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1,3 - Butadiene

RTECS #: EI9275000

CAS #: 106-99-0


UPDATE: May 2009 MW: 54.10 MF: C4H6


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. 1,3 - Butadiene (ACGIH:OSHA)
  2. Biethylene
  3. Bivinyl
  4. Buta - 1,3 - dieen (Dutch)
  5. Buta - 1,3 - dien (German)
  6. Buta - 1,3 - diene
  7. Butadieen (Dutch)
  8. Butadien (Polish)
  9. Butadiene
  1. Butadiene (OSHA)
  2. Butadiene - 1,3
  3. Divinyl
  4. Erythrene
  5. NCI - C50602
  6. Pyrrolylene
  7. Vinylethylene
  8. alpha,gamma - Butadiene


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis hamster lung 20 pph/6 hour (+/-enzymatic activation step) MUREAV 652,122,2008
cytogenetic analysis inhalation
mouse
625 ppm/6 hour/10 day- intermittent ENMUDM 9,235,1987
cytogenetic analysis inhalation
mouse
1,250 ppm/5 day/2 week- intermittent TOXID9 66,71,2002
cytogenetic analysis inhalation
rat
1,250 ppm/5 day/2 week- intermittent TOXID9 66,71,2002
dominant lethal test inhalation
mouse
1,250 ppm/6 hour/10 week- intermittent MUREAV 309,295,1994
DNA adduct inhalation
mouse
200 ppm/5 day/6 hour- continuous MUREAV 397,3,1998
DNA adduct inhalation
mouse
20 ppm/6 hour CBINA8 147,195,2004
DNA adduct inhalation
mouse
1 ppm/5 day CBINA8 147,195,2004
DNA adduct inhalation
mouse
21 mg/kg/6 hour CBINA8 148,69,2004
DNA adduct inhalation
mouse
20 ppm MUREAV 577S,1,2005
DNA adduct inhalation
rat
20 ppm/6 hour CBINA8 147,195,2004
DNA adduct inhalation
rat
1 ppm/5 day CBINA8 147,195,2004
DNA adduct inhalation
rat
10 mg/kg/6 hour CBINA8 148,69,2004
DNA damage inhalation
mouse
125 ppm/6 hour- continuous MUREAV 397,67,1998
DNA damage inhalation
mouse
20 ppm/1 year- intermittent CBINA8 135-136,373,2001
DNA damage inhalation
mouse
1,250 ppm/2 week- intermittent EMMUEG 43,75,2004
DNA damage mouse lung 500 g/L/6 hour/28 day- intermittent MUREAV 608,49,2006
DNA damage inhalation
rat
1,250 ppm/2 week- intermittent EMMUEG 43,75,2004
DNA repair mouse lung 500 g/L/6 hour/28 day- intermittent MUREAV 608,49,2006
mutation in microorganisms Salmonella typhimurium 20 pph/20 hour- continuous (+enzymatic activation step) TOERD9 3,131,1981
mutation in microorganisms Salmonella typhimurium 2 pph (-enzymatic activation step) TOLED5 6,125,1980
micronucleus test inhalation
mouse
6,250 ppb/6 hour/13 week- intermittent MUREAV 209,171,1988
micronucleus test inhalation
mouse
500 ppm/5 day MUREAV 491,81,2001
micronucleus test mouse lung 500 g/L/6 hour/28 day- intermittent MUREAV 608,49,2006
mutation in mammalian somatic cells mouse lymphocyte 20 pph ENMUDM 8(Suppl 6),75,1986
mutation in mammalian somatic cells inhalation
mouse
625 ppm/6 hour/2 week- intermittent CRNGDP 15,719,1994
sister chromatid exchange hamster ovary 25 mol/L MUREAV 263,47,1991
sister chromatid exchange human lymphocyte 500 mol/L MUREAV 261,117,1991
sister chromatid exchange inhalation
mouse
6,250 ppb/6 hour/10 day- intermittent ENMUDM 9,235,1987
specific locus test inhalation
human
150 ppb/24 year EMMUEG 41,140,2003
specific locus test inhalation
mouse
500 ppm/6 hour/5 day- continuous MUREAV 309,307,1994
specific locus test inhalation
mouse
3 ppm/14 day- intermittent CBINA8 135-136,343,2001
specific locus test inhalation
mouse
1,250 ppm/2 week- intermittent EMMUEG 43,75,2004
specific locus test inhalation
mouse
20 ppm/6 hour/4 week TOXID9 78,391,2004
specific locus test inhalation
mouse
20 ppm MUREAV 577S,1,2005
specific locus test inhalation
mouse
1,250 ppm/2 week/6 hour EMMUEG 43,75,2004
specific locus test inhalation
mouse
20 ppm/7 hour/24 day EMMUEG 42,106,2003
specific locus test inhalation
rat
1,250 ppm/2 week- intermittent EMMUEG 43,75,2004
specific locus test inhalation
rat
1,250 ppm/2 week/6 hour EMMUEG 43,75,2004
sperm morphology inhalation
mouse
130 ppm/5 day/6 hour- continuous MUREAV 397,55,1998
heritable translocation test inhalation
mouse
500 ppm/6 hour/5 day- continuous MUREAV 397,85,1998


