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Acetone

RTECS #: AL3150000

CAS #: 67-64-1


UPDATE: May 2009 MW: 58.09 MF: C3H6O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. 2 - Propanone
  2. Aceton (German, Dutch, Polish)
  3. Acetone (ACGIH:OSHA)
  4. Chevron acetone
  5. Dimethylformaldehyde
  6. Dimethylketal
  7. Dimethyl ketone
  8. Ketone propane
  1. Ketone, dimethyl
  2. Methyl ketone
  3. Propanone
  4. Pyroacetic acid
  5. Pyroacetic ether
  6. RCRA waste number U002
  7. beta - Ketopropane


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
human
500 ppm N/R JIHTAB 25,282,1943
eye
human
186,300 ppm mild CRTXB2 32,43,2002
eye
rabbit
20 mg/24 hour moderate 85JCAE -,280,1986
eye
rabbit
10 L mild JTPAE7 29,187,2001
eye
rabbit
20 mg severe ENTOX* -,27,2005
skin
rabbit
395 mg open irritation test mild UCDS** 5/7/1970
skin
rabbit
500 mg/24 hour mild 85JCAE -,280,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis hamster fibroblast 40 gm/L FCTOD7 22,623,1984
sex chromosome loss and nondisjunction inhalation
mouse
12 gm/L VCVGK* -,409,1994
sex chromosome loss and nondisjunction Saccharomyes cerevisiae 47,600 ppm ANYAA9 407,186,1983


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mammal (species unspecified)
lowest published toxic concentration: 31,500 g/m3/24 hour (1-13 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) GTPZAB 26(6),24,1982
inhalation
mouse
lowest published toxic concentration: 6,600 ppm (6-17 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)
NTIS** #DE89-005671
inhalation
rat
lowest published toxic concentration: 30 mg/m3 (1-13 day pregnant) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetal death
VCVGK* -,409,1994
inhalation
rat
lowest published toxic concentration: 11,000 ppm (6-19 day pregnant) Reproductive: Other developmental abnormalities NTIS** #DE89-005671
oral
rat
lowest published toxic dose: 273 gm/kg (13 week male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) NTIS** PB91-185975


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
cat
lowest published toxic concentration: 8,000 mg/m3 Eye: Conjunctiva irritation

Behavioral: Sleep
VCVGK* -,408,1984
inhalation
guinea pig
lowest published toxic concentration: 72,000 mg/m3/2 hour Behavioral: Alteration of classical conditioning VCVGK* -,408,1984
inhalation
human
lowest published toxic concentration: 500 ppm Olfaction: Other olfaction effects

Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Other changes
JIHTAB 25,282,1943
inhalation
human
lowest published toxic concentration: 12,000 mg/m3/3 minute Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Cough
VCVGK* -,408,1984
inhalation
human
lowest published toxic concentration: 10 mg/m3/6 hour Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase VCVGK* -,408,1984
inhalation
man
lowest published toxic concentration: 440 g/m3/6 minute Brain and Coverings: Recordings from specific areas of CNS GISAAA 42(8),42,1977
inhalation
man
lowest published toxic concentration: 10 mg/m3/6 hour Biochemical: Metabolism (intermediary): Other carbohydrates GISAAA 42(8),42,1977
inhalation
man
lowest published toxic concentration: 12,000 ppm/4 hour Gastrointestinal: Nausea or vomiting

Behavioral: Muscle weakness
AOHYA3 16,73,1973
inhalation
mouse
lethal concentration (50 percent kill): 44 gm/m3/4 hour N/R CUTOEX 1,47,1993
inhalation
mouse
lowest published toxic concentration: 30,000 mg/m3/2 hour Behavioral: Alteration of classical conditioning VCVGK* -,408,1984
inhalation
mouse
lowest published lethal concentration: 150,000 mg/m3 N/R VCVGK* -,408,1984
inhalation
mouse
lowest published toxic concentration: 10,000 ppm/6 minute Lung, Thorax, or Respiration: Respiratory depression TOLED5 9,137,1981
inhalation
rat
lethal concentration (50 percent kill): 50,100 mg/m3/8 hour N/R AIHAAP 20,364,1959
inhalation
rat
lowest published toxic concentration: 30,000 mg/m3/2 hour Behavioral: Alteration of classical conditioning VCVGK* -,408,1984
inhalation
rat
lethal concentration (50 percent kill): 50,100 mg/m3 N/R ENTOX* -,27,2005
inhalation
rabbit
lowest published toxic concentration: 1,250 mg/m3 Behavioral: Alteration of classical conditioning VCVGK* -,408,1984
intraperitoneal
dog
lowest published lethal dose: 8 gm/kg Behavioral: Coma

