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Lactic acid, butyl ester

RTECS #: OD4025000

CAS #: 138-22-7


UPDATE: May 2009 MW: 146.21 MF: C7H14O3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. REVIEWS:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. Butyl 2 - hydroxypropanoate
  2. Butyl alpha - hydroxypropionate
  3. Butyl lactate
  4. Butylester kyseliny mlecne (Czech)
  1. Propanoic acid, 2 - hydroxy - , butyl ester (9CI)
  2. n - Butyl lactate
  3. n - Butyl lactate (ACGIH)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
skin
rabbit
500 mg/24 hour moderate FCTXAV 17,727,1979


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lethal concentration (50 percent kill): >5.14 gm/m3/4 hour N/R FEREAC 67,56225,2002
oral
rat
lethal dose (50 percent kill): >2,000 mg/kg N/R FEREAC 67,56225,2002
oral
rabbit
lethal dose (50 percent kill): >5 gm/kg N/R IJTOFN 17(Suppl 1),71,1998
subcutaneous
mouse
lowest published lethal dose: 11 gm/kg Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea
FCTXAV 17,727,1979
subcutaneous
rat
lethal dose (50 percent kill): 12 gm/kg N/R NPIRI* 1,15,1974
skin
rat
lethal dose (50 percent kill): >5,000 mg/kg N/R FEREAC 69,34945,2004
skin
rabbit
lethal dose (50 percent kill): >5 gm/kg N/R FCTXAV 17,727,1979


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 5 ppm DTLVS* TLV/BEI,2007


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 1 ppm (5 mg/m3) DTLVS* 3,33,1971
Occupational Exposure Limit - AUSTRALIA time-weighted average 5 ppm (30 mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 5 ppm (30 mg/m3), MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 5 ppm (30 mg/m3), OCT 2002
Occupational Exposure Limit - FINLAND time-weighted average 1 ppm (6 mg/m3), short term exposure limit 3 ppm (18 mg/m3), JAN1999
Occupational Exposure Limit - FRANCE VME 5 ppm (25 mg/m3), FEB2006
Occupational Exposure Limit - KOREA time-weighted average 5 ppm (25 mg/m3), 2006
Occupational Exposure Limit - MEXICO time-weighted average 5 ppm (25 mg/m3), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 20 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 5 ppm (30 mg/m3), JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 5 ppm (25 mg/m3), JAN1999
Occupational Exposure Limit - SWEDEN time-weighted average 5 ppm (30 mg/m3);
short term exposure limit 10 ppm (60 mg/m3), JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 5 ppm (30 mg/m3), DEC2006
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 5 ppm (30 mg/m3), 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 5 ppm
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 5 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO n-BUTYL LACTATE-air 10 hour time-weighted average 5 ppm NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M1128;
Number of Industries 8;
Total Number of Facilities 242;
Number of Occupations 10;
Total Number of Employees Exposed 3,107
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M1128;
Number of Industries 9;
Total Number of Facilities 170;
Number of Occupations 15;
Total Number of Employees Exposed 5,342;
Total Number of Female Employees Exposed 1,381


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE

DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
IJTOFN International Journal of Toxicology. (Taylor & Francis, 47 Runway Rd., Suite g, Levittown, PA 19057) V.16- 1997-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NPIRI* Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. (National Assoc. of Printing Ink Research Institute, Francis McDonald Sinclair Memorial Laboratory, Lehigh Univ., Bethlehem, PA 18015)

RTECS Compound Description:
   Agricultural Chemical
   Primary Irritant

Click Here for Additional Information about RTECS

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