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lowest published toxic concentration: 500 ppm/6 hour (5 day male) Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Effects on embryo or fetus: Cytological changes (including somatic cell genetic material)
MUREAV 397,55,1998
inhalation
mouse
lowest published toxic concentration: 1,000 ppm/6 hour (6-15 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
EVHPAZ 86,79,1990
inhalation
mouse
lowest published toxic concentration: 1,000 ppm/6 hour (6-15 day pregnant) Reproductive: Maternal effects: Uterus, cervix, vagina EVHPAZ 86,79,1990
inhalation
rat
lowest published toxic concentration: 8,000 ppm/6 hour (6-15 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system EPASR* 8EHQ-0382-0441


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lowest published toxic concentration: 625 ppm/6 hour/13 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Olfaction: Tumors

Cardiac: Tumors
CNREA8 50,6592,1990
inhalation
mouse
toxic concentration (other than lowest) : 200 ppm/40 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Gastrointestinal: Tumors
EVHPAZ 86,37,1990
inhalation
mouse
toxic concentration (other than lowest) : 625 ppm/6 hour/65 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Eye: Tumors

Cardiac: Tumors
EVHPAZ 86,27,1990
inhalation
mouse
toxic concentration (other than lowest) : 63 ppm/6 hour/2 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Vascular: Tumors

Liver: Tumors
NTPTR* NTP-TR-434,1993
inhalation
mouse
toxic concentration (other than lowest) : 200 ppm/6 hour/1 year- intermittent Tumorigenic: Neoplastic by RTECS criteria

Gastrointestinal: Tumors

Tumorigenic: Increased incidence of tumors in susceptible strains
CBINA8 135-136,373,2001
inhalation
mouse
lowest published toxic concentration: 20 ppm/6 hour/1 year- intermittent Tumorigenic: Neoplastic by RTECS criteria

Gastrointestinal: Tumors

Tumorigenic: Increased incidence of tumors in susceptible strains
CBINA8 135-136,373,2001
inhalation
mouse
toxic concentration (other than lowest) : 216 mg/kg/8 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Other changes
CALEDQ 152,129,2000
inhalation
mouse
lowest published toxic concentration: 22,500 mg/kg/60 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Cardiac: Tumors

Lung, Thorax, or Respiration: Tumors
NTIS** PB85-179646/AS
inhalation
mouse
lowest published toxic concentration: 22,875 mg/kg/61 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Cardiac: Tumors

Lung, Thorax, or Respiration: Tumors
NTIS** PB85-179646/AS
inhalation
mouse
lowest published toxic concentration: 45,750 mg/kg/61 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Skin and Appendages: Tumors
NTIS** PB85-179646/AS
inhalation
mouse
lowest published toxic concentration: 1,730.4 mg/kg/103 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Blood: Lymphoma including Hodgkin's disease
NTIS** PB94-101631
inhalation
mouse
lowest published toxic concentration: 540.75 mg/kg/103 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Blood: Lymphoma including Hodgkin's disease
NTIS** PB94-101631
inhalation
mouse
lowest published toxic concentration: 625 ppm/6 hour/13 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Brain and Coverings: Tumors
TOPADD 33,307,2005
inhalation
rat
lowest published toxic concentration: 625 ppm/6 hour/61 week Tumorigenic: Carcinogenic by RTECS criteria