Gastrointestinal: Alteration in gastric secretion
AEXPBL 18,218,1884
intraperitoneal
mouse
lethal dose (50 percent kill): 1,297 mg/kg N/R SCCUR* -,1,1961
intraperitoneal
rat
lowest published lethal dose: 500 mg/kg Behavioral: General anesthetic

Behavioral: Muscle weakness

Kidney, Ureter, and Bladder: Renal function tests depressed
JPPMAB 11,150,1959
intravenous
mouse
lowest published lethal dose: 4 gm/kg N/R FAONAU 48A,86,1970
intravenous
rat
lethal dose (50 percent kill): 5,500 mg/kg N/R NPIRI* 1,1,1974
intravenous
rabbit
lowest published lethal dose: 1,576 mg/kg Behavioral: Muscle contraction or spasticity

Lung, Thorax, or Respiration: Respiratory depression
JPETAB 33,175,1928
oral
dog
lowest published lethal dose: 8 gm/kg Behavioral: Ataxia

Behavioral: Coma

Musculoskeletal: Joints
AEXPBL 18,218,1884
oral
dog
lowest published lethal dose: 8,000 mg/kg N/R VCVGK* -,408,1984
oral
human
lowest published lethal dose: 714 mg/kg N/R VCVGK* -,409,1984
oral
mammal (species unspecified)
lowest published toxic dose: 3.49 gm/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes

Biochemical: Effect on specific coenzyme: NAD, NADP
VCVGK* -,408,1984
oral
man
lowest published toxic dose: 2,857 mg/kg Behavioral: Coma

Kidney, Ureter, and Bladder: Other changes
34ZIAG -,64,1969
oral
man
lowest published toxic dose: 2,857 mg/kg Behavioral: Coma

Biochemical: Metabolism (intermediary): Other
DIAEAZ 15,810,1966
oral
mouse
lethal dose (50 percent kill): 3 gm/kg N/R PCJOAU 14,162,1980
oral
rat
lethal dose (50 percent kill): 5,800 mg/kg Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Tremor
JTEHD6 15,609,1985
oral
rat
lowest published toxic dose: 5 mL/kg Olfaction: Other olfaction effects

Lung, Thorax, or Respiration: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)
TOXID9 60,404,2001
oral
rat
lethal dose (50 percent kill): 5,800 mg/kg N/R ENTOX* -,27,2005
oral
rabbit
lethal dose (50 percent kill): 5,340 mg/kg N/R FAONAU 48A,86,1970
subcutaneous
dog
lowest published lethal dose: 5 gm/kg N/R AEXPBL 18,218,1884
subcutaneous
guinea pig
lowest published lethal dose: 5 gm/kg N/R AGGHAR 5,1,1933
skin
guinea pig
lethal dose (50 percent kill): >9,400 L/kg N/R TXAPA9 7,559,1965
skin
rabbit
lowest published lethal dose: 20 mL/kg N/R UCDS** 5/7/1970
unreported route
man
lowest published lethal dose: 1,159 mg/kg N/R 85DCAI 2,73,1970


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
human
lowest published toxic concentration: 100 mg/m3/6 hour/5 day- intermittent Cardiac: EKG changes not diagnostic of above

Cardiac: Pulse rate increased without fall in BP

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
VCVGK* -,409,1994
inhalation
human
lowest published toxic concentration: 440 mg/m3/3 year- intermittent Blood: Changes in erythrocyte (RBC) count

Blood: Granulocytopenia
VCVGK* -,410,1994
inhalation
mouse
lowest published toxic concentration: 11,000 ppm/12 day- intermittent Behavioral: General anesthetic NTIS** #DE89-005671
inhalation
rat
lowest published toxic concentration: 19,000 ppm/3 hour/8 week- intermittent Brain and Coverings: Changes in brain weight TXAPA9 61,302,1981
inhalation
rat
lowest published toxic concentration: 199 mg/m3/8 hour/45 day- intermittent Behavioral: Muscle contraction or spasticity GISAAA 25(5),3,1960
inhalation
rat
lowest published toxic concentration: 30 mg/m3/13 day- intermittent Biochemical: Metabolism (intermediary): Lipids including transport VCVGK* -,409,1994
inhalation
rat
lowest published toxic concentration: 2,000 mg/m3/4 hour/45 day- intermittent Endocrine: Change in gonadotropins

