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Phosphorothioic acid, O,O - dimethyl O - (4 - (methylthio) - m - tolyl) ester

RTECS #: TF9625000

CAS #: 55-38-9


UPDATE: May 2009 MW: 278.34 MF: C10H15O3PS2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. 4 - Methylmercapto - 3 - methylphenyl dimethyl thiophosphate
  2. B 29493
  3. BAY 29493
  4. Baycid
  5. Bayer 29493
  6. Bayer 9007
  7. Bayer S - 1752
  8. Baytex
  9. ENT 25,540
  10. Entex
  11. Fenthion
  12. Fenthion (ACGIH)
  13. Fenthion 4E
  14. Fenthion - methyl
  15. Lebaycid
  16. MPP (pesticide)
  17. Mercaptophos
  18. NCI - C08651
  19. O,O - Dimethyl O - (3 - methyl - 4 - methylmercaptophenyl) phosphorothioate
  1. O,O - Dimethyl O - (4 - (methylthio) - m - tolyl) phosphorothioate
  2. O,O - Dimethyl O - (4 - methylthio - 3 - methylphenyl) phosphorothioate
  3. O,O - Dimethyl O - 3 - methyl - 4 - methylthiophenyl phosphorothioate
  4. O,O - Dimethyl O - 4 - (methylmercapto) - 3 - methylphenyl phosphorothioate
  5. O,O - Dimethyl - O - (3 - methyl - 4 - methylthio - fenyl) - monothiofosfaat (Dutch)
  6. O,O - Dimethyl - O - (3 - methyl - 4 - methylthio - phenyl) - thionophosphat (German)
  7. O,O - Dimethyl - O - (3 - methyl - 4 - methylthiophenyl) - monothiophosphat (German)
  8. O,O - Dimethyl - O - 4 - (methylmercapto) - 3 - methylphenyl thiophosphate
  9. O,O - Dimetil - O - (3 - metil - 4 - metiltio - fenil) - monotiofosfato (Italian)
  10. OMS 2
  11. Phosphorothioic acid O,O - dimethyl O - (3 - methyl - 4 - (methylthio) phenyl) ester
  12. Queletox
  13. S 1752
  14. Spotton
  15. Sulfidophos
  16. Talodex
  17. Thiophosphate de O,O - dimethyle et de O - (3 - methyl - 4 - methylthiophenyle) (French)
  18. Tiguvon
  19. m - Cresol, 4 - (methylthio) - , O - ester with O,O - dimethyl phosphorothioate


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
mutation in microorganisms Salmonella typhimurium 333 g/plate (-enzymatic activation step) ENMUDM 8(Suppl 7),1,1986
sister chromatid exchange hamster lung 40 mg/L ENMUDM 4,621,1982


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
mouse
lowest published toxic dose: 40 mg/kg (11 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
TXAPA9 24,324,1973
oral
mouse
lowest published toxic dose: 1,050 mg/kg (multigenerations) Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated)

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)

Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4)
TXAPA9 26,29,1973
oral
rat
lowest published toxic dose: 10 mg/kg (6-15 day pregnant) Reproductive: Other effects on female TIHEEC 14,869,1998


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 1,730 mg/kg/103 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors
NCITR* NCI-TR-103,1979


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intracerebral
mouse
lethal dose (50 percent kill): 50 mg/kg N/R PCBPBS 8,302,1978
inhalation
guinea pig
lowest published lethal concentration: 1 gm/m3/2 hour N/R 85GYAV -,27,1971
inhalation
mouse
lowest published lethal concentration: 1 gm/m3/2 hour N/R 85GYAV -,27,1971
inhalation
rat
lethal concentration (50 percent kill): 800 mg/m3/4 hour N/R 85INA8 6,646,1991
inhalation
rabbit
lowest published lethal concentration: 1 gm/m3/2 hour N/R 85GYAV -,27,1971
intramuscular
dog
lethal dose (50 percent kill): 40 mg/kg N/R VMRVAN (2-3),273,1967
intramuscular
domestic animal
lethal dose (50 percent kill): 46 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Reactivates cholinesterase VETNAL 54(12),94,1978
intramuscular
mammal (species unspecified)
lethal dose (50 percent kill): 46,200 g/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Food intake (animal)

Behavioral: Muscle contraction or spasticity
VETNAL 54(12),94,1978
intraperitoneal
chicken
lethal dose (50 percent kill): 20 mg/kg N/R EQSFAP 3,173,1974
intraperitoneal
guinea pig
lethal dose (50 percent kill): 310 mg/kg N/R TXAPA9 6,86,1964
intraperitoneal
mouse
lethal dose (50 percent kill): 125 mg/kg N/R TXAPA9 6,86,1964
intraperitoneal
mouse
lowest published toxic dose: 300 mg/kg Brain and Coverings: Other degenerative changes TOLED5 135,89,2002
intraperitoneal
rat
lethal dose (50 percent kill): 260 mg/kg N/R TXAPA9 6,86,1964
intravenous
mouse
lethal dose (50 percent kill): 320 mg/kg N/R CSLNX* NX#00142
oral
wild bird
lethal dose (50 percent kill): 1,300 g/kg N/R TXAPA9 21,315,1972
oral
chicken
lethal dose (50 percent kill): 20 mg/kg N/R EQSFAP 3,173,1974
oral
duck
lethal dose (50 percent kill): 5,900 g/kg N/R DOEAAH 35,25,1979
oral
guinea pig
lethal dose (50 percent kill): 260 mg/kg N/R TXAPA9 6,86,1964
oral
mammal (species unspecified)
lethal dose (50 percent kill): 105 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Food intake (animal)

