Phosphoric acid, 2,2-dichlorovinyl dimethyl ester

RTECS #

TC0350000

CAS #

62-73-7; 8023-22-1; 8072-21-7; 8072-39-7; 11095-17-3; 11096-21-2; 12772-40-6; 55819-32-4; 62139-95-1; 95828-55-0; 116788-91-1
See: NMAM or OSHA Methods

Updated

December 2018

Molecular Weight

220.98

Molecular Formula

C₄H₇Cl₂O₄P

Synonyms

(2,2-Dichloor-vinyl)-dimethyl-fosfaat (Dutch)
(2,2-Dichloro-vinil)dimetil-fosfato (Italian)
(2,2-Dichlor-vinyl)-dimethyl-phosphat (German)
2,2-Dichloroethenyl dimethyl phosphate
2,2-Dichloroethenyl phosphoric acid dimethyl ester
2,2-Dichlorovinyl dimethyl phosphate
2,2-Dichlorovinyl dimethyl phosphoric acid ester
Apavap
Astrobot
Atgard
Atgard C
Atgard V
BAY-19149
Bayer 19149
Benfos
Bibesol
Brevinyl
Brevinyl E50
Canogard
Chlorvinphos
Cypona
DDVP
DDVP (insecticide)
DDVP (OSHA)
Dedevap
Denkavepon
Deriban
Derribante
Devikol
Dichlofos
Dichloorvo (Dutch)
Dichlorfos (Polish)
Dichlorman
Dichlorovos
Dichlorvos
Dichlorvos (ACGIH:OSHA)
Dimethyl 2,2-dichloroethenyl phosphate
Dimethyl 2,2-dichlorovinyl phosphate
Dimethyl dichlorovinyl phosphate
Divipan
ENT 20738
Equigard
Equigel
Estrosel
Estrosol
Ethenol, 2,2-dichloro-, dimethyl phosphate
Fecama
Fekama
Fly fighter
Fly-Die
Insectigas D
MAFU strip
Marvex
Mopari
NCI-C00113
Nefrafos
Nerkol
Nogos
Nogos 50
Nogos 50 EC
Nogos G
NO-Pest
NO-Pest strip
Novotox
NSC-6738
Nuvan
Nuvan 100EC
Nuvan 7
O-(2,2-Dichlorvinyl)-O,O-dimethylphosphat (German)
O,O-Dimethyl 2,2-dichlorovinyl phosphate
O,O-Dimethyl dichlorovinyl phosphate
O,O-Dimethyl O-2,2-dichlorovinyl phosphate
O,O-dimethyl-O-(2,2-dichlorovinyl)phosphate
O,O-Dimethyl-O-(2,2-dichlor-vinyl)-phosphat (German)
O,O-Dwumetylo-O-dwuchlorowinylofosforan (Polish)
OKO
OMS 14
Panaplate
Phosphate de dimethyle et de 2,2-dichlorovinyle (French)
Phosphoric acid, 2,2-dichloroethenyl dimethyl ester (9CI)
Phosvit
SD-1750
Szklarniak
TAP 9VP
Task
Tetravos
Unifos
Unifos (pesticide)
Unifos 50 EC
Unitox
Vapona
Vapona insecticide
Vaponite
Vapora II
Vinyl alcohol, 2,2-dichloro-, dimethyl phosphate
Vinylofos
Vinylophos
Winylophos

