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Phenol, pentachloro -

RTECS #: SM6300000

CAS #: 87-86-5


UPDATE: May 2009 MW: 266.32 MF: C6HCl5O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. TUMORIGENIC DATA:
  6. ACUTE TOXICITY DATA:
  7. OTHER MULTIPLE DOSE DATA:
  8. REVIEWS:
  9. STANDARDS AND REGULATIONS:
  10. NIOSH DOCUMENTATION AND SURVEILLANCE:
  11. STATUS IN FEDERAL AGENCIES:
  12. REFERENCES:

SYNONYMS:

  1. 1 - Hydroxypentachlorobenzene
  2. 2,3,4,5,6 - Pentachlorophenol
  3. AD 73
  4. CM 613
  5. CP 1309
  6. Chem - Penta
  7. Chem - Tol
  8. Chlon
  9. Chlorophen
  10. Dow pentachlorophenol DP - 2 antimicrobial
  11. Dowicide 7
  12. Dowicide EC - 7
  13. Durotox
  14. EP 30
  15. Fungifen
  16. Grundier arbezol
  17. Lauxtol
  18. Lauxtol A
  19. Liroprem
  20. MB 333
  21. NCI - C54933
  22. NCI - C55378
  23. NCI - C56655
  24. PCP
  25. PCP (pesticide)
  26. Penchlorol
  27. Penta
  28. Penta WR
  29. Penta ready
  30. Penta - kil
  1. Pentachloorfenol (Dutch)
  2. Pentachlorofenol
  3. Pentachlorofenolo
  4. Pentachlorophenol
  5. Pentachlorophenol (ACGIH:OSHA)
  6. Pentachlorophenol, DP - 2
  7. Pentachlorophenol, EC - 7
  8. Pentachlorophenol, technical - grade
  9. Pentachlorphenol
  10. Pentachlorphenol (German)
  11. Pentaclorofenolo (Italian)
  12. Pentacon
  13. Penwar
  14. Peratox
  15. Permacide
  16. Permagard
  17. Permasan
  18. Permatox DP - 2
  19. Permatox penta
  20. Permite
  21. Pol Nu
  22. Pole topper fluid
  23. Preventol P
  24. RCRA waste number U242
  25. Santophen 20
  26. Thompson's wood fix
  27. Weedone
  28. Witophen P
  29. Woodtreat A


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
100 L/24 hour mild NTIS** OTS0546023
skin
rabbit
10 mg/24 hour open irritation test mild AIHAAP 23,95,1962


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis hamster ovary 80 mg/L EMMUEG 10(Suppl 10),1,1987
cytogenetic analysis hamster fibroblast 300 mg/L (-enzymatic activation step) HBPTO* 2,1491,2001
DNA damage human Ascites tumor 50 mg/L/2 hour FCTOD7 42,1323,2004
DNA damage multiple
non-mammalian species
100 g/L/2 hour MUREAV 605,78,2006
mutation in microorganisms other microorganisms 40 mg/L HBPTO* 2,1491,2001
mutation in microorganisms Salmonella typhimurium 40 nmol/plate (-enzymatic activation step) AIDZAC 10,305,1982
mutation in microorganisms Saccharomyes cerevisiae 400 mg/L (-enzymatic activation step) EVSRBT 12,325,1978
micronucleus test multiple
non-mammalian species
10 g/L/24 hour MUREAV 605,78,2006
gene conversion and mitotic recombination Saccharomyes cerevisiae 190 mol/L IARCCD 10,161,1974
morphological transform hamster embryo 100 mg/L AETODY 1,241,1980
morphological transform mouse fibroblast 0.1 mg/L/21 day (-enzymatic activation step) EMMUEG 37,231,2001
other mutation test systems oral
mouse
30 mg/kg MUREAV 343,157,1995
other mutation test systems other microorganisms 10 mg/L EESADV 13,7,1987
sister chromatid exchange hamster ovary 3 mg/L EMMUEG 10(Suppl 10),1,1987
specific locus test intraperitoneal
mouse
50 mg/kg EVSRBT 12,325,1978
specific locus test multiple
other fish
5 g/L/10 day- continuous MUREAV 609,92,2006