Behavioral: Muscle contraction or spasticity
VETNAL 54(12),94,1978
oral
man
lowest published toxic dose: 1,429 L/kg Lung, Thorax, or Respiration: Other changes

Kidney, Ureter, and Bladder: Other changes

Skin and Appendages: Other: Sweating
JJAMA* 14,789,1990
oral
man
lowest published toxic dose: 3,571 L/kg Eye: Miosis (pupilliary constriction)

Behavioral: General anesthetic

Behavioral: Convulsions or effect on seizure threshold
YAKUD5 32,1456,1990
oral
man
lowest published toxic dose: 643 L/kg Peripheral Nerve and Sensation: Fasciculations

Behavioral: Ataxia

Cardiac: Pulse rate decreased with fall in BP
HETOEA 14,600,1995
oral
man
lowest published toxic dose: 257 mg/kg Cardiac: Pulse rate increased without fall in BP

Gastrointestinal: Hypermotility, diarrhea

Gastrointestinal: Nausea or vomiting
JTCTDW 19,425,1982
oral
mouse
lethal dose (50 percent kill): 88,100 g/kg N/R HOEKAN 30,53,1980
oral
pigeon
lethal dose (50 percent kill): 1,780 g/kg N/R ASTTA8 (680),157,1979
oral
quail
lethal dose (50 percent kill): 11 mg/kg N/R TXAPA9 20,57,1971
oral
rat
lethal dose (50 percent kill): 180 mg/kg N/R KSKZAN 16(2),59,1978
oral
rabbit
lethal dose (50 percent kill): 150 mg/kg Behavioral: Muscle weakness

Gastrointestinal: Changes in structure or function of salivary glands

Kidney, Ureter, and Bladder: Other changes
BWHOA6 29,205,1963
oral
woman
lowest published toxic dose: 1,200 L/kg Behavioral: Coma

Cardiac: Pulse rate decreased with fall in BP

Gastrointestinal: Hypermotility, diarrhea
HETOEA 14,600,1995
oral
woman
lowest published toxic dose: 525 mg/kg Eye: Miosis (pupilliary constriction)

Behavioral: Muscle contraction or spasticity

Lung, Thorax, or Respiration: Respiratory depression
HETOEA 9,187,1990
subcutaneous
mouse
lethal dose (50 percent kill): 144 mg/kg N/R OYYAA2 1,74,1967
skin
duck
lethal dose (50 percent kill): 44 mg/kg N/R TXAPA9 47,451,1979
skin
mouse
lethal dose (50 percent kill): 500 mg/kg N/R OYYAA2 1,74,1967
skin
rat
lethal dose (50 percent kill): 330 mg/kg Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Excitement
TXAPA9 2,88,1960
unreported route
human
lowest published lethal dose: 50 mg/kg N/R 85INA8 5,267,1986


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
rat
lowest published toxic dose: 1,200 mg/kg/60 day- continuous Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field TXAPA9 6,86,1964
oral
domestic bird
lowest published toxic dose: 7,500 g/kg/5 day- continuous Behavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
AECTCV 11,617,1982
oral
rat
lowest published toxic dose: 172 mg/kg/6 day- intermittent Peripheral Nerve and Sensation: Structural change in nerve or sheath

Blood: Changes in bone marrow not included in above

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
ZYYZEW 2,126,1988
subcutaneous
rat
lowest published toxic dose: 5,200 mg/kg/1 year- intermittent Eye: Retinal changes pigmentary deposition, retinitis, other)

Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
ENVRAL 30,453,1983
subcutaneous
rat
lowest published toxic dose: 260 mg/kg/13 week- intermittent Eye: Retinal changes pigmentary deposition, retinitis, other) TOXID9 15,26,1995
skin
chicken
lowest published toxic dose: 35 mg/kg/7 day- intermittent Behavioral: Ataxia

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases
JTEHD6 21,455,1987
skin
chicken
lowest published toxic dose: 24 mg/kg/24 week- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Musculoskeletal: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
VHTODE 41,302,1999
skin
rat
lowest published toxic dose: 380 mg/kg/19 day- intermittent Brain and Coverings: Other degenerative changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
BWHOA6 29,205,1963
skin
rat
lowest published toxic dose: 3,225 mg/kg/43 week- intermittent Brain and Coverings: Other degenerative changes TXAPA9 104,440,1990
skin
rat
lowest published toxic dose: 365 mg/kg/5 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field BWHOA6 29,205,1963
unreported route
rat
lowest published toxic dose: 3,000 mg/kg/40 week- intermittent Brain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
HBPTO* 1,878,2001


