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Registry of Toxic Effects of Chemical Substances (RTECS)

Phosphorothioic acid, O,O-diethyl O-(3,5,6-trichloro-2-pyridyl) ester

RTECS #

TF6300000

CAS #

2921-88-2

Updated

December 2013

Molecular Weight

350.59

Molecular Formula

C9H11Cl3NO3PS

Synonyms

2-Pyridinol, 3,5,6-trichloro-, O-ester with O,O-diethyl phosphorothioate
Analytical grade chlorpyrifos
Brodan
Chlorpyrifos
Chlorpyrifos (ACGIH)
Chlorpyrifos-ethyl
Chlorpyriphos
Chlorpyriphos-ethyl
Detmol U.A.
Dowco 179
Dursban
Dursban F
ENT 27311
Ethion, dry
Lorsban
Lorsban 4E
Lorsban 50SL
O,O-Diaethyl-O-3,5,6-trichlor-2-pyridylmonothiophosphat (German)
O,O-Diethyl O-(3,5,6-trichloro-2-pyridinyl) phosphorothioate
O,O-Diethyl O-3,5,6-trichloro-2-pyridyl phosphorothioate
OMS-0971
Piridane
Pyrinex
Stipend
Zidil

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisother cell types/mouse500 µg/LMUREAV 279,165,1992
Cytogenetic Analysissperm/human500 µmol/L/1HREPTED 25,455,2008
DNA Damagesperm/human4.302 mmol/L/1HREPTED 25,455,2008
DNA Damagemultiple/other fish68 µg/L/1DFCTOD7 47,650,2009
DNA Damageother cell types/human1 µmol/L/1HTOXID9 -,223,2009
DNA Damagemultiple/non-mammalian species0.08 mg/L/96HMUREAV 680,2,2009
DNA Damageintramuscular/rat50 mg/kgEMMUEG 49,426,2008
DNA Damageintramuscular/rat100.8 mg/kg/90D- intermittentEMMUEG 49,426,2008
DNA Damageoral/mouse0.28 mg/kgMUREAV 516,139,2002
DNA Damageliver/human10 µmol/LTOXID9 -,73,2008
DNA inhibitionother cell types/human3 µmol/L/1HTXAPA9 206,17,2005
micronucleus testmultiple/non-mammalian species0.16 mg/L/96HMUREAV 680,2,2009
micronucleus testmultiple/other fish68 µg/L/3D-continuousFCTOD7 47,650,2009
micronucleus testmultiple/other fish102 µg/L/1DFCTOD7 47,650,2009
sex chromosome loss and nondisjunctionoral/Drosophila melanogaster50 ppbENMUDM 5,835,1983
sister chromatid exchangelymphocyte/human2 mg/LMUREAV 102,89,1982
sister chromatid exchangeother cell types/mouse1 mg/LMUREAV 279,165,1992
specific locus testoral/Drosophila melanogaster50 ppbMUREAV 279,15,1992

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
intraperitoneal/rat 210 µg/kg (1-7D pregnant)Reproductive: Specific developmental abnormalities: Central nervous systemVHTODE 34,498,1992
intraperitoneal/rat 4500 µg/kg (7-21D pregnant)Reproductive: Specific developmental abnormalities: Central nervous systemVHTODE 34,498,1992
intraperitoneal/mouse 80 mg/kg (1D prior to copulation)Reproductive: Effects on embryo or fetus: Cytological changes (including somatic cell genetic material)REPTED 17,401,2003
intraperitoneal/mouse 40 mg/kg (10D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)
REPTED 20,267,2005
intraperitoneal/mouse 80 mg/kg (10D pregnant)Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
REPTED 20,267,2005
oral/rat 45 mg/kg (6-20D pregnant)Reproductive: Effects on newborn: Biochemical and metabolicTOXID9 60,240,2001
oral/rat 75 mg/kg (6-20D pregnant)Reproductive: Specific developmental abnormalities: Central nervous systemTOXID9 66,131,2002
oral/rat 8 mg/kg (14D preg-7D after birth)Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Blood and lymphatic systems (including spleen and marrow)

Reproductive: Specific developmental abnormalities: Hepatobiliary system
TOXID9 66,138,2002
oral/rat 5 mg/kg (14-18D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)TOXID9 66,130,2002
oral/rat 50 mg/kg (14D pregnant)Reproductive: Other effects on female

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
ARTODN 76,30,2002
oral/mouse 6 mg/kg (multigenerations)Reproductive: Specific developmental abnormalities: Endocrine systemREPTED 22,263,2006
oral/mouse 24 mg/kg (15-18D pregnant)Reproductive: Specific developmental abnormalities: Endocrine systemREPTED 22,263,2006
oral/mouse 12 mg/kg (15-18D pregnant)Reproductive: Effects on newborn: Biochemical and metabolic

Reproductive: Effects on newborn: Behavioral
TOSCF2 93,105,2006
oral/rat 252 mg/kg (1-21D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)JTSCDR 31,521,2006
oral/rat 315 mg/kg (1-21D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)JTSCDR 31,521,2006
oral/rat 180 mg/kg (6-15D pregnant)Reproductive: Other effects on female

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
INJPD2 39,145,2007
oral/rat 45 mg/kg (6-20D pregnant)Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Effects on newborn: Biochemical and metabolic
TOSCF2 77,83,2004
oral/rat 250 mg/kg (6-15D pregnant)Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
REPTED 17,203,2003
oral/rat 250 mg/kg (6-15D pregnant)Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Hepatobiliary system
REPTED 17,203,2003
oral/rat 250 mg/kg (6-15D pregnant)Reproductive: Specific developmental abnormalities: Eye, earREPTED 17,203,2003
oral/rat 150 mg/kg (6-15D pregnant)Reproductive: Specific developmental abnormalities: Central nervous systemREPTED 17,203,2003
oral/rat 25 mg/kg (14-18D pregnant)Reproductive: Other effects on femaleTOSCF2 52,92,1999
oral/rat 135 mg/kg (6-22D preg/10D after birth)Reproductive: Other effects on female

Reproductive: Effects on newborn: Biochemical and metabolic
TOSCF2 53,438,2000
oral/mouse 250 mg/kg (6-15D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)TXAPA9 54,31,1980
oral/rabbit 12180 mg/kg (6-19D pregnant)Reproductive: Specific developmental abnormalities: Musculoskeletal systemFEREAC 60,7509,1995
oral/pigeon 35 mg/kg (7D prior to copulation)Reproductive: Effects on fertility: Other measures of fertility

