CDC logo, Safer Healthier People  CDC HomeCDC SearchCDC Health Topics A-Z
NIOSH - National Institute for Occupational Safety and Health

Search NIOSH  |  NIOSH Home  |  NIOSH Topics  |  Site Index  |  Databases and Information Resources  |  NIOSH Products  |  Contact Us






Methane, tetranitro -

RTECS #: PB4025000

CAS #: 509-14-8


UPDATE: May 2009 MW: 196.05 MF: CN4O8


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. NCI - C55947
  2. RCRA waste number P112
  3. TNM
  1. Tetan
  2. Tetranitromethane
  3. Tetranitromethane (ACGIH:OSHA)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis hamster ovary 20 mg/L NTPTR* NTP-TR-386,1990
DNA damage human lung 1.95 mol/L/20 hour MUREAV 605,94,2006
DNA damage rat liver 70 mol/L MUREAV 368,59,1996
DNA damage rat lung 3.9 mol/L/20 hour MUREAV 605,94,2006
DNA damage oral
rat
65 mg/kg MUREAV 605,94,2006
DNA damage rat liver 50 mol/L/3 hour MUREAV 629,49,2007
mutation in microorganisms Escherichia coli 500 g/plate (+enzymatic activation step) SAIGBL 29,34,1987
mutation in microorganisms Salmonella typhimurium 2 g/plate (+enzymatic activation step) ENMUDM 9(Suppl 9),1,1987
sister chromatid exchange hamster ovary 1,700 g/L NTPTR* NTP-TR-386,1990


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lowest published toxic concentration: 500 ppb/6 hour/2 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Lung, Thorax, or Respiration: Bronchogenic carcinoma
NTPTR* NTP-TR-386,1990
inhalation
mouse
toxic concentration (other than lowest) : 500 ppb/6 hour/2 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Bronchogenic carcinoma
CALEDQ 57,95,1991
inhalation
mouse
lowest published toxic concentration: 30.9 mg/kg/103 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors
NTIS** PB91-113373
inhalation
rat
lowest published toxic concentration: 2 ppm/6 hour/2 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Lung, Thorax, or Respiration: Bronchogenic carcinoma
NTPTR* NTP-TR-386,1990
inhalation
rat
toxic concentration (other than lowest) : 2 ppm/6 hour/2 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Bronchogenic carcinoma
CALEDQ 57,95,1991
inhalation
rat
lowest published toxic concentration: 61.8 mg/kg/103 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors
NTIS** PB91-113373
inhalation
rat
lowest published toxic concentration: 51.5 mg/kg/103 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors
NTIS** PB91-113373


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
cat
lethal concentration (50 percent kill): 100 ppm/20 minute N/R 85JCAE -,403,1986
inhalation
human
lowest published toxic concentration: 0.5 gm/m3 Eye: Lacrimation

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Respiratory depression
TPKVAL 4,134,1962
inhalation
mouse
lethal concentration (50 percent kill): 54 ppm/4 hour Blood: Methemoglobinemia- Carboxhemoglobinemia NTIS** AD-A051-334
inhalation
mouse
lethal concentration (50 percent kill): 54.4 ppm N/R ENTOX* -,159,2005
inhalation
mouse
lowest published lethal concentration: 0.2 gm/m3 Eye: Lacrimation

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Respiratory depression
TPKVAL 4,134,1962
inhalation
mouse
lowest published toxic concentration: 0.1 gm/m3 Vascular: Other changes

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Acute pulmonary edema
TPKVAL 4,134,1962
inhalation
mouse
lethal concentration (50 percent kill): 0.6 gm/m3 N/R TPKVAL 4,134,1962
inhalation
rat
lethal concentration (50 percent kill): 18 ppm/4 hour Blood: Methemoglobinemia- Carboxhemoglobinemia AMRL** TR-77-25,1977
inhalation
rat
lethal concentration (50 percent kill): 17.5 ppm N/R ENTOX* -,159,2005
inhalation
rat
lowest published lethal concentration: 0.2 gm/m3 Brain and Coverings: Other degenerative changes TPKVAL 4,134,1962
inhalation
rat
lowest published toxic concentration: 0.1 gm/m3 Lung, Thorax, or Respiration: Other changes

Biochemical: Metabolism (intermediary): Other
TPKVAL 4,134,1962
inhalation
rat
lethal concentration : 0.6 gm/m3/2 hour N/R TPKVAL 4,134,1962
inhalation
rat
lowest published lethal concentration: 1.5 gm/m3 Brain and Coverings: Changes in circulation

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Emphysema
TPKVAL 4,167,1962
inhalation
rabbit
lowest published lethal concentration: 0.2 gm/m3 Brain and Coverings: Changes in circulation

Brain and Coverings: Other degenerative changes

Peripheral Nerve and Sensation: Recording from peripheral motor nerve
TPKVAL 4,134,1962
inhalation
rabbit
lowest published toxic concentration: 0.1 gm/m3 Behavioral: Tetany TPKVAL 4,134,1962
intraperitoneal
mammal (species unspecified)
lowest published lethal dose: 500 mg/kg Blood: Methemoglobinemia- Carboxhemoglobinemia COREAF 171,1396,1920
intraperitoneal
mouse
lethal dose (50 percent kill): 53 mg/kg N/R KHFZAN 10(6),53,1976
intravenous
mouse
lethal dose (50 percent kill): 63,100 g/kg Blood: Methemoglobinemia- Carboxhemoglobinemia AMRL** TR-77-25,1977
intravenous
rat
lethal dose (50 percent kill): 12,600 g/kg Blood: Methemoglobinemia- Carboxhemoglobinemia AMRL** TR-77-25,1977
oral
mouse
lethal dose (50 percent kill): 375 mg/kg Olfaction: Other olfaction effects

