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Ethylenimine

RTECS #: KX5075000

CAS #: 151-56-4


UPDATE: May 2009 MW: 43.08 MF: C2H5N


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. TUMORIGENIC DATA:
  6. ACUTE TOXICITY DATA:
  7. OTHER MULTIPLE DOSE DATA:
  8. REVIEWS:
  9. STANDARDS AND REGULATIONS:
  10. NIOSH DOCUMENTATION AND SURVEILLANCE:
  11. STATUS IN FEDERAL AGENCIES:
  12. REFERENCES:

SYNONYMS:

  1. 1H - Azirine, dihydro -
  2. Aethylenimin (German)
  3. Azacyclopropane
  4. Aziran
  5. Aziridin (German)
  6. Aziridine
  7. Dihydro - 1H - azirine
  8. Dihydroazirene
  9. Dimethyleneimine
  1. EI
  2. ENT - 50324
  3. Ethyleenimine (Dutch)
  4. Ethylene imine
  5. Ethyleneimine
  6. Ethyleneimine (ACGIH:OSHA)
  7. Etilenimina (Italian)
  8. RCRA waste number P054
  9. TL 337


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
mouse
2 ppm/1 minute N/R JIHTAB 30,7,1948
eye
rabbit
2 mg severe AJOPAA 29,1363,1946
skin
rabbit
10 mg/24 hour open irritation test severe JIHTAB 30,63,1948


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis chicken fibroblast 770 mol/L MUREAV 81,123,1981
cytogenetic analysis parenteral
Drosophila melanogaster
10 mmol/L MUREAV 6,129,1968
cytogenetic analysis human lymphocyte 1 mol/L/1 hour ARTODN 46,61,1980
cytogenetic analysis human leukocyte 10 mol/L/1 hour 22XWAN -,367,1970
cytogenetic analysis human lung 10 mol/L MUREAV 4,83,1967
cytogenetic analysis intraperitoneal
mammal (species unspecified)
5 mg/kg TPKVAL 11,111,1969
cytogenetic analysis intraperitoneal
rat
5 mg/kg BJPCAL 6,357,1951
cytogenetic analysis inhalation
rat
8 g/L/17 week TPKVAL 13,51,1973
cytogenetic analysis inhalation
rat
0.1 mg/L/45 day- intermittent TPKVAL 11,111,1969
cytogenetic analysis inhalation
rat
0.6 mg/L/8 day- intermittent TPKVAL 11,111,1969
dominant lethal test inhalation
Drosophila melanogaster
1,250 ppm SOGEBZ 11,883,1975
dominant lethal test intraperitoneal
mouse
5 mg/kg EVSRBT 24,943,1981
dominant lethal test parenteral
other insects
20 mmol/L MUREAV 15,67,1972
DNA damage inhalation
other insects
100 ppm MUREAV 476,149,2001
DNA inhibition human HeLa cell 500 mol/L CNREA8 38,4445,1978
DNA inhibition intravaginal
mouse
1 pph JIDEAE 62,378,1974
DNA inhibition intraperitoneal
mouse
1 mg/kg MUREAV 46,305,1977
DNA repair Bacillus subtilis 800 mg/L EVSRBT 24,19,1981
DNA repair Escherichia coli 1 pph AGACBH 4,286,1974
DNA repair Salmonella typhimurium 1 pph AGACBH 4,286,1974
unscheduled DNA synthesis parenteral
mouse
5 mg/kg EVSRBT 24,943,1981
mutation in microorganisms Aspergillus nidulans 10 mmol/L (-enzymatic activation step) SOGEBZ 6,220,1970
mutation in microorganisms Bacillus subtilis 19,300 nmol/L (-enzymatic activation step) JACBBD 25,73,1975
mutation in microorganisms Escherichia coli 100 mmol/plate (-enzymatic activation step) PCJOAU 22,292,1988
mutation in microorganisms Neurospora crassa 20 g/plate (-enzymatic activation step) MUREAV 53,297,1978
mutation in microorganisms other microorganisms 100 mmol/plate (-enzymatic activation step) PCJOAU 22,292,1988
mutation in microorganisms other microorganisms 600 ppm/2 hour- continuous (-enzymatic activation step) DBANAD 31,1477,1978
mutation in microorganisms other microorganisms 500 mg/L (-enzymatic activation step) AMBBBR 6,15,1974
mutation in microorganisms other microorganisms 2,000 ppm (-enzymatic activation step) SOGEBZ 7,948,1971
mutation in microorganisms other microorganisms 100 mmol/plate (-enzymatic activation step) PCJOAU 15,482,1981
mutation in microorganisms other microorganisms 1 pph (-enzymatic activation step) ANTBAL 27,738,1982
mutation in microorganisms Salmonella typhimurium 1 pph (+enzymatic activation step) AGACBH 4,286,1974
mutation in microorganisms Salmonella typhimurium 10 g/plate (-enzymatic activation step) PNASA6 72,5135,1975
mutation in microorganisms Saccharomyes cerevisiae 1 pph (-enzymatic activation step) AGACBH 4,286,1974
micronucleus test multiple
non-mammalian species
500 ppb/8 day- continuous MUREAV 125,275,1984
gene conversion and mitotic recombination inhalation
Drosophila melanogaster
2,700 ppm SOGEBZ 11,1073,1975
gene conversion and mitotic recombination Saccharomyes cerevisiae 1 pph AGACBH 4,286,1974
mutation in mammalian somatic cells hamster ovary 2 mg/L MUREAV 94,449,1982
sex chromosome loss and nondisjunction multiple
Drosophila melanogaster
1 pph/8 hour- continuous GNKAA5 21,958,1985
sex chromosome loss and nondisjunction oral
Drosophila melanogaster
2 ppm NTIS** PB81-160848
sex chromosome loss and nondisjunction parenteral
Drosophila melanogaster
10 mmol/L GENTAE 56,273,1967
sex chromosome loss and nondisjunction intraperitoneal
Drosophila melanogaster
10 mmol/L PNASA6 53,282,1965
specific locus test parenteral
silkworm
2 mmol/L MUREAV 7,425,1969
heritable translocation test parenteral
Drosophila melanogaster
6,500 mol/L IDZAAW 39,155,1964