Endocrine: Evidence of thyroid hyperfunction

Biochemical: Metabolism (intermediary): Effect on Na-K pump
VCVGK* -,409,1994
inhalation
rat
lowest published toxic concentration: 199 mg/m3/8 hour/45 day- intermittent Behavioral: Alteration of classical conditioning VCVGK* -,409,1994
inhalation
rat
lowest published toxic concentration: 206 mg/m3/21 day- continuous Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Reproductive: Other effects on female
GISAAA 4,12,1994
inhalation
rat
lowest published toxic concentration: 11,000 ppm/9 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain NTIS** #DE89-005671
oral
mouse
lowest published toxic dose: 546 gm/kg/13 week- continuous Liver: Changes in liver weight

Endocrine: Changes in spleen weight
NTPTR* NIH-91-3122
oral
mouse
lowest published toxic dose: 2 mg/kg/5 day- continuous Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
LIFSAK 69,923,2001
oral
rat
lowest published toxic dose: 273 gm/kg/13 week- continuous Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Blood: Normocytic anemia
NTPTR* NIH-91-3122
oral
rat
lowest published toxic dose: 5 mg/kg/5 day- continuous Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
LIFSAK 69,923,2001
oral
rat
lowest published toxic dose: 7 gm/kg/7 day- continuous Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation) BCPCA6 67,875,2004
oral
rat
lowest published toxic dose: 15 mL/kg/3 day- intermittent Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)
TOLED5 144,55,2003
oral
rat
lowest published toxic dose: 8.75 mL/kg/7 day- continuous Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects

Biochemical: Metabolism (intermediary): Lipids including transport
CBCPAI 128,503,2001
oral
rat
lowest published toxic dose: 145,600 mg/kg/13 week- continuous Kidney, Ureter, and Bladder: Other changes

Blood: Macrocytosis

Blood: Other hemolysis with or without anemia
TOXID9 60,432,2001
skin
mouse
lowest published toxic dose: 31.6 g/kg/2 week- intermittent Biochemical: Metabolism (intermediary): Other MOCAE8 44,122,2005


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 500 ppm;short term exposure limit 750 ppm DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not classifiable as human carcinogen DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
TOLED5 127,111,2002
TOXICOLOGY REVIEW
CRTXB2 32,43,2002
TOXICOLOGY REVIEW
CRTXB2 32,43,2002
TOXICOLOGY REVIEW
MUREAV 566,209,2004
TOXICOLOGY REVIEW
CHHSA* 9,6,2002
TOXICOLOGY REVIEW
ENTOX* -,27,2005
TOXICOLOGY REVIEW
REPTED 25,192,2008
TOXICOLOGY REVIEW
MUREAV 659,93,2008
TOXICOLOGY REVIEW
HUTOX* -,577,1996


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Cancelled RBREV* -,289,1998
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 1000 ppm (2400 mg/m3) DTLVS* 3,3,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 1000 ppm (2400 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 1000 ppm (2400 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 1000 ppm (2400 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 1000 ppm (2400 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 500 ppm (1185 mg/m3), short term exposure limit 1000 ppm (2375 mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 500 ppm (1210 mg/m3), MAR2002
Occupational Exposure Limit - BELGIUM short term exposure limit 1000 ppm (2420 mg/m3), MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 250 ppm (600 mg/m3), OCT 2002
Occupational Exposure Limit - EC time-weighted average 1210 mg/m3 (500 ppm), FEB 2006
Occupational Exposure Limit - FINLAND time-weighted average 500 ppm (1200 mg/m3), short term exposure limit 625 ppm (1500 mg/m3), JAN1993
Occupational Exposure Limit - FRANCE VME 500 ppm (1210 mg/m3), FEB2006
Occupational Exposure Limit - GERMANY MAK 1200 mg/m3 (500 mL/m3), 2005
Occupational Exposure Limit - HUNGARY time-weighted average 1210 mg/m3, short term exposure limit 2420 mg/m3, SEP2000
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 200 ppm (470 mg/m3), APR2007
Occupational Exposure Limit - KOREA time-weighted average 750 ppm (1780 mg/m3), short term exposure limit 1000 ppm (2375 mg/m3), 2006
Occupational Exposure Limit - MEXICO time-weighted average 1000 ppm (2400 mg/m3);
short term exposure limit 1260 ppm(3000 mg/m3), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 1780 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 500 ppm (1.185 mg/m3);
short term exposure limit 1 ppm (2.375 mg/m3),JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 125 ppm (295 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 1000 ppm (2400 mg/m3), JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 600 mg/m3, MAC(short term exposure limit) 1800 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA time-weighted average 200 mg/m3, short term exposure limit 800 mg/m3, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 250 ppm (600 mg/m3);
short term exposure limit 500 ppm (1200 mg/m3), JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 500 ppm (1200 mg/m3);
KZG- week 1000 ppm (2400 mg/m3), DEC2006
Occupational Exposure Limit - TURKEY time-weighted average 1000 ppm (2400 mg/m3), JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 500 ppm (1210 mg/m3);
short term exposure limit 1500 ppm, 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not classifiable as human carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not classifiable as human carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ACETONE-air 10 hour time-weighted average 250 ppm NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 02820;
Number of Industries 350;
Total Number of Facilities 99,713;
Number of Occupations 188;
Total Number of Employees Exposed 1,287,794
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 02820;
Number of Industries 358;
Total Number of Facilities 97,342;
Number of Occupations 215;
Total Number of Employees Exposed 1,740,164;
Total Number of Female Employees Exposed 540,313