Mutation Data and Reference

System Test	Route/Organism/Tissue	Dose	Reference
Cytogenetic Analysis	multiple/other fish	10 ppb	MUREAV 344,1,1995
Cytogenetic Analysis	lymphocyte/human	1 mg/L	TSITAQ 18,1490,1976
Cytogenetic Analysis	other cell types/rat	80 mg/L	MUREAV 206,439,1988
Cytogenetic Analysis	intraperitoneal/hamster	3 mg/kg	ARTODN 58,152,1986
Cytogenetic Analysis	lung/hamster	100 mg/L	AMONDS 3,253,1980
Cytogenetic Analysis	ovary/hamster	160 mg/L	NTPTR* NTP-TR-342,1989
DNA Damage	lymphocyte/mammal (species unspecified)	100 µL	NATWAY 57,393,1970
DNA Damage	lung/hamster	2000 ppm/60M	MUREAV 24,365,1974
DNA Damage	intraperitoneal/rat	795.5 µg/kg	TXCYAC 253,8,2008
DNA Damage	other cell types/human	2.7 nmol/L/10M	TXCYAC 253,13,2008
DNA Damage	other cell types/human	1 µmol/L/1H	TOXID9 -,223,2009
DNA Damage	other cell types/human	100 µmol/L	RTOPDW 55,188,2009
DNA Damage	intraperitoneal/mouse	420 µg/kg	APTSAI 49(5),56,1981
DNA Damage	inhalation/mouse	8 mg/kg	PCBPBS 6,101,1976
DNA Damage	sperm/salmon	14 mmol/L	CBINA8 8,171,1974
DNA Damage	lymphocyte/human	62 mg/L	TUMOAB 66,425,1980
DNA Damage	HeLa cell/human	970 µmol/L	CBINA8 8,171,1974
DNA Damage	/Escherichia coli	1 gm/L	MUREAV 52,161,1978
DNA inhibition	lymphocyte/human	62 mg/L	TUMOAB 66,425,1980
DNA repair	/Escherichia coli	60 nmol/plate	CNREA8 33,458,1973
DNA repair	/Bacillus subtilis	10 pph	MUREAV 40,19,1976
DNA repair	/Other microorganisms	10 µmol/plate	CBINA8 39,339,1982
gene conversion and mitotic recombination	/Saccharomyes cerevisiae	19 mmol/L/6H	IARCCD 10,161,1974
gene conversion and mitotic recombination	/Aspergillus nidulans	28 mg/plate	MUREAV 46,395,1977
host-mediated assay	Saccharomyes cerevisiae/mouse	4 mg/L	ATXKA8 30,61,1972
morphological transform	embryo/hamster	110 µmol/L	ENMUDM 8,515,1986
morphological transform	other cell types/rat	40 mg/L	MUREAV 206,439,1988
morphological transform	embryo/mouse	24 mg/L/10D	MUREAV 702,100,2010
mutation in mammalian somatic cells	intraperitoneal/mouse	55 mg/kg/22D- intermittent	CALEDQ 146,155,1999
mutation in mammalian somatic cells	lymphocyte/mouse	12500 mg/L	NTPTR* NTP-TR-342,1989
mutation in microorganisms	/Schizosaccharomyces pombe	5 mmol/L (-enzymatic activation step)	MUREAV 117,139,1983
mutation in microorganisms	/Schizosaccharomyces pombe	5 mmol/L (+enzymatic activation step)	MUREAV 117,139,1983
mutation in microorganisms	/Aspergillus nidulans	14 mg/plate (-enzymatic activation step)	MUREAV 46,395,1977
mutation in microorganisms	/Serratia marcescens	25 mg/L (-enzymatic activation step)	ATXKA8 30,67,1972
mutation in microorganisms	/Klebsiella pneumoniae	1000 ppm (-enzymatic activation step)	MUREAV 16,413,1972
mutation in microorganisms	/Other microorganisms	5600 µg/plate (-enzymatic activation step)	CBINA8 22,297,1978
mutation in microorganisms	/Other microorganisms	1000 ppm (-enzymatic activation step)	MUREAV 16,413,1972
mutation in microorganisms	/Other microorganisms	80 mmol/L (-enzymatic activation step)	MUREAV 21,175,1973
mutation in microorganisms	/Salmonella typhimurium	333 µg/plate (+enzymatic activation step)	EMMUEG 11(Suppl 12),1,1988
mutation in microorganisms	/Escherichia coli	5 pph (-enzymatic activation step)	MUREAV 40,19,1976
other mutation test systems	/Escherichia coli	3820 nmol/L	EMMUEG 19,98,1992
phage inhibition capacity	/Escherichia coli	70 µmol/L	MUREAV 182,193,1987
phage inhibition capacity	/Escherichia coli	0.284 mmol/L (+enzymatic activation step)	EMMUEG 36,206,2000
sex chromosome loss and nondisjunction	oral/Drosophila melanogaster	750 ppb	MUREAV 28,405,1975
sex chromosome loss and nondisjunction	/Aspergillus nidulans	800 mg/L	EVHPAZ 31,81,1979
sister chromatid exchange	other cell types/rat	10 mg/L	MUREAV 206,439,1988
sister chromatid exchange	ovary/hamster	30 µmol/L	JTEHD6 8,939,1981
sister chromatid exchange	lung/hamster	100 µmol/L	MUREAV 78,177,1980
sperm morphology	intraperitoneal/mouse	35 mg/kg/5D	PNASA6 72,4425,1975
Unscheduled DNA Synthesis	other cell types/human	65 mmol/L	PSSCBG 15,439,1984

Reproductive Effects Data and References

Route/Organism	Dose	Effect	Reference
inhalation/rabbit	4 mg/m³/23H (1-28D pregnant)	Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)	ATXKA8 30,29,1972
intraperitoneal/rat	15 mg/kg (11D pregnant)	Reproductive: Specific developmental abnormalities: Body wall	AEHLAU 16,805,1968
oral/rat	39200 µg/kg (14-21D pregnant)	Reproductive: Effects on newborn: Biochemical and metabolic	NUPOBT 15,255,1977
oral/rat	220 mg/kg (multigeneration)	Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) Reproductive: Effects on newborn: Physical Reproductive: Effects on newborn: Delayed effects	IJEREO 5,239,1995
oral/mouse	180 mg/kg (18D male)	Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)	BECTA6 11(5),429,1974
oral/rabbit	65 mg/kg (6-13D pregnant)	Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)	TJADAB 20,383,1979
oral/rabbit	60 mg/kg (22-31D pregnant)	Reproductive: Effects on newborn: Biochemical and metabolic	FHCYAI 16,335,1978
oral/pig	255 mg/kg (41-70D pregnant)	Reproductive: Specific developmental abnormalities: Central nervous system Reproductive: Specific developmental abnormalities: Blood and lymphatic systems (including spleen and marrow) Reproductive: Specific developmental abnormalities: Endocrine system	ZVRAAX 27,662,1980
oral/pig	759 mg/kg (1-15W preg/4W after birth)	Reproductive: Effects on newborn: Biochemical and metabolic	CNJNAT 71,227,1991
oral/rat	80 mg/kg (6-15D pregnant)	Reproductive: Effects on newborn: Behavioral	NETEEC 26,607,2004
unreported route/guinea pig	90 mg/kg (42-44D pregnant)	Reproductive: Specific developmental abnormalities: Central nervous system	NEREDZ 19,569,1994
unreported route/rabbit	60 mg/kg (22-31D pregnant)	Reproductive: Effects on newborn: Biochemical and metabolic	FHCYAI 16,139,1978
unreported route/rat	40 mg/kg (2D male)	Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Reproductive: Paternal effects: Testes, epididymis, sperm duct	BECTA6 15,458,1976

