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Ethane, 1,1,2 - trichloro - 1,2,2 - trifluoro -

RTECS #: KJ4000000

CAS #: 76-13-1


UPDATE: May 2009 MW: 187.37 MF: C2Cl3F3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 1,1,2 - Trichloro - 1,2,2 - trifluoroethane
  2. 1,1,2 - Trichloro - 1,2,2 - trifluoroethane (ACGIH:OSHA)
  3. 1,1,2 - Trichlorotrifluoroethane
  4. 1,1,2 - Trifluoro - 1,2,2 - trichloroethane
  5. 1,1,2 - Trifluorotrichloroethane
  6. 1,2,2 - Trichlorotrifluoroethane
  7. Arcton 63
  8. Arklone P
  9. Asahifron 113
  10. CFC - 113
  11. Chlorofluorethane
  12. Chlorofluorocarbon 113
  13. Daiflon S 3
  14. F 113
  15. FC 113
  16. Fluorocarbon 113
  17. Freon 113
  18. Freon 113, commercial grade
  19. Freon 113, contaminated
  20. Freon 113, specially purified
  1. Freon 113TR - T
  2. Freon F113
  3. Freon TF
  4. Freon - TF
  5. Frigen 113
  6. Frigen 113 TR - T
  7. Frigen 113TR
  8. Frigen 113TR - N
  9. Frigen 113a
  10. Genetron 113
  11. Halocarbon 113
  12. Isceon 113
  13. Kaiser chemicals 11
  14. Khladon 113
  15. Ledon 113
  16. R 113
  17. R 113 (Halocarbon)
  18. Racon 113
  19. Refrigerant 113
  20. Refrigerant R 113


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
skin
rabbit
500 mg open irritation test mild UCDS** 7/10/1970
skin
rabbit
500 mg/24 hour mild 85JCAE -,137,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rabbit
lowest published toxic concentration: 20 ppm (8-16 day pregnant) Reproductive: Other effects on female

Reproductive: Effects on newborn: Physical
EPASR* #86-890000920S
oral
rabbit
lowest published toxic dose: 5 gm/kg (8 day pregnant) Reproductive: Other effects on female

Reproductive: Effects on fertility: Abortion

Reproductive: Effects on embryo or fetus: Fetal death
NTIS** OTS0571230


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
guinea pig
lethal concentration (50 percent kill): >12 pph/2 hour N/R AMPMAR 29,381,1968
inhalation
guinea pig
lowest published lethal concentration: 4 pph/60 minute Lung, Thorax, or Respiration: Other changes

Blood: Hemorrhage
TJIDAH 95,1283,1980
inhalation
human
lowest published toxic concentration: 2,500 ppm/90 minute Behavioral: Change in psychophysiological tests AIHAAP 28,43,1967
inhalation
mouse
lethal concentration (50 percent kill): 260 gm/m3/2 hour Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Lung, Thorax, or Respiration: Cyanosis
TLSMA6 75,241,1963
inhalation
mouse
lowest published lethal concentration: 230,000 mg/m3/2 hour N/R VCVGH* -,636,1990
inhalation
mouse
lowest published toxic concentration: 393,000 mg/m3/1 hour Behavioral: Convulsions or effect on seizure threshold

Behavioral: Excitement

Behavioral: General anesthetic
VCVGH* -,636,1990
inhalation
rat
lethal concentration (50 percent kill): 38,500 ppm/4 hour Behavioral: General anesthetic

Behavioral: Excitement

Behavioral: Ataxia
NTIS** OTS0520341
inhalation
rat
lowest published lethal concentration: 57,500 ppm/4 hour Behavioral: Tremor

Behavioral: Excitement
EPASR* #86-890000906S
inhalation
rat
lowest published lethal concentration: 37,000 ppm/4 hour Behavioral: Tremor

