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n - Propyl nitrate

RTECS #: UK0350000

CAS #: 627-13-4


UPDATE: May 2009 MW: 105.11 MF: C3H7NO3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. REVIEWS:
  4. STANDARDS AND REGULATIONS:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. Nitrate de propyle normal (French)
  2. Nitric acid, propyl ester
  3. Propyl nitrate
  1. Propylester kyseliny dusicne (Czech)
  2. n - Propyl nitrate (ACGIH:OSHA)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lowest published lethal concentration: 5,816 ppm/4 hour Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Cyanosis
AIHAAP 19,80,1958
inhalation
rat
lowest published lethal concentration: 5,816 ppm/4 hour Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Cyanosis
AIHAAP 19,80,1958
intravenous
cat
lowest published lethal dose: 100 mg/kg N/R JPETAB 118,77,1956
intravenous
dog
lowest published lethal dose: 200 mg/kg N/R JPETAB 118,77,1956
intravenous
rabbit
lethal dose (50 percent kill): 200 mg/kg N/R JPETAB 118,77,1956


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 25 ppm;short term exposure limit 40 ppm DTLVS* TLV/BEI,2007


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 25 ppm (110 mg/m3) DTLVS* 3,217,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 25 ppm (110 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 25 ppm (110 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 25 ppm (110 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 25 ppm (110 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 25 ppm (107 mg/m3), short term exposure limit 40 ppm (172 mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 25 ppm (109 mg/m3), short term exposure limit 40 ppm (174 mg/m3), MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 25 ppm (110 mg/m3), OCT 2002
Occupational Exposure Limit - FINLAND time-weighted average 25 ppm (105 mg/m3), JAN1999
Occupational Exposure Limit - FRANCE VME 25 ppm (105 mg/m3), FEB2006
Occupational Exposure Limit - GERMANY MAK 110 mg/m3 (25 mL/m3), 2005
Occupational Exposure Limit - KOREA time-weighted average 25 ppm (105 mg/m3), short term exposure limit 40 ppm (170 mg/m3), 2006
Occupational Exposure Limit - MEXICO time-weighted average 25 ppm (105 mg/m3);
short term exposure limit 40 ppm (170 mg/m3), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 1 10 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 25 ppm (107 mg/m3), short term exposure limit 40 ppm (172 mg/m3), JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 20 ppm (90 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 25 ppm (110 mg/m3), JAN1993
Occupational Exposure Limit - SWITZERLAND MAK- week 25 ppm (110 mg/m3),KZG- week 50 ppm (220 mg/m3), DEC2006
Occupational Exposure Limit - TURKEY time-weighted average 25 ppm (110 mg/m3), JAN1993
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 25 ppm;
short term exposure limit 40 ppm
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 25 ppm;
short term exposure limit 40 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO n-PROPYL NITRATE-air 10 hour time-weighted average 25 ppm;
short term exposure limit 40 ppm
NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X7139;
Number of Industries 2;
Total Number of Facilities 30;
Number of Occupations 2;
Total Number of Employees Exposed 1,844;
Total Number of Female Employees Exposed 272


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE

AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.

Used as a fuel ignition promoter, in rocket fuels, and as an intermediate

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