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lowest published toxic concentration: 0.15 mg/m3 (122 day prior to copulation) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on newborn: Other postnatal measures or effects
VCVGK* -,258,1994
oral
man
lowest published toxic dose: 124 mg/kg (multigeneration) Reproductive: Effects on newborn: Delayed effects JRPFA4 113,95,1998
oral
rat
lowest published toxic dose: 60 mg/kg (9 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) DABBBA 37,1184,1976
oral
rat
lowest published toxic dose: 50 mg/kg (6-15 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system TXAPA9 28,151,1974
oral
rat
lowest published toxic dose: 4 gm/kg (77 day prior to copulation-28 day after birth) Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
TXAPA9 41,138,1977
oral
rat
lowest published toxic dose: 120 mg/kg (8-11 day pregnant) Reproductive: Specific developmental abnormalities: Homeostasis TXAPA9 28,151,1974
oral
rat
lowest published toxic dose: 50 mg/kg (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on newborn: Sex ratio

Reproductive: Specific developmental abnormalities: Musculoskeletal system
HBPTO* 2,1496,2001
oral
rat
lowest published toxic dose: 5 gm/kg (26 week male/26 week prior to copulation/0-20 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Other effects to embryo or fetus
HBPTO* 2,1496,2001
oral
rat
lowest published toxic dose: 800 mg/kg (6-15 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
IJTOFN 20,353,2001
oral
rat
lowest published toxic dose: 3,300 mg/kg (multigeneration) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Germ cell effects (in offspring)
IJTOFN 21,301,2002
oral
rat
lowest published toxic dose: 6,600 mg/kg (multigeneration) Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)

Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4)
IJTOFN 21,301,2002
subcutaneous
mouse
lowest published toxic dose: 450 mg/kg (6-14 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death NTIS** PB223-160
unreported route
rat
lowest published toxic dose: 5 mg/kg (8 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Other postnatal measures or effects
VCVGK* -,249,1994
unreported route
rat
lowest published toxic dose: 5 mg/kg (9 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Other postnatal measures or effects
VCVGK* -,249,1994
unreported route
rat
lowest published toxic dose: 5 mg/kg (10 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Other postnatal measures or effects
VCVGK* -,249,1994
unreported route
rat
lowest published toxic dose: 5 mg/kg (11 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Other postnatal measures or effects
VCVGK* -,249,1994
unreported route
rat
lowest published toxic dose: 5 mg/kg (12 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Other postnatal measures or effects
VCVGK* -,249,1994
unreported route
rat
lowest published toxic dose: 5 mg/kg (13 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Other postnatal measures or effects
VCVGK* -,249,1994


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 8,736 mg/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Endocrine: Tumors
NTPTR* NTP-TR-349,1989
oral
mouse
lowest published toxic dose: 8,652 mg/kg/103 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Endocrine: Adrenal cortex tumors
NTIS** PB89-216536/AS
oral
mouse
lowest published toxic dose: 17,304 mg/kg/103 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
NTIS** PB89-216536/AS
oral
mouse
lowest published toxic dose: 51,912 mg/kg/103 week- continuous Tumorigenic: Neoplastic by RTECS criteria

Endocrine: Adrenal cortex tumors

Blood: Tumors
NTIS** PB89-216536/AS
oral
mouse
lowest published toxic dose: 17,304 mg/kg/103 week- continuous Tumorigenic: Neoplastic by RTECS criteria

Blood: Tumors
NTIS** PB89-216536/AS
oral
rat
lowest published toxic dose: 21,840 mg/kg/52 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Olfaction: Tumors
NTIS** PB99-152878
oral
rat
lowest published toxic dose: 21.9 gm/kg/1 year- continuous Tumorigenic: Neoplastic by RTECS criteria HBPTO* 2,1489,2001
subcutaneous
mouse
lowest published toxic dose: 46 mg/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Liver: Tumors
NTIS** PB223-159


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lethal concentration (50 percent kill): 225 mg/m3 Behavioral: Excitement

Behavioral: Muscle contraction or spasticity

Lung, Thorax, or Respiration: Dyspnea
GTPZAB 13(9),58,1969
inhalation
mouse
lethal concentration (50 percent kill): 225 mg/m3 Cardiac: Other changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,248,1994
inhalation
rat
lethal concentration (50 percent kill): 355 mg/m3 Behavioral: Excitement