Behavioral: Ataxia
EPASR* #86-890000902S
inhalation
rat
lethal concentration (50 percent kill): 38,000 ppm/4 hour N/R EPASR* #86-890000902S
inhalation
rat
lowest published lethal concentration: 786,000 mg/m3/4 hour N/R VCVGH* -,636,1990
inhalation
rabbit
lethal concentration (50 percent kill): 59,500 ppm/2 hour Eye: Other eye effects

Behavioral: Excitement

Lung, Thorax, or Respiration: Respiratory stimulation
NTIS** OTS0520343
inhalation
rabbit
lowest published lethal concentration: 55,120 ppm/2 hour Eye: Lacrimation

Gastrointestinal: Changes in structure or function of salivary glands
EPASR* #86-890000904S
inhalation
rabbit
lethal concentration (50 percent kill): 59,500 ppm/2 hour Vascular: Regional or general arteriolar or venous dilation

Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Respiratory obstruction
EPASR* #86-890000904S
intraperitoneal
mouse
lowest published toxic dose: 23,200 mg/kg Liver: Other changes

Biochemical: Metabolism (intermediary): Other proteins
ENVRAL 45,101,1988
intravenous
mouse
lethal dose (50 percent kill): 9 gm/kg Autonomic Nervous System: Other (direct) parasympathomimetic

Behavioral: Altered sleep time (including change in righting reflex)

Skin: After systemic exposure: Dermatitis, other
NTIS** OTS0520355
oral
guinea pig
lowest published lethal dose: >10 gm/kg N/R NTIS** OTS0520705
oral
rat
lethal dose (50 percent kill): 43 gm/kg Behavioral: Somnolence (general depressed activity)

Gastrointestinal: Other changes

Skin and Appendages: Other: Hair
JMCMAR 7,378,1964
oral
rat
lethal dose (50 percent kill): 43 gm/kg Behavioral: General anesthetic VCVGH* -,636,1990
oral
rabbit
lowest published lethal dose: 17 gm/kg N/R AIHAAP 29,521,1968
skin
rabbit
lethal dose : >11 gm/kg N/R AIHAAP 29,521,1968
unreported route
mouse
lethal dose (50 percent kill): 40 gm/kg N/R USXXAM #4164653


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
guinea pig
lowest published toxic concentration: 70,000 mg/m3/4 hour/16 week- intermittent Brain and Coverings: Recordings from specific areas of CNS

Lung, Thorax, or Respiration: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
VCVGH* -,636,1990
inhalation
human
lowest published toxic concentration: 4,300 mg/m3/5 day- intermittent Brain and Coverings: Recordings from specific areas of CNS VCVGH* -,637,1990
inhalation
human
lowest published toxic concentration: 178 mg/m3/10 year- intermittent Behavioral: Headache VCVGH* -,637,1990
inhalation
rat
lowest published toxic concentration: 20 pph/6 hour/2 year- intermittent Kidney, Ureter, and Bladder: Other changes in urine composition

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FAATDF 11,68,1988
inhalation
rat
lowest published toxic concentration: 2,000 ppm/6 hour/2 week- intermittent Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases
TXCYAC 18,17,1980
inhalation
rat
lowest published toxic concentration: 17,500 ppm/6 hour/13 week - intermittent Lung, Thorax, or Respiration: Changes in lung weight EPASR* #86-890000892S
inhalation
rat
lowest published toxic concentration: 20,000 ppm/6 hour/13 week - intermittent Lung, Thorax, or Respiration: Fibrosis (interstitial)

Lung, Thorax, or Respiration: Other changes

Lung, Thorax, or Respiration: Changes in lung weight
EPASR* #86-890000892S
multiple
guinea pig
lowest published toxic concentration: 60 mL/kg/3 week- intermittent Lung, Thorax, or Respiration: Other changes

Blood: Hemorrhage

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TJIDAH 95,1283,1980


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 1000 ppm;short term exposure limit 1250 ppm DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not classifiable as human carcinogen DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
FAZMAE 18,365,1974
TOXICOLOGY REVIEW
AIHAAP 29,521,1968
TOXICOLOGY REVIEW
ENTOX* -,384,2005
TOXICOLOGY REVIEW
HUTOX* -,577,1996