Tumorigenic Data and References

Route/Organism	Dose	Effect	Reference
oral/mouse	lowest published toxic dose: 20600 mg/kg/2Y- continuous	Tumorigenic: Carcinogenic by RTECS criteria Gastrointestinal: Tumors	NTPTR* NTP-TR-342,1989
oral/mouse	lowest published toxic dose: 10300 mg/kg/103W- intermittent	Tumorigenic: Neoplastic by RTECS criteria Gastrointestinal: Tumors	NTIS** PB90-198508
oral/mouse	lowest published toxic dose: 20600 mg/kg/103W- intermittent	Tumorigenic: Neoplastic by RTECS criteria Gastrointestinal: Tumors	NTIS** PB90-198508
oral/rat	lowest published toxic dose: 2060 mg/kg/103W- intermittent	Tumorigenic: Carcinogenic by RTECS criteria Gastrointestinal: Tumors Blood: Leukemia	NTIS** PB90-198508
oral/rat	lowest published toxic dose: 2060 mg/kg/103W- intermittent	Tumorigenic: Neoplastic by RTECS criteria Skin and Appendages: Tumors	NTIS** PB90-198508
oral/rat	lowest published toxic dose: 4120 mg/kg/2Y- continuous	Tumorigenic: Neoplastic by RTECS criteria Lung, Thorax, or Respiration: Tumors Gastrointestinal: Tumors	NTPTR* NTP-TR-342,1989
oral/rat	lowest published toxic dose: 2060 mg/kg/2Y- continuous	Tumorigenic: Carcinogenic by RTECS criteria Gastrointestinal: Tumors Blood: Leukemia	JJCREP 82,157,1991

