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Ethane, 1,1,2,2 - tetrabromo -

RTECS #: KI8225000

CAS #: 79-27-6


UPDATE: May 2009 MW: 345.68 MF: C2H2Br4


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. 1,1,2,2 - Tetrabromaethan (German)
  2. 1,1,2,2 - Tetrabromoetano (Italian)
  3. 1,1,2,2 - Tetrabromoethane
  4. 1,1,2,2 - Tetrabroomethaan (Dutch)
  5. Acetylene tetrabromide
  1. Acetylene tetrabromide (ACGIH:OSHA)
  2. Muthmann's liquid
  3. TBE
  4. Tetrabromoacetylene
  5. s - Tetrabromoethane


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
100 mg mild AIHAAP 24,28,1963
skin
rabbit
500 mg/24 hour moderate AIHAAP 24,28,1963


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
DNA repair Escherichia coli 29,640 g/disc MUREAV 41,61,1976
mutation in microorganisms Salmonella typhimurium 10 g/plate (+/-enzymatic activation step) TECSDY 15,101,1987
sister chromatid exchange hamster ovary 158 mg/L EMMUEG 10(Suppl 10),1,1987


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
skin
mouse
lowest published toxic dose: 130 gm/kg/74 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Skin and Appendages: Tumors
JJIND8 63,1433,1979


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lowest published toxic concentration: 500 mg/m3/3 hour Behavioral: General anesthetic VCVGH* -,591,1990
inhalation
rat
lethal concentration (50 percent kill): 549 mg/m3/4 hour N/R 85GMAT -,107,1982
inhalation
rat
lethal concentration (50 percent kill): 550 mg/m3 N/R VCVGH* -,572,1990
intraperitoneal
mouse
lethal dose (50 percent kill): 443 mg/kg N/R ABMGAJ 41,945,1982
oral
guinea pig
lethal dose (50 percent kill): 400 mg/kg N/R AIHAAP 30,251,1969
oral
mouse
lethal dose (50 percent kill): 269 mg/kg N/R 85GMAT -,107,1982
oral
rat
lethal dose (50 percent kill): 1,200 mg/kg N/R VCVGH* -,572,1990
oral
rabbit
lethal dose (50 percent kill): 400 mg/kg Behavioral: General anesthetic

Liver: Fatty liver degeneration

Blood: Hemorrhage
AMIHBC 2,407,1950
skin
rat
lethal dose (50 percent kill): 5,250 mg/kg N/R 85GMAT -,107,1982


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
guinea pig
lowest published toxic concentration: 14 ppm/7 hour/14 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain AIHAAP 24,28,1963
inhalation
guinea pig
lowest published toxic concentration: 4 ppm/7 hour/26 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain AIHAAP 24,28,1963
inhalation
mouse
lowest published toxic concentration: 14 ppm/7 hour/15 week- intermittent Liver: Changes in liver weight AIHAAP 24,28,1963
inhalation
rat
lowest published toxic concentration: 100 mg/m3/4 hour/17 week- intermittent Liver: Liver function tests impaired

Liver: Changes in liver weight

Blood: Hemorrhage
VRDEA5 (3),80,1967
inhalation
rat
lowest published toxic concentration: 14 ppm/7 hour/14 week- intermittent Liver: Changes in liver weight AIHAAP 24,28,1963
inhalation
rat
lowest published toxic concentration: 4 ppm/7 hour/26 week- intermittent Liver: Changes in liver weight AIHAAP 24,28,1963
inhalation
rabbit
lowest published toxic concentration: 14 ppm/7 hour/15 week- intermittent Liver: Changes in liver weight AIHAAP 24,28,1963
oral
rat
lowest published toxic dose: 10,920 mg/kg/13 week- intermittent Liver: Liver function tests impaired

Liver: Changes in liver weight

Blood: Other changes
VRDEA5 (3),80,1967
oral
rat
lowest published toxic dose: 1,400 mg/kg/14 day- intermittent Blood: Other changes JTSCDR 30,29,2005
oral
rat
lowest published toxic dose: 2,800 mg/kg/14 day- intermittent Blood: Other changes

Blood: Changes in other cell count (unspecified)

