CDC logo, Safer Healthier People  CDC HomeCDC SearchCDC Health Topics A-Z
NIOSH - National Institute for Occupational Safety and Health

Search NIOSH  |  NIOSH Home  |  NIOSH Topics  |  Site Index  |  Databases and Information Resources  |  NIOSH Products  |  Contact Us






Phosphoric acid, 2,2 - dichlorovinyl dimethyl ester

RTECS #: TC0350000

CAS #: 62-73-7


UPDATE: May 2009 MW: 220.98 MF: C4H7Cl2O4P


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. (2,2 - Dichloor - vinyl) - dimethyl - fosfaat (Dutch)
  2. (2,2 - Dichlor - vinyl) - dimethyl - phosphat (German)
  3. (2,2 - Dichloro - vinil) dimetil - fosfato (Italian)
  4. 2,2 - Dichloroethenyl dimethyl phosphate
  5. 2,2 - Dichloroethenyl phosphoric acid dimethyl ester
  6. 2,2 - Dichlorovinyl dimethyl phosphate
  7. 2,2 - Dichlorovinyl dimethyl phosphoric acid ester
  8. Apavap
  9. Astrobot
  10. Atgard
  11. Atgard C
  12. Atgard V
  13. BAY - 19149
  14. Bayer 19149
  15. Benfos
  16. Bibesol
  17. Brevinyl
  18. Brevinyl E50
  19. Canogard
  20. Chlorvinphos
  21. Cypona
  22. DDVP
  23. DDVP (OSHA)
  24. DDVP (insecticide)
  25. Dedevap
  26. Denkavepon
  27. Deriban
  28. Derribante
  29. Devikol
  30. Dichlofos
  31. Dichloorvo (Dutch)
  32. Dichlorfos (Polish)
  33. Dichlorman
  34. Dichlorovos
  35. Dichlorvos
  36. Dichlorvos (ACGIH:OSHA)
  37. Dimethyl 2,2 - dichloroethenyl phosphate
  38. Dimethyl 2,2 - dichlorovinyl phosphate
  39. Dimethyl dichlorovinyl phosphate
  40. Divipan
  41. ENT 20738
  42. Equigard
  43. Equigel
  44. Estrosel
  45. Estrosol
  46. Ethenol, 2,2 - dichloro - , dimethyl phosphate
  47. Fecama
  48. Fekama
  49. Fly fighter
  1. Fly - Die
  2. Insectigas D
  3. MAFU strip
  4. Marvex
  5. Mopari
  6. NCI - C00113
  7. NO - Pest
  8. NO - Pest strip
  9. NSC - 6738
  10. Nefrafos
  11. Nerkol
  12. Nogos
  13. Nogos 50
  14. Nogos 50 EC
  15. Nogos G
  16. Novotox
  17. Nuvan
  18. Nuvan 100EC
  19. Nuvan 7
  20. O,O - Dimethyl 2,2 - dichlorovinyl phosphate
  21. O,O - Dimethyl O - 2,2 - dichlorovinyl phosphate
  22. O,O - Dimethyl dichlorovinyl phosphate
  23. O,O - Dimethyl - O - (2,2 - dichlor - vinyl) - phosphat (German)
  24. O,O - Dwumetylo - O - dwuchlorowinylofosforan (Polish)
  25. O,O - dimethyl - O - (2,2 - dichlorovinyl) phosphate
  26. O - (2,2 - Dichlorvinyl) - O,O - dimethylphosphat (German)
  27. OKO
  28. OMS 14
  29. Panaplate
  30. Phosphate de dimethyle et de 2,2 - dichlorovinyle (French)
  31. Phosphoric acid, 2,2 - dichloroethenyl dimethyl ester (9CI)
  32. Phosvit
  33. SD - 1750
  34. Szklarniak
  35. TAP 9VP
  36. Task
  37. Tetravos
  38. Unifos
  39. Unifos (pesticide)
  40. Unifos 50 EC
  41. Unitox
  42. Vapona
  43. Vapona insecticide
  44. Vaponite
  45. Vapora II
  46. Vinyl alcohol, 2,2 - dichloro - , dimethyl phosphate
  47. Vinylofos
  48. Vinylophos
  49. Winylophos


