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Crotonic acid, 3 - hydroxy - , methyl ester, dimethyl phosphate

RTECS #: GQ5250000

CAS #: 7786-34-7


UPDATE: May 2009 MW: 224.17 MF: C7H13O6P


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. (2 - Methoxycarbonyl - 1 - methyl - vinyl) - dimethyl - fosfaat (Dutch)
  2. (2 - Methoxycarbonyl - 1 - methyl - vinyl) - dimethyl - phosphat (German)
  3. (2 - Metossicarbonil - 1 - metil - vinil) - dimetil - fosfato (Italian)
  4. 1 - Methoxycarbonyl - 1 - propen - 2 - yl dimethyl phosphate
  5. 2 - Butenoic acid, 3 - ( (dimethoxyphosphinyl) oxy) - , methyl ester (9CI)
  6. 2 - Carbomethoxy - 1 - methyl - vinyl dimethyl phosphare
  7. 2 - Carbomethoxy - 1 - methylvinyl dimethyl phosphate
  8. 2 - Carbomethoxy - 1 - propen - 2 - yl dimethyl phosphate
  9. 2 - Methoxycarbonyl - 1 - methylvinyl dimethyl phosphate
  10. 3 - ( (Dimethoxyphosphinyl) oxy) - 2 - butenoic acid methyl ester
  11. 3 - Hydroxycrotonic acid methyl ester dimethyl phosphate
  12. CMDP
  13. Dimethyl (1 - methoxycarboxypropen - 2 - yl) phosphate
  14. Dimethyl 2 - methoxycarbonyl - 1 - methylvinyl phosphate
  15. Dimethyl methoxycarbonylpropenyl phosphate
  16. Dimethyl - 1 - carbomethoxy - 1 - propen - 2 - yl phosphate
  17. ENT 22,374
  1. Fosdrin
  2. Gesfid
  3. Meniphos
  4. Methyl 3 - (dimethoxyphosphinyloxy) crotonate
  5. Mevinfos (Dutch)
  6. Mevinphos
  7. Mevinphos (ACGIH:OSHA)
  8. O,O - Dimethyl O - (1 - methyl - 2 - carboxyvinyl) phosphate
  9. O,O - Dimethyl - O - (2 - carbomethoxy - 1 - methylvinyl) phosphate
  10. O,O - Dimethyl - O - 2 - methoxycarbonyl - 1 - methyl - vinyl - phosphat (German)
  11. PD 5 (pesticide)
  12. Phosdrin (OSHA)
  13. Phosphate de dimethyle et de 2 - methoxycarbonyl - 1 methylvinyle (French)
  14. Phosphoric acid, (1 - methoxycarboxypropen - 2 - yl) dimethyl ester
  15. Phosphoric acid, dimethyl ester, ester with methyl 3 - hydroxycrotonate
  16. alpha - 2 - Carbomethoxy - 1 - methylvinyl dimethyl phosphate


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
mutation in microorganisms Salmonella typhimurium 2,500 g/plate (+enzymatic activation step) CHYCDW 20,12,1986
sister chromatid exchange human lymphocyte 2 mg/L MUREAV 102,89,1982


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lethal concentration (50 percent kill): 14 ppm/1 hour Behavioral: Tremor

Lung, Thorax, or Respiration: Acute pulmonary edema

Gastrointestinal: Changes in structure or function of salivary glands
AMIHBC 9,45,1954
inhalation
rat
lethal concentration (50 percent kill): 0.125 gm/m3/1 hour Lung, Thorax, or Respiration: Acute pulmonary edema

Gastrointestinal: Changes in structure or function of salivary glands
ENTOX* -,104,2005
intraperitoneal
gerbil
lethal dose (50 percent kill): 450 g/kg N/R TXAPA9 36,195,1976
intraperitoneal
mouse
lethal dose (50 percent kill): 2 mg/kg N/R CJBPAZ 39,1790,1961
intraperitoneal
rat
lethal dose (50 percent kill): 800 g/kg N/R APCRAW 4,117,1961
intravenous
mouse
lethal dose (50 percent kill): 680 g/kg N/R JPPMAB 19,612,1967
oral
wild bird
lethal dose (50 percent kill): 1,400 g/kg N/R JTCEEM 6(3),175,1986
oral
duck
lethal dose (50 percent kill): 4,600 g/kg N/R DOEAAH 35,25,1979
oral
man
lowest published toxic dose: 700 g/kg/28 day- intermittent Peripheral Nerve and Sensation: Recording from peripheral motor nerve TXAPA9 42,351,1977
oral
mouse
lethal dose (50 percent kill): 4 mg/kg Gastrointestinal: Changes in structure or function of salivary glands

