CDC logo, Safer Healthier People  CDC HomeCDC SearchCDC Health Topics A-Z
NIOSH - National Institute for Occupational Safety and Health

Search NIOSH  |  NIOSH Home  |  NIOSH Topics  |  Site Index  |  Databases and Information Resources  |  NIOSH Products  |  Contact Us






Nitrogen monoxide

RTECS #: QX0525000

CAS #: 10102-43-9


UPDATE: May 2009 MW: 30.01 MF: NO


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Amidogen, oxo -
  2. Bioxyde d'azote (French)
  3. Nitric oxide
  4. Nitric oxide (ACGIH:OSHA)
  5. Nitric oxide trimer
  1. Nitrosyl radical
  2. Oxyde nitrique (French)
  3. RCRA waste number P076
  4. Stickmonoxyd (German)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
mutation in microorganisms Salmonella typhimurium 30 ppm (+enzymatic activation step) MUREAV 136,119,1984
mutation in mammalian somatic cells hamster fibroblast 10 ppm MUREAV 136,119,1984
mutation in mammalian somatic cells inhalation
rat
27 ppm/3 hour- continuous MUREAV 136,119,1984


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
dog
lowest published lethal concentration: 5,000 ppm/25 minute Lung, Thorax, or Respiration: Acute pulmonary edema

Blood: Methemoglobinemia- Carboxhemoglobinemia
BJANAD 39,393,1967
inhalation
dog
lowest published toxic concentration: 20 ppm/6 hour Lung, Thorax, or Respiration: Other changes CYLPDN 23,278,2002
inhalation
human
lowest published toxic concentration: 76 mg/m3 Behavioral: Muscle weakness VCVN5* -,32,1993
inhalation
mouse
lowest published lethal concentration: 320 ppm Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Cyanosis

Blood: Methemoglobinemia- Carboxhemoglobinemia
AEPPAE 181,145,1936
inhalation
mouse
lowest published toxic concentration: 6,000 mg/m3/4 minute Behavioral: Alteration of classical conditioning VCVN5* -,32,1993
inhalation
mouse
lowest published lethal concentration: 6,000 mg/m3/6 minute N/R VCVN5* -,32,1993
inhalation
mouse
lowest published toxic concentration: 3,000 mg/m3/6 minute Behavioral: Alteration of classical conditioning VCVN5* -,32,1993
inhalation
mouse
lowest published lethal concentration: 3,000 mg/m3/12 minute N/R VCVN5* -,32,1993
inhalation
mouse
lowest published lethal concentration: 320 ppm/1 hour N/R TXCYAC 208,177,2005
inhalation
rat
lethal concentration (50 percent kill): 160 mg/m3 N/R VCVN5* -,32,1993
inhalation
rat
lowest published toxic concentration: 140 mg/m3 Blood: Methemoglobinemia- Carboxhemoglobinemia VCVN5* -,32,1993
inhalation
rat
lowest published lethal concentration: 797 ppm/15 minute N/R TXCYAC 208,177,2005
inhalation
rat
lethal concentration (50 percent kill): 1,068 mg/kg N/R ENTOX* -,230,2005
inhalation
rabbit
lowest published toxic concentration: 10 pph/20 minute Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
CEXPB9 27,95,2000
inhalation
rabbit
lowest published lethal concentration: 315 ppm/15 minute N/R TXCYAC 208,177,2005
inhalation
rabbit
lowest published toxic concentration: 90 ppm/8 hour Eye: Corneal damage TXCYAC 208,177,2005


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
infant
lowest published toxic concentration: 20 ppm/5 day- continuous Lung, Thorax, or Respiration: Other changes NEJMAG 342,469,2000
inhalation
mammal (species unspecified)
lowest published toxic concentration: 50 mg/m3/6 hour/7 week- intermittent Blood: Normocytic anemia VCVN5* -,33,1989
inhalation
mouse
lowest published toxic concentration: 10 ppm/2 hour/30 week- intermittent Lung, Thorax, or Respiration: Emphysema

Blood: Pigmented or nucleated red blood cells

Blood: Changes in leukocyte (WBC) count
ENVRAL 19,154,1979
inhalation
rat
lowest published toxic concentration: 200 ppm/6 hour/7 day- intermittent Lung, Thorax, or Respiration: Acute pulmonary edema

Blood: Methemoglobinemia- Carboxhemoglobinemia
TOXID9 42,253,1998
inhalation
rat
lowest published toxic concentration: 50 mg/m3/6 hour/7 week- intermittent Lung, Thorax, or Respiration: Changes in lung weight

Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
GTPZAB 19(4),52,1975
inhalation
rat
lowest published toxic concentration: 3 mg/m3/24 hour/16 day- continuous Brain and Coverings: Recordings from specific areas of CNS

Blood: Methemoglobinemia- Carboxhemoglobinemia

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
GISAAA 48(9),69,1983
inhalation
rat
lowest published toxic concentration: 160 ppm/6 hour/4 week- intermittent Blood: Methemoglobinemia- Carboxhemoglobinemia TOXID9 42,253,1998
inhalation
rat
lowest published toxic concentration: 14 mg/m3/24 hour/17 week- continuous Cardiac: EKG changes not diagnostic of above

Blood: Changes in erythrocyte (RBC) count
VCVN5* -,33,1989
inhalation
rat
lowest published toxic concentration: 1 mg/m3/3240 hour- continuous Lung, Thorax, or Respiration: Emphysema