Cardiac: Tumors

Lung, Thorax, or Respiration: Tumors
NTPTR* NTP-TR-288,1984
inhalation
rat
toxic concentration (other than lowest) : 1,000 ppm/6 hour/2 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Skin and Appendages: Tumors
AIHAAP 48,407,1987
inhalation
rat
toxic concentration (other than lowest) : 8,000 ppm/6 hour/2 year- intermittent Tumorigenic: Neoplastic by RTECS criteria

Gastrointestinal: Tumors

Endocrine: Thyroid tumors
AIHAAP 48,407,1987
inhalation
rat
toxic concentration (other than lowest) : 8,000 ppm/6 hour/15 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Endocrine: Tumors
EPASR* 8EHQ-0482-0370
inhalation
rat
toxic concentration (other than lowest) : 8,000 ppm/6 hour/2 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Endocrine: Thyroid tumors

Skin and Appendages: Tumors
EVHPAZ 86,19,1990


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
human
lowest published toxic concentration: 2,000 ppm/7 hour Eye: Other eye effects

Behavioral: Hallucinations, distorted perceptions
JIHTAB 26,69,1944
inhalation
human
lowest published toxic concentration: 8,000 ppm Eye: Visual field changes

Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Cough
INMEAF 17,199,1948
inhalation
human
lowest published toxic concentration: 1 pph/5 minute Cardiac: Pulse rate decreased with fall in BP

Gastrointestinal: Changes in structure or function of salivary glands
VCVGH* -,60,1990
inhalation
mouse
lethal concentration (50 percent kill): 270,000 mg/m3/2 hour N/R VCVGH* -,60,1990
inhalation
mouse
lethal concentration (16 percent kill): 203,000 mg/m3/2 hour N/R VCVGH* -,60,1990
inhalation
mouse
lethal concentration (84 percent kill): 375,000 mg/m3/2 hour N/R VCVGH* -,60,1990
inhalation
mouse
lowest published toxic concentration: 62.5 ppm/6 hour Kidney, Ureter, and Bladder: Other changes in urine composition

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
TOXID9 72(Suppl 1),242,2003
inhalation
mouse
lethal concentration (50 percent kill): 117,000 ppm/4 hour N/R ENTOX* -,353,2005
inhalation
rat
lethal concentration (50 percent kill): 285 gm/m3/4 hour Behavioral: General anesthetic

Lung, Thorax, or Respiration: Respiratory depression
RPTOAN 31,162,1968
inhalation
rat
lethal concentration (50 percent kill): 285,000 mg/m3/4 hour N/R VCVGH* -,60,1990
inhalation
rat
lethal concentration (16 percent kill): 175,000 mg/m3/4 hour N/R VCVGH* -,60,1990
inhalation
rat
lethal concentration (84 percent kill): 460,000 mg/m3/4 hour N/R VCVGH* -,60,1990
inhalation
rat
lowest published toxic concentration: 62.5 ppm/6 hour Kidney, Ureter, and Bladder: Other changes in urine composition

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
TOXID9 72(Suppl 1),242,2003
inhalation
rat
lethal concentration (50 percent kill): 128,000 ppm/4 hour N/R ENTOX* -,353,2005
inhalation
rabbit
lowest published lethal concentration: 25 pph/23 minute Eye: Mydriasis (pupilliary dilation)

Behavioral: Tremor

Behavioral: Muscle weakness
JIHTAB 26,69,1944
inhalation
rabbit
lowest published lethal concentration: 250,000 ppm N/R VCVGH* -,60,1990
inhalation
rabbit
lowest published toxic concentration: 200,000 mg/m3/2 hour Blood: Changes in leukocyte (WBC) count VCVGH* -,60,1990
oral
mouse
lethal dose (50 percent kill): 3,210 mg/kg N/R ENTOX* -,353,2005
oral
rat
lethal dose (50 percent kill): 5,480 mg/kg N/R ENTOX* -,353,2005


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
guinea pig
lowest published toxic concentration: 14,800 mg/m3/7 hour/32 week- intermittent Kidney, Ureter, and Bladder: Other changes VCVGH* -,61,1990
inhalation
mouse
lowest published toxic concentration: 1,250 ppm/6 hour/14 week- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTPTR* NTP-TR-288,1984
inhalation
mouse
lowest published toxic concentration: 1,250 ppm/6 hour/6 week- intermittent Blood: Normocytic anemia

