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Methane, bromotrifluoro -

RTECS #: PA5425000

CAS #: 75-63-8


UPDATE: May 2009 MW: 148.92 MF: CBrF3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. REVIEWS:
  4. STANDARDS AND REGULATIONS:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. Bromofluoroform
  2. Bromotrifluoromethane
  3. Daiflon 13B1
  4. F - 13B1
  5. FE 1301
  6. Flugex 13B1
  7. Freon 13B1
  1. Halon 1301
  2. R 13B1
  3. Refrigerant 13B1
  4. Trifluorobromomethane
  5. Trifluorobromomethane (ACGIH:OSHA)
  6. Trifluoromonobromomethane


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
dog
lethal concentration : >30 pph/15 minute Behavioral: Tremor

Gastrointestinal: Changes in structure or function of salivary glands
NTIS** OTS0571524
inhalation
dog
lowest published toxic concentration: 1,662 gm/m3/45 minute Blood: Other changes VCVGH* -,625,1990
inhalation
dog
lowest published toxic concentration: 1,330 gm/m3/20S Behavioral: Convulsions or effect on seizure threshold

Cardiac: Arrythmias (indlucing changes in conduction)

Vascular: BP lowering not characterized in autonomic section
VCVGH* -,625,1990
inhalation
guinea pig
lethal concentration (50 percent kill): 88,000 ppm/15 minute N/R 85INA8 6,1640,1991
inhalation
human
lowest published toxic concentration: 997.5 gm/m3/1 minute Behavioral: Ataxia VCVGH* -,626,1990
inhalation
human
lowest published toxic concentration: 399 gm/m3/3 minute Peripheral Nerve and Sensation: Paresthesia

Behavioral: Ataxia

Behavioral: Headache
VCVGH* -,626,1990
inhalation
man
lethal concentration : >15 pph/1 minute Behavioral: Hallucinations, distorted perceptions

Cardiac: Pulse rate increased without fall in BP
NTIS** OTS0571524
inhalation
monkey
lowest published toxic concentration: 2,660 gm/m3/2 minute Behavioral: Convulsions or effect on seizure threshold

Behavioral: General anesthetic
VCVGH* -,625,1990
inhalation
monkey
lowest published toxic concentration: 1,330 gm/m3/15 minute Behavioral: Convulsions or effect on seizure threshold

Behavioral: General anesthetic
VCVGH* -,625,1990
inhalation
mouse
lethal concentration (50 percent kill): 381 gm/m3 N/R GTPZAB 26(8),53,1982
inhalation
mouse
lethal concentration (50 percent kill): 350 gm/m3/2 hour N/R VCVGH* -,625,1990
inhalation
rat
lethal concentration (50 percent kill): 84,000 ppm/15 minute N/R 85INA8 6,1640,1991
inhalation
rat
lowest published lethal concentration: 5,054 gm/m3/15 minute N/R VCVGH* -,625,1990
inhalation
rat
lowest published toxic concentration: 4,056 gm/m3/2 minute Behavioral: General anesthetic VCVGH* -,625,1990
inhalation
rat
lowest published toxic concentration: 2,128 gm/m3/12 minute Behavioral: General anesthetic VCVGH* -,625,1990
inhalation
rat
lethal concentration (50 percent kill): 430 gm/m3/4 hour N/R VCVGH* -,625,1990


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 1000 ppm DTLVS* TLV/BEI,2007


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 1000 ppm (6100 mg/m3) DTLVS* 3,268,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 1000 ppm (6100 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 1000 ppm (6100 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 1000 ppm (6100 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 1000 ppm (6100 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 1000 ppm (6090 mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 1000 ppm (6178 mg/m3), MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 1000 ppm (6100 mg/m3), OCT 2002
Occupational Exposure Limit - FINLAND time-weighted average 1000 ppm (6100 mg/m3), short term exposure limit 1250 ppm (7625 mg/m3), JAN1999
Occupational Exposure Limit - FRANCE VME 1000 ppm (6100 mg/m3), FEB2006
Occupational Exposure Limit - GERMANY MAK 6200 mg/m3 (1000 mL/m3), 2005
Occupational Exposure Limit - KOREA time-weighted average 1000 ppm (6100 mg/m3), 2006
Occupational Exposure Limit - MEXICO time-weighted average 1000 ppm (6100 mg/m3);
short term exposure limit 1200 ppm, 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 6100 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 1000 ppm (6090 mg/m3), JAN2002
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 1000 ppm (6100 mg/m3), JAN1993
Occupational Exposure Limit - RUSSIA short term exposure limit 3000 mg/m3, JUN2003
Occupational Exposure Limit - SWITZERLAND MAK- week 1000 ppm (6100 mg/m3), DEC2006
Occupational Exposure Limit - TURKEY time-weighted average 1000 ppm (6100 mg/m3), JAN1993
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 1000 ppm
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 1000 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO TRIFLUOROBROMOMETHANE-air 10 hour time-weighted average 1000 ppm NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M0424;
Number of Industries 1;
Total Number of Facilities 32;
Number of Occupations 1;
Total Number of Employees Exposed 32


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a fire extinquishant and as a chemical intermediate
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Bromotrifluoromethane, 1017
NIOSH Analytical Method, 1994: Trifluorobromomethane, 1017


REFERENCES:

CODEN
REFERENCE

85INA8 "Documentation of the Threshold Limit Values and Biological Exposure Indices," 5th ed., Cincinnati, OH, American Conference of Governmental Industrial Hygienists, Inc., 1986
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
VCVGH* "Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances: Galogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990.

Used as a fire extinquishant and as a chemical intermediate

NIOSH PROFILE (FIREFIGHTING), FIRL, 4/78

RTECS Compound Description:
   Human Data

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