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis intraperitoneal
hamster
3 mg/kg ARTODN 58,152,1986
cytogenetic analysis hamster lung 100 mg/L AMONDS 3,253,1980
cytogenetic analysis hamster ovary 160 mg/L NTPTR* NTP-TR-342,1989
cytogenetic analysis human lymphocyte 1 mg/L TSITAQ 18,1490,1976
cytogenetic analysis multiple
other fish
10 ppb MUREAV 344,1,1995
cytogenetic analysis rat other cell types 80 mg/L MUREAV 206,439,1988
DNA damage Escherichia coli 1 gm/L MUREAV 52,161,1978
DNA damage hamster lung 2,000 ppm/60 minute MUREAV 24,365,1974
DNA damage human lymphocyte 62 mg/L TUMOAB 66,425,1980
DNA damage human HeLa cell 970 mol/L CBINA8 8,171,1974
DNA damage mammal (species unspecified) lymphocyte 100 L NATWAY 57,393,1970
DNA damage intraperitoneal
mouse
420 g/kg APTSAI 49(5),56,1981
DNA damage inhalation
mouse
8 mg/kg PCBPBS 6,101,1976
DNA damage salmon sperm 14 mmol/L CBINA8 8,171,1974
DNA inhibition human lymphocyte 62 mg/L TUMOAB 66,425,1980
DNA repair Bacillus subtilis 10 pph MUREAV 40,19,1976
DNA repair Escherichia coli 60 nmol/plate CNREA8 33,458,1973
DNA repair other microorganisms 10 mol/plate CBINA8 39,339,1982
unscheduled DNA synthesis human other cell types 65 mmol/L PSSCBG 15,439,1984
host-mediated assay mouse
Saccharomyes cerevisiae
4 mg/L ATXKA8 30,61,1972
mutation in microorganisms Aspergillus nidulans 14 mg/plate (-enzymatic activation step) MUREAV 46,395,1977
mutation in microorganisms Escherichia coli 5 pph (-enzymatic activation step) MUREAV 40,19,1976
mutation in microorganisms Klebsiella pneumoniae 1,000 ppm (-enzymatic activation step) MUREAV 16,413,1972
mutation in microorganisms other microorganisms 5,600 g/plate (-enzymatic activation step) CBINA8 22,297,1978
mutation in microorganisms other microorganisms 1,000 ppm (-enzymatic activation step) MUREAV 16,413,1972
mutation in microorganisms other microorganisms 80 mmol/L (-enzymatic activation step) MUREAV 21,175,1973
mutation in microorganisms Salmonella typhimurium 333 g/plate (+enzymatic activation step) EMMUEG 11(Suppl 12),1,1988
mutation in microorganisms Serratia marcescens 25 mg/L (-enzymatic activation step) ATXKA8 30,67,1972
mutation in microorganisms Schizosaccharomyces pombe 5 mmol/L (-enzymatic activation step) MUREAV 117,139,1983
mutation in microorganisms Schizosaccharomyces pombe 5 mmol/L (+enzymatic activation step) MUREAV 117,139,1983
gene conversion and mitotic recombination Aspergillus nidulans 28 mg/plate MUREAV 46,395,1977
gene conversion and mitotic recombination Saccharomyes cerevisiae 19 mmol/L/6 hour IARCCD 10,161,1974
mutation in mammalian somatic cells mouse lymphocyte 12,500 mg/L NTPTR* NTP-TR-342,1989
mutation in mammalian somatic cells intraperitoneal
mouse
55 mg/kg/22 day- intermittent CALEDQ 146,155,1999
morphological transform hamster embryo 110 mol/L ENMUDM 8,515,1986
morphological transform rat other cell types 40 mg/L MUREAV 206,439,1988
other mutation test systems Escherichia coli 3,820 nmol/L EMMUEG 19,98,1992
phage inhibition capacity Escherichia coli 70 mol/L MUREAV 182,193,1987
phage inhibition capacity Escherichia coli 0.284 mmol/L (+enzymatic activation step) EMMUEG 36,206,2000
sister chromatid exchange hamster ovary 30 mol/L JTEHD6 8,939,1981
sister chromatid exchange hamster lung 100 mol/L MUREAV 78,177,1980
sister chromatid exchange rat other cell types 10 mg/L MUREAV 206,439,1988
sex chromosome loss and nondisjunction Aspergillus nidulans 800 mg/L EVHPAZ 31,81,1979
sex chromosome loss and nondisjunction oral
Drosophila melanogaster
750 ppb MUREAV 28,405,1975
sperm morphology intraperitoneal
mouse
35 mg/kg/5 day PNASA6 72,4425,1975


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rabbit
lowest published toxic concentration: 4 mg/m3/23 hour (1-28 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) ATXKA8 30,29,1972
intraperitoneal
rat
lowest published toxic dose: 15 mg/kg (11 day pregnant) Reproductive: Specific developmental abnormalities: Body wall AEHLAU 16,805,1968
oral
mouse
lowest published toxic dose: 180 mg/kg (18 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) BECTA6 11(5),429,1974
oral
pig
lowest published toxic dose: 255 mg/kg (41-70 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Blood and lymphatic systems (including spleen and marrow)