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.05 mg/m3 (inhalable, vapor, skin) DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not classifiable as human carcinogen DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
RREVAH 46,1,1973
TOXICOLOGY REVIEW
CNDQA8 10(3),43,1975
TOXICOLOGY REVIEW
RREVAH 63,1,1976
TOXICOLOGY REVIEW
MUTAEX 21,93,2006
TOXICOLOGY REVIEW
ENTOX* -,325,2005
TOXICOLOGY REVIEW
ENTOX* -,306,2005
TOXICOLOGY REVIEW
ENTOX* -,308,2005
TOXICOLOGY REVIEW
MUREAV 584,1,2005
TOXICOLOGY REVIEW
MUTAEX 21,93,2006


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Supported RBREV* -,120,1998
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.2 mg/m3, JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 0.2 mg/m3, Skin, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 0.1 mg/m3, OCT 2002
Occupational Exposure Limit - GERMANY MAK 0.2 mg/m3 (inhalable), 2005
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 0.2 mg/m3, skin, APR2007
Occupational Exposure Limit - KOREA time-weighted average 0.2 mg/m3, skin, 2006
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.1 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 0.2 mg/m3, skin, JAN2002
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0.2 mg/m3, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 0.1 mg/m3,KZG- week 0.2 mg/m3, Skin, DEC2006
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not classifiable as human carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not classifiable as human carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X9267;
Number of Industries 4;
Total Number of Facilities 221;
Number of Occupations 6;
Total Number of Employees Exposed 2,142;
Total Number of Female Employees Exposed 442


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Negative: In vitro UDS-human fibroblast; TRP reversion
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay; E coli polA without S9
EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal
Used as an agricultural chemical and pesticide
NCI Carcinogenesis Bioassay (feed);clear evidence:mouse NCITR* NCI-TR-103,1979
NCI Carcinogenesis Bioassay (feed);no evidence:rat NCITR* NCI-TR-103,1979


REFERENCES:

CODEN
REFERENCE

85GYAV "Pflanzenschutz-und Schaedlingsbekaempfungsmittel: Abriss einer Toxikologie und Therapie von Vergiftungen," 2nd ed., Klimmer, O.R., Hattingen, Fed. Rep. Ger., Hundt-Verlag, 1971
85INA8 "Documentation of the Threshold Limit Values and Biological Exposure Indices," 5th ed., Cincinnati, OH, American Conference of Governmental Industrial Hygienists, Inc., 1986
AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973-
ASTTA8 ASTM Special Technical Publication. (American Soc. for Testing Materials, 1916 Race St., Philadelphia, PA 19103) No.1- 1911-
BWHOA6 Bulletin of the World Health Organization. (WHO, Pub. Center USA, 49 Sheridan Ave., Albany, NY 12210)
CNDQA8 Cahiers de Nutrition et de Dietetique. (Editions Meteore, 42, rue du Louvre, 75001 Paris, France) V.1- 1966-
CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010)
DOEAAH Down to Earth. (Dow Chemical USA, Agricultural Products Dept., Midland, MI 48640) V.1- 1945-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1967-
EQSFAP Environmental Quality and Safety. (Stuttgart, Fed. Rep. Ger.) V.1-5, 1972-76. Discontinued.
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
HBPTO* Handbook of pesticide toxicology. Robert Krieger ed, Academic press, 2001
HETOEA Human & Experimental Toxicology. (Macmillan Press Ltd., Brunel Road, Houndmills, Basingstoke, Hampshire, RG21 2XS, UK) V.9- 1990-
HOEKAN Hokkaidoritsu Eisei Kenkyushoho. Report of the Hokkaido Institute of Public Health. (Nishi- 12-chome, Kita-19-jo, Kita-ku, Sapporo 060, Japan) No.1- 1951-
JJAMA* Japanese Journal of Acute Medicine. (Nihon Kyukyu Igakkai Jun Kikanshi, Herusu Shuppan, 2-3 Nakano 2-chome, Nakanoku Tokyo 164, Japan) V.1- 196(?)-
JTCTDW Journal of Toxicology, Clinical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.19- 1982-
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
KSKZAN Khimiya v Sel'skom Khozyaistve. Chemistry in Agriculture. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) No.1- 1963-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
NCITR* National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967-
PCBPBS Pesticide Biochemistry and Physiology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1971-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962-
TIHEEC Toxicology and Industrial Health. (Princeton Scientific Pub. Co., POB 2155, Princeton, NJ 08540) V.1- 1985-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VETNAL Veterinariya. Veterinary Science. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1924-
VHTODE Veterinary and Human Toxicology. (American College of Veterinary and Comparative Toxicology, Publication Office, Comparative Toxicology, Manhattan, KS 66506) V.19- 1977-
VMRVAN Veterinary Medical Review. No.1, 1964- No.1/2, 1975. For Publisher information, see: VVMRDI
YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959-
ZYYZEW Zhongguo Yaolixue Yu Dulixue Zazhi. (Chinese Pharmacological Society, 27 Tai-Ping Road, Beijing 100850, China) V.1- 1986-

Used as an agricultural chemical and pesticide

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen
   Reproductive Effector
   Human Data

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