988, Positive: Mammalian micronucleus; N crassa-forward mutation
EPA GENETOX PROGRAM 1988, Positive: N crassa-reversion; E coli polA with S9
EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Positive: D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Positive: In vitro UDS in rat liver; V79 cell culture-gene mutation
EPA GENETOX PROGRAM 1988, Positive: TRP reversion; S cerevisiae gene conversion
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae-forward mutation; S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Positive: S pombe-forward mutation
EPA GENETOX PROGRAM 1988, Positive/dose response: In vitro cytogenetics-nonhuman
EPA GENETOX PROGRAM 1988, Positive/dose response: In vitro SCE-nonhuman; In vivo SCE-nonhuman
EPA GENETOX PROGRAM 1988, Positive/dose response: In vitro UDS-human fibroblast
EPA GENETOX PROGRAM 1988, Negative: Cytogenetics-male germ cell; Sperm morphology-mouse
EPA GENETOX PROGRAM 1988, Negative: UDS in mouse germ cells
EPA GENETOX PROGRAM 1988, Inconclusive: SHE-clonal assay; Cell transform.-RLV F344 rat embryo
EPA GENETOX PROGRAM 1988, Inconclusive: Rodent dominant lethal; Mouse spot test
EPA GENETOX PROGRAM 1988, Inconclusive: E coli polA without S9
EPA GENETOX PROGRAM 1988, Positive: CHO gene mutation
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as an intermediate in the production of 1,1-DIMETHYLHYDRAZINE
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Nitrosamines, 2522
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen
OSHA ANALYTICAL METHOD #6
OSHA ANALYTICAL METHOD #27


REFERENCES:

CODEN
REFERENCE

85CVA2 "Oncology 1970, Proceedings of the Tenth International Cancer Congress," Chicago, Year Book Medical Pub., 1971
AGACBH Agents and Actions, A Swiss Journal of Pharmacology. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1969/70-
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU.
APJAAG Acta Pathologica Japonica. (Japan Publications Trading Co., Ltd., POB 5030, Tokyo International, Tokyo 101-31, Japan) V.1- 1951-
APLMAS Archives of Pathology and Laboratory Medicine. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1-5(2), 1926-28; V.100- 1976-
ARGEAR Archiv fuer Geschwulstforschung. (VEB Verlag Volk und Gesundheit Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1949-
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
ATXKA8 Archiv fuer Toxikologie. (Berlin, Fed. Rep. Ger.) V.15-31, 1954-74. For publisher information, see ARTODN.
AVSCA7 Acta Veterinaria Scandinavica. (Danske Dyrlargeforening, Alhambravej 15, DK-1826 Copenhagen V, Denmark) V.1- 1959-
BANRDU Banbury Report. (Cold Spring Harbor Laboratory, POB 100, Cold Spring Harbor, NY 11724) V.1- 1979-
BBACAQ Biochimica et Biophysica Acta. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1947-
BBRCA9 Biochemical and Biophysical Research Communications. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958-
BEXBAN Bulletin of Experimental Biology and Medicine (English Translation). Translation of BEBMAE. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) V.41- 1956-
BIMDB3 Biomedicine. (Paris, France) V.18-34, 1973-81.
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1947-
BJEPA5 British Journal of Experimental Pathology. (Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK) V.1- 1920-
BJIMAG British Journal of Industrial Medicine. (British Medical Journal, Box 560B, Kennebunkport, ME 04046) V.1- 1944-
BLFSBY Basic Life Sciences. (Plenum Pub. Corp., 223 Spring St., New York, NY 10003) V.1- 1973-
BPBLEO Biological and Pharmaceutical Bulletin. (Pharmaceutical Society of Japan, 2-12-15-201 Shibuya Shibuya-ku, Tokyo 150, Japan) V.16- 1993-
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975-
CANCAR Cancer (Philadelphia). (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1948-
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969-
CEXPB9 Clinical and Experimental Pharmacology and Physiology. (Blackwell Scientific Publications, (Australia) Pty Ltd., 107 Barry St., Carlton, Vic. 3053, Australia) V.1- 1974-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CGCYDF Cancer Genetics and Cytogenetics. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1979-
CHMED*
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
CUGED5 Current Genetics. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1979-
DIMON* Disease-a Month (Chicago : Year Book Publishers) V. 24- 1978-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
DTLWS* "Documentation of the Threshold Limit Values for Substances in Workroom Air," Supplements. For publisher information, see 85INA8.
EJCAAH European Journal of Cancer (Elsevier Science, P.O.Box 7247-7682,Philadelphia,PA 19170 -7682,USA OR Elsevier Science B.V.,P.O.Box 1270,1000 BG Amsterdam,The Netherlands) V. 1- 1965-
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
EVSRBT Environmental Science Research. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) V.1- 1972-
EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1945-
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939-
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GMCRDC Gann Monograph on Cancer Research. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No. 11- 1971-
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IJCNAW International Journal of Cancer. (International Union Against Cancer, 3 rue du Conseil- General, 1205 Geneva, Switzerland) V.1- 1966-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
INURAQ Investigative Urology. (Baltimore, MD) V.1-19, 1963-81. For publisher information, see JOURAA.
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JEPTDQ Journal of Environmental Pathology and Toxicology. (Park Forest South, IL) V.1-5(3), 1977-81(?). For publisher information, see JEPOEC.
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JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8.
JSONAU Journal of Surgical Oncology. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1969-
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
JTPAE7 Journal of Toxicologic Pathology. (Nihon Dokusei Byori Gakkai, editor, 3-25-8 Nishi- shinbashi, Minato-ku, Tokyo 105, Japan) V.1- 1988
MGGEAE Molecular and General Genetics. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.99- 1967-
MOTOEX Molecular Toxicology. (Taylor & Francis, Inc., 242 Cherry St., Philadelphia, PA USA 19106) V.1- 1987-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869-
NCIMAV National Cancer Institute, Monograph. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) No.1- 1959-
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Used as an intermediate in the production of 1,1-DIMETHYLHYDRAZINE

RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector
   Human Data

Click Here for Additional Information about RTECS

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