Reproductive: Other effects to embryo or fetus

Reproductive: Effects on newborn: Other neonatal measures or effects
TOXID9 -,14,2008
oral/rat 787.5 mg/kg (7D preg-21D after birth)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Biochemical and metabolic

Reproductive: Effects on newborn: Other postnatal measures or effects
NETEEC 30,125,2008
oral/mouse 18 mg/kg (15D preg-14D after birth)Reproductive: Effects on newborn: BehavioralNETEEC 32,234,2010
oral/rat 225 mg/kg (30D male)Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females)TIHEEC 23,439,2007
skin/rat 30 mg/kg (18D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Central nervous system
JTEHD6 63,173,2001
skin/rat 1.6 mg/kg (5-20D pregnant)Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Blood and lymphatic systems (including spleen and marrow)
TOXID9 72,127,2003
skin/rat 17 mg/kg (4-20D pregnant)Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Effects on newborn: Behavioral

Reproductive: Effects on newborn: Delayed effects
ARTODN 80,620,2006
skin/rat 1.7 mg/kg (4-20D pregnant)Reproductive: Effects on newborn: Biochemical and metabolic

Reproductive: Effects on newborn: Delayed effects
TOXID9 78,274,2004
skin/rat 1.7 mg/kg (4-20D pregnant)Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Effects on newborn: Biochemical and metabolic

Reproductive: Effects on newborn: Delayed effects
ARTODN 78,467,2004
skin/rat 17 mg/kg (4-20D pregnant)Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Effects on newborn: Biochemical and metabolic

Reproductive: Effects on newborn: Behavioral
TOXID9 90,295,2006
subcutaneous/mouse 180 mg/kg (6-17D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)TERPM* -,394,2006
subcutaneous/rat 4 mg/kg (9-12D pregnant)Reproductive: Effects on newborn: Behavioral

Reproductive: Effects on newborn: Delayed effects
NETEEC 26,95,2004
subcutaneous/rat 20 mg/kg (17-20D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)TOXID9 66,130,2002
subcutaneous/rat 200 mL/kg (12D pregnant)Reproductive: Other effects on female

Reproductive: Specific developmental abnormalities: Central nervous system
JTEHD6 44,189,1995
subcutaneous/rat 50 mg/kg (12-19D pregnant)Reproductive: Other effects on female

Reproductive: Other effects to embryo or fetus
PBBHAU 53,771,1996
subcutaneous/rat 200 mg/kg (12-19D pregnant)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Behavioral
PBBHAU 53,771,1996
subcutaneous/mouse 24 mg/kg (6-17D pregnant)Reproductive: Specific developmental abnormalities: Central nervous systemTXAPA9 245,310,2010
subcutaneous/mouse 100 mg/kg (9-18D pregnant)Reproductive: Other developmental abnormalitiesNETEEC 32,498,2010
subcutaneous/mouse 144 mg/kg (6-17D pregnant)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)NETEEC 32,504,2010
subcutaneous/mouse 20 mg/kg (17-20D pregnant)Reproductive: Specific developmental abnormalities: Endocrine systemREPTED 29,74,2010
subcutaneous/mouse 4 mg/kg (17-20D pregnant)Reproductive: Effects on newborn: BehavioralREPTED 29,74,2010
subcutaneous/mouse 15 mg/kg (17-20 D pregnant)Reproductive: Effects on newborn: BehavioralTOXID9 12,466,2008
subcutaneous/rat 4 mg/kg (17-20D pregnant)Reproductive: Effects on newborn: Biochemical and metabolic

Reproductive: Effects on newborn: Drug dependence
NETEEC 24,733,2002

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat lethal concentration (50 percent kill): >0.2 gm/m3/4HENTOX* -,583,2005
intraperitoneal/mouse lowest published toxic dose: 10 mg/kgBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other hydrolases
TXAPA9 205,149,2005
intraperitoneal/mouse lowest published toxic dose: 30 mg/kgBrain and Coverings: Other degenerative changes

Behavioral: Change in motor activity (specific assay)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
TXAPA9 211,78,2006
intraperitoneal/mouse lethal dose (50 percent kill): 192 mg/kgTXAPA9 65,144,1982
intraperitoneal/mouse lowest published toxic dose: 30 mg/kgBlood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other hydrolases
TXAPA9 224,98,2007
intraperitoneal/mouse lowest published toxic dose: 30 mg/kgBrain and Coverings: Other degenerative changesTOLED5 135,89,2002
intraperitoneal/mouse lowest published toxic dose: 100 mg/kgBrain and Coverings: Other degenerative changes

Behavioral: Tremor
TXAPA9 227,42,2008
intraperitoneal/non-mammalian species lowest published toxic dose: 2 mg/kgBlood: Changes in spleen

Blood: Changes in leukocyte (WBC) count

Immunological Including Allergic: Increase in cellular immune response
TOXID9 78,321,2004
intraperitoneal/non-mammalian species lowest published toxic dose: 50 mg/kgKidney, Ureter, and Bladder: Other changes

Immunological Including Allergic: Decreased immune response

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TOXID9 78,321,2004
intraperitoneal/rat lowest published toxic dose: 15 mg/kgBrain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TOXID9 66,312,2002
multiple/man lowest published toxic concentration: 45 pph/15MPeripheral Nerve and Sensation: Sensory change involving peripheral nerve

Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Gastrointestinal: Nausea or vomiting
JTCTDW 41,883,2003
oral/chicken lethal dose (50 percent kill): 25400 µg/kgPeripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold
TXAPA9 11,49,1967
oral/chicken lowest published toxic dose: 150 mg/kgBehavioral: AtaxiaARTODN 76,367,2002
oral/chicken lethal dose (50 percent kill): 18.14 mg/kgTOLED5 174,110,2007
oral/chicken lowest published toxic dose: 5 mg/kgEye: Lacrimation

Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold
TOLED5 174,110,2007
oral/chicken lowest published toxic dose: 2 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Change in motor activity (specific assay)

Behavioral: Alteration of classical conditioning
TOLED5 174,110,2007
oral/Dog lowest published toxic dose: 1 mg/kgBlood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TOXID9 66,311,2002
oral/duck lethal dose (50 percent kill): 76 mg/kgTXAPA9 20,57,1971
oral/guinea pig lethal dose (50 percent kill): 504 mg/kgFMCHA2 -,C74,1991
oral/guinea pig lowest published lethal dose: 299 mg/kgRTOPDW 35,105,2002
oral/human lowest published toxic dose: 2 mg/kgEndocrine: Differential effect of sex or castration on observed toxicity

