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m - Cresol, 4,4' - thiobis (6 - tert - butyl -

RTECS #: GP3150000

CAS #: 96-69-5


UPDATE: May 2009 MW: 358.58 MF: C22H30O2S


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 1,1' - Thiobis (2 - methyl - 4 - hydroxy - 5 - tert - butylbenzene)
  2. 4,4' - Thiobis
  3. 4,4' - Thiobis (2 - (1,1 - dimethylethyl) - 5 - methylphenol)
  4. 4,4' - Thiobis (2 - tert - butyl - 5 - methylphenol)
  5. 4,4' - Thiobis (3 - methyl - 6 - tert - butylphenol)
  6. 4,4' - Thiobis (6 - tert - butyl - 3 - methylphenol)
  7. 4,4' - Thiobis (6 - tert - butyl - m - cresol)
  8. 4,4' - Thiobis (6 - tert - butyl - m - cresol) (ACGIH,OSHA)
  9. AO 4
  10. Antage Crystal
  11. Antioxidant AO
  12. Antioxidant TMB 6
  13. Bis (3 - tert - butyl - 4 - hydroxy - 6 - methylphenyl) sulfide
  14. Bis (4 - hydroxy - 5 - tert - butyl - 2 - methylphenyl) sulfide
  15. Disperse MB - 61
  16. Nocrac 300
  1. Nonflex BPS
  2. Phenol, 4,4' - thiobis (2 - (1,1 - dimethylethyl) - 5 - methyl - (9CI)
  3. Santonox
  4. Santonox BM
  5. Santonox R
  6. Santowhite crystals
  7. Santox
  8. Sumilizer WX
  9. Sumilizer WX - R
  10. Thioalkofen BM 4
  11. Thioalkofen BMCH
  12. Thioalkofen MBCH
  13. Thioalkophene BM - 4
  14. USAF B - 15
  15. Yoshinox S
  16. Yoshinox SR


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 5,508.3 mg/kg (61 day male) Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands
ARTODN 80,225,2006
oral
mouse
lowest published toxic dose: 25,803 mg/kg (61 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands
ARTODN 80,225,2006
oral
rat
lowest published toxic dose: 11,742.5 mg/kg (61 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands
ARTODN 80,225,2006


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
mouse
lethal dose (50 percent kill): 50 mg/kg N/R NTIS** AD277-689
oral
rat
lethal dose (50 percent kill): 2,345 mg/kg N/R IPSTB3 3,93,1976
oral
rabbit
lethal dose (50 percent kill): 3,200 mg/kg N/R IPSTB3 3,93,1976


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 1,400 mg/kg/14 day- intermittent Liver: Changes in liver weight

Endocrine: Changes in spleen weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
FAATDF 10,691,1988
oral
mouse
lowest published toxic dose: 5,915 mg/kg/13 week- continuous Liver: Changes in liver weight

Endocrine: Changes in spleen weight
NTPTR* NTP-TR-435,1994
oral
mouse
lowest published toxic dose: 5,508.3 mg/kg/61 day- intermittent Related to Chronic Data: Changes in testicular weight ARTODN 80,225,2006
oral
mouse
lowest published toxic dose: 10,980 mg/kg/61 day- intermittent Endocrine: Androgenic ARTODN 80,225,2006
oral
mouse
lowest published toxic dose: 25,803 mg/kg/61 day- intermittent Liver: Changes in liver weight

Related to Chronic Data: Changes in prostate weight

Related to Chronic Data: Changes in testicular weight
ARTODN 80,225,2006
oral
mouse
lowest published toxic dose: 18,239 mg/kg/61 day- intermittent Nutritional and Gross Metabolic: Body temperature decrease

Related to Chronic Data: Changes in uterine weight
ARTODN 80,225,2006
oral
rat
lowest published toxic dose: 5,475 mg/kg/15 day- continuous Gastrointestinal: Ulceration or bleeding from stomach

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Changes in leukocyte (WBC) count
NTPTR* NTP-TR-435,1994
oral
rat
lowest published toxic dose: 15,015 mg/kg/13 week- continuous Liver: Changes in liver weight

Blood: Normocytic anemia

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
NTPTR* NTP-TR-435,1994
oral
rat
lowest published toxic dose: 11,742.5 mg/kg/61 day- intermittent Blood: Changes in spleen

Related to Chronic Data: Changes in prostate weight

Related to Chronic Data: Changes in testicular weight
ARTODN 80,225,2006
subcutaneous
mouse
lowest published toxic dose: 150 mg/kg/3 day- intermittent Related to Chronic Data: Changes in uterine weight ARTODN 80,225,2006
subcutaneous
mouse
lowest published toxic dose: 240 mg/kg/4 day- intermittent Related to Chronic Data: Changes in uterine weight ARTODN 80,225,2006


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 10 mg/m3 DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not classifiable as human carcinogen DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
MUREAV 543,201,2003
TOXICOLOGY REVIEW
TOPADD 33,517,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 15 mg/m3, total dust CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 5 mg/m3, respirable fraction CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 15 mg/m3, total dust CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 5 mg/m3, respirable fraction CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 15 mg/m3, total dust CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 5 mg/m3, respirable fraction CFRGBR 29,1915.1000,1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 10 mg/m3, JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 10 mg/m3, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 10 mg/m3, OCT 2002
Occupational Exposure Limit - FRANCE VME 10 mg/m3, FEB2006
Occupational Exposure Limit - KOREA time-weighted average 10 mg/m3, 2006
Occupational Exposure Limit - MEXICO time-weighted average 10 mg/m3;
short term exposure limit 20 mg/m3, 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 10 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 10 mg/m3, JAN2002
Occupational Exposure Limit - SWITZERLAND MAK- week 10 mg/m3, DEC2006
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 10 mg/m3;
short term exposure limit 20 mg/m3, 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not classifiable as human carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not classifiable as human carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO 4,4'-THIOBIS(6-t-BUTYL-m-CRESOL), dust-air time-weighted average 10 mg/m3 NIOSH* DHHS #92-100,1992
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO 4,4'-THIOBIS(6-t-BUTYL-m-CRESOL)-air 10 hour time-weighted average 5 mg/m3 NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 84755;
Number of Industries 51;
Total Number of Facilities 4,402;
Number of Occupations 47;
Total Number of Employees Exposed 36,695
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84755;
Number of Industries 10;
Total Number of Facilities 1,286;
Number of Occupations 11;
Total Number of Employees Exposed 12,349;
Total Number of Female Employees Exposed 2,177


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as an antioxidant in rubber and plastics industry
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9277;8EHQ-0892-9283
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (feed);no evidence:mouse,rat


REFERENCES:

CODEN
REFERENCE

ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
IPSTB3 International Polymer Science and Technology. (Rapra Technology Ltd., Shawbury, Shrewsbury, Shropshire SY4 4NR, UK)
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
TOPADD Toxicologic Pathology. (c/o Dr. F.A. de la Iglesia, Warner-Lambert Co., Pharmaceutical Research Div., POB 1047, Ann Arbor, MI 48106) V.6(3/4)- 1978-

Used as an antioxidant in rubber and plastics industry

RTECS Compound Description:
   Tumorigen
   Reproductive Effector

Click Here for Additional Information about RTECS

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