Eye: Other eye effects

Behavioral: Somnolence (general depressed activity)
NTIS** AD-A051-334
oral
mouse
lethal dose (50 percent kill): 375 mg/kg N/R ENTOX* -,159,2005
oral
rat
lethal dose (50 percent kill): 130 mg/kg Olfaction: Other olfaction effects

Eye: Other eye effects

Behavioral: Somnolence (general depressed activity)
NTIS** AD-A051-334
oral
rat
lethal dose (50 percent kill): 130 mg/kg N/R ENTOX* -,159,2005


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lowest published toxic concentration: 25 ppm/6 hour/14 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTPTR* NTP-TR-386,1990
inhalation
mouse
lowest published toxic concentration: 10 ppm/6 hour/13 week- intermittent Olfaction: Other olfaction effects

Lung, Thorax, or Respiration: Other changes

Liver: Changes in liver weight
NTPTR* NTP-TR-386,1990
inhalation
rat
lowest published toxic concentration: 6,350 ppb/6 hour/26 week- intermittent Olfaction: Other olfaction effects

Lung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
AMIHBC 10,213,1954
inhalation
rat
lowest published toxic concentration: 25 ppm/6 hour/14 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTPTR* NTP-TR-386,1990
inhalation
rat
lowest published toxic concentration: 10 ppm/6 hour/13 week- intermittent Lung, Thorax, or Respiration: Other changes

Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTPTR* NTP-TR-386,1990
inhalation
rat
lowest published toxic concentration: 0.2 gm/m3/7 day- intermittent Behavioral: Alteration of classical conditioning TPKVAL 4,134,1962


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.005 ppm DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Confirmed animal carcinogen DTLVS* TLV/BEI,2007
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 65,437,1996
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 65,437,1996
International Agency for Research on Cancer (IARC) Cancer Review Group 2B IMEMDT 65,437,1996
TOXICOLOGY REVIEW
ENTOX* -,159,2005
TOXICOLOGY REVIEW
MUREAV 584,1,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 1 ppm (8 mg/m3) DTLVS* 3,254,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 1 ppm (8 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 1 ppm (8 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 1 ppm (8 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 1 ppm (8 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 1 ppm (8 mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 0.005 ppm (0.04 mg/m3), MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 0.005 ppm (0.04 mg/m3), OCT 2002
Occupational Exposure Limit - FINLAND time-weighted average 1 ppm (8 mg/m3), short term exposure limit 3 ppm (24 mg/m3), JAN1999
Occupational Exposure Limit - FRANCE VME 1 ppm (8 mg/m3), FEB2006
Occupational Exposure Limit - KOREA time-weighted average 1 ppm (8 mg/m3), 2006
Occupational Exposure Limit - MEXICO time-weighted average 1 ppm (8 mg/m3), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.04 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 1 ppm (8 mg/m3), skin, JAN2002
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 1 ppm (8 mg/m3), JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0.04 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 0.3 mg/m3, Skin, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 0.05 ppm (0.4 mg/m3);
short term exposure limit 0.1 ppm (0.8 mg/m3), JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 1 ppm (8 mg/m3), Skin, Carcinogen, DEC2006
Occupational Exposure Limit - TURKEY time-weighted average 1 ppm (8 mg/m3), JAN1993
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Confirmed animal carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Confirmed animal carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO TETRANITROMETHANE-air 10 hour time-weighted average 1 ppm NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X7237;
Number of Industries 1;
Total Number of Facilities 7;
Number of Occupations 1;
Total Number of Employees Exposed 1,445;
Total Number of Female Employees Exposed 230


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as solvent for polymers and as stabilizer
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Tetranitromethane, 3513
NCI Carcinogenesis Studies (inhal);clear evidence:mouse,rat
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen


REFERENCES:

CODEN
REFERENCE

85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
AMRL** Aerospace Medical Research Laboratory Report. (Aerospace Technical Div., Air Force Systems Command, Wright-Patterson Air Force Base, OH 45433)
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
COREAF Comptes Rendus Hebdomadaires des Seances, Academie des Sciences. (Paris, France) V.1-261, 1835-1965. For publisher information, see CRASEV.
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
KHFZAN Khimiko-Farmatsevticheskii Zhurnal. Chemical Pharmaceutical Journal. For English translation, see PCJOAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1967-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
SAIGBL Sangyo Igaku. Japanese Journal of Industrial Health. (Nippon Sangyo Eisei Igakkai, Kosu Eisei Bldg., 1-29-8, Shinjuku, Shinjuku-ku, Tokyo 160, Japan) V.1- 1959-
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-

Used as solvent for polymers and as stabilizer

NIOSH PROFILE (NITROPARAFFINS), SRC, 11/81

RTECS Compound Description:
   Tumorigen
   Mutagen

Click Here for Additional Information about RTECS

NIOSH Home |  NIOSH Search  |  Site Index  |  Topic List |  Contact Us