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Methane, tribromo -

RTECS #: PB5600000

CAS #: 75-25-2


UPDATE: May 2009 MW: 252.75 MF: CHBr3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. Bromoform
  2. Bromoform (ACGIH:OSHA)
  3. Bromoforme (French)
  4. Bromoformio (Italian)
  5. Methenyl tribromide
  6. Methyl tribromide
  1. NCI - C55130
  2. RCRA waste number U225
  3. Tribrommethaan (Dutch)
  4. Tribrommethan (German)
  5. Tribromometan (Italian)
  6. Tribromomethane


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis hamster ovary 110 g/L ENMUDM 7,1,1985
cytogenetic analysis intraperitoneal
rat
25,300 g/kg MUREAV 242,111,1990
cytogenetic analysis oral
rat
1,265 mg/kg/5 day- intermittent MUREAV 242,111,1990
DNA damage human lung 100 mol/L/3 hour MUREAV 538,41,2003
mutation in microorganisms Salmonella typhimurium 666 g/plate (+enzymatic activation step) ENMUDM 5(Suppl 1),3,1983
mutation in microorganisms Salmonella typhimurium 100 g/plate (-enzymatic activation step) NTPTR* NTP-TR-350,1989
mutation in microorganisms Salmonella typhimurium 1,000 mg/L/2 hour (-enzymatic activation step) EMMUEG 44,329,2004
micronucleus test intratracheal
mouse
800 mg/kg/48 hour- intermittent NTPTR* NTP-TR-350,1989
micronucleus test multiple
non-mammalian species
5 ppm MUREAV 292,83,1993
mutation in mammalian somatic cells mouse lymphocyte 200 mg/L NTPTR* NTP-TR-350,1989
morphological transform mouse fibroblast 0.5 mg/L/21 day (-enzymatic activation step) EMMUEG 37,231,2001
sister chromatid exchange hamster ovary 290 g/L ENMUDM 7,1,1985
sister chromatid exchange human lymphocyte 80 mol/L ENVRAL 32,72,1983
sister chromatid exchange oral
mouse
100 mg/kg/4 day- intermittent ENVRAL 32,72,1983
sister chromatid exchange intratracheal
mouse
800 gm/L NTPTR* NTP-TR-350,1989
sister chromatid exchange rat leukocyte 20 mol/L MUREAV 300,241,1993
sex chromosome loss and nondisjunction oral
Drosophila melanogaster
3,000 ppm ENMUDM 7,677,1985
specific locus test oral
Drosophila melanogaster
3,000 ppm NTPTR* NTP-TR-350,1989


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 5.6 gm/kg (7 day prior to copulation/21 day pregnant) Reproductive: Maternal effects: Postpartum NTIS** #PB89169254
oral
mouse
lowest published toxic dose: 47 gm/kg (15 week male/15 week prior to copulation-4 day after birth) Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
NTIS** #PB89169254
oral
mouse
lowest published toxic dose: 200 mg/kg (multigenerations) Reproductive: Specific developmental abnormalities: Hepatobiliary system

Reproductive: Specific developmental abnormalities: Urogenital system
NTIS** #PB89169254
oral
mouse
lowest published toxic dose: 200 mg/kg (multigenerations) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) NTIS** #PB89169254


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
mouse
lowest published toxic dose: 1,100 mg/kg/8 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors
CNREA8 37,2717,1977
oral
rat
lowest published toxic dose: 10,400 mg/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors
NTPTR* NTP-TR-350,1989
oral
rat
lowest published toxic dose: 103,000 mg/kg/103 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Gastrointestinal: Tumors
NTIS** PB90-110149/AS
oral
rat
lowest published toxic dose: 103,000 mg/kg/103 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors
NTIS** PB90-110149/AS


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mammal (species unspecified)
lethal concentration (50 percent kill): 12,100 mg/m3 N/R GTPZAB 18(4),55,1974
inhalation
mouse
lethal concentration (50 percent kill): 12,100 mg/m3/2 hour Lung, Thorax, or Respiration: Other changes VCVGH* -,581,1990
inhalation
rat
lowest published lethal concentration: 45 gm/m3/4 hour N/R 85GMAT -,28,1982
inhalation
rat
lowest published toxic concentration: 3,900 mg/m3/2 hour Brain and Coverings: Changes in surface EEG VCVGH* -,581,1990
intraperitoneal
mouse
lethal dose (50 percent kill): 1,274 mg/kg N/R VCVGH* -,572,1990
intraperitoneal
rat
lethal dose (50 percent kill): 414 mg/kg Eye: Lacrimation

Behavioral: Somnolence (general depressed activity)

Behavioral: Antipsychotic
TOLED5 15,251,1983
oral
human
lowest published lethal dose: 143 mg/kg N/R 34ZIAG -,141,1969
oral
mouse
lethal dose (50 percent kill): 1,072 mg/kg Lung, Thorax, or Respiration: Dyspnea NTPTR* NTP-TR-350,1989
oral
rat
lethal dose (50 percent kill): 933 mg/kg Lung, Thorax, or Respiration: Dyspnea NTPTR* NTP-TR-350,1989
subcutaneous
mouse
lethal dose (50 percent kill): 1,820 mg/kg N/R TXAPA9 4,354,1962
subcutaneous
rabbit
lowest published lethal dose: 410 mg/kg N/R AEXPBL 28,201,1891