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 800 g/m3/24 hour (1 day male) Reproductive: Paternal effects: Testes, epididymis, sperm duct TPKVAL 14,16,1975
inhalation
rat
lowest published toxic concentration: 19 mg/m3 (6 week male) Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Maternal effects: Ovaries, fallopian tubes

Reproductive: Effects on embryo or fetus: Fetal death
TPKVAL 9,59,1967
inhalation
rat
lowest published toxic concentration: 19 mg/m3 (6 week male) Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Behavioral
TPKVAL 9,59,1967
inhalation
rat
lowest published toxic concentration: 700 g/m3 (17 week male) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Delayed effects
TPKVAL 9,59,1967
inhalation
rat
lowest published toxic concentration: 0.7 gm/m3 (1-20 day pregnant) Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated)

Reproductive: Effects on embryo or fetus: Fetal death
TPKVAL 13,70,1973
inhalation
rat
lowest published toxic concentration: 0.2 gm/m3 (1-4DD pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) TPKVAL 13,70,1973
inhalation
rat
lowest published toxic concentration: 0.1 gm/m3 (51 day male) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) TPKVAL 8,41,1966
inhalation
rat
lowest published toxic concentration: 19 mg/m3 (45 day male) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)
TPKVAL 9,59,1967
inhalation
rat
lowest published toxic concentration: 19 mg/m3 (45 day male) Reproductive: Effects on newborn: Behavioral

Reproductive: Effects on newborn: Other postnatal measures or effects

Reproductive: Effects on newborn: Delayed effects
TPKVAL 9,59,1967
inhalation
rat
lowest published toxic concentration: 0.7 mg/m3 (122 day male) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Other postnatal measures or effects

Reproductive: Effects on newborn: Delayed effects
TPKVAL 9,59,1967
subcutaneous
mouse
lowest published toxic dose: 41,760 g/kg (6-14 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Eye, ear

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)
NTIS** PB223-160
subcutaneous
mouse
lowest published toxic dose: 41,760 g/kg (6-14 day pregnant) Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord)

Reproductive: Effects on embryo or fetus: Fetal death
NTIS** PB223-160


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 6,500 g/kg/5 day- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
VOONAW 27(5),88,1981
oral
mouse
lowest published toxic dose: 235 mg/kg/76 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Liver: Tumors
JNCIAM 42,1101,1969
subcutaneous
rat
lowest published toxic dose: 20 mg/kg/67 day- intermittent Tumorigenic: Neoplastic by RTECS criteria