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases
TOSCF2 66,34,2002
oral/man lowest published toxic dose: 1.71 mL/kgBehavioral: Muscle weakness

Vascular: BP lowering not characterized in autonomic section

Lung, Thorax, or Respiration: Respiratory depression
VHTODE 43,34,2001
oral/man lowest published toxic dose: 300 mg/kgPeripheral Nerve and Sensation: Paresthesia

Behavioral: Muscle weakness

Behavioral: Coma
ARTODN 59,176,1986
oral/mouse lowest published toxic dose: 25 mg/kgBrain and Coverings: Other degenerative changes

Peripheral Nerve and Sensation: Fasciculations

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TXCYAC 234,90,2007
oral/mouse lethal dose (50 percent kill): 60 mg/kgTXCYAC 234,90,2007
oral/mouse lethal dose (50 percent kill): 75 mg/kgNutritional and Gross Metabolic: Weight loss or decreased weight gainTXCYAC 234,90,2007
oral/mouse lowest published toxic dose: 10 mg/kgLiver: Liver function tests impaired

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
FCTOD7 46,797,2008
oral/pigeon lowest published toxic dose: 3 mg/kgBehavioral: Alteration of classical conditioningTOXID9 -,270,2009
oral/pigeon lowest published toxic dose: 1 mg/kgBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesteraseTOXID9 -,270,2009
oral/pigeon lethal dose (50 percent kill): 10 mg/kgASTTA8 (680),157,1979
oral/quail lethal dose (50 percent kill): 13300 µg/kgASTTA8 (680),157,1979
oral/rabbit lowest published lethal dose: 1000 mg/kgRTOPDW 35,105,2002
oral/rabbit lethal dose (50 percent kill): 1 gm/kgENTOX* -,583,2005
oral/rat lowest published toxic dose: 0.1 mg/kgBrain and Coverings: Other degenerative changesTXAPA9 248,144,2010
oral/rat lowest published toxic dose: 2 mg/kgBrain and Coverings: Other degenerative changes

Behavioral: Somnolence (general depressed activity)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TXAPA9 210,142,2006
oral/rat lowest published lethal dose: 10 mg/kgPeripheral Nerve and Sensation: Fasciculations

Gastrointestinal: Hypermotility, diarrhea
TXCYAC 220,13,2006
oral/rat lowest published toxic dose: 1 mg/kgBrain and Coverings: Other degenerative changes

Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TXCYAC 220,13,2006
oral/rat lowest published toxic dose: 2.4 mg/kgLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TOVEFN (3),15,1993
oral/rat lowest published toxic dose: 1.5 mg/kgBrain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TOXID9 66,312,2002
oral/rat lethal dose (40 percent kill): 80 mg/kgTOXID9 66,313,2002
oral/rat lethal dose (10 percent kill): 136 mg/kgBrain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TOXID9 60,241,2001
oral/rat lowest published toxic dose: 35 mg/kgBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
TOXID9 -,117,2009
oral/rat lowest published lethal dose: 8 mg/kgBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesteraseTXAPA9 210,142,2006
oral/rat lowest published toxic dose: 3 mg/kgBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterasesTXCYAC 217,1,2006
oral/rat lowest published toxic dose: 30 mg/kgGastrointestinal: Changes in structure or function of salivary glands

Nutritional and Gross Metabolic: Body temperature decrease

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases
TXCYAC 217,1,2006
oral/rat lowest published toxic dose: 15 mg/kgBrain and Coverings: Other degenerative changes

Blood: Other changes

Nutritional and Gross Metabolic: Body temperature decrease
TOXID9 60,246,2001
oral/rat lowest published toxic dose: 1 mg/kgBehavioral: Change in motor activity (specific assay)TOXID9 60,246,2001
oral/rat lowest published toxic dose: 10 mg/kgBrain and Coverings: Changes in surface EEGTOXID9 60,246,2001
oral/rat lowest published lethal dose: 69 mg/kgRTOPDW 35,105,2002
oral/rat lowest published toxic dose: 10 mg/kgBrain and Coverings: Other degenerative changes

Biochemical: Metabolism (intermediary): Other proteins
ARTODN 83,319,2009
oral/rat lowest published toxic dose: 30 mg/kgBehavioral: Change in motor activity (specific assay)

Nutritional and Gross Metabolic: Body temperature decrease
TOXID9 66,35,2002
oral/rat lowest published toxic dose: 50 mg/kgBehavioral: Tremor

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases
ARTODN 76,30,2002
oral/rat lowest published toxic dose: 30 mg/kgBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Nutritional and Gross Metabolic: Body temperature decrease

Biochemical: Metabolism (intermediary): Other
NRTXDN 30,377,2009
oral/rat lowest published toxic dose: 30 mg/kgBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)TOXID9 -,337,2009
oral/rat lowest published toxic dose: 1.5 mg/kgBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesteraseTOSCF2 77,63,2004
oral/rat lowest published lethal dose: 8 mg/kgBrain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TOXID9 72,308,2003
oral/rat lowest published toxic dose: 10 mg/kgNutritional and Gross Metabolic: Body temperature decreaseTOXID9 72,308,2003
oral/rat lowest published toxic dose: 5 mg/kgBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TOXID9 72,309,2003
oral/rat lowest published toxic dose: 10 mg/kgBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases
TOSCF2 66,34,2002
oral/rat lowest published toxic dose: 23.5 mg/kgBrain and Coverings: Other degenerative changes

Autonomic Nervous System: Other (direct) parasympathomimetic

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
NRTXDN 22,39,2001
oral/rat lowest published toxic dose: 25 mg/kgBehavioral: Change in psychophysiological testsTXCYAC 146,1,2000
oral/rat lowest published toxic dose: 25 mg/kgCardiac: Pulse rate increased without fall in BP

Vascular: BP elevation not characterized in autonomic section

Nutritional and Gross Metabolic: Body temperature decrease
BCLPT* 96,503,2005
oral/rat lowest published toxic dose: 1 mg/kgNutritional and Gross Metabolic: Body temperature increaseTXCYAC 177,215,2002
oral/rat lowest published toxic dose: 5 mg/kgBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Eye: Miosis (pupilliary constriction)
TOSCF2 92,235,2006
oral/rat lowest published toxic dose: 20 mg/kgBehavioral: Alteration of classical conditioning