Behavioral: Muscle contraction or spasticity

Lung, Thorax, or Respiration: Dyspnea
GTPZAB 13(9),58,1969
inhalation
rat
lethal concentration (50 percent kill): 200 mg/m3 N/R HBPTO* 2,1229,2001
inhalation
rat
lethal concentration (50 percent kill): 335 mg/m3 Cardiac: Other changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,248,1994
intraperitoneal
mouse
lethal dose (50 percent kill): 32 mg/kg N/R ARTODN 40,63,1978
intraperitoneal
mouse
lowest published toxic dose: 120 mg/kg Immunological Including Allergic: Decrease in humoral immune response TXCYAC 36,307,1985
intraperitoneal
mouse
lowest published lethal dose: 250 mg/kg N/R VCVGK* -,257,1994
intraperitoneal
rat
lethal dose (50 percent kill): 56 mg/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea

Nutritional and Gross Metabolic: Body temperature increase
BJPCAL 13,20,1958
intraperitoneal
rat
lowest published toxic dose: 1.86 mg/kg Endocrine: Other changes TXCYAC 67,107,1991
intraperitoneal
rat
lethal dose (50 percent kill): 60 mg/kg N/R HBPTO* 2,1486,2001
intraperitoneal
rat
lethal dose (50 percent kill): 56 mg/kg Cardiac: Other changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,246,1994
intraperitoneal
rabbit
lowest published lethal dose: 135 mg/kg N/R HBTXAC 5,123,1959
oral
duck
lethal dose (50 percent kill): 380 mg/kg N/R HBPTO* 2,1229,2001
oral
gerbil
lethal dose (50 percent kill): 294 mg/kg N/R ARTODN 40,63,1978
oral
hamster
lethal dose (50 percent kill): 168 mg/kg N/R TXAPA9 48,A192,1979
oral
man
lowest published lethal dose: 401 mg/kg Behavioral: Change in motor activity (specific assay)

Skin and Appendages: Other: Sweating

Nutritional and Gross Metabolic: Body temperature increase
EESADV 1,343,1977
oral
mouse
lethal dose (50 percent kill): 36 mg/kg N/R ARTODN 40,63,1978
oral
mouse
lethal dose (50 percent kill): 117 mg/kg Behavioral: Somnolence (general depressed activity) TOLED5 29,39,1985
oral
mouse
lethal dose (50 percent kill): 30 mg/kg Cardiac: Other changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,246,1994
oral
mouse
lowest published toxic dose: 30 mg/kg Liver: Other changes

Biochemical: Metabolism (intermediary): Other proteins
TOSCF2 73,26,2003
oral
rat
lethal dose (50 percent kill): 27 mg/kg Vascular: BP elevation not characterized in autonomic section

Endocrine: Hyperglycemia

Nutritional and Gross Metabolic: Body temperature increase
JPETAB 76,104,1942
oral
rat
lethal dose (50 percent kill): 27 mg/kg Cardiac: Other changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,246,1994
oral
rat
lethal dose (50 percent kill): 50 mg/kg N/R VCVGK* -,249,1994
oral
rat
lowest published toxic dose: 5 mg/kg Liver: Other changes

Biochemical: Metabolism (intermediary): Other proteins
TOSCF2 73,26,2003
oral
rabbit
lowest published lethal dose: 70 mg/kg Behavioral: Muscle weakness

Vascular: BP elevation not characterized in autonomic section

Kidney, Ureter, and Bladder: Urine volume increased
JPETAB 76,104,1942
oral
rabbit
lethal dose (50 percent kill): 200 mg/kg Cardiac: Other changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,246,1994
oral
rabbit
lowest published lethal dose: 70 mg/kg N/R VCVGK* -,249,1994
subcutaneous
dog
lowest published lethal dose: 135 mg/kg N/R HBTXAC 5,123,1959
subcutaneous
rat
lethal dose (50 percent kill): 100 mg/kg Cardiac: Other changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,246,1994
subcutaneous
rabbit
lowest published lethal dose: 70 mg/kg Behavioral: Muscle weakness

Vascular: BP elevation not characterized in autonomic section

Kidney, Ureter, and Bladder: Urine volume increased
JPETAB 76,104,1942
subcutaneous
rabbit
lowest published lethal dose: 70 mg/kg N/R VCVGK* -,249,1994
skin
rat
lethal dose (50 percent kill): 96 mg/kg Behavioral: Excitement