Tumorigenic: Tumors at site of application
BJPCAL 9,306,1954
subcutaneous
rat
toxic dose : 10 mg/kg/8 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Tumorigenic: Tumors at site of application
BJPCAL 9,306,1954


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
guinea pig
lowest published lethal concentration: 25 ppm/8 hour Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Lung, Thorax, or Respiration: Dyspnea

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)
JIHTAB 30,2,1948
inhalation
guinea pig
lethal concentration (50 percent kill): 170 ppm/1 hour N/R ENTOX* -,293,2005
inhalation
mouse
lethal concentration (50 percent kill): 150 ppm/1 hour N/R ENTOX* -,293,2005
inhalation
mouse
lethal concentration (50 percent kill): 400 mg/m3/2 hour Behavioral: Muscle weakness

Lung, Thorax, or Respiration: Other changes

Nutritional and Gross Metabolic: Body temperature decrease
TPKVAL 8,41,1966
inhalation
mouse
lowest published toxic concentration: 0.1 gm/m3/2 hour Lung, Thorax, or Respiration: Other changes TPKVAL 10,25,1968
inhalation
mouse
lethal concentration : 0.64 gm/m3/2 hour Lung, Thorax, or Respiration: Changes in pulmonary vascular resistance

Liver: Other changes

Kidney, Ureter, and Bladder: Changes in blood vessels or in circulation of kidney
TPKVAL 8,41,1966
inhalation
mouse
lethal concentration : 0.24 gm/m3/2 hour Kidney, Ureter, and Bladder: Changes in both tubules and glomeruli

Blood: Changes in bone marrow not included in above

Blood: Changes in spleen
TPKVAL 8,41,1966
inhalation
mouse
lethal concentration (50 percent kill): 0.4 gm/m3 N/R TPKVAL 9,3,1967
inhalation
rat
lethal concentration (50 percent kill): 100 mg/m3/2 hour N/R 85GMAT -,67,1982
inhalation
rat
lowest published lethal concentration: 15 ppm/8 hour N/R TOXID9 78,149,2004
inhalation
rat
lethal concentration (50 percent kill): 185 ppm/1 hour N/R ENTOX* -,293,2005
inhalation
rat
lowest published toxic concentration: 0.8 mg/m3 Peripheral Nerve and Sensation: Recording from peripheral motor nerve

Lung, Thorax, or Respiration: Other changes
TPKVAL 14,16,1975
inhalation
rat
lethal concentration (50 percent kill): 0.1 gm/m3/2 hour Peripheral Nerve and Sensation: Recording from afferent nerve

Lung, Thorax, or Respiration: Changes in pulmonary vascular resistance

Kidney, Ureter, and Bladder: Changes in blood vessels or in circulation of kidney
TPKVAL 8,41,1966
inhalation
rat
lowest published toxic concentration: 0.1 gm/m3/4 hour Eye: Lacrimation

Behavioral: Irritability

Lung, Thorax, or Respiration: Dyspnea
TPKVAL 8,41,1966
inhalation
rat
lowest published toxic concentration: 0.8 gm/m3/4 hour N/R TPKVAL 9,86,1967
inhalation
rabbit
lowest published lethal concentration: 100 mg/m3/2 hour Brain and Coverings: Other degenerative changes

Lung, Thorax, or Respiration: Other changes

Blood: Other changes
TPKVAL 8,41,1966
intraperitoneal
mouse
lethal dose (50 percent kill): 4 mg/kg Kidney, Ureter, and Bladder: Urine volume increased BJPCAL 25,223,1965
intraperitoneal
rat
lethal dose (50 percent kill): 3,500 g/kg Kidney, Ureter, and Bladder: Urine volume increased BJPCAL 21,581,1963
oral
mouse
lethal dose (50 percent kill): 15 mg/kg N/R ENTOX* -,293,2005
oral
rat
lethal dose (50 percent kill): 15 mg/kg Behavioral: General anesthetic

Gastrointestinal: Other changes

Kidney, Ureter, and Bladder: Other changes
JIHTAB 23,259,1941
oral
rat
lethal dose (50 percent kill): 15 mg/kg N/R ENTOX* -,293,2005
skin
guinea pig
lethal dose (50 percent kill): 14 mg/kg N/R JIHTAB 30,63,1948
skin
guinea pig
lowest published toxic dose: 0.6 mg/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory depression