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
In Vitro/Hamster, ovary	Inhibitor Concentration (50 percent kill): 1 mmol/L/3H	In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.	TIVIEQ 21,1409,2007
In Vitro/Human, kidney tumor	Inhibitor Concentration (50 percent kill): 35.4 mg/L	In Vitro Toxicity Studies: Cell viability (dye exclusion): trypan blue assay etc.	TIVIEQ 27,1347,2013
In Vitro/Human, liver tumor	Inhibitor Concentration (50 percent kill): 85.7 mg/L	In Vitro Toxicity Studies: Cell viability (dye exclusion): trypan blue assay etc.	TIVIEQ 27,1347,2013
In Vitro/Human, liver tumor	Inhibitor Concentration (50 percent kill): 89.2 mg/L/24H	In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.	TIVIEQ 27,1347,2013
In Vitro/Human, neuroblastoma	Inhibitor Concentration (50 percent kill): 23 µmol/L/60M	Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase	TXAPA9 245,191,2010
In Vitro/Human, neuroblastoma	Inhibitor Concentration (50 percent kill): 158 mg/L	In Vitro Toxicity Studies: Cell viability (dye exclusion): trypan blue assay etc.	TIVIEQ 27,1347,2013
In Vitro/Human, skin	Inhibitor Concentration (50 percent kill): 11.3 mg/L/48H	In Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.	TIVIEQ 27,1347,2013
In Vitro/Mouse, fibroblast	Inhibitor Concentration (50 percent kill): 18.7 mg/L/48H	In Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.	TIVIEQ 27,1347,2013
In Vitro/Mouse, fibroblast	Inhibitor Concentration (50 percent kill): 21.9 mg/L/24H	In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.	TIVIEQ 27,1347,2013
In Vitro/paa	Inhibitor Concentration Low: 5.77 µmol/L/44H	In Vitro Toxicity Studies: Other assays	TIVIEQ 27,1416,2013
In Vitro/Rat, liver	Inhibitor Concentration (50 percent kill): 60.8 mg/L/24H	In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.	TIVIEQ 27,1347,2013
inhalation/mouse	lethal concentration (50 percent kill): 13 mg/m³/4H	Eye: Lacrimation Behavioral: Tremor Gastrointestinal: Changes in structure or function of salivary glands	GISAAA 33(12),35,1968
inhalation/rat	lethal concentration (50 percent kill): 15 mg/m³/4H	Eye: Lacrimation Behavioral: Tremor Gastrointestinal: Changes in structure or function of salivary glands	GISAAA 33(12),35,1968
intracerebral/rat	lowest published toxic dose: 1.8 mg/kg	Lung, Thorax, or Respiration: Respiratory depression	NRTXDN 39,132,2013
intramuscular/rat	lethal dose (50 percent kill): 10.2 mg/kg		EKFAE9 56,57,1993
intramuscular/rat	lethal dose (50 percent kill): 1.5 mg/kg	Behavioral: Anticonvulsant	EKFAE9 62,55,1999
intraperitoneal/hamster	lethal dose (50 percent kill): 30 mg/kg		ARTODN 58,152,1986
intraperitoneal/mouse	lowest published toxic dose: 19.7 mg/kg	Behavioral: Convulsions or effect on seizure threshold	TOSCF2 72,289,2003
intraperitoneal/mouse	lowest published lethal dose: 22.4 mg/kg	Behavioral: Convulsions or effect on seizure threshold	TOSCF2 72,289,2003
intraperitoneal/mouse	lethal dose (50 percent kill): 22 mg/kg	Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase	JAFCAU 11,91,1963
intraperitoneal/mouse	lethal dose (50 percent kill): 41.64 mg/kg		TXAPA9 219,114,2007
intraperitoneal/mouse	lowest published toxic dose: 83.28 mg/kg	Brain and Coverings: Other degenerative changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase	TXAPA9 219,114,2007
intraperitoneal/rat	lowest published toxic dose: 10 mg/kg	Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Reactivates cholinesterase Biochemical: Neurotransmitters or modulators (putative): Catecholamine levels in CNS Biochemical: Neurotransmitters or modulators (putative): Dopamine at other sites	FATOAO 44,334,1981
intraperitoneal/rat	lethal dose (50 percent kill): 15 mg/kg	Brain and Coverings: Other degenerative changes Blood: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase	APTSAI 49(5),67,1981
intraperitoneal/rat	lowest published toxic dose: 8 mg/kg	Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases Biochemical: Metabolism (intermediary): Lipids including transport	TOLED5 135,S86,2002
intravenous/Dog	lowest published lethal dose: 2200 µg/kg	Behavioral: Somnolence (general depressed activity) Gastrointestinal: Hypermotility, diarrhea Gastrointestinal: Nausea or vomiting	AUVJA2 49,113,1973
intravenous/mouse	lethal dose (50 percent kill): 18 mg/kg		CSLNX* NX#00004
oral/chicken	lethal dose (50 percent kill): 6450 µg/kg	Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase	INJPD2 10,323,1978
oral/Dog	lethal dose (50 percent kill): 100 mg/kg		85JFAN A141,1984
oral/duck	lethal dose (50 percent kill): 7800 µg/kg		DOEAAH 35,25,1979
oral/man	lowest published lethal dose: 1000 mg/kg		JFSCAS 53,997,2008
oral/monkey	lowest published toxic dose: 75 mg/kg	Lung, Thorax, or Respiration: Respiratory depression Cardiac: Change in rate Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase	TXCYAC 317,1,2014
oral/mouse	lowest published toxic dose: 40 mg/kg	Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Reproductive: Paternal effects: Testes, epididymis, sperm duct	BECTA6 11,429,1974
oral/mouse	lethal dose (50 percent kill): 61 mg/kg		OSDIAF 15,553,1966
oral/pig	lethal dose (50 percent kill): 157 mg/kg	Gastrointestinal: Nausea or vomiting Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase	AJVRAH 40,315,1979
oral/pigeon	lethal dose (50 percent kill): 23700 µg/kg		ASTTA8 (680),157,1979
oral/quail	lethal dose (50 percent kill): 22010 µg/kg	Behavioral: Tremor Behavioral: Convulsions or effect on seizure threshold Gastrointestinal: Hypermotility, diarrhea	HOEKAN 24,35,1974