Behavioral: Muscle contraction or spasticity

Lung, Thorax, or Respiration: Dyspnea
GTPZAB 13(9),58,1969
skin
rat
lethal dose (50 percent kill): 26 mg/kg Cardiac: Other changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,246,1994
skin
rabbit
lowest published lethal dose: 40 mg/kg Behavioral: Muscle weakness

Vascular: BP elevation not characterized in autonomic section

Kidney, Ureter, and Bladder: Urine volume increased
JPETAB 76,104,1942
skin
rabbit
lowest published lethal dose: 40 mg/kg N/R VCVGK* -,249,1994
unreported route
dog
lethal dose (50 percent kill): 70 mg/kg N/R PHPHA6 1,3,1953
unreported route
frog
lethal dose (50 percent kill): 36 mg/kg N/R PHPHA6 1,3,1953
unreported route
guinea pig
lethal dose (50 percent kill): 100 mg/kg N/R PHPHA6 1,3,1953


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 29 mg/m3/4 hour/15 day- intermittent Brain and Coverings: Other degenerative changes

Liver: Other changes

Blood: Normocytic anemia
VCVGK* -,249,1994
inhalation
rat
lowest published toxic concentration: 29 mg/m3/4 hour/60 day- intermittent Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Gastrointestinal: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
VCVGK* -,249,1994
inhalation
rabbit
lowest published toxic concentration: 29 mg/m3/4 hour/15 day- intermittent Brain and Coverings: Other degenerative changes

Liver: Other changes

Blood: Normocytic anemia
VCVGK* -,249,1994
inhalation
rabbit
lowest published toxic concentration: 29 mg/m3/4 hour/60 day- intermittent Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Gastrointestinal: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
VCVGK* -,249,1994
oral
cattle
lowest published toxic dose: 2,610 mg/kg/23 week- continuous Endocrine: Changes in thymus weight

Blood: Changes in erythrocyte (RBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
TXAPA9 52,468,1980
oral
cattle
lowest published toxic dose: 2,610 mg/kg/160 day- intermittent Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
TXAPA9 52,468,1980
oral
cattle
lowest published toxic dose: 2,610 mg/kg/160 day- intermittent Lung, Thorax, or Respiration: Changes in lung weight

Blood: Normocytic anemia

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TXAPA9 52,468,1980
oral
mouse
lowest published toxic dose: 45 gm/kg/30 day- continuous Liver: Changes in liver weight

Endocrine: Changes in spleen weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTPTR* NTP-TR-349,1989
oral
mouse
lowest published toxic dose: 1,680 mg/kg/8 week- continuous Liver: Changes in liver weight

Immunological Including Allergic: Decrease in humoral immune response

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
FAATDF 2,90,1982
oral
mouse
lowest published toxic dose: 10,920 mg/kg/26 week- continuous Liver: Changes in liver weight

Endocrine: Changes in spleen weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
NTPTR* NTP-TR-349,1989
oral
mouse
lowest published toxic dose: 420 ppm/6 week- intermittent Immunological Including Allergic: Decrease in humoral immune response TXCYAC 36,307,1985
oral
mouse
lowest published toxic dose: 140 mg/kg/14 day- intermittent Immunological Including Allergic: Decrease in humoral immune response HBPTO* 2,1499,2001
oral
mouse
lowest published toxic dose: 14,168 mg/kg/23 week- continuous Tumorigenic: Facilitates action of known carcinogens CRNGDP 24,1105,2003
oral
mouse
lowest published toxic dose: 728 mg/kg/2 week- continuous Liver: Other changes

Liver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
CRNGDP 24,1105,2003
oral
pig
lowest published toxic dose: 150 mg/kg/30 day- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Blood: Changes in leukocyte (WBC) count
BECTA6 31,599,1983
oral
rat
lowest published toxic dose: 840 mg/kg/12 week- continuous Liver: Changes in liver weight

