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Gasoline, natural

RTECS #: LX3300000

CAS #: 8006-61-9


UPDATE: May 2009 MW: N/R MF: N/R


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Automobile regular unleaded gasoline
  2. Gasoline
  3. Gasoline (ACGIH:OSHA)
  1. Natural gasoline
  2. Petrol
  3. Petrol, natural


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
human
140 ppm/8 hour mild JIHTAB 25,225,1943
eye
man
500 ppm/1 hour moderate AEHLAU 1,548,1960


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
guinea pig
lethal concentration (50 percent kill): 300 gm/m3/5 minute Lung, Thorax, or Respiration: Dyspnea NTIS** PB158-508
inhalation
mammal (species unspecified)
lowest published lethal concentration: 30,000 ppm/5 minute N/R AEPPAE 138,65,1928
inhalation
man
lowest published toxic concentration: 900 ppm/1 hour Eye: Conjunctiva irritation

Behavioral: Hallucinations, distorted perceptions

Lung, Thorax, or Respiration: Cough
JIHTAB 25,225,1943
inhalation
mouse
lethal concentration (50 percent kill): 300 gm/m3/5 minute N/R NTIS** PB158-508
inhalation
rat
lethal concentration (50 percent kill): 300 gm/m3/5 minute N/R NTIS** PB158-508
parenteral
man
lowest published toxic dose: 53 mg/kg Skin: After systemic exposure: Dermatitis, allergic JTCTDW 21,409,1983/1984


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 3,200 ppm/6 hour/4 week- intermittent Kidney, Ureter, and Bladder: Other changes in urine composition

Blood: Pigmented or nucleated red blood cells

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases
TIHEEC 11,343,1995
inhalation
rat
lowest published toxic concentration: 3 gm/m3/4 hour/43 week- intermittent Eye: Conjunctiva irritation VEOFA6 78(1),36,1965
inhalation
rat
lowest published toxic concentration: 500 ppm/4 week- intermittent Brain and Coverings: Other degenerative changes

Kidney, Ureter, and Bladder: Other changes in urine composition

Kidney, Ureter, and Bladder: Changes in kidney weight
JAPTO* 25,193,2005
inhalation
rat
lowest published toxic concentration: 500 ppm/4 week- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Blood: Changes in leukocyte (WBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
JAPTO* 25,193,2005
inhalation
rat
lowest published toxic concentration: 500 ppm/4 week- intermittent Biochemical: Neurotransmitters or modulators (putative): Dopamine at other sites JAPTO* 25,193,2005
inhalation
rat
lowest published toxic concentration: 500 ppm/4 week- intermittent Brain and Coverings: Other degenerative changes

Cardiac: Changes in heart weight

Kidney, Ureter, and Bladder: Other changes in urine composition
JAPTO* 25,193,2005
inhalation
rat
lowest published toxic concentration: 500 ppm/4 week- intermittent Endocrine: Hyperglycemia

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Blood: Other changes
JAPTO* 25,193,2005
inhalation
rat
lowest published toxic concentration: 500 ppm/4 week- intermittent Blood: Changes in leukocyte (WBC) count

Biochemical: Metabolism (intermediary): Other

Biochemical: Neurotransmitters or modulators (putative): Dopamine at other sites
JAPTO* 25,193,2005
oral
rat
lowest published toxic dose: 1,500 mg/kg/3 day- intermittent Kidney, Ureter, and Bladder: Other changes in urine composition JAPTO* 21,461,2001
oral
rat
lowest published toxic dose: 5 mg/kg/2 week- intermittent Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Changes in kidney weight
TOLED5 44,13,1988
unreported route
man
lowest published toxic dose: 16.5 mL/kg/7 year- intermittent Peripheral Nerve and Sensation: Recording from peripheral motor nerve

Behavioral: Tremor
DADEDV 73,183,2004


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 45,159,1989
International Agency for Research on Cancer (IARC) Cancer Review Group 2B IMEMDT 45,159,1989
TOXICOLOGY REVIEW
NEJMAG 342,186,2000
TOXICOLOGY REVIEW
TOLED5 128,85,2002
TOXICOLOGY REVIEW
MUREAV 566,209,2004
TOXICOLOGY REVIEW
MUREAV 613,138,2006
TOXICOLOGY REVIEW
ENTOX* -,408,2005
TOXICOLOGY REVIEW
HUTOX* -,577,1996


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) see Appendix A3 CFRGBR 29,1926.55,1994
Occupational Exposure Limit - BELGIUM time-weighted average 300 ppm (903 mg/m3), MAR2002
Occupational Exposure Limit - BELGIUM short term exposure limit 500 ppm (1501 mg/m3), MAR2002
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 100 ppm (300 mg/m3), 2B carcinogen, APR2007
Occupational Exposure Limit - KOREA time-weighted average 300 ppm (900 mg/m3), short term exposure limit 500 ppm (1500 mg/m3), 2006
Occupational Exposure Limit - NEW ZEALAND time-weighted average 300 ppm (890 mg/m3), short term exposure limit 500 ppm (1480 mg/m3), JAN2002
Occupational Exposure Limit - TURKEY time-weighted average 500 ppm (2000 mg/m3), JAN1993
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO GASOLINE-air Carcinogen (15 ppm LOQ) NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X6705;
Number of Industries 1;
Total Number of Facilities 7;
Number of Occupations 2;
Total Number of Employees Exposed 70;
Total Number of Female Employees Exposed 7


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St., NW, Washington, DC 20016) V.1- 1960-
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC.
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DADEDV Drug and Alcohol Dependence. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975-
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
HUTOX*
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
JAPTO* Journal of Applied Toxicology (John Wiley & Sons, Ltd., Oldlands Way Bognor Regis West Sussex, PO22 9SA England) V.1- 1981-
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
JTCTDW Journal of Toxicology, Clinical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.19- 1982-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NEJMAG New England Journal of Medicine. (Massachusetts Medical Soc., 10 Shattuck St., Boston, MA 02115) V.198- 1928-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TIHEEC Toxicology and Industrial Health. (Princeton Scientific Pub. Co., POB 2155, Princeton, NJ 08540) V.1- 1985-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
VEOFA6 Vestnik Oftal'mologii. (Mezhdunarodnaya Kniga, ul. B. Yakimanka, 39, 117049 Moscow, Russia) V.1-34, 1884-1917; New Series V.1- 1932-

RTECS Compound Description:
   Tumorigen
   Human Data
   Primary Irritant

Click Here for Additional Information about RTECS

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