Reproductive: Specific developmental abnormalities: Endocrine system
ZVRAAX 27,662,1980
oral
pig
lowest published toxic dose: 759 mg/kg (1-15 week pregnant/4 week after birth) Reproductive: Effects on newborn: Biochemical and metabolic CNJNAT 71,227,1991
oral
rat
lowest published toxic dose: 39,200 g/kg (14-21 day pregnant) Reproductive: Effects on newborn: Biochemical and metabolic NUPOBT 15,255,1977
oral
rat
lowest published toxic dose: 220 mg/kg (multigeneration) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Physical

Reproductive: Effects on newborn: Delayed effects
IJEREO 5,239,1995
oral
rat
lowest published toxic dose: 80 mg/kg (6-15 day pregnant) Reproductive: Effects on newborn: Behavioral NETEEC 26,607,2004
oral
rabbit
lowest published toxic dose: 65 mg/kg (6-13 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) TJADAB 20,383,1979
oral
rabbit
lowest published toxic dose: 60 mg/kg (22-31 day pregnant) Reproductive: Effects on newborn: Biochemical and metabolic FHCYAI 16,335,1978
unreported route
guinea pig
lowest published toxic dose: 90 mg/kg (42-44 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system NEREDZ 19,569,1994
unreported route
rat
lowest published toxic dose: 40 mg/kg (2 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct
BECTA6 15,458,1976
unreported route
rabbit
lowest published toxic dose: 60 mg/kg (22-31 day pregnant) Reproductive: Effects on newborn: Biochemical and metabolic FHCYAI 16,139,1978


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 20,600 mg/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors
NTPTR* NTP-TR-342,1989
oral
mouse
lowest published toxic dose: 10,300 mg/kg/103 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Gastrointestinal: Tumors
NTIS** PB90-198508
oral
mouse
lowest published toxic dose: 20,600 mg/kg/103 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Gastrointestinal: Tumors
NTIS** PB90-198508
oral
rat
lowest published toxic dose: 4,120 mg/kg/2 year- continuous Tumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Gastrointestinal: Tumors
NTPTR* NTP-TR-342,1989
oral
rat
lowest published toxic dose: 2,060 mg/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors

Blood: Leukemia
JJCREP 82,157,1991
oral
rat
lowest published toxic dose: 2,060 mg/kg/103 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors

Blood: Leukemia
NTIS** PB90-198508
oral
rat
lowest published toxic dose: 2,060 mg/kg/103 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Skin and Appendages: Tumors
NTIS** PB90-198508


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lethal concentration (50 percent kill): 13 mg/m3/4 hour Eye: Lacrimation

Behavioral: Tremor

Gastrointestinal: Changes in structure or function of salivary glands
GISAAA 33(12),35,1968
inhalation
rat
lethal concentration (50 percent kill): 15 mg/m3/4 hour Eye: Lacrimation

Behavioral: Tremor

Gastrointestinal: Changes in structure or function of salivary glands
GISAAA 33(12),35,1968
intramuscular
rat
lethal dose (50 percent kill): 10.2 mg/kg N/R EKFAE9 56,57,1993
intramuscular
rat
lethal dose (50 percent kill): 1.5 mg/kg Behavioral: Anticonvulsant EKFAE9 62,55,1999
intraperitoneal
hamster
lethal dose (50 percent kill): 30 mg/kg N/R ARTODN 58,152,1986
intraperitoneal
mouse
lethal dose (50 percent kill): 22 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase JAFCAU 11,91,1963
intraperitoneal
mouse
lowest published toxic dose: 19.7 mg/kg Behavioral: Convulsions or effect on seizure threshold TOSCF2 72,289,2003
intraperitoneal
mouse
lowest published lethal dose: 22.4 mg/kg Behavioral: Convulsions or effect on seizure threshold TOSCF2 72,289,2003
intraperitoneal
mouse
lethal dose (50 percent kill): 41.64 mg/kg N/R TXAPA9 219,114,2007
intraperitoneal
mouse
lowest published toxic dose: 83.28 mg/kg Brain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TXAPA9 219,114,2007
intraperitoneal
rat
lethal dose (50 percent kill): 15 mg/kg Brain and Coverings: Other degenerative changes

Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
APTSAI 49(5),67,1981
intraperitoneal
rat
lowest published toxic dose: 8 mg/kg Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases

Biochemical: Metabolism (intermediary): Lipids including transport
TOLED5 135,S86,2002
intraperitoneal
rat
lowest published toxic dose: 10 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Reactivates cholinesterase

Biochemical: Neurotransmitters or modulators (putative): Catecholamine levels in CNS

Biochemical: Neurotransmitters or modulators (putative): Dopamine at other sites
FATOAO 44,334,1981
intravenous
dog
lowest published lethal dose: 2,200 g/kg Behavioral: Somnolence (general depressed activity)