Blood: Changes in erythrocyte (RBC) count

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TXCYAC 2,141,1974
oral
rat
lowest published toxic dose: 84 mg/kg/28 day- intermittent Endocrine: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
TOLED5 71,9,1994
oral
rat
lowest published toxic dose: 21,840 mg/kg/2 year- continuous Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
EVSRBT 12,301,1978
oral
rat
lowest published toxic dose: 11.76 gm/kg/28 week- continuous Liver: Other changes HBPTO* 2,1489,2001
oral
rat
lowest published toxic dose: 300 mg/kg/10 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain HBPTO* 2,1496,2001
oral
rat
lowest published toxic dose: 8,643 mg/kg/201 day- continuous Reproductive: Maternal effects: Uterus, cervix, vagina

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
HBPTO* 2,1496,2001
oral
rat
lowest published toxic dose: 800 mg/kg/10 day- intermittent Behavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
IJTOFN 20,353,2001
oral
rat
lowest published toxic dose: 2,556 mg/kg/142 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field VCVGK* -,249,1994
oral
rat
lowest published toxic dose: 2,060 mg/kg/57 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field VCVGK* -,249,1994
oral
rat
lowest published toxic dose: 3,600 mg/kg/120d- intermittent Liver: Hepatitis (hepatocellular necrosis), zonal

Liver: Changes in liver weight

Related to Chronic Data: Changes in ovarian weight
IJTOFN 21,301,2002
oral
rat
lowest published toxic dose: 7,200 mg/kg/120d- intermittent Gastrointestinal: Changes in structure or function of salivary glands

Liver: Other changes

Related to Chronic Data: Changes in uterine weight
IJTOFN 21,301,2002
oral
rat
lowest published toxic dose: 1,000 mg/kg/100 day- intermittent Liver: Other changes

Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight
IJTOFN 21,301,2002
oral
rat
lowest published toxic dose: 6,000 mg/kg/100 day- intermittent Brain and Coverings: Changes in brain weight

Liver: Hepatitis (hepatocellular necrosis), zonal

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
IJTOFN 21,301,2002
oral
rabbit
lowest published toxic dose: 195 mg/kg/13 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain IJTOFN 20,345,2001
oral
rabbit
lowest published toxic dose: 390 mg/kg/13 day- intermittent Behavioral: Food intake (animal) IJTOFN 20,345,2001
subcutaneous
pig
lowest published toxic dose: 560 mg/kg/14 day- intermittent Reproductive: Maternal effects: Ovaries, fallopian tubes

Reproductive: Maternal effects: Uterus, cervix, vagina

Reproductive: Maternal effects: Menstrual cycle changes or disorders
REPTED 16,29,2002
unreported route
mouse
lowest published toxic dose: 60 mg/kg/3 day- intermittent Related to Chronic Data: Changes in uterine weight TOXID9 54,262,2000


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.5 mg/m3 (skin) DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Confirmed animal carcinogen DTLVS* TLV/BEI,2007
International Agency for Research on Cancer (IARC) Cancer Review Human Limited Evidence IMEMDT 41,319,1986
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 53,371,1991
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 71,769,1999
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 20,303,1979
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 53,371,1991
International Agency for Research on Cancer (IARC) Cancer Review Group 2B IMEMDT 53,371,1991
TOXICOLOGY REVIEW
TOLED5 127,101,2002
TOXICOLOGY REVIEW
AIHAAP 43,799,1982
TOXICOLOGY REVIEW
MUREAV 567,227,2004
TOXICOLOGY REVIEW
ENTOX* -,567,2005
TOXICOLOGY REVIEW
ENTOX* -,343,2005
TOXICOLOGY REVIEW
JTEHD6 7,1,2004
TOXICOLOGY REVIEW
ADMOL* 1,85,2006
TOXICOLOGY REVIEW
REPTED 23,260,2007
TOXICOLOGY REVIEW
REPTED 26,185,2008
TOXICOLOGY REVIEW
HTOPA* 1,501,2002