Behavioral: Tremor

Lung, Thorax, or Respiration: Respiratory depression
AMIHBC 9,45,1954
oral
pigeon
lethal dose (50 percent kill): 4,210 g/kg N/R ASTTA8 (680),157,1979
oral
quail
lethal dose (50 percent kill): 23,700 g/kg N/R ASTTA8 (680),157,1979
oral
rat
lethal dose (50 percent kill): 3 mg/kg N/R DOEAAH 35,25,1979
subcutaneous
mouse
lethal dose (50 percent kill): 1,180 g/kg N/R JPPMAB 19,612,1967
subcutaneous
rat
lethal dose (50 percent kill): 940 g/kg N/R FOLMA8 24(4),23,1982
skin
duck
lethal dose (50 percent kill): 11 mg/kg N/R TXAPA9 47,451,1979
skin
mouse
lethal dose (50 percent kill): 12 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase JTEHD6 9,491,1982
skin
mouse
lethal dose (50 percent kill): 40 mg/kg N/R ENTOX* -,104,2005
skin
rat
lethal dose (50 percent kill): 4,200 g/kg Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Excitement
TXAPA9 2,88,1960
skin
rat
lethal dose (50 percent kill): 4.2 mg/kg N/R ENTOX* -,104,2005
skin
rabbit
lethal dose (50 percent kill): 4,700 g/kg N/R GUCHAZ 6,353,1973


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
human
lowest published toxic dose: 700 g/kg/28 day- intermittent Peripheral Nerve and Sensation: Recording from peripheral motor nerve

Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
HBPTO* 2,1069,2001
oral
rat
lowest published toxic dose: 5,400 mg/kg/90 day- continuous Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase CHYCDW 20,12,1986
oral
rat
lowest published toxic dose: 150 mg/kg/60 day- continuous Gastrointestinal: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
AMIHBC 9,45,1954


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value short term exposure limit 0.01 mg/m3 (inhal, vapor, skin) DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not classifiable as human carcinogen DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
AQMOAC #73-19,1973
TOXICOLOGY REVIEW
RREVAH 46,1,1973
TOXICOLOGY REVIEW
DTTIAF 80,485,1973
TOXICOLOGY REVIEW
RREVAH 63,1,1976
TOXICOLOGY REVIEW
MUTAEX 21,93,2006
TOXICOLOGY REVIEW
ENTOX* -,104,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: RED Completed RBREV* -,134,1998
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 0.1 mg/m3 (skin) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.1 mg/m3 (skin) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 0.1 mg/m3 (skin) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 0.1 mg/m3 (skin) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 0.01 ppm (0.1 mg/m3), Skin, JAN1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.01 ppm (0.092 mg/m3), short term exposure limit 0.03 ppm (0.27 mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 0.01 mg/m3 (vapor, aerosol), Skin, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 0.01 ppm (0.1 mg/m3), OCT 2002
Occupational Exposure Limit - FINLAND time-weighted average 0.001 ppm, JAN1999
Occupational Exposure Limit - FRANCE VME 0.01 ppm (0.1 mg/m3), Skin, FEB2006
Occupational Exposure Limit - GERMANY MAK 0.093 mg/m3 (0.01 mL/m3), 2005
Occupational Exposure Limit - KOREA time-weighted average 0.01 ppm (0.1 mg/m3), short term exposure limit 0.03 ppm (0.3 mg/m3), skin,2006
Occupational Exposure Limit - MEXICO time-weighted average 0.01 ppm (0.1 mg/m3);
short term exposure limit 0.03 ppm (skin), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.1 mg/m3, Skin, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 0.01 ppm (0.092 mg/m3), skin, JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 25 ppm (125 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.1 mg/m3, Skin, JAN1993
Occupational Exposure Limit - SWITZERLAND MAK- week 0.01 ppm (0.1 mg/m3),KZG- week 0.02 ppm (0.2 mg/m3), Skin, DEC2006
Occupational Exposure Limit - THAILAND time-weighted average 0.1 mg/m3, JAN1993
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not classifiable as human carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not classifiable as human carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO PHOSDRIN-air 10 hour time-weighted average 0.01 ppm;
short term exposure limit 0.03 ppm (Sk)
NIOSH* DHHS #92-100,1992


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Organophosphorus pesticides, 5600


REFERENCES:

CODEN
REFERENCE

AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
APCRAW Advances in Pest Control Research. (New York, NY) V.1-18, 1957-68.
AQMOAC Air Quality Monographs. (Washington, DC) No.69-1 - No.75-25, 1969-75(?). Discontinued.
ASTTA8 ASTM Special Technical Publication. (American Soc. for Testing Materials, 1916 Race St., Philadelphia, PA 19103) No.1- 1911-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CHYCDW Zhonghua Yufangyixue Zazhi. Chinese Journal of Preventive Medicine. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) Beginning history not known.
CJBPAZ Canadian Journal of Biochemistry and Physiology. (Ottawa, Ont., Canada) V.32-41, 1954-63. For publisher information, see CJBIAE.
DOEAAH Down to Earth. (Dow Chemical USA, Agricultural Products Dept., Midland, MI 48640) V.1- 1945-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
DTTIAF Deutsche Tieraerztliche Wochenschrift. (Hanover, Fed. Rep. Ger.) V.1-77, 1893-1970.
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
FOLMA8 Folia Medica (Plovdiv). (Higher Medical Institute I.P. Pavlov, Plovdiv, Bulgaria) V.1- 1959-
GUCHAZ Guide to the Chemicals Used in Crop Protection. (Information Canada, 171 Slater St., Ottawa, Ont., Canada)
HBPTO* Handbook of pesticide toxicology. Robert Krieger ed, Academic press, 2001
JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of Great Britain, 1 Lambeth High St., London SEI 7JN, UK) V.1- 1949-
JTCEEM Journal de Toxicologie Clinique et Experimentale. (SPPIF, B.P.22, F-41353 Vineuil, France) V.5- 1985-
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

RTECS Compound Description:
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   Mutagen
   Human Data

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