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TOSCF2 92,235,2006
oral/rat lowest published toxic dose: 15 mg/kgPeripheral Nerve and Sensation: FasciculationsTXCYAC 238,157,2007
oral/rat lowest published lethal dose: 50 mg/kgBehavioral: Sleep

Behavioral: Tremor
TXCYAC 237,145,2007
oral/rat lethal dose (50 percent kill): 82 mg/kgTXAPA9 14,515,1969
oral/rat lowest published toxic dose: 60 mg/kgPeripheral Nerve and Sensation: Fasciculations

Gastrointestinal: Hypermotility, diarrhea
TXAPA9 205,31,2005
oral/rat lowest published toxic dose: 68 mg/kgPeripheral Nerve and Sensation: Fasciculations

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TXCYAC 238,157,2007
oral/rat lowest published toxic dose: 7.5 mg/kgNutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TXCYAC 238,157,2007
oral/wild bird lethal dose (50 percent kill): 5 mg/kgTXAPA9 21,315,1972
oral/woman lowest published toxic dose: 0.33 mL/kgPeripheral Nerve and Sensation: Flaccid paralysis with appropriate anesthesia

Eye: Miosis (pupilliary constriction)

Gastrointestinal: Hypermotility, diarrhea
TOLED5 159,235,2005
oral/woman lowest published toxic dose: 3 mL/kgPeripheral Nerve and Sensation: Recording from peripheral motor nerve

Behavioral: Rigidity (includes catalepsy)

Gastrointestinal: Nausea or vomiting
JTCTDW 43,877,2005
skin/mouse lethal dose (50 percent kill): 120 mg/kgYKYUA6 38,745,1987
skin/mouse lowest published toxic dose: 100 mg/kgBrain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TOLED5 151,219,2004
skin/rabbit lethal dose (50 percent kill): 2000 mg/kgUSXXAM #6193990
skin/rat lethal dose (50 percent kill): 202 mg/kgTXAPA9 14,515,1969
skin/rat lowest published toxic dose: 30 mg/kgBrain and Coverings: Other degenerative changes

Liver: Other changes

Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord)
JTEHD6 63,173,2001
subcutaneous/guinea pig lowest published lethal dose: 100 mg/kgJEENAI 60,733,1967
subcutaneous/guinea pig lowest published toxic dose: 390 mg/kgBrain and Coverings: Other degenerative changes

Lung, Thorax, or Respiration: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TOXID9 60,242,2001
subcutaneous/mouse lowest published toxic dose: 0.5 mg/kgBehavioral: Change in motor activity (specific assay)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TOXID9 -,441,2009
subcutaneous/rat lowest published toxic dose: 250 mg/kgBehavioral: Alteration of classical conditioningNRTXDN 30,1025,2009
subcutaneous/rat lowest published toxic dose: 60 mg/kgBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases
JTEHF8 67,431,2004
subcutaneous/rat lowest published toxic dose: 60 mg/kgBrain and Coverings: Other degenerative changesTOXID9 72,305,2003
subcutaneous/rat lowest published toxic dose: 13.5 mg/kgBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesteraseNETEEC 25,599,2003
subcutaneous/rat lowest published toxic dose: 45 mg/kgNutritional and Gross Metabolic: Weight loss or decreased weight gainNETEEC 25,599,2003
subcutaneous/rat lowest published toxic dose: 166 mg/kgBrain and Coverings: Other degenerative changes

Behavioral: Alteration of classical conditioning

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
NETEEC 26,305,2004
subcutaneous/rat lowest published toxic dose: 84 mg/kgBrain and Coverings: Other degenerative changes

Behavioral: Change in motor activity (specific assay)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TXAPA9 216,150,2006
subcutaneous/rat lowest published toxic dose: 250 mg/kgBehavioral: Change in motor activity (specific assay)

Behavioral: Alteration of classical conditioning

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
NRTXDN 28,541,2007
subcutaneous/rat lowest published toxic dose: 250 mg/kgBrain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Neurotransmitters or modulators (putative): Dopamine in striatum
TOLED5 176,162,2008
subcutaneous/rat lowest published toxic dose: 60 mg/kgBrain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TXAPA9 219,136,2007
subcutaneous/rat lowest published toxic dose: 84 mg/kgBrain and Coverings: Recordings from specific areas of CNS

Nutritional and Gross Metabolic: Body temperature decrease

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TOXID9 90,301,2006
subcutaneous/rat lowest published toxic dose: 250 mg/kgBrain and Coverings: Other degenerative changes

Behavioral: Alteration of classical conditioning

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NRTXDN 32,836,2011
subcutaneous/rat lowest published toxic dose: 2.5 mg/kgBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
JPETAB 305,375,2003
subcutaneous/rat lowest published toxic dose: 60 mg/kgBehavioral: Change in motor activity (specific assay)TOXID9 66,316,2002
Tank with water/Carp lowest published toxic concentration: 0.04 mg/L/10DBlood: Changes in erythrocyte (RBC) count

Blood: Changes in leukocyte (WBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases
FCTOD7 50,2703 ,2012
Tank with water/Shrimp lethal concentration (50 percent kill): 0.063 µg/L/96HEESADV 73,360,2010
Tank with water/Zebrafish lowest published toxic concentration: 1.39 µmol/L 144HBlood: Other changes

Musculoskeletal: Other changes
REPTED 33,142,2012
Tank with water/Zebrafish lowest published toxic concentration: 0.02 mmol/L 144HRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldREPTED 33,142,2012
unreported route/mammal (species unspecified) lethal dose (50 percent kill): 163 mg/kgJAFCAU 27,712,1979
unreported route/rat lethal dose (50 percent kill): 150 mg/kg30ZDA9 -,339,1971
unreported route/rat lowest published toxic dose: 1 mg/kgBrain and Coverings: Other degenerative changes

Biochemical: Metabolism (intermediary): Other
TOXID9 44,197,2005
unreported route/rat lowest published toxic dose: 279 mg/kgBrain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TOXID9 60,241,2001
unreported route/rat lowest published toxic dose: 279 mg/kgBrain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Metabolism (intermediary): Other
TOXID9 60,241,2001

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
intramuscular/rat lowest published toxic dose: 300 mg/kg/3D- intermittentLiver: Other changes