Blood: Changes in erythrocyte (RBC) count
JTSCDR 30,29,2005
oral
rat
lowest published toxic dose: 2,800 mg/kg/14 day- intermittent Kidney, Ureter, and Bladder: Changes in kidney weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Blood: Changes in erythrocyte (RBC) count
JTSCDR 30,29,2005
oral
rat
lowest published toxic dose: 1,400 mg/kg/14 day- intermittent Kidney, Ureter, and Bladder: Changes in kidney weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
JTSCDR 30,29,2005
oral
rat
lowest published toxic dose: 700 mg/kg/14 day- intermittent Liver: Changes in liver weight JTSCDR 30,29,2005
oral
rat
lowest published toxic dose: 5,600 mg/kg/28 day- intermittent Endocrine: Other changes

Blood: Changes in platelet count
JTSCDR 30,29,2005
oral
rat
lowest published toxic dose: 560 mg/kg/28 day- intermittent Liver: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
JTSCDR 30,29,2005
oral
rat
lowest published toxic dose: 560 mg/kg/28 day- intermittent Liver: Other changes JTSCDR 30,29,2005
oral
rat
lowest published toxic dose: 5,600 mg/kg/28 day- intermittent Endocrine: Other changes JTSCDR 30,29,2005
oral
rat
lowest published toxic dose: 3,600 mg/kg/18 day- intermittent Lung, Thorax, or Respiration: Respiratory depression

Liver: Changes in liver weight

Endocrine: Changes in spleen weight
JTSCDR 30,29,2005
oral
rat
lowest published toxic dose: 3,600 mg/kg/18 day- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Endocrine: Changes in spleen weight
JTSCDR 30,29,2005
oral
rat
lowest published toxic dose: 1,600 mg/kg/8 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain JTSCDR 30,29,2005


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 1 ppm (inhalable, vapor) DTLVS* TLV/BEI,2007


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 1 ppm (14 mg/m3) DTLVS* 3,248,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 1 ppm (14 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 1 ppm (14 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 1 ppm (14 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 1 ppm (14 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 1 ppm (14 mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 1 ppm (14 mg/m3), MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 1 ppm (14 mg/m3), OCT 2002
Occupational Exposure Limit - FINLAND time-weighted average 1 ppm (14 mg/m3), short term exposure limit 3 ppm (42 mg/m3), JAN1999
Occupational Exposure Limit - FRANCE VME 1 ppm (15 mg/m3), FEB2006
Occupational Exposure Limit - KOREA time-weighted average 1 ppm (15 mg/m3), 2006
Occupational Exposure Limit - MEXICO time-weighted average 1 ppm (15 mg/m3);
short term exposure limit 1.5 ppm (20 mg/m3), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 7 mg/m3, Skin, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 1 ppm (14 mg/m3), JAN2002
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 1 ppm (14 mg/m3), JAN1993
Occupational Exposure Limit - SWEDEN time-weighted average 1 ppm (14 mg/m3);
short term exposure limit 2 ppm (30 mg/m3), JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 1 ppm (14 mg/m3),KZG- week 2 ppm (28 mg/m3), DEC2006
Occupational Exposure Limit - TURKEY time-weighted average 1 ppm (14 mg/m3), JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.5 ppm (7.2 mg/m3) (skin), 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 1 ppm (inhalable, vapor)
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 1 ppm (inhalable, vapor)


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 71401;
Number of Industries 2;
Total Number of Facilities 39;
Number of Occupations 3;
Total Number of Employees Exposed 440
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 71401;
Number of Industries 5;
Total Number of Facilities 172;
Number of Occupations 5;
Total Number of Employees Exposed 2,516


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Positive: E coli polA without S9
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a solvent and emulsifier
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: 1,1,2,2-Tetrabromoethane, 2003
NTP Toxicity studies, RPT# TOX-45, October 2000


REFERENCES:

CODEN
REFERENCE

85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
ABMGAJ Acta Biologica et Medica Germanica. (Berlin, Ger. Dem. Rep.) V.1-41, 1958-82. For publisher information, see BBIADT.
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC) V.61-79, 1978-87. For publisher information, see JNCIEQ.
JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
TECSDY Toxicological and Environmental Chemistry. (Gordon & Breach Science Pub. Inc., 1 Park Ave., New York, NY 10016) V.3(3/4)- 1981-
VCVGH* "Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances: Galogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990.
VRDEA5 Vrachebnoe Delo. Medical Practice. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) No.1- 1918-

Used as a solvent and emulsifier

NIOSH PROFILE (ALIPHATICS, BROMINATED), SRI, 2/77

RTECS Compound Description:
   Tumorigen
   Mutagen
   Primary Irritant

Click Here for Additional Information about RTECS

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