Gastrointestinal: Hypermotility, diarrhea

Gastrointestinal: Nausea or vomiting
AUVJA2 49,113,1973
intravenous
mouse
lethal dose (50 percent kill): 18 mg/kg N/R CSLNX* NX#00004
oral
wild bird
lethal dose (50 percent kill): 12 mg/kg N/R TXAPA9 21,315,1972
oral
chicken
lethal dose (50 percent kill): 6,450 g/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase INJPD2 10,323,1978
oral
duck
lethal dose (50 percent kill): 7,800 g/kg N/R DOEAAH 35,25,1979
oral
dog
lethal dose (50 percent kill): 100 mg/kg N/R 85JFAN A141,1984
oral
mouse
lethal dose (50 percent kill): 61 mg/kg N/R OSDIAF 15,553,1966
oral
mouse
lowest published toxic dose: 40 mg/kg Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct
BECTA6 11,429,1974
oral
pigeon
lethal dose (50 percent kill): 23,700 g/kg N/R ASTTA8 (680),157,1979
oral
pig
lethal dose (50 percent kill): 157 mg/kg Gastrointestinal: Nausea or vomiting

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
AJVRAH 40,315,1979
oral
quail
lethal dose (50 percent kill): 22,010 g/kg Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Hypermotility, diarrhea
HOEKAN 24,35,1974
oral
rat
lethal dose (50 percent kill): 17 mg/kg N/R JPIFAN (13),36,1972
oral
rabbit
lethal dose (50 percent kill): 10 mg/kg Autonomic Nervous System: Other (direct) parasympathomimetic

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
BEXBAN 83,32,1977
parenteral
man
lowest published lethal dose: 35.7 mg/kg Eye: Miosis (pupilliary constriction)

Cardiac: Pulse rate decreased with fall in BP

Lung, Thorax, or Respiration: Respiratory depression
AJEMEN 18,640,2000
subcutaneous
mouse
lethal dose (50 percent kill): 24 mg/kg Behavioral: Convulsions or effect on seizure threshold

Eye: Other eye effects

Lung, Thorax, or Respiration: Dyspnea
IMSUAI 31,170,1962
subcutaneous
mouse
lowest published lethal dose: 16.8 mg/kg N/R ARTODN 76,173,2002
subcutaneous
rat
lethal dose (50 percent kill): 10,800 g/kg N/R APYPAY 32,507,1981
subcutaneous
rat
lowest published lethal dose: 25 mg/kg Lung, Thorax, or Respiration: Respiratory obstruction AEMME* 9,1369,2002
subcutaneous
rat
lowest published toxic dose: 13 mg/kg Brain and Coverings: Other degenerative changes

Behavioral: Convulsions or effect on seizure threshold

Biochemical: Metabolism (intermediary): Effect on cyclic nucleotides
TXCYAC 191,35,2003
subcutaneous
rat
lethal dose (50 percent kill): 9.8 mg/kg Lung, Thorax, or Respiration: Respiratory obstruction PHTOEH 93,211,2003
subcutaneous
rat
lowest published toxic dose: 5 mg/kg Autonomic Nervous System: Other (direct) parasympathomimetic

Behavioral: Change in motor activity (specific assay)

Behavioral: Alteration of operant conditioning
PHTOEH 93,211,2003
subcutaneous
rat
lowest published toxic dose: 2 mg/kg Behavioral: Alteration of classical conditioning

Behavioral: Alteration of operant conditioning
PHTOEH 93,211,2003
subcutaneous
rat
lowest published toxic dose: 3 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Tremor

Gastrointestinal: Changes in structure or function of salivary glands
TXAPA9 219,151,2007
subcutaneous
rat
lowest published toxic dose: 5 mg/kg Behavioral: Change in motor activity (specific assay) PHTOEH 93,211,2003
subcutaneous
rat
lowest published toxic dose: 2 mg/kg Behavioral: Ataxia

Behavioral: Alteration of operant conditioning
PHTOEH 93,211,2003
subcutaneous
rat
lethal dose (50 percent kill): 9.8 mg/kg Lung, Thorax, or Respiration: Respiratory depression PHTOEH 93,211,2003
subcutaneous
rat
lethal dose (50 percent kill): 33.3 mg/kg Vascular: BP lowering not characterized in autonomic section