Blood: Changes in bone marrow not included in above

Blood: Changes in erythrocyte (RBC) count
TXAPA9 85,450,1986
inhalation
mouse
lowest published toxic concentration: 1,250 ppm/6 hour/24 week- intermittent Blood: Pigmented or nucleated red blood cells

Blood: Changes in erythrocyte (RBC) count

Blood: Changes in leukocyte (WBC) count
TXAPA9 83,95,1986
inhalation
mouse
lowest published toxic concentration: 8,000 ppm/6 hour/15 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain NTPTR* NTP-TR-288,1984
inhalation
mouse
lowest published toxic concentration: 500 ppm/9 day- intermittent Blood: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TIHEEC 21,15,2005
inhalation
mouse
lowest published toxic concentration: 1,000 ppm/20 hour/4 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain TIHEEC 21,15,2005
inhalation
mouse
lowest published toxic concentration: 500 ppm/25 hour/5 day- intermittent Blood: Other changes TIHEEC 21,15,2005
inhalation
rat
lowest published toxic concentration: 1,000 ppm/6 hour/13 week- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight
FAATDF 32,1,1996
inhalation
rat
lowest published toxic concentration: 1,000 ppm/6 hour/1 year- intermittent Liver: Changes in liver weight

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
AIHAAP 48,407,1987
inhalation
rat
lowest published toxic concentration: 2,200 mg/m3/4 hour/17 week- intermittent Blood: Luekopenia

Biochemical: Metabolism (intermediary): Lipids including transport

Biochemical: Metabolism (intermediary): Other proteins
GISAAA 31(12),18,1966
inhalation
rat
lowest published toxic concentration: 8,000 ppm/6 hour/2 year- intermittent Behavioral: Ataxia

Kidney, Ureter, and Bladder: Changes in bladder weight

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTIS** OTS0538010
inhalation
rabbit
lowest published toxic concentration: 100 mg/m3/4 hour/17 week- intermittent Immunological Including Allergic: Decrease in cellular immune response

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
GISAAA 31(12),18,1966


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 2 ppm DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Suspected human carcinogen DTLVS* TLV/BEI,2007
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 39,155,1986
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 71,109,1999
International Agency for Research on Cancer (IARC) Cancer Review Animal SUFFICENT EVIDENCE IMEMDT 54,237,1992
International Agency for Research on Cancer (IARC) Cancer Review Human LIMITED EVIDENC IMEMDT 54,237,1992
International Agency for Research on Cancer (IARC) Cancer Review Human Limited Evidence IMEMDT 71,109,1999
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 39,155,1986
International Agency for Research on Cancer (IARC) Cancer Review Group 2A IMEMDT 71,109,1999
TOXICOLOGY REVIEW
MUREAV 566,21,2004
TOXICOLOGY REVIEW
CBINA8 135-136,65,2001
TOXICOLOGY REVIEW
TOLED5 134,51,2002
TOXICOLOGY REVIEW
TOLED5 134,31,2002
TOXICOLOGY REVIEW
MUREAV 543,201,2003
TOXICOLOGY REVIEW
MUREAV 543,201,2003
TOXICOLOGY REVIEW
MUREAV 567,227,2004
TOXICOLOGY REVIEW
MUREAV 567,109,2004
TOXICOLOGY REVIEW
MUREAV 567,347,2004
TOXICOLOGY REVIEW
MUTAEX 14,141,1999
TOXICOLOGY REVIEW
MUREAV 566,209,2004
TOXICOLOGY REVIEW
ENTOX* -,353,2005
TOXICOLOGY REVIEW
FCTOD7 44,1699,2006
TOXICOLOGY REVIEW
MUREAV 627,10,2007
TOXICOLOGY REVIEW
MUREAV 584,1,2005
TOXICOLOGY REVIEW
BCLPT* 96,131,2005
TOXICOLOGY REVIEW
MUREAV 636,95,2007
TOXICOLOGY REVIEW
JTEHD6 6,55,2003
TOXICOLOGY REVIEW
REPTED 25,192,2008
TOXICOLOGY REVIEW
MUREAV 544,273,2003
TOXICOLOGY REVIEW
REPTED 23,428,2007
TOXICOLOGY REVIEW
MUREAV 658,215,2008
TOXICOLOGY REVIEW
MUREAV 659,202,2008
TOXICOLOGY REVIEW
MUREAV 659,202,2008
TOXICOLOGY REVIEW
MUREAV 544,313,2003
TOXICOLOGY REVIEW
MUREAV 544,339,2003
TOXICOLOGY REVIEW
HUTOX* -,577,1996
TOXICOLOGY REVIEW
MUREAV 608,136,2006
TOXICOLOGY REVIEW
HTOPA* 1,501,2002
TOXICOLOGY REVIEW
MUREAV 543,195,2003
TOXICOLOGY REVIEW
MUREAV 681,3,2009
TOXICOLOGY REVIEW
MUREAV 681,93,2009


