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Phosphoric acid, triphenyl ester

RTECS #: TC8400000

CAS #: 115-86-6


UPDATE: May 2009 MW: 326.30 MF: C18H15O4P


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. OTHER MULTIPLE DOSE DATA:
  4. REVIEWS:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. Celluflex TPP
  2. Disflamoll TP
  3. Phosflex TPP
  4. Reolube TPP
  5. Reomol TPP
  1. TPP
  2. Trifenylfosfat (Czech)
  3. Triphenyl phosphate
  4. Triphenyl phosphate (ACGIH:OSHA)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mammal (species unspecified)
lethal concentration (50 percent kill): 4,200 mg/m3 Olfaction: Other olfaction effects

Behavioral: Somnolence (general depressed activity)

Behavioral: Change in motor activity (specific assay)
GISAAA 39(8),98,1974
intramuscular
rabbit
lethal dose : >1 gm/kg N/R NIHBAZ 160,1,1932
intraperitoneal
cat
lethal dose : >400 mg/kg Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Behavioral: Somnolence (general depressed activity)

Behavioral: Muscle weakness
AEHLAU 1,33,1960
intraperitoneal
mouse
lethal dose (50 percent kill): 1,273 mg/kg N/R ABCHA6 31,1288,1967
intraperitoneal
rat
lethal dose : >5 gm/kg Gastrointestinal: Other changes

Skin and Appendages: Other: Hair
NTIS** OTS0535042
oral
cat
lowest published lethal dose: 2 gm/kg Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Tremor

Behavioral: Muscle weakness
ARZNAD 7,585,1957
oral
chicken
lowest published lethal dose: 5 gm/kg Spinal Cord: Other degenerative changes NTIS** OTS0539872
oral
guinea pig
lethal dose : >4 gm/kg N/R AEHLAU 1,33,1960
oral
mouse
lethal dose (50 percent kill): 1,320 mg/kg Olfaction: Other olfaction effects

Behavioral: Somnolence (general depressed activity)

Behavioral: Change in motor activity (specific assay)
GISAAA 39(8),98,1974
oral
rat
lethal dose (50 percent kill): 3,500 mg/kg Behavioral: Tremor

Behavioral: Ataxia

Gastrointestinal: Hypermotility, diarrhea
ARZNAD 7,585,1957
oral
rabbit
lowest published lethal dose: 3 gm/kg N/R AEHLAU 1,33,1960
subcutaneous
cat
lowest published lethal dose: 300 mg/kg Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Tremor

Behavioral: Muscle weakness
NIHBAZ 160,1,1932
subcutaneous
guinea pig
lethal dose : >3 gm/kg N/R AEHLAU 1,33,1960
subcutaneous
monkey
lowest published lethal dose: 500 mg/kg N/R DTLVS* 4,420,1980
subcutaneous
mouse
lethal dose : >3 gm/kg N/R AEHLAU 1,33,1960
subcutaneous
rat
lethal dose : >3 gm/kg N/R AEHLAU 1,33,1960
subcutaneous
rabbit
lowest published lethal dose: 1 gm/kg N/R AEHLAU 1,33,1960
skin
guinea pig
lethal dose (50 percent kill): >4 gm/kg N/R KODAK* 21MAY1971
skin
rabbit
lethal dose (50 percent kill): >7,900 mg/kg N/R TXAPA9 41,291,1977


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
cat
lowest published toxic dose: 600 mg/kg/10 day- intermittent Behavioral: Tremor

Nutritional and Gross Metabolic: Other changes
ARZNAD 7,585,1957
oral
chicken
lowest published toxic dose: 25 gm/kg/5 day- intermittent Spinal Cord: Other degenerative changes

Behavioral: Ataxia
NTIS** OTS0539873
oral
rat
lowest published toxic dose: 65 gm/kg/65 day- continuous Spinal Cord: Other degenerative changes

Peripheral Nerve and Sensation: Sensory syndrome diagnostic of central lesion

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
ARZNAD 7,585,1957
oral
rat
lowest published toxic dose: 59,353 mg/kg/35 day- continuous Liver: Changes in liver weight AEHLAU 1,33,1960
skin
domestic bird
lowest published toxic dose: 1,200 mg/kg/3 day- intermittent Spinal Cord: Other degenerative changes

Behavioral: Ataxia
NEZAAQ 52,281,1997


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 3 mg/m3 DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not classifiable as human carcinogen DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
CRTXB2 3,289,1975


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 3 mg/m3 DTLVS* 3,272,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 3 mg/m3 CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 3 mg/m3 CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 3 mg/m3 CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 3 mg/m3 CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 3 mg/m3, JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 3 mg/m3, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 3 mg/m3, OCT 2002
Occupational Exposure Limit - FINLAND time-weighted average 3 mg/m3, short term exposure limit 6 mg/m3, Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 3 mg/m3, FEB2006
Occupational Exposure Limit - KOREA time-weighted average 3 mg/m3, 2006
Occupational Exposure Limit - MEXICO time-weighted average 3 mg/m3;
short term exposure limit 6 mg/m3, 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 3 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 3 mg/m3, JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 3 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 1 mg/m3, JUN2003
Occupational Exposure Limit - SWITZERLAND MAK- week 3 mg/m3, DEC2006
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 3 mg/m3;
short term exposure limit 6 mg/m3, 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not classifiable as human carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not classifiable as human carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO TRIPHENYL PHOSPHATE-air 10 hour time-weighted average 3 mg/m3 NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 74635;
Number of Industries 11;
Total Number of Facilities 341;
Number of Occupations 30;
Total Number of Employees Exposed 7,631
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 74635;
Number of Industries 51;
Total Number of Facilities 2,869;
Number of Occupations 54;
Total Number of Employees Exposed 91,754;
Total Number of Female Employees Exposed 22,800


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE FEREAC 47,26992,82
Used as fire-resistant plasticizer
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9169;8EHQ-0892-8839
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9290
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Triphenyl phosphate, 5038


REFERENCES:

CODEN
REFERENCE

ABCHA6 Agricultural and Biological Chemistry. (Maruzen Co. Ltd., POB 5050, Tokyo International, Tokyo 100-31, Japan) V.25- 1961-
AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St., NW, Washington, DC 20016) V.1- 1960-
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CRTXB2 CRC Critical Reviews in Toxicology. (CRC Press, Inc., 2000 Corporate Blvd., NW, Boca Raton, FL 33431) V.1- 1971-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
KODAK* Kodak Company Reports. (343 State St., Rochester, NY 14650)
NEZAAQ Nippon Eiseigaku Zasshi. Japanese Journal of Hygiene. (Nippon Eisei Gakkai, c/o Kyoto Daigaku Igakubu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.1- 1946-
NIHBAZ National Institutes of Health, Bulletin. (Bethesda, MD)
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

Used as fire-resistant plasticizer

NIOSH PROFILE (ARYL PHOSPHATES), SRC, 12/79

NIOSH PROFILE (PLASTIC AND RESIN MANUFACTURE), SRI, 2/77

NIOSH PROFILE (PLASTIC AND RESIN MANUFACTURE), FIRL, 4/78

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