oral/rabbit	lethal dose (50 percent kill): 10 mg/kg	Autonomic Nervous System: Other (direct) parasympathomimetic Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase	BEXBAN 83,32,1977
oral/rat	lethal dose (50 percent kill): 17 mg/kg		JPIFAN (13),36,1972
oral/rat	lowest published toxic dose: 47 mg/kg	Brain and Coverings: Other degenerative changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase	NRTXDN 32,931,2011
oral/wild bird	lethal dose (50 percent kill): 12 mg/kg		TXAPA9 21,315,1972
parenteral/man	lowest published lethal dose: 35.7 mg/kg	Eye: Miosis (pupilliary constriction) Cardiac: Pulse rate decreased with fall in BP Lung, Thorax, or Respiration: Respiratory depression	AJEMEN 18,640,2000
skin/mouse	lethal dose (50 percent kill): 206 mg/kg		ABCHA6 27,684,1963
skin/rabbit	lethal dose (50 percent kill): 107 mg/kg		BESAAT 12,117,1966
skin/rat	lethal dose (50 percent kill): 0.75 mg/kg		TOVEFN (2),37,1995
subcutaneous/mouse	lethal dose (50 percent kill): 24 mg/kg	Behavioral: Convulsions or effect on seizure threshold Eye: Other eye effects Lung, Thorax, or Respiration: Dyspnea	IMSUAI 31,170,1962
subcutaneous/mouse	lowest published lethal dose: 16.8 mg/kg		ARTODN 76,173,2002
subcutaneous/mouse	lowest published toxic dose: 7.5 mg/kg	Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Reactivates cholinesterase	TXAPA9 255,214,2011
subcutaneous/rat	lethal dose (50 percent kill): 8.84 mg/kg		NRTXDN 55,33,2016
subcutaneous/rat	lowest published lethal dose: 6.6 mg/kg	Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase	NRTXDN 55,33,2016
subcutaneous/rat	lowest published lethal dose: 25 mg/kg	Lung, Thorax, or Respiration: Respiratory obstruction	AEMME* 9,1369,2002
subcutaneous/rat	lowest published toxic dose: 13 mg/kg	Brain and Coverings: Other degenerative changes Behavioral: Convulsions or effect on seizure threshold Biochemical: Metabolism (intermediary): Effect on cyclic nucleotides	TXCYAC 191,35,2003
subcutaneous/rat	lethal dose (50 percent kill): 9.8 mg/kg	Lung, Thorax, or Respiration: Respiratory obstruction	PHTOEH 93,211,2003
subcutaneous/rat	lowest published toxic dose: 5 mg/kg	Autonomic Nervous System: Other (direct) parasympathomimetic Behavioral: Change in motor activity (specific assay) Behavioral: Alteration of operant conditioning	PHTOEH 93,211,2003
subcutaneous/rat	lowest published toxic dose: 2 mg/kg	Behavioral: Alteration of classical conditioning Behavioral: Alteration of operant conditioning	PHTOEH 93,211,2003
subcutaneous/rat	lowest published toxic dose: 3 mg/kg	Behavioral: Somnolence (general depressed activity) Behavioral: Tremor Gastrointestinal: Changes in structure or function of salivary glands	TXAPA9 219,151,2007
subcutaneous/rat	lowest published toxic dose: 5.76 mg/kg	Lung, Thorax, or Respiration: Respiratory depression	CTOXAO 47,725,2009
subcutaneous/rat	lowest published toxic dose: 5.12 mg/kg	Lung, Thorax, or Respiration: Respiratory depression Nutritional and Gross Metabolic: Body temperature decrease Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase	TOLED5 213,142,2012
subcutaneous/rat	lowest published toxic dose: 5.76 mg/kg	Brain and Coverings: Other degenerative changes Lung, Thorax, or Respiration: Respiratory depression	FCLPH* 23(Suppl 1),8,2009
subcutaneous/rat	lowest published toxic dose: 5 mg/kg	Behavioral: Change in motor activity (specific assay)	PHTOEH 93,211,2003
subcutaneous/rat	lowest published toxic dose: 2 mg/kg	Behavioral: Ataxia Behavioral: Alteration of operant conditioning	PHTOEH 93,211,2003
subcutaneous/rat	lethal dose (50 percent kill): 9.8 mg/kg	Lung, Thorax, or Respiration: Respiratory depression	PHTOEH 93,211,2003
subcutaneous/rat	lethal dose (50 percent kill): 33.3 mg/kg	Vascular: BP lowering not characterized in autonomic section Lung, Thorax, or Respiration: Respiratory obstruction Lung, Thorax, or Respiration: Other changes	NRTXDN 28,664,2007
subcutaneous/rat	lowest published lethal dose: 100 mg/kg	Lung, Thorax, or Respiration: Respiratory depression	NRTXDN 30,298,2009
subcutaneous/rat	lowest published lethal dose: 200 mg/kg	Brain and Coverings: Other degenerative changes Behavioral: Ataxia Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphokinase	BCLPT* 98,447,2006
Tank with water/Lobster	lethal concentration (50 percent kill): 11 µg/L/72H		TIVIEQ 34,237,1996
Tank with water/Lobster	lethal concentration (50 percent kill): 8.7 µg/L/96H		TIVIEQ 34,237,1996
Tank with water/Lobster	lethal concentration (50 percent kill): 2.8 µg/L/8D		TIVIEQ 34,237,1996
Tank with water/Lobster	lethal concentration (50 percent kill): 1.4 µg/L/16D		TIVIEQ 34,237,1996
Tank with water/Lobster	lethal concentration (50 percent kill): 1.25 µg/L/23D		TIVIEQ 34,237,1996
Tank with water/Lobster	Lowest published lethal concentration: 10 µg/L/48H		TIVIEQ 34,237,1996
Tank with water/Zebrafish	toxic concentration: 15 mg/L/24H	Biochemical: Metabolism (intermediary): Lipids including transport	TOXIA6 4,240,2017
unreported route/mammal (species unspecified)	lethal dose (50 percent kill): 125 mg/kg		GISAAA 41(8),82,1976
unreported route/mouse	lethal dose (50 percent kill): 75 mg/kg	Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase	GISAAA 33(12),35,1968
unreported route/rabbit	lethal dose (50 percent kill): 23 mg/kg	Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase	GISAAA 33(12),35,1968
unreported route/rat	lethal dose (50 percent kill): 57 mg/kg	Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase	GISAAA 33(12),35,1968
unreported route/rat	lethal dose (50 percent kill): 40 mg/kg		FATOAO 50,97,1987