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 1000 ppm (2200 mg/m3) DTLVS* 3,28,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 1000 ppm (2200 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 1000 ppm (2200 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 1000 ppm (2200 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 1000 ppm (2200 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 10 ppm (22 mg/m3), Carcinogen, JUL2008
Occupational Exposure Limit - AUSTRIA TRK 11 mg/m3 (5 mL/m3), JAN 2006
Occupational Exposure Limit - AUSTRIA TRK 34 mg/m3 (15 mL/m3), JAN 2006
Occupational Exposure Limit - BELGIUM time-weighted average 2 ppm (4.5 mg/m3), Carcinogen, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 10 ppm (22 mg/m3), OCT 2002
Occupational Exposure Limit - FINLAND time-weighted average 50 ppm (73 mg/m3), Carcinogen, JAN1999
Occupational Exposure Limit - HUNGARY ceiling concentration 1 mg/m3, Carcinogen, SEP2000
Occupational Exposure Limit - KOREA time-weighted average 10 ppm (22 mg/m3), 2006
Occupational Exposure Limit - MEXICO time-weighted average 1000 ppm (2200 mg/m3);
short term exposure limit 1250 ppm, 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 46.2 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 10 ppm (22 mg/m3), JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 1 ppm (2.2 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 1000 ppm (2200 mg/m3), JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 10 mg/m3, short term exposure limit 40 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 100 mg/m3, MAR2004
Occupational Exposure Limit - SWEDEN time-weighted average 0.5 ppm (1 mg/m3);
short term exposure limit 5 ppm (10 mg/m3), Carcinogen, JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 5 ppm (11 mg/m3), Carcinogen, DEC2006
Occupational Exposure Limit - TURKEY time-weighted average 1000 ppm (2200 mg/m3), JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 10 ppm (22 mg/m3), 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Suspected human carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Suspected human carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO 1,3-BUTADIENE-air Carcinogen lowest feasible conc. NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 13410;
Number of Industries 26;
Total Number of Facilities 3,086;
Number of Occupations 71;
Total Number of Employees Exposed 66,326
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 13410;
Number of Industries 20;
Total Number of Facilities 2,201;
Number of Occupations 34;
Total Number of Employees Exposed 51,971;
Total Number of Female Employees Exposed 1,410


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in production of SBR, POLYBUTADIENE RUBBER, NITRILE RUBBER,NEOPRENE and ABS resins
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH CURRENT INTELLIGENCE BULLETIN 41, 1984
NIOSH Analytical Method, 1994: 1,3-Butadiene, 1024
NCI Carcinogenesis Studies (inhal);clear evidence:mouse
NTP Carcinogenesis studies (inhalation);clear evidence:mouse NTPTR* NTP-TR-434,1993
NTP 11th Report on Carcinogens,2004:Known to be human carcinogen
OSHA ANALYTICAL METHOD #ID-56


REFERENCES:

CODEN
REFERENCE

AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
BCLPT* Basic & clinical pharmacology & toxicology (Copenhagen, Denmark : Nordic Pharmacological Society Oxford, UK : Distributed by Blackwell Munksgaard) V.94- 2004-
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975-
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown.
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
HTOPA*
HUTOX*
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
INMEAF Industrial Medicine. (Chicago, IL) V.1-18, 1932-49. For publisher information, see IOHSA5.
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Used in production of SBR, POLYBUTADIENE RUBBER, NITRILE RUBBER,NEOPRENE and ABS resins

Top 50 chemical production: 3.18 billions lbs in 1992, 3.05 billions in 1991

NIOSH PROFILE (ALKENES), SRI, 2/77

NIOSH PROFILE (ALKENES), SRC, 4/78

RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector
   Human Data

ALT CAS #: 130983-70-9
Click Here for Additional Information about RTECS

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