Kidney, Ureter, and Bladder: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
PCBPBS 88,191,2007
multiple/non-mammalian species lowest published toxic dose: 101.67 mg/m3/6D- continuousBehavioral: Alteration of classical conditioning

Behavioral: Alteration of operant conditioning
NETEEC 31,242,2009
oral/chicken lowest published toxic dose: 28 mg/kg/7D- intermittentBrain and Coverings: Other degenerative changes

Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TOLED5 174,110,2007
oral/chicken lowest published toxic dose: 980 mg/kg/2W- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TXAPA9 11,49,1967
oral/Dog lowest published toxic dose: 2190 mg/kg/2Y- continuousLiver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
FCTXAV 12,47,1974
oral/Dog lowest published toxic dose: 2190 mg/kg/2Y- intermittentBrain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
RTOPDW 35,105,2002
oral/Dog lowest published toxic dose: 7 mg/kg/1W- continuousBlood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TOXID9 66,311,2002
oral/Dog lowest published toxic dose: 84 mg/kg/6W- continuousCardiac: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TOXID9 66,311,2002
oral/Dog lowest published toxic dose: 8.4 mg/kg/4W- continuousBlood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TOXID9 66,312,2002
oral/Dog lowest published toxic dose: 365 mg/kg/1Y- continuousBlood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TOXID9 60,322,2001
oral/Dog lowest published toxic dose: 8.7 mg/kg/4W- continuousBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesteraseRTOPDW 47,240,2007
oral/Dog lowest published toxic dose: 4.2 mg/kg/1W- continuousBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesteraseRTOPDW 47,240,2007
oral/Dog lowest published toxic dose: 21 mg/kg/6W- continuousBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesteraseRTOPDW 47,240,2007
oral/mouse lowest published toxic dose: 24 mg/kg/4D- intermittentEndocrine: Evidence of thyroid hypofunctionREPTED 22,263,2006
oral/mouse lowest published toxic dose: 639 mg/kg/10W- intermittentBlood: Luekopenia

Blood: Changes in erythrocyte (RBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
JTSCDR 32,111,2007
oral/mouse lowest published toxic dose: 447.3 mg/kg/7W- intermittentBehavioral: Tremor

Lung, Thorax, or Respiration: Dyspnea

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
JTSCDR 32,111,2007
oral/mouse lowest published toxic dose: 125 mg/kg/5D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldTXCYAC 234,90,2007
oral/mouse lowest published toxic dose: 93.6 mg/kg/30D- intermittentBrain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TXCYAC 234,90,2007
oral/mouse lowest published toxic dose: 31.25 mg/kg/5D- intermittentBrain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TXCYAC 234,90,2007
oral/mouse lowest published toxic dose: 15.6 mg/kg/5D- intermittentLiver: Other changes

Endocrine: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
TXCYAC 234,90,2007
oral/mouse lowest published toxic dose: 39.6 mg/kg/30D- continuousBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
FCTOD7 41,767,2003
oral/mouse lowest published toxic dose: 79.2 mg/kg/60D- continuousBlood: Normocytic anemia

Blood: Luekopenia
FCTOD7 41,767,2003
oral/rabbit lowest published toxic dose: 1960 mg/kg/13D- intermittentBehavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FEREAC 60,7509,1995
oral/rat lowest published toxic dose: 75 mg/kg/5D- intermittentBehavioral: Tremor

Gastrointestinal: Changes in structure or function of salivary glands

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
REPTED 17,203,2003
oral/rat lowest published toxic dose: 75 mg/kg/5D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainREPTED 17,203,2003
oral/rat lowest published toxic dose: 1820 mg/kg/1Y- continuousBrain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TOXID9 72,309,2003
oral/rat lowest published toxic dose: 9 mg/kg/5D- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesteraseTOSCF2 76,400,2003
oral/rat lowest published toxic dose: 12 mg/kg/4D- intermittentBrain and Coverings: Other degenerative changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TOSCF2 77,63,2004
oral/rat lowest published toxic dose: 4.2 mg/kg/28D- continuousEndocrine: Changes in thyroid weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
FCTOD7 42,1269,2004
oral/rat lowest published toxic dose: 4.2 mg/kg/28D- continuousBlood: Other changesFCTOD7 42,1269,2004
oral/rat lowest published toxic dose: 119 mg/kg/17D- intermittentNutritional and Gross Metabolic: Body temperature increaseTXCYAC 177,215,2002
oral/rat lowest published toxic dose: 210 mg/kg/2W- intermittentBrain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TOSCF2 55,124,2000
oral/rat lowest published toxic dose: 60 mg/kg/4W- intermittentEye: Miosis (pupilliary constriction)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
NETEEC 22,237,2000
oral/rat lowest published toxic dose: 200 mg/kg/4W- intermittentBehavioral: Tremor

Behavioral: Alteration of operant conditioning

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
NETEEC 22,237,2000
oral/rat lowest published toxic dose: 50 mg/kg/5D- intermittentEye: Miosis (pupilliary constriction)

Gastrointestinal: Changes in structure or function of salivary glands

Nutritional and Gross Metabolic: Body temperature increase
NETEEC 22,237,2000
oral/rat lowest published toxic dose: 50 mg/kg/3D- intermittentBehavioral: Alteration of operant conditioning

Behavioral: Change in motor activity (specific assay)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
NETEEC 23,33,2001
oral/rat lowest published toxic dose: 730 mg/kg/2Y- continuousBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesteraseFCTXAV 12,47,1974
oral/rat lowest published toxic dose: 21840 µg/kg/28D- intermittentKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
ESKHA5 (106),48,1988
oral/rat lowest published toxic dose: 800 mg/kg/8W- intermittentEye: Miosis (pupilliary constriction)

Behavioral: Somnolence (general depressed activity)

Behavioral: Tremor
TOXID9 36(1 Pt2),345,1997
oral/rat lowest published toxic dose: 57 mg/kg/12D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainTOSCF2 59,260,2001
oral/rat lowest published toxic dose: 111 mg/kg/21D- intermittentBehavioral: Change in motor activity (specific assay)TOSCF2 59,260,2001
oral/rat lowest published toxic dose: 18 mg/kg/6D- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesteraseTOSCF2 59,260,2001
oral/rat lowest published toxic dose: 213 mg/kg/24W- intermittentBehavioral: Change in motor activity (specific assay)