Skin: After topical application: Corrosive
TPKVAL 8,41,1966
skin
mouse
lethal dose (50 percent kill): 100 pph/5S Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory depression

Skin: After topical application: Corrosive
TPKVAL 8,41,1966
skin
rabbit
lowest published lethal dose: 50 mg/kg/1 hour Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory depression

Skin: After topical application: Corrosive
TPKVAL 8,41,1966
skin
rabbit
lowest published toxic dose: 10 mg/kg/3 hour Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory depression

Skin: After topical application: Corrosive
TPKVAL 8,41,1966
unreported route
mouse
lethal dose (50 percent kill): 15 mg/kg N/R BJCAAI 6,160,1952
unreported route
rat
lethal dose (50 percent kill): 0.15 mg/kg N/R TPKVAL 9,3,1967


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 0.4 mg/m3/122 day- intermittent Peripheral Nerve and Sensation: Recording from peripheral motor nerve

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Liver: Other changes
TOVEFN 9,50,1967
inhalation
rat
lowest published toxic concentration: 0.4 mg/m3/122 day- intermittent Kidney, Ureter, and Bladder: Other changes

Blood: Changes in spleen

Blood: Changes in other cell count (unspecified)
TOVEFN 9,50,1967
inhalation
rat
lowest published toxic concentration: 0.4 mg/m3/30 day- intermittent Peripheral Nerve and Sensation: Recording from peripheral motor nerve

Blood: Changes in other cell count (unspecified)
TOVEFN 9,50,1967
inhalation
rat
lowest published toxic concentration: 0.4 mg/m3/122 day- intermittent Liver: Liver function tests impaired

Kidney, Ureter, and Bladder: Changes primarily in glomeruli

Kidney, Ureter, and Bladder: Proteinuria
TOVEFN 9,50,1967
inhalation
rat
lowest published toxic concentration: 0.4 mg/m3/122 day- intermittent Blood: Luekopenia

Blood: Angranulocytosis

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
TOVEFN 9,50,1967
inhalation
rat
lowest published toxic concentration: 0.4 mg/m3/122 day- intermittent Immunological Including Allergic: Decrease in cellular immune response TOVEFN 9,50,1967
inhalation
rat
lowest published toxic concentration: 0.4 mg/m3/122 day- intermittent Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct
TOVEFN 9,50,1967
inhalation
rat
lowest published toxic concentration: 19 mg/m3/45 day- intermittent Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females)
TOVEFN 9,59,1967
inhalation
rat
lowest published toxic concentration: 19 mg/m3/45 day- intermittent Related to Chronic Data: Changes in testicular weight TOVEFN 9,59,1967
inhalation
rat
lowest published toxic concentration: 700 g/m3/4 hour/17 week- intermittent Kidney, Ureter, and Bladder: Proteinuria

Blood: Changes in other cell count (unspecified)

Immunological Including Allergic: Decrease in cellular immune response
TPKVAL 9,50,1967
inhalation
rat
lowest published toxic concentration: 10 mg/m3/4 hour/6 week- intermittent Behavioral: Muscle weakness

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TPKVAL 8,41,1966
inhalation
rat
lowest published toxic concentration: 10 mg/m3/30 day- intermittent Reproductive: Paternal effects: Testes, epididymis, sperm duct

Biochemical: Metabolism (intermediary): Effect on mitochondrial function
TPKVAL 14,16,1975
inhalation
rat
lowest published toxic concentration: 0.1 gm/m3/20 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain TPKVAL 13,70,1973
inhalation
rat
lowest published toxic concentration: 0.1 gm/m3/51 day- intermittent Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Changes in testicular weight
TPKVAL 8,41,1966