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

ATSDR TOXICOLOGY PROFILE (NTIS** PB/95/100095/AS)
EPA GENETOX PROGRAM 1988, Negative: SHE-clonal assay; Cell transform.-mouse embryo
EPA GENETOX PROGRAM 1988, Negative: Cell transform.-RLV F344 rat embryo
EPA GENETOX PROGRAM 1988, Negative: In vitro cytogenetics-nonhuman
EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test; In vitro SCE-nonhuman
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a solubilizer
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Ketones I, 1300
NIOSH Analytical Method, 1996: Volatile organic compound, 2549
NTP Toxicity studies, RPT# TOX-03, October 2000
OSHA ANALYTICAL METHOD #ID-69


REFERENCES:

CODEN
REFERENCE

34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969
85DCAI "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AEXPBL Archiv fuer Experimentelle Pathologie und Pharmakologie. (Leipzig, Ger. Dem. Rep.) V.1-109, 1873-1925. For publisher information, see NSAPCC.
AGGHAR Archiv fuer Gewerbepathologie und Gewerbehygiene. (Berlin, Ger.) V.1-18, 1930-61. For publisher information, see IAEHDW.
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
ANYAA9 Annals of the New York Academy of Sciences. (New York Academy of Sciences, 2 E. 63rd St., New York, NY 10021) V.1- 1877-
AOHYA3 Annals of Occupational Hygiene. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958-
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958-
CBCPAI Comparative Biochemistry and Physiology. (Elmsford, NY) V.1-37, 1960-70. For publisher information, see CBPBB8.
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CHHSA* Chemical Health & Safety (Orlando, FL : Published by Elsevier Inc. for the ACS Division of Chemical Health and Safety) V.1- 1994-
CRTXB2 CRC Critical Reviews in Toxicology. (CRC Press, Inc., 2000 Corporate Blvd., NW, Boca Raton, FL 33431) V.1- 1971-
CUTOEX Current Toxicology. (Nova Science Publishers, Inc., 6080 Jericho Turnpike, Suite 207, Commack, NY 11725) V.1 1993-
DIAEAZ Diabetes. (American Diabetes Assoc., 2 Park Ave., New York, NY 10016) V.1- 1952-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57, 1948-77. Discontinued.
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
HUTOX*
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of Great Britain, 1 Lambeth High St., London SEI 7JN, UK) V.1- 1949-
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
JTPAE7 Journal of Toxicologic Pathology. (Nihon Dokusei Byori Gakkai, editor, 3-25-8 Nishi- shinbashi, Minato-ku, Tokyo 105, Japan) V.1- 1988
LIFSAK Life Sciences. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1-8, 1962-69; V.14- 1974-
MOCAE8 Molecular Carcinogenesis. (John Wiley & Sons, 605 Third Avenue, New York, NY 10158) V.1- 1988-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NPIRI* Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. (National Assoc. of Printing Ink Research Institute, Francis McDonald Sinclair Memorial Laboratory, Lehigh Univ., Bethlehem, PA 18015)
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987-
SCCUR* Shell Chemical Company. Unpublished Report. (2401 Crow Canyon Rd., San Romon, CA 94583)
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

Used as a solubilizer

Top 50 chemical production: 2.39 billions lbs in 1992, 2.35 billions in 1991

NIOSH PROFILE (CORROSION INHIBITORS, MANUFACTURE and USE), FIRL,

NIOSH PROFILE (PAINT AND ALLIED PRODUCTS MANUFACTURING), FIRL, 4/78

NIOSH PROFILE (SPRAY PAINTING), FIRL, 4/78

NIOSH PROFILE (PAINT AND ALLIED PRODUCTS MANUFACTURING), SRI, 2/7

FDA-over the counter drug

RTECS Compound Description:
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   Mutagen
   Reproductive Effector
   Human Data
   Primary Irritant

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