Nutritional and Gross Metabolic: Body temperature decrease

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TXCYAC 177,215,2002
oral/rat lowest published toxic dose: 127.5 mg/kg/24W- intermittentBiochemical: Metabolism (intermediary): Plasma proteins not involving coagulationTXCYAC 177,215,2002
oral/rat lowest published toxic dose: 15 mg/kg/15D- intermittentNutritional and Gross Metabolic: Body temperature increaseTXCYAC 177,215,2002
oral/rat lowest published toxic dose: 270 mg/kg/1Y- intermittentEye: Retinal changes pigmentary deposition, retinitis, other)TOXID9 60,245,2001
oral/rat lowest published toxic dose: 80 mg/kg/20D- intermittentBrain and Coverings: Other degenerative changes

Biochemical: Metabolism (intermediary): Other proteins
TOXID9 90,295,2006
oral/rat lowest published toxic dose: 14 mg/kg/14D- intermittentBlood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TOXID9 66,313,2002
oral/rat lowest published toxic dose: 42 mg/kg/14D- intermittentBrain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TOXID9 66,313,2002
oral/rat lowest published toxic dose: 364 mg/kg/1Y- intermittentBlood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TOXID9 66,313,2002
oral/rat lowest published toxic dose: 1820 mg/kg/1Y- intermittentBrain and Coverings: Other degenerative changes

Behavioral: Change in psychophysiological tests

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TOXID9 66,313,2002
oral/rat lowest published toxic dose: 21 mg/kg/21D- intermittentBehavioral: Alteration of classical conditioning

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TOXID9 44,198,2005
oral/rat lowest published toxic dose: 66 mg/kg/11D- intermittentBrain and Coverings: Other degenerative changes

Biochemical: Metabolism (intermediary): Other proteins

Biochemical: Metabolism (intermediary): Other
TOXID9 44,199,2005
oral/rat lowest published toxic dose: 21 mg/kg/21D- intermittentBrain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TOXID9 44,199,2005
oral/rat lowest published toxic dose: 79.5 mg/kg/21D- intermittentBiochemical: Metabolism (intermediary): OtherTOXID9 44,199,2005
oral/rat lowest published toxic dose: 4.5 mg/kg/6D- intermittentBrain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TOXID9 66,131,2002
oral/rat lowest published toxic dose: 8 mg/kg/16D- intermittentBrain and Coverings: Other degenerative changes

Liver: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
TOXID9 66,138,2002
oral/rat lowest published toxic dose: 45 mg/kg/9D- intermittentBrain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
RTOPDW 35,105,2002
oral/rat lowest published toxic dose: 53 mg/kg/21D- intermittentBehavioral: Alteration of operant conditioning

Endocrine: Differential effect of sex or castration on observed toxicity

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TOXID9 78,273,2004
oral/rat lowest published toxic dose: 120 mg/kg/24D- intermittentBrain and Coverings: Other degenerative changes

Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases
TOXID9 78,276,2004
oral/rat lowest published toxic dose: 42 mg/kg/31D- intermittentBrain and Coverings: Other degenerative changes

Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TOXID9 1,113,2001
oral/rat lowest published toxic dose: 126 mg/kg/31D- intermittentBiochemical: Metabolism (intermediary): OtherTOXID9 1,113,2001
oral/rat lowest published toxic dose: 30 mg/kg/5D- intermittentBehavioral: Change in motor activity (specific assay)TOXID9 1,113,2001
oral/rat lowest published toxic dose: 30 mg/kg/5D- intermittentBehavioral: ExcitementTOXID9 1,113,2001
oral/rat lowest published toxic dose: 26 mg/kg/17D- intermittentBehavioral: Alteration of classical conditioningTOXID9 1,113,2001
oral/rat lowest published toxic dose: 18 mg/kg/6D- intermittentBrain and Coverings: Other degenerative changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TOSCF2 92,500,2006
oral/rat lowest published toxic dose: 9 mg/kg/6D- intermittentBrain and Coverings: Other degenerative changesTOSCF2 92,500,2006
oral/rat lowest published toxic dose: 378 mg/kg/8W- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TOLED5 169,26,2007
oral/rat lowest published toxic dose: 180 mg/kg/9D- intermittentLiver: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Metabolism (intermediary): Lipids including transport
INJPD2 39,145,2007
oral/rat lowest published toxic dose: 315 mg/kg/21D- intermittentOlfaction: Other olfaction effects

Eye: Hemorrhage

Behavioral: Tremor
JTSCDR 31,521,2006
oral/rat lowest published toxic dose: 105 mg/kg/7D- intermittentBehavioral: Food intake (animal)JTSCDR 31,521,2006
oral/rat lowest published toxic dose: 252 mg/kg/21D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainJTSCDR 31,521,2006
oral/rat lowest published toxic dose: 378 mg/kg/8W- intermittentLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
TOLED5 163,235,2006
oral/rat lowest published toxic dose: 450 mg/kg/15D- intermittentLiver: Liver function tests impaired

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
PCBPBS 89,118,2007
oral/rat lowest published toxic dose: 35 mg/kg/7D- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
TOXID9 -,117,2009
oral/rat lowest published toxic dose: 30 mg/kg/15D- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases
TOXID9 -,118,2009
oral/rat lowest published toxic dose: 35 mg/kg/7D- intermittentBrain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TOXID9 -,37,2009
oral/rat lowest published toxic dose: 151.2 mg/kg/4W- intermittentLung, Thorax, or Respiration: Emphysema

Lung, Thorax, or Respiration: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases
FCTOD7 48,1714,2010
oral/rat lowest published toxic dose: 1261.4 mg/kg/17W- intermittentBlood: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport
FCTOD7 48,3477,2010
oral/rat lowest published toxic dose: 225 mg/kg/30D- intermittentReproductive: Paternal effects: Testes, epididymis, sperm ductTIHEEC 23,439,2007
oral/rat lowest published toxic dose: 375 mg/kg/30D- intermittentEndocrine: Androgenic

Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Related to Chronic Data: Changes in testicular weight
TIHEEC 23,439,2007
oral/rat lowest published toxic dose: 103.6 mg/kg/21D- intermittentBrain and Coverings: Other degenerative changes

Biochemical: Neurotransmitters or modulators (putative): Dopamine in striatum
NETEEC 31,98,2009
skin/rat lowest published toxic dose: 3 mg/kg/30D- intermittentBehavioral: Change in psychophysiological testsARTODN 77,452,2003
skin/rat lowest published toxic dose: 30 mg/kg/30D- intermittentBrain and Coverings: Other degenerative changes

