CDC logo, Safer Healthier People  CDC HomeCDC SearchCDC Health Topics A-Z
NIOSH - National Institute for Occupational Safety and Health

Search NIOSH  |  NIOSH Home  |  NIOSH Topics  |  Site Index  |  Databases and Information Resources  |  NIOSH Products  |  Contact Us






p - Toluidine

RTECS #: XU3150000

CAS #: 106-49-0


UPDATE: May 2009 MW: 107.17 MF: C7H9N


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 1 - Amino - 4 - methylbenzene
  2. 4 - Amino - 1 - methylbenzene
  3. 4 - Aminotoluen (Czech)
  4. 4 - Aminotoluene
  5. 4 - Methylaniline
  6. 4 - Methylbenzenamine
  7. 4 - Toluidine
  8. Aniline, p - methyl -
  9. Benzenamine, 4 - methyl - (9CI)
  10. C.I. 37107
  11. C.I. Azoic Coupling Component 107
  1. Naphtol AS - KG
  2. Naphtol AS - KGLL
  3. RCRA waste number U353
  4. Tolylamine
  5. p - Aminotoluene
  6. p - Methylaniline
  7. p - Methylbenzenamine
  8. p - Toluidin (Czech)
  9. p - Toluidyna (Polish)
  10. p - Toluidine (ACGIH)
  11. p - Tolylamine


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
20 mg/24 hour moderate 85JCAE -,460,1986
skin
rabbit
500 mg/24 hour mild 85JCAE -,460,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
DNA damage intraperitoneal
mouse
35 mg/kg ATSUDG 5,355,1982
DNA inhibition oral
mouse
200 mg/kg MUREAV 46,305,1977
unscheduled DNA synthesis rat liver 100 Ámol/L ENMUDM 5,803,1983


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
mouse
lethal dose (50 percent kill): 50 mg/kg N/R NTIS** AD691-490
oral
wild bird
lethal dose (50 percent kill): 42 mg/kg N/R TXAPA9 21,315,1972
oral
mouse
lethal dose (50 percent kill): 330 mg/kg N/R ENTOX* -,206,2005
oral
quail
lethal dose (50 percent kill): 237 mg/kg N/R AECTCV 12,355,1983
oral
rat
lethal dose (50 percent kill): 336 mg/kg Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold
BCTKAG 17,51,1984
oral
rat
lethal dose (50 percent kill): 3,360 mg/kg N/R ENTOX* -,206,2005
oral
rabbit
lethal dose (50 percent kill): 270 mg/kg N/R VINIT* #4035-77


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 4,560 mg/kg/30 day- intermittent Kidney, Ureter, and Bladder: Proteinuria

Blood: Normocytic anemia

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
VINIT* #4035-77
oral
rat
lowest published toxic dose: 1,722 mg/kg/6 week- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain IJTOFN 24,365,2005
oral
rat
lowest published toxic dose: 2,086 mg/kg/2 week- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain IJTOFN 24,365,2005
oral
rat
lowest published toxic dose: 1,230 mg/kg/30 day- continuous Liver: Other changes

Blood: Methemoglobinemia- Carboxhemoglobinemia
IJTOFN 24,365,2005


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 2 ppm (skin) DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Confirmed animal carcinogen DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
ENTOX* -,206,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - AUSTRALIA time-weighted average 2 ppm (8.8 mg/m3), Carcinogen, JUL2008
Occupational Exposure Limit - AUSTRIA TRK 1 mg/m3 (0.2 mL/m3) (vapor and aerosol), JAN 2006
Occupational Exposure Limit - BELGIUM time-weighted average 2 ppm (8.9 mg/m3), Skin, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 2 ppm (9 mg/m3), OCT 2002
Occupational Exposure Limit - HUNGARY time-weighted average 1 mg/m3, short term exposure limit 4 mg/m3, Skin, SEP2000
Occupational Exposure Limit - KOREA time-weighted average 2 ppm (9 mg/m3), skin, 2006
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 9 mg/m3, Skin, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 2 ppm (8.8 mg/m3), skin, JAN2002
Occupational Exposure Limit - RUSSIA short term exposure limit 1 mg/m3, Skin, JUN2003
Occupational Exposure Limit - SWITZERLAND MAK- week 0.2 ppm, Skin, DEC2006
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Confirmed animal carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Confirmed animal carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO p-TOLUIDINE-air Carcinogen lowest feasible conc. (Sk) NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M0854;
Number of Industries 8;
Total Number of Facilities 508;
Number of Occupations 5;
Total Number of Employees Exposed 2,267
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M0854;
Number of Industries 4;
Total Number of Facilities 206;
Number of Occupations 2;
Total Number of Employees Exposed 428;
Total Number of Female Employees Exposed 87


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Negative: E coli polA without S9; E coli polA with S9
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae-homozygosis
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a chemical intermediate
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
OSHA ANALYTICAL METHOD #ID-73


REFERENCES:

CODEN
REFERENCE

85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973-
ATSUDG Archives of Toxicology, Supplement. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) No.1- 1978-
BCTKAG Bromatologia i Chemia Toksykologiczna. (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland) V.4- 1971-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
IJTOFN International Journal of Toxicology. (Taylor & Francis, 47 Runway Rd., Suite g, Levittown, PA 19057) V.16- 1997-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VINIT* Vsesoyuznyi Institut Nauchnoi i Tekhnicheskoi Informatsii (VINITI). All-Union Institute of Scientific and Technical Information. (Moscow, USSR) Use information broker to obtain publications.

Used as a chemical intermediate

NIOSH PROFILE (AMINES, PRIMARY AROMATIC), SRI, 2/77

RTECS Compound Description:
   Mutagen
   Primary Irritant

Click Here for Additional Information about RTECS

NIOSH Home |  NIOSH Search  |  Site Index  |  Topic List |  Contact Us