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 3,500 mg/kg/14 day- intermittent Liver: Changes in liver weight

Endocrine: Changes in spleen weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
EVHPAZ 46,117,1982
oral
mouse
lowest published toxic dose: 6,500 mg/kg/13 week- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTPTR* NTP-TR-350,1989
oral
mouse
lowest published toxic dose: 296 mg/kg/14 day- intermittent Kidney, Ureter, and Bladder: Changes primarily in glomeruli

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
VCVGH* -,581,1990
oral
mouse
lowest published toxic dose: 21,000 mg/kg/15 week- intermittent Behavioral: Fluid intake NTIS** #PB89169254
oral
rat
lowest published toxic dose: 6,230 mg/kg/4 week- continuous Liver: Other changes

Liver: Changes in liver weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
JTSCDR 17,119,1992
oral
rat
lowest published toxic dose: 13 gm/kg/13 week- intermittent Liver: Other changes NTPTR* NTP-TR-350,1989
oral
rat
lowest published toxic dose: 5,600 mg/kg/14 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTPTR* NTP-TR-350,1989
oral
rat
lowest published toxic dose: 5,840 mg/kg/1 year- continuous Kidney, Ureter, and Bladder: Other changes in urine composition TOXID9 14,281,1994


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.5 ppm (skin) DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Confirmed animal carcinogen DTLVS* TLV/BEI,2007
International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMEMDT 52,213,1991
International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMEMDT 71,1309,1999
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 52,213,1991
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 71,1309,1999
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMEMDT 71,1309,1999
TOXICOLOGY REVIEW
MUREAV 564,179,2004
TOXICOLOGY REVIEW
MUREAV 567,347,2004
TOXICOLOGY REVIEW
TXCYAC 198,239,2004
TOXICOLOGY REVIEW
ENTOX* -,345,2005
TOXICOLOGY REVIEW
ENTOX* -,546,2005
TOXICOLOGY REVIEW
MUREAV 584,1,2005
TOXICOLOGY REVIEW
MUREAV 636,242,2007
TOXICOLOGY REVIEW
MUREAV 654,114,2008
TOXICOLOGY REVIEW
MUREAV 654,114,2008


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.5 ppm (5 mg/m3) (skin) DTLVS* 3,28,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 0.5 ppm (5 mg/m3) (skin) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.5 ppm (5 mg/m3) (skin) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 0.5 ppm (5 mg/m3) (skin) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 0.5 ppm (5 mg/m3) (skin) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.5 ppm (5.2 mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 0.5 ppm (5.3 mg/m3), Skin, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 0.5 ppm (5 mg/m3), OCT 2002
Occupational Exposure Limit - FINLAND time-weighted average 0.5 ppm (5 mg/m3), short term exposure limit 1.5 ppm (15 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 0.5 ppm (5 mg/m3), Skin, FEB2006
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 1 ppm (10.3 mg/m3), APR2007
Occupational Exposure Limit - KOREA time-weighted average 0.5 ppm (5 mg/m3), skin, 2006
Occupational Exposure Limit - MEXICO time-weighted average 0.5 ppm (5 mg/m3) (skin), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 5 mg/m3, Skin, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 0.5 ppm (5.2 mg/m3), skin, JAN2002
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.5 ppm (5 mg/m3), Skin, JAN1993
Occupational Exposure Limit - POLAND time-weighted average 5 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 5 mg/m3, JUN2003
Occupational Exposure Limit - SWITZERLAND MAK- week 0.5 ppm (5 mg/m3), DEC2006
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Confirmed animal carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Confirmed animal carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO BROMOFORM-air 10 hour time-weighted average 0.5 ppm (Sk) NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 13160;
Number of Industries 3;
Total Number of Facilities 43;
Number of Occupations 3;
Total Number of Employees Exposed 242
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 13160;
Number of Industries 1;
Total Number of Facilities 14;
Number of Occupations 2;
Total Number of Employees Exposed 1,473;
Total Number of Female Employees Exposed 230


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

ATSDR TOXICOLOGY PROFILE (NTIS** PB/91/180323/AS)
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a chemical intermediate and solvent
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Hydrocarbons, halogenated, 1003
NCI Carcinogenesis Studies (gavage);clear evidence:rat
NCI Carcinogenesis Studies (gavage);no evidence:mouse


REFERENCES:

CODEN
REFERENCE

34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
AEXPBL Archiv fuer Experimentelle Pathologie und Pharmakologie. (Leipzig, Ger. Dem. Rep.) V.1-109, 1873-1925. For publisher information, see NSAPCC.
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1967-
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
VCVGH* "Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances: Galogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990.

Used as a chemical intermediate and solvent

RTECS Compound Description:
   Tumorigen
   Drug
   Mutagen
   Reproductive Effector
   Human Data

Click Here for Additional Information about RTECS

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