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
inhalation/rat	lowest published toxic dose: 8200 µg/m³/45D- intermittent	Nutritional and Gross Metabolic: Weight loss or decreased weight gain Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	GISAAA 33(12),35,1968
intraperitoneal/rat	lowest published toxic dose: 16 mg/kg/2D- intermittent	Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases Biochemical: Metabolism (intermediary): Lipids including transport	TOLED5 135,S86,2002
intraperitoneal/rat	lowest published toxic dose: 24 mg/kg/3D- intermittent	Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases Biochemical: Metabolism (intermediary): Lipids including transport	TOLED5 135,S86,2002
intraperitoneal/rat	lowest published toxic dose: 150 mg/kg/30D- intermittent	Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases	EXMPA6 56,144,1992
oral/chicken	lowest published toxic dose: 2450 mg/kg/28D- continuous	Brain and Coverings: Other degenerative changes Nutritional and Gross Metabolic: Weight loss or decreased weight gain Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase	INJPD2 10,323,1978
oral/Dog	lowest published toxic dose: 56250 µg/kg/90D- continuous	Brain and Coverings: Other degenerative changes Kidney, Ureter, and Bladder: Urine volume increased Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase	NYZZA3 26,739,1974
oral/domestic animal	lowest published toxic dose: 112 mg/kg/28D- intermittent	Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases	IVEJAC 66,821,1989
oral/mouse	lowest published toxic dose: 90 mg/kg/9D- intermittent	Reproductive: Paternal effects: Testes, epididymis, sperm duct	BECTA6 11,429,1974
oral/mouse	lowest published toxic dose: 180 mg/kg/18D- intermittent	Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)	BECTA6 11,429,1974
oral/mouse	lowest published toxic dose: 5200 mg/kg/13W- intermittent	Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	NTPTR* NTP-TR-342,1989
oral/mouse	lowest published toxic dose: 36.6 mg/kg/30D- intermittent	Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects	FCTOD7 70,222,2014
oral/rat	lowest published toxic dose: 1209.6 mg/kg/24W- continuous	Kidney, Ureter, and Bladder: Renal function tests depressed Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases	TOLED5 206,306,2011
oral/rat	lowest published toxic dose: 360 mg/kg/90D- intermittent	Liver: Other changes Blood: Other changes Biochemical: Metabolism (intermediary): Lipids including transport	BCTKAG 21,31,1988
oral/rat	lowest published toxic dose: 56 mg/kg/14D- intermittent	Liver: Other changes Kidney, Ureter, and Bladder: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other hydrolases	BCTKAG 7,201,1974
oral/rat	lowest published toxic dose: 45 mg/kg/6W- intermittent	Brain and Coverings: Changes in surface EEG Peripheral Nerve and Sensation: Recording from peripheral motor nerve Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase	NETEEC 10,429,1988
oral/rat	lowest published toxic dose: 70 mg/kg/2W- intermittent	Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	BECTA6 18,231,1977
oral/rat	lowest published toxic dose: 150 mg/kg/30D- intermittent	Brain and Coverings: Other degenerative changes Blood: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase	GISAAA -,64,1993
skin/monkey	lowest published toxic dose: 750 mg/kg/10D- intermittent	Blood: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase	AMIHAB 15,340,1957
skin/monkey	lowest published toxic dose: 400 mg/kg/4D- intermittent	Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	YKYUA6 30,1229,1979
skin/rat	lowest published toxic dose: 141 mg/kg/17W- intermittent	Brain and Coverings: Other degenerative changes Liver: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase	APYPAY 32,507,1981
subcutaneous/mouse	lowest published toxic dose: 100 mg/kg/10D- intermittent	Brain and Coverings: Other degenerative changes Behavioral: Somnolence (general depressed activity) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase	JHSCFD 45,191,1999
subcutaneous/rat	lowest published toxic dose: 28 mg/kg/28D- intermittent	Liver: Other changes Nutritional and Gross Metabolic: Weight loss or decreased weight gain Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase	APYPAY 31,575,1980
subcutaneous/rat	lowest published toxic dose: 21600 µg/kg/17W- intermittent	Liver: Other changes Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) Nutritional and Gross Metabolic: Weight loss or decreased weight gain	APYPAY 32,507,1981
subcutaneous/rat	lowest published toxic dose: 54 mg/kg/9W- intermittent	Liver: Changes in liver weight Endocrine: Changes in adrenal weight	TXAPA9 197,353,2004
subcutaneous/rat	lowest published toxic dose: 108 mg/kg/9W- intermittent	Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)	TXAPA9 197,353,2004
subcutaneous/rat	lowest published toxic dose: 54 mg/kg/9W- intermittent	Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases	TXCYAC 213,129,2005
subcutaneous/rat	lowest published toxic dose: 216 mg/kg/9W- intermittent	Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Nutritional and Gross Metabolic: Weight loss or decreased weight gain Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases	TXCYAC 213,129,2005
subcutaneous/rat	lowest published toxic dose: 21 mg/kg/7D- intermittent	Brain and Coverings: Other degenerative changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase	TXAPA9 219,151,2007
subcutaneous/rat	lowest published toxic dose: 504 mg/kg/12W- intermittent	Brain and Coverings: Other degenerative changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation) Biochemical: Metabolism (intermediary): Effect on mitochondrial function	NRTXDN 28,1208,2007
subcutaneous/rat	lowest published toxic dose: 84 mg/kg/12W- intermittent	Behavioral: Change in psychophysiological tests Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects	TXCYAC 256,175,2009
subcutaneous/rat	lowest published toxic dose: 2 mg/kg/2D- intermittent	Behavioral: Alteration of operant conditioning	TXCYAC 256,175,2009
subcutaneous/rat	lowest published toxic dose: 252 mg/kg/6W- intermittent	Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase	TXCYAC 256,175,2009
subcutaneous/rat	lowest published toxic dose: 504 mg/kg/12W- intermittent	Liver: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation) Biochemical: Metabolism (intermediary): Effect on mitochondrial function	TXCYAC 270,77,2010
subcutaneous/rat	lowest published toxic dose: 336 mg/kg/8W- intermittent	Nutritional and Gross Metabolic: Weight loss or decreased weight gain Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase Biochemical: Metabolism (intermediary): Effect on cyclic nucleotides	TIHEEC 23,25,2007
subcutaneous/rat	lowest published toxic dose: 105 mg/kg/6W- intermittent	Behavioral: Change in motor activity (specific assay) Behavioral: Ataxia	TXAPA9 256,73,2011
subcutaneous/rat	lowest published toxic dose: 210 mg/kg/12W- intermittent	Brain and Coverings: Other degenerative changes Behavioral: Ataxia Biochemical: Neurotransmitters or modulators (putative): Dopamine in striatum	TXAPA9 256,73,2011