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Supported RBREV* -,197,1998
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.5 mg/m3 (skin) DTLVS* 3,198,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 0.5 mg/m3 (skin) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.5 mg/m3 (skin) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 0.5 mg/m3 (skin) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 0.5 mg/m3 (skin) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.5 mg/m3, JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 0.5 mg/m3, Skin, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 0.005 ppm (0.05 mg/m3), OCT 2002
Occupational Exposure Limit - FINLAND time-weighted average 0.5 mg/m3, short term exposure limit 1.5 mg/m3, Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 0.5 mg/m3, Skin, continuous3 Carcinogen, FEB2006
Occupational Exposure Limit - HUNGARY time-weighted average 0.001 mg/m3, Skin, SEP2000
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 0.5 mg/m3, skin, APR2007
Occupational Exposure Limit - KOREA time-weighted average 0.5 mg/m3, skin, 2006
Occupational Exposure Limit - MEXICO time-weighted average 0.5 mg/m3;
short term exposure limit 1.5 mg/m3 (skin), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.06 mg/m3, Skin, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 0.5 mg/m3, skin, JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 0.05 ppm (0.5 mg/m3), JAN1999
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0.5 mg/m3, MAC(short term exposure limit) 1.5 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA time-weighted average 0.1 mg/m3, short term exposure limit 0.3 mg/m3, Skin, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 0.5 mg/m3;
short term exposure limit 1.5 mg/m3, Skin, JUN2005
Occupational Exposure Limit - SWEDEN time-weighted average 0.5 mg/m3;
short term exposure limit 1.5 mg/m3, Skin, JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 0.005 ppm (0.05 mg/m3), Skin, DEC2006
Occupational Exposure Limit - TURKEY time-weighted average 0.5 mg/m3, Skin, JAN1993
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Confirmed animal carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Confirmed animal carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO PENTACHLOROPHENOL-air 10 hour time-weighted average 0.5 mg/m3 (Sk) NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 54160;
Number of Industries 47;
Total Number of Facilities 3,548;
Number of Occupations 42;
Total Number of Employees Exposed 29,154
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 54160;
Number of Industries 29;
Total Number of Facilities 2,248;
Number of Occupations 38;
Total Number of Employees Exposed 26,806;
Total Number of Female Employees Exposed 4,191


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

ATSDR TOXICOLOGY PROFILE (NTIS** PB/2001/109106/AS)
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-SA7/SHE; S cerevisiae gene conversion
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae-forward mutation
EPA GENETOX PROGRAM 1988, Negative: Host-mediated assay; Mouse spot test
EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test; S cerevisiae-homozygosis
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a wood preservative and as an herbicide and defoliant
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Pentachlorophenol, 5512; in blood, 8001; in urine, 8303
NCI Carcinogenesis Studies (feed);clear evidence:mouse
NCI Carcinogenesis Studies (feed);equivocal evidence:rat
OSHA ANALYTICAL METHOD #39


REFERENCES:

CODEN
REFERENCE

ADMOL*
AETODY Advances in Modern Environmental Toxicology. (Senate Press, Inc., P.O. Box 252, Princeton Junction, NJ 08550) V.1- 1980-
AIDZAC Aichi Ika Daigaku Igakkai Zasshi. Journal of the Aichi Medical University Association. (Aichi Ika Daigaku Igakkai, Yazako, Nagakute-machi, Aichi-gun, Aichi-ken, Japan) V.1- 1973-
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966-
BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM.
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
DABBBA Dissertation Abstracts International, B: The Sciences and Engineering. (University Microfilms International, 300 N. Zeeb Rd., Ann Arbor, MI 48106) V.30- 1969-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EESADV Ecotoxicology and Environmental Safety. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1977-
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
EVSRBT Environmental Science Research. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) V.1- 1972-
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
HBPTO* Handbook of pesticide toxicology. Robert Krieger ed, Academic press, 2001
HBTXAC "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59
HTOPA*
IARCCD IARC Scientific Publications. (Geneva, Switzerland) No.1-26, 1971-78. For publisher information, see IAPUDO.
IJTOFN International Journal of Toxicology. (Taylor & Francis, 47 Runway Rd., Suite g, Levittown, PA 19057) V.16- 1997-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960-
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
PHPHA6 Phytiatrie-Phytopharmacie. (Societe Francaise de Phytiatrie et de Phytopharmacie, Etoile de Choisy, Route de St-Cyr, 78000 Versailles, France) V.1- 1952-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOSCF2 Toxicological Sciences (Oxford University Press, 6277 Sea Harbor Drive, Orlando, FL 32887 ) V. 41, Jan. 1998-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

Used as a wood preservative and as an herbicide and defoliant

NOISH PROFILE (CHLOROPHENOLS), SRC, 3/81

NIOSH PROFILE (WOOD PRESERVING), SRI, 2/77

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen
   Reproductive Effector
   Human Data
   Primary Irritant

Click Here for Additional Information about RTECS

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