Lung, Thorax, or Respiration: Respiratory obstruction

Lung, Thorax, or Respiration: Other changes
NRTXDN 28,664,2007
skin
mouse
lethal dose (50 percent kill): 206 mg/kg N/R ABCHA6 27,684,1963
skin
rat
lethal dose (50 percent kill): 0.75 mg/kg N/R TOVEFN (2),37,1995
skin
rabbit
lethal dose (50 percent kill): 107 mg/kg N/R BESAAT 12,117,1966
unreported route
mammal (species unspecified)
lethal dose (50 percent kill): 125 mg/kg N/R GISAAA 41(8),82,1976
unreported route
mouse
lethal dose (50 percent kill): 75 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase GISAAA 33(12),35,1968
unreported route
rat
lethal dose (50 percent kill): 57 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase GISAAA 33(12),35,1968
unreported route
rat
lethal dose (50 percent kill): 40 mg/kg N/R FATOAO 50,97,1987
unreported route
rabbit
lethal dose (50 percent kill): 23 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase GISAAA 33(12),35,1968


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic dose: 8,200 g/m3/45 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
GISAAA 33(12),35,1968
intraperitoneal
rat
lowest published toxic dose: 16 mg/kg/2 day- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases

Biochemical: Metabolism (intermediary): Lipids including transport
TOLED5 135,S86,2002
intraperitoneal
rat
lowest published toxic dose: 24 mg/kg/3 day- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases

Biochemical: Metabolism (intermediary): Lipids including transport
TOLED5 135,S86,2002
intraperitoneal
rat
lowest published toxic dose: 150 mg/kg/30 day- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases
EXMPA6 56,144,1992
oral
chicken
lowest published toxic dose: 2,450 mg/kg/28 day- continuous Brain and Coverings: Other degenerative changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
INJPD2 10,323,1978
oral
dog
lowest published toxic dose: 56,250 g/kg/90 day- continuous Brain and Coverings: Other degenerative changes

Kidney, Ureter, and Bladder: Urine volume increased

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
NYZZA3 26,739,1974
oral
domestic animal
lowest published toxic dose: 112 mg/kg/28 day- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases
IVEJAC 66,821,1989
oral
mouse
lowest published toxic dose: 5,200 mg/kg/13 week- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTPTR* NTP-TR-342,1989
oral
mouse
lowest published toxic dose: 90 mg/kg/9 day- intermittent Reproductive: Paternal effects: Testes, epididymis, sperm duct BECTA6 11,429,1974
oral
mouse
lowest published toxic dose: 180 mg/kg/18 day- intermittent Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) BECTA6 11,429,1974
oral
rat
lowest published toxic dose: 360 mg/kg/90 day- intermittent Liver: Other changes

Blood: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport
BCTKAG 21,31,1988
oral
rat
lowest published toxic dose: 56 mg/kg/14 day- intermittent Liver: Other changes

Kidney, Ureter, and Bladder: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other hydrolases
BCTKAG 7,201,1974
oral
rat
lowest published toxic dose: 45 mg/kg/6 week- intermittent Brain and Coverings: Changes in surface EEG

Peripheral Nerve and Sensation: Recording from peripheral motor nerve

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
NETEEC 10,429,1988
oral
rat
lowest published toxic dose: 150 mg/kg/30 day- intermittent Brain and Coverings: Other degenerative changes

Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
GISAAA -,64,1993
oral
rat
lowest published toxic dose: 70 mg/kg/2 week- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field BECTA6 18,231,1977
subcutaneous
mouse
lowest published toxic dose: 100 mg/kg/10 day- intermittent Brain and Coverings: Other degenerative changes

Behavioral: Somnolence (general depressed activity)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
JHSCFD 45,191,1999
subcutaneous
rat
lowest published toxic dose: 28 mg/kg/28 day- intermittent Liver: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
APYPAY 31,575,1980
subcutaneous
rat
lowest published toxic dose: 21,600 g/kg/17 week- intermittent Liver: Other changes

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
APYPAY 32,507,1981
subcutaneous
rat
lowest published toxic dose: 54 mg/kg/9 week- intermittent Liver: Changes in liver weight

Endocrine: Changes in adrenal weight
TXAPA9 197,353,2004
subcutaneous
rat
lowest published toxic dose: 108 mg/kg/9 week- intermittent Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) TXAPA9 197,353,2004
subcutaneous
rat
lowest published toxic dose: 54 mg/kg/9 week- intermittent Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases
TXCYAC 213,129,2005
subcutaneous
rat
lowest published toxic dose: 216 mg/kg/9 week- intermittent Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases
TXCYAC 213,129,2005
subcutaneous
rat
lowest published toxic dose: 21 mg/kg/7 day- intermittent Brain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TXAPA9 219,151,2007
subcutaneous
rat
lowest published toxic dose: 504 mg/kg/12 week- intermittent Brain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)

Biochemical: Metabolism (intermediary): Effect on mitochondrial function
NRTXDN 28,1208,2007
skin
monkey
lowest published toxic dose: 750 mg/kg/10 day- intermittent Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
AMIHAB 15,340,1957
skin
monkey
lowest published toxic dose: 400 mg/kg/4 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field YKYUA6 30,1229,1979
skin
rat
lowest published toxic dose: 141 mg/kg/17 week- intermittent Brain and Coverings: Other degenerative changes

Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
APYPAY 32,507,1981


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.1 mg/m3 (inhal, vapor, skin, sen) DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not classifiable as human carcinogen DTLVS* TLV/BEI,2007
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 53,267,1991
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 20,97,1979
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 20,97,1979
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 53,267,1991
International Agency for Research on Cancer (IARC) Cancer Review Group 2B IMEMDT 53,267,1991
TOXICOLOGY REVIEW
RREVAH 46,1,1973
TOXICOLOGY REVIEW
MUREAV 32,133,1975
TOXICOLOGY REVIEW
CNDQA8 10(3),43,1975
TOXICOLOGY REVIEW
NYZZA3 26,739,1974
TOXICOLOGY REVIEW
NWSCAL 53,489,1972
TOXICOLOGY REVIEW
RREVAH 63,1,1976
TOXICOLOGY REVIEW
ALLVAR 50,77,1962
TOXICOLOGY REVIEW
TOLED5 128,45,2002
TOXICOLOGY REVIEW
MUREAV 543,201,2003
TOXICOLOGY REVIEW
MUREAV 567,347,2004
TOXICOLOGY REVIEW
CRTOEC 17,983,2004
TOXICOLOGY REVIEW
MUREAV 613,17,2006
TOXICOLOGY REVIEW
MUTAEX 21,93,2006
TOXICOLOGY REVIEW
MUREAV 627,10,2007
TOXICOLOGY REVIEW
ENTOX* -,13,2005
TOXICOLOGY REVIEW
ENTOX* -,308,2005
TOXICOLOGY REVIEW
MUREAV 584,1,2005
TOXICOLOGY REVIEW
FEREAC 72,68662,2007
TOXICOLOGY REVIEW
FEREAC 72,68662,2007
TOXICOLOGY REVIEW
JTPAE7 19,1,2006
TOXICOLOGY REVIEW
ITODC* -,355,2004
TOXICOLOGY REVIEW
HUTOX* -,683,1996
TOXICOLOGY REVIEW
MUREAV 672,10,2009
TOXICOLOGY REVIEW
MUREAV 672,17,2009
TOXICOLOGY REVIEW
HTOPA* 1,501,2002


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Supported RBREV* -,107,1998
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.1 ppm (1.0 mg/m3) DTLWS* 3,16,1973
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 1 mg/m3 (skin) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 1 mg/m3 (skin) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 1 mg/m3 (skin) CFRGBR 29,1915.1000,1993
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 0.1 ppm (1 mg/m3), JAN1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.1 ppm (0.9 mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 0.1 mg/m3 (vapor, aerosol), Skin, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 0.1 ppm (1 mg/m3), OCT 2002
Occupational Exposure Limit - FINLAND time-weighted average 1 mg/m3, short term exposure limit 3 mg/m3, Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 0.1 ppm (1 mg/m3), Skin, FEB2006
Occupational Exposure Limit - GERMANY MAK 1 mg/m3 (0.11 mL/m3), 2005
Occupational Exposure Limit - HUNGARY time-weighted average 0.9 mg/m3, short term exposure limit 3.6 mg/m3, Skin, SEP2000
Occupational Exposure Limit - INDIA time-weighted average 0.1 ppm (1 mg/m3), Skin, JAN1993
Occupational Exposure Limit - KOREA time-weighted average 0.1 ppm (1 mg/m3), skin, 2006
Occupational Exposure Limit - MEXICO time-weighted average 0.16 ppm (1.5 mg/m3) (skin), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 1 mg/m3, Skin, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 0.1 ppm (0.9 mg/m3), skin, JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 0.1 ppm (1 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 1 mg/m3, Skin, JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 1 mg/m3, short term exposure limit 3 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA time-weighted average 0.2 mg/m3, short term exposure limit 0.6 mg/m3, Skin, JUN2003
Occupational Exposure Limit - SWITZERLAND MAK- week 0.1 ppm (1 mg/m3),KZG- week 0.2 ppm (2 mg/m3), Skin, DEC2006
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not classifiable as human carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not classifiable as human carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO DICHLORVOS-air 10 hour time-weighted average 1 mg/m3 (Sk) NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M0377;
Number of Industries 16;
Total Number of Facilities 2,139;
Number of Occupations 20;
Total Number of Employees Exposed 29,515
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M0377;
Number of Industries 10;
Total Number of Facilities 1,356;
Number of Occupations 17;
Total Number of Employees Exposed 24,205;
Total Number of Female Employees Exposed 2,466