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.5 ppm (skin) DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Confirmed animal carcinogen DTLVS* TLV/BEI,2007
International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMEMDT 9,37,1975
International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMEMDT 71,337,1999
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 9,37,1975
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 71,337,1999
International Agency for Research on Cancer (IARC) Cancer Review Group 2B IMEMDT 71,337,1999
TOXICOLOGY REVIEW
ENTOX* -,293,2005
TOXICOLOGY REVIEW
MUREAV 584,1,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.5 ppm (1 mg/m3) (skin) DTLVS* 3,111,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) see Code of Federal Regulations (CFR) 29,1926.1112 CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 0.5 ppm (1 mg/m3) (skin) CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) cancer suspect agent CFRGBR 29,1910.1012,1987
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.5 ppm (0.88 mg/m3), Carcinogen, JUL2008
Occupational Exposure Limit - AUSTRIA TRK 0.9 mg/m3 (0.5 mL/m3), JAN 2006
Occupational Exposure Limit - BELGIUM time-weighted average 0.5 ppm (0.89 mg/m3), Skin, Carcinogen, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 0.5 ppm (1 mg/m3), OCT 2002
Occupational Exposure Limit - FINLAND short term exposure limit 0.5 ppm (1 mg/m3), Skin, Carcinogen, JAN1999
Occupational Exposure Limit - HUNGARY ceiling concentration 0.9 mg/m3, Carcinogen, SEP2000
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 0.5 ppm (0.88 mg/m3), skin, APR2007
Occupational Exposure Limit - KOREA time-weighted average 0.5 ppm (1 mg/m3), skin, 2006
Occupational Exposure Limit - MEXICO time-weighted average 0.5 ppm (1 mg/m3) (skin), 2004
Occupational Exposure Limit - NEW ZEALAND time-weighted average 0.5 ppm (0.88 mg/m3), skin, JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 0.5 ppm (1 mg/m3), JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 0.02 mg/m3, Skin, JUN2003
Occupational Exposure Limit - SWEDEN Group B Carcinogen, JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 0.5 ppm (0.9 mg/m3), Skin, Carcinogen, DEC2006
Occupational Exposure Limit - TURKEY time-weighted average 0.5 ppm (1 mg/m3), Skin, JAN1993
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Confirmed animal carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Confirmed animal carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ETHYLENEIMINE-air Carcinogen use 29 Code of Federal Regulations (CFR) 1910.1012 NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M0492;
Number of Industries 2;
Total Number of Facilities 19;
Number of Occupations 17;
Total Number of Employees Exposed 1,712
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M0492;
Number of Industries 1;
Total Number of Facilities 4;
Number of Occupations 13;
Total Number of Employees Exposed 1,093


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Positive: Aspergillus-reversion; In vitro cytogenetics-human
EPA GENETOX PROGRAM 1988, Positive: In vitro cytogenetics-human lymphocyte
EPA GENETOX PROGRAM 1988, Positive: D melanogaster-reciprocal translocation
EPA GENETOX PROGRAM 1988, Positive: N crassa-forward mutation; N crassa-reversion
EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Positive: D melanogaster Sex-linked lethal; UDS in mouse germ cells
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae gene conversion
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae-forward mutation; S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Positive: S pombe-forward mutation
EPA GENETOX PROGRAM 1988, Positive/limited: Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Positive: CHO gene mutation
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in production of binding agents, formation of plastics and improving paper strength
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Ethylenimine, 3514


REFERENCES:

CODEN
REFERENCE

22XWAN "Chemical Mutagenesis in Mammals and Man," Vogel, F., and G. Roehrborn, eds., Berlin, Fed. Rep. Ger., Springer, 1970
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
AGACBH Agents and Actions, A Swiss Journal of Pharmacology. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1969/70-
AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918-
AMBBBR Acta Microbiologica Polonica, Series B: Microbiologica Applicata. (Warsaw, Poland) V.1-7, 1969-75. For publisher information, see AMPOAX.
ANTBAL Antibiotiki. (Moscow, USSR) V.1-29, 1956-84. For publisher information, see AMBIEH.
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1947-
BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM.
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
DBANAD Doklady Bolgarskoi Akademii Nauk. (Hemus, Blvd. Russki 6, Sofia, Bulgaria) V.1- 1948-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
EVSRBT Environmental Science Research. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) V.1- 1972-
GENTAE Genetics. (Genetics Business Office, POB 64025, Baltimore, MD 21264) V.1- 1916-
GNKAA5 Genetika (Moscow). For English translation, see SOGEBZ. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) No.1- 1965-
IDZAAW Japanese Journal of Genetics. Idengaku Zasshi. (Genetics Soc. of Japan, 111 Tanida, Mishima, Shizuoka-ken, Japan) V.1- 1921-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
JACBBD Journal of Applied Chemistry and Biotechnology. (London, UK) V.21-28, 1971-78.
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NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
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Used in production of binding agents, formation of plastics and improving paper strength

NIOSH PROFILE (IMINES, ALIPHATIC), SRC, 4/78

RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector
   Human Data
   Primary Irritant

Click Here for Additional Information about RTECS

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