Behavioral: Change in psychophysiological tests

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TOXID9 66,314,2002
skin/rat lowest published toxic dose: 26 mg/kg/13D- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)TOXID9 72,89,2003
subcutaneous/mouse lowest published toxic dose: 300 mg/kg/2W- intermittentBrain and Coverings: Other degenerative changes

Biochemical: Neurotransmitters or modulators (putative): Dopamine in striatum
NRTXDN 23,537,2002
subcutaneous/mouse lowest published toxic dose: 4.5 mg/kg/2W- intermittentBiochemical: Neurotransmitters or modulators (putative): Dopamine at other sitesTOXID9 60,238,2001
subcutaneous/mouse lowest published toxic dose: 300 mg/kg/2W- intermittentBiochemical: Neurotransmitters or modulators (putative): Dopamine in striatumTOXID9 60,238,2001
subcutaneous/mouse lowest published toxic dose: 75 mg/kg/2W- intermittentBrain and Coverings: Other degenerative changes

Behavioral: Alteration of classical conditioning

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TOXID9 60,242,2001
subcutaneous/mouse lowest published toxic dose: 120 mg/kg/12D- intermittentBrain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TXAPA9 245,310,2010
subcutaneous/mouse lowest published toxic dose: 48 mg/kg/12D- intermittentBrain and Coverings: Other degenerative changesTXAPA9 245,310,2010
subcutaneous/mouse lowest published toxic dose: 120 mg/kg/12D- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesteraseTERPM* -,394,2006
subcutaneous/mouse lowest published toxic dose: 4 mg/kg/4D- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesteraseTOSCF2 93,105,2006
subcutaneous/mouse lowest published toxic dose: 12 mg/kg/4D- intermittentBehavioral: Change in motor activity (specific assay)

Behavioral: Alteration of classical conditioning

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TOSCF2 93,105,2006
subcutaneous/mouse lowest published toxic dose: 12 mg/kg/4D- intermittentBehavioral: Change in motor activity (specific assay)

Behavioral: Aggression

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TOSCF2 93,105,2006
subcutaneous/mouse lowest published toxic dose: 4 mg/kg/4D- intermittentBehavioral: Alteration of classical conditioning

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TOSCF2 93,105,2006
subcutaneous/rat lowest published toxic dose: 120 mg/kg/35D- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesteraseTOPADD 33,378,2005
subcutaneous/rat lowest published toxic dose: 35 mg/kg/7D- intermittentBrain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TOXID9 -,37,2009
subcutaneous/rat lowest published toxic dose: 120 mg/kg/42D- intermittentBrain and Coverings: Other degenerative changes

Peripheral Nerve and Sensation: Structural change in nerve or sheath
TOXID9 -,443,2009
subcutaneous/rat lowest published toxic dose: 270 mg/kg/30D- intermittentBrain and Coverings: Other degenerative changes

Behavioral: Alteration of classical conditioning

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
JPETAB 322,1117,2007
subcutaneous/rat lowest published toxic dose: 150 mg/kg/30D- intermittentBehavioral: Alteration of classical conditioning

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Reactivates cholinesterase
JPETAB 322,1117,2007
subcutaneous/rat lowest published toxic dose: 37.5 mg/kg/30D- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Reactivates cholinesterase
JPETAB 322,1117,2007
subcutaneous/rat lowest published toxic dose: 10 mg/kg/7D- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Reactivates cholinesteraseJPETAB 322,1117,2007
subcutaneous/rat lowest published toxic dose: 70 mg/kg/7D- intermittentBehavioral: Antianxiety

Behavioral: Alteration of classical conditioning
NRTXDN 32,355,2011
subcutaneous/rat lowest published toxic dose: 54 mg/kg/3D- intermittentBehavioral: Alteration of operant conditioningNETEEC 32,415,2010
subcutaneous/rat lowest published toxic dose: 54 mg/kg/5D- intermittentBehavioral: Alteration of operant conditioningNETEEC 32,415,2010
subcutaneous/rat lowest published toxic dose: 252 mg/kg/14D- intermittentBehavioral: Alteration of operant conditioning

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
NETEEC 32,415,2010
subcutaneous/rat lowest published toxic dose: 270 mg/kg/30D- intermittentBehavioral: Alteration of operant conditioning

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
NETEEC 32,415,2010
subcutaneous/rat lowest published toxic dose: 21 mg/kg/9D- intermittentBrain and Coverings: Other degenerative changes

Behavioral: Alteration of classical conditioning

Biochemical: Metabolism (intermediary): Other
TOXID9 60,241,2001
subcutaneous/rat lowest published toxic dose: 250 mg/kg/10D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainJPETAB 305,375,2003
subcutaneous/rat lowest published toxic dose: 300 mg/kg/6D- intermittentBehavioral: Tremor

Gastrointestinal: Changes in structure or function of salivary glands

Gastrointestinal: Hypermotility, diarrhea
JPETAB 305,375,2003
subcutaneous/rat lowest published toxic dose: 10 mg/kg/4D- intermittentBehavioral: Change in psychophysiological testsJPETAB 305,375,2003
subcutaneous/rat lowest published toxic dose: 20 mg/kg/4D- intermittentBrain and Coverings: Other degenerative changes

Biochemical: Metabolism (intermediary): Other proteins
TXAPA9 195,203,2004
subcutaneous/rat lowest published toxic dose: 20 mg/kg/4D- intermittentBrain and Coverings: Other degenerative changes

Endocrine: Differential effect of sex or castration on observed toxicity

Biochemical: Metabolism (intermediary): Other proteins
TXAPA9 203,132,2005
subcutaneous/rat lowest published toxic dose: 20 mg/kg/4D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainTOXID9 66,130,2002
subcutaneous/rat lowest published toxic dose: 20 mg/kg/4D- intermittentBehavioral: Change in motor activity (specific assay)

Behavioral: Alteration of classical conditioning

Behavioral: Alteration of operant conditioning
TOXID9 1,114,2001
subcutaneous/rat lowest published toxic dose: 250 mg/kg/7D- intermittentBehavioral: Alteration of operant conditioning