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

ATSDR TOXICOLOGY PROFILE (NTIS** PB/98/101124/AS)
EPA GENETOX PROGRAM 1988, Positive: B subtilis rec assay; E coli polA without S9
EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test; TRP reversion
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae gene conversion
EPA GENETOX PROGRAM 1988, Negative: In vivo cytogenetics-nonhuman bone marrow
EPA GENETOX PROGRAM 1988, Negative: Cytogenetics-male germ cell; Host-mediated assay
EPA GENETOX PROGRAM 1988, Negative: Mammalian micronucleus; In vitro SCE-human lymphocytes
EPA GENETOX PROGRAM 1988, Negative: In vitro SCE-human; D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Inconclusive: Carcinogenicity-mouse/rat; Rodent dominant lethal
EPA GENETOX PROGRAM 1988, Inconclusive: Sperm morphology-mouse
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as an insecticide and as an anthelminthic for swine and dogs
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (gavage);clear evidence:mouse
NTP Carcinogenesis Studies (gavage);some evidence:rat NTPTR* NTP-TR-342,1989
NCI Carcinogenesis Studies (gavage);equivocal evidence:rat
OSHA ANALYTICAL METHOD #62


REFERENCES:

CODEN
REFERENCE

85JFAN "Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd, eds., Nottingham, Royal Soc. of Chemistry, 1983-86
ABCHA6 Agricultural and Biological Chemistry. (Maruzen Co. Ltd., POB 5050, Tokyo International, Tokyo 100-31, Japan) V.25- 1961-
AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St., NW, Washington, DC 20016) V.1- 1960-
AEMME* Academic emergency medicine: official journal of the Society for Academic Emergency Medicine (Philadelphia Pa Hanley And Belfus) V.1- 1994-
AJEMEN American Journal of Emergency Medicine. (WB Saunders, Philadelphia, PA) V.1- 1983-
AJVRAH American Journal of Veterinary Research. (American Veterinary Medical Assoc., 930 N. Meacham Rd., Schaumburg, IL 60196) V.1- 1940-
ALLVAR Alimentation et la Vie. (Societe Scientifique d'Hygiene Alimentaire, 16, rue de l'Estrapade, 75005 Paris, France) V.39- 1951-
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU.
AMONDS Applied Methods in Oncology. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1978-
APTSAI Acta Pharmacologica et Toxicologica, Supplementun. (Munksgaard International Pub., POB 2148, DK-1016 Copenhagen K, Denmark) No.1- 1947-
APYPAY Acta Physiologica Polonica. (Karger-Libri, POB CH-4009, Warszawa, Switzerland) V.1-41, 1950-90.
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
ASTTA8 ASTM Special Technical Publication. (American Soc. for Testing Materials, 1916 Race St., Philadelphia, PA 19103) No.1- 1911-
ATXKA8 Archiv fuer Toxikologie. (Berlin, Fed. Rep. Ger.) V.15-31, 1954-74. For publisher information, see ARTODN.
AUVJA2 Australian Veterinary Journal. (Australian Veterinary Assoc., Executive Director, 134-136 Hampden Road, Artarmon, N.S.W., Australia) V.2- 1927-
BCTKAG Bromatologia i Chemia Toksykologiczna. (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland) V.4- 1971-
BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966-
BESAAT Bulletin of the Entomological Society of America. (Entomological Soc. of America, 4603 Calvert Rd., College Park, MD 20740) V.1- 1955-
BEXBAN Bulletin of Experimental Biology and Medicine (English Translation). Translation of BEBMAE. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) V.41- 1956-
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975-
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CNDQA8 Cahiers de Nutrition et de Dietetique. (Editions Meteore, 42, rue du Louvre, 75001 Paris, France) V.1- 1966-
CNJNAT Canadian Journal of Animal Science. (Agricultural Institute of Canada, 151 Slater St., Suite 907, Ottawa, ON K1P 5H4, Canada) V.37- 1957-
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
CRTOEC Chemical Research in Toxicology. (American Chemical Soc., Distribution Office Dept. 223, POB 57/36, West End Station, Washington, DC 20037) V.1- 1988-
CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010)
DOEAAH Down to Earth. (Dow Chemical USA, Agricultural Products Dept., Midland, MI 48640) V.1- 1945-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
DTLWS* "Documentation of the Threshold Limit Values for Substances in Workroom Air," Supplements. For publisher information, see 85INA8.
EKFAE9 Eksperimental'naya i Klinicheskaya Farmakologiya. Experimental and Clinical Pharmacology. (Mezhdunarodnaya Kniga, ul. B. Yakimanka, 39, 117049 Moscow, Russia) V.55- 1992-
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
