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Benzidine, 3,3' - dimethyl -

RTECS #: DD1225000

CAS #: 119-93-7


UPDATE: May 2009 MW: 212.32 MF: C14H16N2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. (1,1' - Biphenyl) - 4,4' - diamine - 3,3' - dimethyl -
  2. 2 - Tolidin (German)
  3. 2 - Tolidina (Italian)
  4. 2 - Tolidine
  5. 3,3' - Dimethylbenzidin
  6. 3,3' - Dimethylbenzidine
  7. 3,3' - Dimethyl - 4,4' - biphenyldiamine
  8. 3,3' - Dimethylbiphenyl - 4,4' - diamine
  9. 3,3' - Dimethyl - 4,4' - diphenyldiamine
  10. 3,3' - Dimethyldiphenyl - 4,4' - diamine
  11. 3,3' - Tolidine
  12. 4,4' - Bi - o - toluidine
  13. 4,4' - Diamino - 3,3' - dimethylbiphenyl
  1. 4,4' - Diamino - 3,3' - dimethyldiphenyl
  2. 4,4' - Di - o - toluidine
  3. Bianisidine
  4. C.I. 37230
  5. C.I. Azoic Diazo Component 113
  6. Diaminoditolyl
  7. Fast Dark Blue Base R
  8. RCRA waste number U095
  9. Tolidine
  10. o,o' - Tolidine
  11. o - Tolidin
  12. o - Tolidine
  13. o - Tolidine (ACGIH)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
body fluid assay rat
Salmonella typhimurium
10 g/plate MUREAV 79,173,1980
cytogenetic analysis hamster ovary 450 mg/L EMMUEG 10(Suppl 10),1,1987
cytogenetic analysis intraperitoneal
mouse
100 mg/kg MUREAV 319,19,1993
DNA damage human lymphocyte 500 mol/L/2 hour TOSCF2 72,283,2003
DNA damage oral
mouse
200 mg/kg MUREAV 440,1,1999
DNA inhibition oral
mouse
100 mg/kg MUREAV 46,305,1977
unscheduled DNA synthesis hamster liver 1 mol/L MUREAV 136,255,1984
unscheduled DNA synthesis human HeLa cell 1 mol/L CNREA8 38,2621,1978
unscheduled DNA synthesis rat liver 1 mol/L MUREAV 136,255,1984
mutation in microorganisms mouse lymphocyte 105 mg/L (+enzymatic activation step) EMMUEG 12(Suppl 13),37,1988
mutation in microorganisms Salmonella typhimurium 100 nmol/plate (+enzymatic activation step) MUREAV 136,33,1984
mutation in microorganisms Salmonella typhimurium 4 g/plate (-enzymatic activation step) BJCAAI 37,873,1978
mutation in microorganisms Salmonella typhimurium 3 g/plate (+enzymatic activation step) TOSCF2 56,351,2000
mutation in microorganisms Salmonella typhimurium 300 g/plate/20 minute (+enzymatic activation step) MUTAEX 20,217,2005
mutation in microorganisms Salmonella typhimurium 600 g/plate/48 hour (+enzymatic activation step) MUTAEX 20,217,2005
micronucleus test oral
mouse
16 mg/kg MUREAV 444,175,1999
mutation in mammalian somatic cells mouse lymphocyte 26 mg/L EMMUEG 12(Suppl 13),37,1988
morphological transform hamster kidney 80 g/L BJCAAI 37,873,1978
morphological transform mouse embryo 1 mg/L JNCIAM 52,1167,1974
morphological transform rat embryo 5 mg/L JNCIAM 51,799,1973
other mutation test systems intraperitoneal
mouse
100 mg/kg MUREAV 319,19,1993
sister chromatid exchange parenteral
chicken
169 g/kg 47JMAE -,137,1982
sister chromatid exchange hamster ovary 5 mg/L EMMUEG 10(Suppl 10),1,1987
sister chromatid exchange rabbit lymphocyte 50 mg/L MUREAV 89,197,1981


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
implant
rat
lowest published toxic dose: 5,040 mg/kg/1 year- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors

Skin and Appendages: Tumors
JNCIAM 45,283,1970
oral
rat
lowest published toxic dose: 4,500 mg/kg/27 day- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Skin and Appendages: Tumors
CNREA8 28,924,1968
subcutaneous
rat
lowest published toxic dose: 1,650 mg/kg/33 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors
VOONAW 20(2),53,1974
subcutaneous
rat
toxic dose : 9 gm/kg/51 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Ear: Tumors
CANCAR 3,789,1950
subcutaneous
rat
toxic dose : 5,040 mg/kg/56 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Ear: Tumors

Endocrine: Tumors
GTPZAB 9(7),18,1965
subcutaneous
rat
toxic dose : 3,240 mg/kg/34 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Endocrine: Tumors

Skin and Appendages: Tumors
JNCIAM 45,283,1970


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
mouse
lowest published lethal dose: 125 mg/kg N/R CBCCT* 6,64,1954
oral
dog
lowest published lethal dose: 600 mg/kg N/R AEXPBL 58,167,1907


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Confirmed animal carcinogen DTLVS* TLV/BEI,2007
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 1,87,1972
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 1,87,1972
International Agency for Research on Cancer (IARC) Cancer Review Group 2B IMSUDL 7,56,1987
TOXICOLOGY REVIEW
MUREAV 567,347,2004
TOXICOLOGY REVIEW
REPTED 19,547,2005
TOXICOLOGY REVIEW
MUREAV 612,58,2006
TOXICOLOGY REVIEW
MUREAV 584,1,2005
TOXICOLOGY REVIEW
MUREAV 654,114,2008
TOXICOLOGY REVIEW
MUREAV 654,114,2008


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - AUSTRALIA Carcinogen, JUL2008
Occupational Exposure Limit - AUSTRIA TRK 0.03 mg/m3 (0.003 mL/m3) (inhalable), JAN 2006
Occupational Exposure Limit - BELGIUM Skin, MAR2002
Occupational Exposure Limit - FINLAND Carcinogen, JAN1999
Occupational Exposure Limit - KOREA skin, 2006
Occupational Exposure Limit - NEW ZEALAND skin, JAN2002
Occupational Exposure Limit - SWEDEN Group B Carcinogen, JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 0.003 ppm (0.03 mg/m3), Carcinogen, DEC2006
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Confirmed animal carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Confirmed animal carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO o-TOLIDINE-air Carcinogen ceiling concentration 0.02 mg/m3/60 minute NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 84756;
Number of Industries 1;
Total Number of Facilities 11;
Number of Occupations 5;
Total Number of Employees Exposed 421
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84756;
Number of Industries 8;
Total Number of Facilities 854;
Number of Occupations 20;
Total Number of Employees Exposed 9,640;
Total Number of Female Employees Exposed 6,005


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-RLV F344 rat embryo
EPA GENETOX PROGRAM 1988, Positive: Mammalian micronucleus; Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Inconclusive: In vitro UDS-human fibroblast
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in the manufacture of dyestuffs and pigments, as a laboratory agent to detect blood
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen
OSHA ANALYTICAL METHOD #ID-71


REFERENCES:

CODEN
REFERENCE

47JMAE "Cytogenetic Assays of Environmental Mutagens," Hsu, T.C., ed., Totowa, NJ, Allanheld, Osmun & Co., 1982
AEXPBL Archiv fuer Experimentelle Pathologie und Pharmakologie. (Leipzig, Ger. Dem. Rep.) V.1-109, 1873-1925. For publisher information, see NSAPCC.
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1947-
CANCAR Cancer (Philadelphia). (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1948-
CBCCT* "Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. (National Academy of Science Library, 2101 Constitution Ave., NW, Washington, DC 20418)
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8.
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987-
TOSCF2 Toxicological Sciences (Oxford University Press, 6277 Sea Harbor Drive, Orlando, FL 32887 ) V. 41, Jan. 1998-
VOONAW Voprosy Onkologii. Problems of Oncology. For English translation, see PONCAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-10, 1928-37; V.1- 1955-

Used in the manufacture of dyestuffs and pigments, as a laboratory agent to detect blood

RTECS Compound Description:
   Tumorigen
   Mutagen
   Human Data

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