Liver: Fatty liver degeneration

Kidney, Ureter, and Bladder: Changes primarily in glomeruli
VCVN5* -,33,1989
inhalation
rat
lowest published toxic concentration: 9.8 ppm/72 week- intermittent Lung, Thorax, or Respiration: Emphysema TXCYAC 208,177,2005
inhalation
rabbit
lowest published toxic concentration: 14 mg/m3/24 hour/17 week- continuous Cardiac: EKG changes not diagnostic of above

Blood: Changes in erythrocyte (RBC) count
VCVN5* -,33,1989


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 25 ppm DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
CTOXAO 7,145,1974
TOXICOLOGY REVIEW
XPHBAO 272,1,1941
TOXICOLOGY REVIEW
TOLED5 139,163,2003
TOXICOLOGY REVIEW
TPHSDY 23,406,2002
TOXICOLOGY REVIEW
TPHSDY 24,560,2003
TOXICOLOGY REVIEW
TPHSDY 24,609,2003
TOXICOLOGY REVIEW
TPHSDY 24,389,2003
TOXICOLOGY REVIEW
ENTOX* -,230,2005
TOXICOLOGY REVIEW
MUREAV 533,65,2003
TOXICOLOGY REVIEW
MUREAV 533,173,2003
TOXICOLOGY REVIEW
MUTAEX 19,169,2004
TOXICOLOGY REVIEW
MUTAEX 19,423,2004
TOXICOLOGY REVIEW
PAREAQ 57,217,2005
TOXICOLOGY REVIEW
MUREAV 659,15,2008
TOXICOLOGY REVIEW
JTPAE7 20,77,2007
TOXICOLOGY REVIEW
MUREAV 658,68,2008
TOXICOLOGY REVIEW
HUTOX* -,661,1996
TOXICOLOGY REVIEW
HTOPA* 1,501,2002


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 25 ppm (30 mg/m3) DTLVS* 3,182,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 25 ppm (30 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 25 ppm (30 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 25 ppm (30 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 25 ppm (30 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 25 ppm (31 mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 25 ppm (31 mg/m3), MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 25 ppm (30 mg/m3), OCT 2002
Occupational Exposure Limit - EC time-weighted average 30 mg/m3 (25 mL/m3)
Occupational Exposure Limit - FRANCE VME 25 ppm (30 mg/m3), FEB2006
Occupational Exposure Limit - HUNGARY time-weighted average 30 mg/m3, SEP2000
Occupational Exposure Limit - KOREA time-weighted average 25 ppm (30 mg/m3), 2006
Occupational Exposure Limit - MEXICO time-weighted average 25 ppm (30 mg/m3);
short term exposure limit 35 ppm (45 mg/m3), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 30 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 25 ppm (31 mg/m3), JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 25 ppm (30 mg/m3), JAN1999
Occupational Exposure Limit - POLAND MAC(time-weighted average) 5 mg/m3, MAC(short term exposure limit) 10 mg/m3, JAN1999
Occupational Exposure Limit - SWEDEN time-weighted average 25 ppm (30 mg/m3);
short term exposure limit 50 ppm (60 mg/m3), JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 25 ppm (30 mg/m3), DEC2006
Occupational Exposure Limit - THAILAND time-weighted average 25 ppm (30 mg/m3), JAN1993
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 25 ppm
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 25 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO NITRIC OXIDE-air 10 hour time-weighted average 25 ppm NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 50745;
Number of Industries 11;
Total Number of Facilities 276;
Number of Occupations 11;
Total Number of Employees Exposed 1,354
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 50745;
Number of Industries 3;
Total Number of Facilities 59;
Number of Occupations 16;
Total Number of Employees Exposed 14,332;
Total Number of Female Employees Exposed 6,183


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Nitric oxide and nitrogen dioxide, 6014
OSHA ANALYTICAL METHOD #ID-109


REFERENCES:

CODEN
REFERENCE

AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC.
BJANAD British Journal of Anesthesia. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1923-
CEXPB9 Clinical and Experimental Pharmacology and Physiology. (Blackwell Scientific Publications, (Australia) Pty Ltd., 107 Barry St., Carlton, Vic. 3053, Australia) V.1- 1974-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher information, see JTCTDW.
CYLPDN Zhongguo Yaoli Xuebao. Acta Pharmacologica Sinica. Chinese Journal of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1980-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1967-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
HTOPA*
HUTOX*
JTPAE7 Journal of Toxicologic Pathology. (Nihon Dokusei Byori Gakkai, editor, 3-25-8 Nishi- shinbashi, Minato-ku, Tokyo 105, Japan) V.1- 1988
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
NEJMAG New England Journal of Medicine. (Massachusetts Medical Soc., 10 Shattuck St., Boston, MA 02115) V.198- 1928-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
PAREAQ Pharmacological Reviews. (Williams & Wilkins, 428 E. Preston St., Baltimore, MD 21202) V.1- 1949-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TPHSDY Trends in Pharmacological Sciences. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1979-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
VCVN5* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov V-VII groopp" (Hazardous substances. Inornanic substances containing V-VII group elements), Bandman A.L. et al., Chimia, 1989.
XPHBAO U.S. Public Health Service, Public Health Bulletin. (Washington, DC)

NIOSH PROFILE (INCINERATION), FIRL, 4/78

RTECS Compound Description:
   Mutagen
   Human Data

ALT CAS #: 51005-21-1
ALT CAS #: 90452-29-2
ALT CAS #: 90880-94-7
Click Here for Additional Information about RTECS

NIOSH Home |  NIOSH Search  |  Site Index  |  Topic List |  Contact Us