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o - Cresol

RTECS #: GO6300000

CAS #: 95-48-7


UPDATE: May 2009 MW: 108.15 MF: C7H8O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. 1 - Hydroxy - 2 - methylbenzene
  2. 2 - Cresol
  3. 2 - Hydroxytoluene
  4. 2 - Methylphenol
  5. Orthocresol
  6. Phenol, 2 - methyl - (9CI)
  7. RCRA waste number U052
  8. m - Cresol
  1. o - Cresol (ACGIH:OSHA)
  2. o - Cresylic acid
  3. o - Hydroxytoluene
  4. o - Kresol (German)
  5. o - Methylphenol
  6. o - Methylphenylol
  7. o - Oxytoluene
  8. o - Toluol


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
sister chromatid exchange human fibroblast 8 mmol/L MUREAV 137,51,1984


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 2.31 gm/kg (7 day prior to copulation/21 day pregnant) Reproductive: Maternal effects: Parturition NTIS** #PB92-176890
oral
mouse
lowest published toxic dose: 660 mg/kg (multigenerations) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) NTIS** #PB92-176890


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
skin
mouse
lowest published toxic dose: 4,800 mg/kg/12 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Skin and Appendages: Tumors
CNREA8 19,413,1959


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lethal concentration (50 percent kill): 179 mg/m3/2 hour N/R 85GMAT -,40,1982
inhalation
mouse
lethal concentration (50 percent kill): 179 mg/m3 Behavioral: Tetany

Lung, Thorax, or Respiration: Acute pulmonary edema

Kidney, Ureter, and Bladder: Hematuria
VCVGK* -,207,1994
inhalation
rat
lethal concentration (50 percent kill): 29 mg/m3 Behavioral: Tetany

Lung, Thorax, or Respiration: Acute pulmonary edema

Kidney, Ureter, and Bladder: Hematuria
VCVGK* -,207,1994
intraperitoneal
guinea pig
lowest published lethal dose: 360 mg/kg N/R VCVGK* -,207,1994
intraperitoneal
mouse
lowest published lethal dose: 200 mg/kg N/R RBPMAZ 22,1,1952
intraperitoneal
rabbit
lowest published lethal dose: 180 mg/kg N/R VCVGK* -,207,1994
intravenous
dog
lowest published lethal dose: 80 mg/kg N/R VCVGK* -,207,1994
intravenous
rabbit
lowest published lethal dose: 180 mg/kg N/R JPETAB 80,233,1944
oral
mammal (species unspecified)
lethal dose (50 percent kill): 100 mg/kg Cardiac: Other changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,207,1994
oral
mouse
lethal dose (50 percent kill): 344 mg/kg N/R GTPZAB 18(2),58,1974
oral
mouse
lethal dose (50 percent kill): 344 mg/kg Cardiac: Other changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,207,1994
oral
rat
lethal dose (50 percent kill): 1,350 mg/kg Cardiac: Other changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,207,1994
oral
rabbit
lowest published lethal dose: 940 mg/kg N/R JPETAB 80,233,1944
oral
rabbit
lethal dose (50 percent kill): 940 mg/kg Cardiac: Other changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,207,1994
subcutaneous
cat
lowest published lethal dose: 55 mg/kg N/R VCVGK* -,207,1994
subcutaneous
frog
lowest published lethal dose: 200 mg/kg N/R HBAMAK 4,1361,1935
subcutaneous
guinea pig
lowest published lethal dose: 35 mg/kg Eye: Miosis (pupilliary constriction)

Behavioral: Excitement

Lung, Thorax, or Respiration: Acute pulmonary edema
RMSRA6 15,561,1895
subcutaneous
mouse
lowest published lethal dose: 410 mg/kg N/R VCVGK* -,207,1994
subcutaneous
rat
lowest published lethal dose: 65 mg/kg Eye: Miosis (pupilliary constriction)

Behavioral: Excitement

Lung, Thorax, or Respiration: Acute pulmonary edema
RMSRA6 15,561,1895
subcutaneous
rat
lowest published lethal dose: 65 mg/kg N/R VCVGK* -,207,1994
subcutaneous
rabbit
lowest published lethal dose: 450 mg/kg N/R HBAMAK 4,1361,1935
skin
human
lowest published toxic concentration: 0.87 pph Skin: After topical application: Dermatitis, allergic AJCDE* 13,198,2002
skin
rat
lethal dose (50 percent kill): 620 mg/kg N/R GTPZAB 18(2),58,1974
skin
rat
lethal dose (50 percent kill): 620 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Tetany
VCVGK* -,207,1994
skin
rabbit
lethal dose (50 percent kill): 890 mg/kg N/R TXAPA9 42,417,1977
skin
rabbit
lethal dose (50 percent kill): 890 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Tetany
VCVGK* -,207,1994