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 0.1 mg/m³ (inhal, vapor, skin, sen)	DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-Not classifiable as a human carcinogen	DTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)	Cancer Review:Animal Sufficient Evidence	IMEMDT 53,267,1991
International Agency for Research on Cancer (IARC)	Cancer Review:Animal Inadequate Evidence	IMEMDT 20,97,1979
International Agency for Research on Cancer (IARC)	Cancer Review:Human No Adequate Data	IMEMDT 20,97,1979
International Agency for Research on Cancer (IARC)	Cancer Review:Human Inadequate Evidence	IMEMDT 53,267,1991
International Agency for Research on Cancer (IARC)	Cancer Review:Group 2B	IMEMDT 53,267,1991
TOXICOLOGY REVIEW		RREVAH 46,1,1973
TOXICOLOGY REVIEW		MUREAV 32,133,1975
TOXICOLOGY REVIEW		CNDQA8 10(3),43,1975
TOXICOLOGY REVIEW		NYZZA3 26,739,1974
TOXICOLOGY REVIEW		NWSCAL 53,489,1972
TOXICOLOGY REVIEW		RREVAH 63,1,1976
TOXICOLOGY REVIEW		ALLVAR 50,77,1962
TOXICOLOGY REVIEW		TOLED5 128,45,2002
TOXICOLOGY REVIEW		MUREAV 543,201,2003
TOXICOLOGY REVIEW		MUREAV 567,347,2004
TOXICOLOGY REVIEW		CRTOEC 17,983,2004
TOXICOLOGY REVIEW		MUREAV 613,17,2006
TOXICOLOGY REVIEW		MUTAEX 21,93,2006
TOXICOLOGY REVIEW		MUREAV 627,10,2007
TOXICOLOGY REVIEW		ENTOX* -,13,2005
TOXICOLOGY REVIEW		ENTOX* -,308,2005
TOXICOLOGY REVIEW		MUREAV 584,1,2005
TOXICOLOGY REVIEW		FEREAC 72,68662,2007
TOXICOLOGY REVIEW		JTPAE7 19,1,2006
TOXICOLOGY REVIEW		ITODC* -,355,2004
TOXICOLOGY REVIEW		HUTOX* -,683,1996
TOXICOLOGY REVIEW		MUREAV 672,10,2009
TOXICOLOGY REVIEW		MUREAV 672,17,2009
TOXICOLOGY REVIEW		HTOPA* 1,501,2002
TOXICOLOGY REVIEW		MUREAV 674,3,2009
TOXICOLOGY REVIEW		RTOPDW 49,316,2007
TOXICOLOGY REVIEW		FEREAC 73,42683,2008
TOXICOLOGY REVIEW		MUTAEX 22,161,2007
TOXICOLOGY REVIEW		HETOEA 26,321,2007
TOXICOLOGY REVIEW		FCTOD7 47,2906,2009
TOXICOLOGY REVIEW		NBREV* 9,479,1985
TOXICOLOGY REVIEW		MUTAEX 26,19,2011
TOXICOLOGY REVIEW		TOLED5 190,107,2009
TOXICOLOGY REVIEW		TXAPA9 258,309,2012
TOXICOLOGY REVIEW		TOLED5 204,148,2011
TOXICOLOGY REVIEW		MUREAV 769,34,2014
TOXICOLOGY REVIEW		NRTXDN 43,10,2014
TOXICOLOGY REVIEW		TXCYAC 307,24,2013
TOXICOLOGY REVIEW		TXCYAC 307,35,2013
TOXICOLOGY REVIEW		TXCYAC 307,46,2013
TOXICOLOGY REVIEW		TXCYAC 307,123,2013
TOXICOLOGY REVIEW		MUREAV 767,67,2016
TOXICOLOGY REVIEW		TXAPA9 268,157,2013
TOXICOLOGY REVIEW		TXAPA9 270,39,2013
TOXICOLOGY REVIEW		MUREAV 802,1,2016
TOXICOLOGY REVIEW		MUREAV 770,183,2016
TOXICOLOGY REVIEW		JOETD7 181,66,2016
TOXICOLOGY REVIEW		FCTOD7 105,456,2017
TOXICOLOGY REVIEW		TOLED5 265,106,2017
TOXICOLOGY REVIEW		RTOPDW 55,43,2009
TOXICOLOGY REVIEW		RTOPDW 58,395,2010