EXMPA6 Experimental and Molecular Pathology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1962-
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
FHCYAI Folia Histochemica et Cytochemica. (Cracow, Poland) V.1-21, 1963-83.
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
HOEKAN Hokkaidoritsu Eisei Kenkyushoho. Report of the Hokkaido Institute of Public Health. (Nishi- 12-chome, Kita-19-jo, Kita-ku, Sapporo 060, Japan) No.1- 1951-
HTOPA*
HUTOX*
IARCCD IARC Scientific Publications. (Geneva, Switzerland) No.1-26, 1971-78. For publisher information, see IAPUDO.
IJEREO International Journal of Environmental Health Research. (Carfax Publishing Co., POB 25, Abingdon, Oxon. Ox14 3UE, UK) V.1- 1991-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
IMSUAI Industrial Medicine and Surgery. (Northbrook, IL) V.18-42, 1949-73. For publisher information, see IOHSA5.
INJPD2 Indian Journal of Pharmacology. (Dept. of Pharmacology, Baranas Hindu Univ., Varanasi 221 005, India) V.1- 1968(?)-
ITODC*
IVEJAC Indian Veterinary Journal. (Dr. R. Krishnamurti, G.M.V.C., 8 Avenue Rd., Madras 600 034, India) V.1- 1924-
JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1953-
JHSCFD Journal of Health Science. (Pharmaceutical Society of Japan, 2-12-15 Shibuya, Shibuya-Ku, Tokyo 150-0002, Japan) V. 45- 1999-
JJCREP Japanese Journal of Cancer Research. (Elsevier Science Pub. BV, POB 211, 1000 AE Amsterdam, Netherlands) V.76- 1985-
JPIFAN Japan Pesticide Information. (Japan Plant Protection Assoc., 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) No.1-61, 1969-92. For publisher information, see AGJAEP.
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
JTPAE7 Journal of Toxicologic Pathology. (Nihon Dokusei Byori Gakkai, editor, 3-25-8 Nishi- shinbashi, Minato-ku, Tokyo 105, Japan) V.1- 1988
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
NATWAY Naturwissenschaften. (Springer-Verlag, Heidelberger Platz 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.1- 1913-
NEREDZ Neurochemical Research. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) V.1- 1976-
NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.9- 1987-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NRTXDN Neurotoxicology. (Intox Press, Inc., POB 34075, Little Rock, AR 72203) V.1- 1979-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
NUPOBT Neuropatologia Polska. (Ars-Polona, POB 1001, 00-068 Warsaw 1, Poland) V.1- 1963-
NWSCAL New Scientist. (IPC Magazines Ltd., King's Reach Tower, Stamford St., London SE1 9LS, UK) V.1- 1956-
NYZZA3 Nippon Yakuzaishikai Zasshi. Journal of the Japan Pharmaceutical Association. (Nippon Yakuznishikai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1949-
OSDIAF Osaka Shiritsu Daigaku Igaku Zasshi. Journal of the Osaka City Medical Center. (Osaka, Japan) V.4-23, 1955-74. For publisher information, see OIGZDE.
PCBPBS Pesticide Biochemistry and Physiology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1971-
PHTOEH Pharmacology and Toxicology (Copenhagen). (Munksgaard International Pub., POB 2148, DK-1016 Copenhagen K, Denmark) V.60- 1987-
PNASA6 Proceedings of the National Academy of Sciences of the United States of America. (National Academy of Sciences, Printing & Pub. Office, 2101 Constitution Ave., Washington, DC 20418) V.1- 1915-
PSSCBG Pesticide Science. (Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK) V.1- 1970-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962-
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOSCF2 Toxicological Sciences (Oxford University Press, 6277 Sea Harbor Drive, Orlando, FL 32887 ) V. 41, Jan. 1998-
TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown
TSITAQ Tsitologiya. Cytology. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1959-
TUMOAB Tumori. (Casa Editrice Ambrosiana, Via G. Frua 6, 20146 Milan, Italy) V.1- 1911-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950-
ZVRAAX Zentralblatt fuer Veterinaermedizin, Reihe A. (Verlag Paul Parey, Linderstr. 44-47, D-1000 Berlin 61, Fed. Rep. Ger.) V.10- 1963-

Used as an insecticide and as an anthelminthic for swine and dogs

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Drug
   Organometallic
   Mutagen
   Reproductive Effector
   Human Data

ALT CAS #: 8023-22-1
ALT CAS #: 8072-21-7
ALT CAS #: 8072-39-7
ALT CAS #: 11095-17-3
ALT CAS #: 11096-21-2
ALT CAS #: 12772-40-6
ALT CAS #: 55819-32-4
ALT CAS #: 62139-95-1
ALT CAS #: 95828-55-0
ALT CAS #: 116788-91-1
Click Here for Additional Information about RTECS

NIOSH Home |  NIOSH Search  |  Site Index  |  Topic List |  Contact Us