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 1000 ppm (7600 mg/m3) DTLVS* 3,267,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 1000 ppm (7600 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 1000 ppm (7600 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 1000 ppm (7600 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 1000 ppm (7600 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 1000 ppm (7670 mg/m3), short term exposure limit 1250 ppm (9590 mg/m3),JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 1000 ppm (7781 mg/m3), MAR2002
Occupational Exposure Limit - BELGIUM short term exposure limit 1250 ppm (9729 mg/m3), MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 500 ppm (3800 mg/m3), OCT 2002
Occupational Exposure Limit - FINLAND time-weighted average 1000 ppm (7600 mg/m3), short term exposure limit 1250 ppm, JAN1999
Occupational Exposure Limit - FRANCE VME 1000 ppm (7600 mg/m3), VLE 1250 ppm (9500 mg/m3), FEB2006
Occupational Exposure Limit - GERMANY MAK 3900 mg/m3 (500 mL/m3), 2005
Occupational Exposure Limit - HUNGARY Prohibited in Hungary, SEP2000
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 500 ppm (3800 mg/m3), APR2007
Occupational Exposure Limit - KOREA time-weighted average 1000 ppm (7600 mg/m3), short term exposure limit 1250 ppm (9500 mg/m3), 2006
Occupational Exposure Limit - MEXICO time-weighted average 1000 ppm (1600 mg/m3);
short term exposure limit 1250 ppm, 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 1170 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 1000 ppm (7670 mg/m3), short term exposure limit 1250 ppm (9590 mg/m3), JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 500 ppm (3800 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 1000 ppm (7600 mg/m3), JAN1993
Occupational Exposure Limit - RUSSIA short term exposure limit 5000 mg/m3, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 500 ppm (4000 mg/m3);
short term exposure limit 750 ppm (6000 mg/m3), JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 500 ppm (3800 mg/m3), DEC2006
Occupational Exposure Limit - TURKEY time-weighted average 1000 ppm (7600 mg/m3), JAN1993
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not classifiable as human carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not classifiable as human carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO THE CHEMICAL-air 10 hour time-weighted average 1000 ppm;
short term exposure limit 1250 ppm
NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 74010;
Number of Industries 175;
Total Number of Facilities 19,387;
Number of Occupations 103;
Total Number of Employees Exposed 282,795
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 74010;
Number of Industries 119;
Total Number of Facilities 12,471;
Number of Occupations 103;
Total Number of Employees Exposed 250,773;
Total Number of Female Employees Exposed 79,790


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a refrigerant, heat transfer medium, and industrial solvent
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: 1,1,2-Trichloro-1,2,2-trifluoroethane, 1020
NIOSH Analytical Method, 1996: Volatile organic compound, 2549
OSHA ANALYTICAL METHOD #113


REFERENCES:

CODEN
REFERENCE

85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
AMPMAR Archives des Maladies Professionnelles de Medecine du Travail et de Securite Sociale. (SPPIF, B.P.22, F-41353 Vineuil, France) V.7- 1946-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1967-
EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown.
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
FAZMAE Fortschritte der Arzneimittelforschung. Progress in Drug Research. (Birkhauser Boston, Inc., c/o Springer-Verlag New York, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1959-
HUTOX*
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TJIDAH Tokyo Jikeikai Ika Daigaku Zasshi. Tokyo Jikeikai Medical Journal. (3-25-8, Nishi Shinbashi, Minato-ku, Tokyo 105, Japan) V.66- 1951-
TLSMA6 Trudy Leningradskogo Sanitarno-Gigienicheskogo Meditsinskogo Instituta. (Leningrad, Russia) V.1-145, 1949-82. Discontinued.
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)
USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231)
VCVGH* "Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances: Galogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990.

Used as a refrigerant, heat transfer medium, and industrial solvent

RTECS Compound Description:
   Drug
   Reproductive Effector
   Human Data
   Primary Irritant

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