Standards and Regulations

Organization	Standard	Reference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION		FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES	Supported	RBREV* -,107,1998
Mine Safety and Health Administration (MSHA) STANDARD-air	time-weighted average 0.1 ppm (1.0 mg/m³)	DTLWS* 3,16,1973
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-ARAB Republic of Egypt	time-weighted average 0.1 ppm (1 mg/m³), JAN1993
Occupational Exposure Limit-AUSTRALIA	time-weighted average 0.1 ppm (0.9 mg/m³), JUL2008
Occupational Exposure Limit-AUSTRIA	MAK-TMW 0.1 ppm (1 mg/m³);KZW 1 ppm (10 mg/m³), skin, 2007
Occupational Exposure Limit-BELGIUM	time-weighted average 0.1 mg/m³ (vapor, aerosol), Skin, MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 0.1 ppm (1 mg/m³), skin, carc, MAY2011
Occupational Exposure Limit-FINLAND	time-weighted average 0.5 mg/m³, short term exposure limit 2 mg/m³, skin, NOV2011
Occupational Exposure Limit-FRANCE	VME 0.1 ppm (1 mg/m³), Skin, FEB2006
Occupational Exposure Limit-GERMANY	MAK 0.11 ppm (1 mg/m³), 2011
Occupational Exposure Limit-HUNGARY	time-weighted average 0.9 mg/m³, short term exposure limit 3.6 mg/m³, Skin, SEP2000
Occupational Exposure Limit-ICELAND	time-weighted average 0.1 ppm (1 mg/m³), skin, NOV2011
Occupational Exposure Limit-INDIA	time-weighted average 0.1 ppm (1 mg/m³), Skin, JAN1993
Occupational Exposure Limit-JAPAN	2B carc, MAY2012
Occupational Exposure Limit-KOREA	time-weighted average 0.1 ppm (1 mg/m³), skin, 2006
Occupational Exposure Limit-MEXICO	time-weighted average 0.16 ppm (1.5 mg/m³) (skin), 2004
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 0.1 ppm (0.9 mg/m³), skin, JAN2002
Occupational Exposure Limit-NORWAY	time-weighted average 0.1 ppm (1 mg/m³), JAN1999
Occupational Exposure Limit-PERU	time-weighted average 0.01 ppm (0.1 mg/m³), JUL2005
Occupational Exposure Limit-POLAND	MAC(time-weighted average) 1 mg/m³, short term exposure limit 3 mg/m³, JAN1999
Occupational Exposure Limit-RUSSIA	time-weighted average 0.2 mg/m³, short term exposure limit 0.6 mg/m³, Skin, JUN2003
Occupational Exposure Limit-SWITZERLAND	MAK-week 0.1 ppm (1 mg/m³), KZG-week 0.2 ppm (2 mg/m³), skin, JAN2011
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 1 mg/m³, Skin, 2003
Occupational Exposure Limit-THE PHILIPPINES	time-weighted average 1 mg/m³, Skin, JAN1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)	8H time-weighted average 1 mg/m³ (skin)	CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)	8H time-weighted average 1 mg/m³ (skin)	CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)	8H time-weighted average 1 mg/m³ (skin)	CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO DICHLORVOS-air	10H time-weighted average 1 mg/m³ (Sk)	NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983	Hazard Code M0377; Number of Industries 10; Total Number of Facilities 1356; Number of Occupations 17; Total Number of Employees Exposed 24205; Total Number of Female Employees Exposed 2466
National Occupational Hazard Survey 1974	Hazard Code M0377; Number of Industries 16; Total Number of Facilities 2139; Number of Occupations 20; Total Number of Employees Exposed 29515

Status in Federal Agencies

Organization	Reference
ATSDR TOXICOLOGY PROFILE (NTIS** PB/98/101124/AS)
EPA GENETOX PROGRAM 1988, Inconclusive: Carcinogenicity-mouse/rat; Rodent dominant lethal
EPA GENETOX PROGRAM 1988, Inconclusive: Sperm morphology-mouse
EPA GENETOX PROGRAM 1988, Negative: Cytogenetics-male germ cell; Host-mediated assay
EPA GENETOX PROGRAM 1988, Negative: In vitro SCE-human; D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Negative: In vivo cytogenetics-nonhuman bone marrow
EPA GENETOX PROGRAM 1988, Negative: Mammalian micronucleus; In vitro SCE-human lymphocytes
EPA GENETOX PROGRAM 1988, Positive: B subtilis rec assay; E coli polA without S9
EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test; TRP reversion
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae gene conversion
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (gavage);clear evidence:mouse
NCI Carcinogenesis Studies (gavage);equivocal evidence:rat
NTP Carcinogenesis Studies (gavage);some evidence:rat NTPTR* NTP-TR-342,1989
On EPA IRIS database
OSHA ANALYTICAL METHOD #62

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health