Behavioral: Change in motor activity (specific assay)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
NETEEC 23,33,2001
subcutaneous/rat lowest published toxic dose: 21 mg/kg/7D- intermittentBehavioral: Change in psychophysiological testsTXAPA9 174,89,2001
subcutaneous/rat lowest published toxic dose: 0.6 mg/kg/5D- intermittentBehavioral: Change in psychophysiological testsTXAPA9 174,89,2001
subcutaneous/rat lowest published toxic dose: 120 mg/kg/42D- intermittentBrain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TOXID9 72,305,2003
subcutaneous/rat lowest published toxic dose: 120 mg/kg/1H/4W- intermittentBrain and Coverings: Other degenerative changes

Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
ARTODN 75,480,2001
subcutaneous/rat lowest published toxic dose: 160 mg/kg/16D- intermittentBrain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Metabolism (intermediary): Other
PBBHAU 46,219,1993
unreported route/rat lowest published toxic dose: 4 mg/kg/4D- intermittentBehavioral: Alteration of classical conditioningTOXID9 44,197,2005
unreported route/rat lowest published toxic dose: 4 mg/kg/4D- intermittentBrain and Coverings: Recordings from specific areas of CNSTOXID9 72,124,2003
unreported route/rat lowest published toxic dose: 10.5 mg/kg/7D- intermittentBrain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TOXID9 72,309,2003
unreported route/rat lowest published toxic dose: 15 mg/kg/5D- intermittentBrain and Coverings: Other degenerative changesTOXID9 72,309,2003
unreported route/rat lowest published toxic dose: 4 mg/kg/4D- intermittentBrain and Coverings: Other degenerative changesTOXID9 66,130,2002
unreported route/rat lowest published toxic dose: 20 mg/kg/4D- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferasesTOXID9 60,241,2001

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.1 mg/m3 (inhal, vapor, skin)DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWMUREAV 539,77,2003
TOXICOLOGY REVIEWTOLED5 127,101,2002
TOXICOLOGY REVIEWRREVAH 63,1,1976
TOXICOLOGY REVIEWTOLED5 127,29,2002
TOXICOLOGY REVIEWPPTHFJ 42,55,2005
TOXICOLOGY REVIEWREPTED 22,196,2006
TOXICOLOGY REVIEWREPTED 22,164,2006
TOXICOLOGY REVIEWMUTAEX 21,93,2006
TOXICOLOGY REVIEWAPHRER 40,1040,2006
TOXICOLOGY REVIEWNETOX* 26,573,2005
TOXICOLOGY REVIEWCCATAR 366,1,2006
TOXICOLOGY REVIEWENTOX* -,583,2005
TOXICOLOGY REVIEWMUREAV 627,10,2007
TOXICOLOGY REVIEWENTOX* -,306,2005
TOXICOLOGY REVIEWENTOX* -,308,2005
TOXICOLOGY REVIEWREPTED 23,260,2007
TOXICOLOGY REVIEWFEREAC 72,44439,2007
TOXICOLOGY REVIEWREPTED 26,1,2008
TOXICOLOGY REVIEWJTPAE7 19,1,2006
TOXICOLOGY REVIEWHUTOX* -,541,1996
TOXICOLOGY REVIEWHTOPA* 1,501,2002
TOXICOLOGY REVIEWMUREAV 681,3,2009
TOXICOLOGY REVIEWTPHSDY 29,322,2008
TOXICOLOGY REVIEWFCTOD7 46,813,2008
TOXICOLOGY REVIEWMUREAV 674,3,2009
TOXICOLOGY REVIEWFEREAC 73,53732,2008
TOXICOLOGY REVIEWREPTED 26,13,2008
TOXICOLOGY REVIEWHETOEA 26,321,2007
TOXICOLOGY REVIEWFCTOD7 47,2906,2009
TOXICOLOGY REVIEWMUTAEX 26,19,2011
TOXICOLOGY REVIEWTOLED5 190,107,2009
TOXICOLOGY REVIEWREPTED 31,297,2011
TOXICOLOGY REVIEWNRTXDN 31,562,2010
TOXICOLOGY REVIEWMUREAV 721,27,2011
TOXICOLOGY REVIEWREPTED 38,1,2013
TOXICOLOGY REVIEWNRTXDN 33,575,2012
TOXICOLOGY REVIEWNETOX* 33,911,2012

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESSupportedRBREV* -,99,1998
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.2 mg/m3, JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 0.2 mg/m3;KZW 0.4 mg/m3, skin, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 0.1 mg/m3 (vapor, aerosol), Skin, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.2 mg/m3, skin, MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 0.2 mg/m3, short term exposure limit 0.6 mg/m3, skin, NOV2011
Occupational Exposure Limit-FRANCEVME 0.2 mg/m3, Skin, FEB2006
Occupational Exposure Limit-ICELANDtime-weighted average 0.2 mg/m3, skin, NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 0.2 mg/m3, short term exposure limit 0.6 mg/m3, skin, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 0.2 mg/m3;short term exposure limit 0.6 mg/m3 (skin), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.2 mg/m3, skin, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 0.2 mg/m3, JAN1999
Occupational Exposure Limit-PERUtime-weighted average 0.2 mg/m3, JUL2005
Occupational Exposure Limit-POLANDtime-weighted average 0.2 mg/m3, short term exposure limit 0.6 mg/m3, JAN1999
Occupational Exposure Limit-SWITZERLANDMAK-week 0.2 mg/m3, inhal, skin, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 0.2 mg/m3, Skin, 2003
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 0.2 mg/m3;short term exposure limit 0.6 mg/m3, skin, OCT2007

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CHLORPYRIFOS-air10H time-weighted average 0.2 mg/m3;short term exposure limit 0.6 mg/m3 (Sk)NIOSH* DHHS #95-121,1995
National Occupational Exposure Survey 1983Hazard Code M4463; Number of Industries 4; Total Number of Facilities 1276; Number of Occupations 3; Total Number of Employees Exposed 11404; Total Number of Female Employees Exposed 842
National Occupational Hazard Survey 1974Hazard Code M4463; Number of Industries 1; Total Number of Facilities 753; Number of Occupations 3; Total Number of Employees Exposed 22523
National Occupational Hazard Survey 1974Hazard Code T0714; Number of Industries 1; Total Number of Facilities 7; Number of Occupations 1; Total Number of Employees Exposed 7

Status in Federal Agencies

OrganizationReference
ATSDR TOXICOLOGY PROFILE (NTIS** PB/98/103088/AS)
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Negative: In vitro UDS-human fibroblast; TRP reversion
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Positive: E coli polA without S9
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Organophosphorus pesticides, 5600
On EPA IRIS database
OSHA ANALYTICAL METHOD #62
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