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
guinea pig
lowest published toxic concentration: 9 mg/m3/4 hour/122 day- intermittent Brain and Coverings: Other degenerative changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,208,1994
inhalation
mouse
lowest published toxic concentration: 50 mg/m3/2 hour/24 day- intermittent Brain and Coverings: Other degenerative changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,208,1994
inhalation
rat
lowest published toxic concentration: 10 mg/m3/4 hour/40 day- intermittent Brain and Coverings: Other degenerative changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,208,1994
inhalation
rat
lowest published toxic concentration: 9 mg/m3/4 hour/122 day- intermittent Brain and Coverings: Other degenerative changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,208,1994
inhalation
rabbit
lowest published toxic concentration: 9 mg/m3/4 hour/122 day- intermittent Brain and Coverings: Other degenerative changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,208,1994
oral
mammal (species unspecified)
lowest published toxic dose: 1,169 mg/kg/28 day- continuous Liver: Changes in liver weight ETOCDK 5,713,1986
oral
mouse
lowest published toxic dose: 101 gm/kg/28 day- continuous Brain and Coverings: Changes in brain weight

Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** PB92-174242
oral
mouse
lowest published toxic dose: 218 gm/kg/13 week- continuous Brain and Coverings: Changes in brain weight

Endocrine: Changes in thymus weight

Related to Chronic Data: Changes in testicular weight
NTIS** PB92-174242
oral
mouse
lowest published toxic dose: 18,480 mg/kg/28 day- continuous Kidney, Ureter, and Bladder: Changes in kidney weight NTIS** #PB92-176890
oral
rat
lowest published toxic dose: 21 gm/kg/28 day- continuous Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight
NTIS** PB92-174242
oral
rat
lowest published toxic dose: 82 gm/kg/13 week- continuous Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Endocrine: Changes in thymus weight
NTIS** PB92-174242


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 5 ppm (skin) DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
MUREAV 47,75,1978
TOXICOLOGY REVIEW
ENTOX* -,678,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 5 ppm (22 mg/m3) DTLVS* 3,61,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 5 ppm (22 mg/m3) (skin) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 5 ppm (22 mg/m3) (skin) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 5 ppm (22 mg/m3) (skin) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 5 ppm (22 mg/m3) (skin) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 5 ppm (22 mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 5 ppm (22 mg/m3), Skin, MAR2002
Occupational Exposure Limit - FRANCE VME 5 ppm (22 mg/m3), FEB2006
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 5 ppm (22 mg/m3), skin, APR2007
Occupational Exposure Limit - NEW ZEALAND time-weighted average 5 ppm (22 mg/m3), skin, JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 5 ppm (22 mg/m3), JAN1999
Occupational Exposure Limit - SWEDEN time-weighted average 1 ppm (4.5 mg/m3);
short term exposure limit 2 ppm (9 mg/m3), Skin, JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 5 ppm (22 mg/m3),KZG- week 5 ppm (22 mg/m3), Skin,DEC2006
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 5 ppm (skin)
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 5 ppm (skin)


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO o-CRESOL-air 10 hour time-weighted average 2.3 ppm NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 84364;
Number of Industries 26;
Total Number of Facilities 1,724;
Number of Occupations 28;
Total Number of Employees Exposed 14,550
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84364;
Number of Industries 16;
Total Number of Facilities 1,707;
Number of Occupations 24;
Total Number of Employees Exposed 10,985;
Total Number of Female Employees Exposed 483


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE FEREAC 47,26992,82
Used as a disinfectant
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Cresol (all isomers) and phenol, 2546
NIOSH Analytical Method, 1996: Volatile organic compound, 2549
NTP Toxicity studies, RPT# TOX-09, October 2000


REFERENCES:

CODEN
REFERENCE

85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
AJCDE* American Journal of Contact Dermatitis: Official Journal of the American Contact Dermatitis Society (Philadelphia, PA : W.B. Saunders, Harcourt Brace Jovanovich) V.1-14 1990-2003.
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
ETOCDK Environmental Toxicology and Chemistry. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1982-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.)
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
RBPMAZ Revue Belge de Pathologie et de Medecine Experimentale. (Brussels, Belgium) V.18-31, 1947-65. For publisher information, see PTEUA6.
RMSRA6 Revue Medicale de la Suisse Romande. (Societe Medicale de La Suisse Romande, 2 rue Bellefontaine, 1003 Lausanne, Switzerland) V.1- 1881-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

Used as a disinfectant

RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector
   Human Data
   Primary Irritant

Click Here for Additional Information about RTECS

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