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p - Anisidine

RTECS #: BZ5450000

CAS #: 104-94-9


UPDATE: May 2009 MW: 123.17 MF: C7H9NO


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 1 - Amino - 4 - methoxybenzene
  2. 4 - Aminoanisole
  3. 4 - Anisidine
  4. 4 - Methoxy - 1 - aminobenzene
  5. 4 - Methoxyaniline
  6. 4 - Methoxybenzenamine
  7. 4 - Methoxybenzeneamine
  8. Aniline, p - methoxy -
  1. Anisole, p - amino -
  2. Benzenamine, 4 - methoxy - (9CI)
  3. p - Aminoanisole
  4. p - Anisidine (ACGIH:OSHA)
  5. p - Anisylamine
  6. p - Methoxyaniline
  7. p - Methoxyphenylamine


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis hamster ovary 160 mg/L EMMUEG 10(Suppl 10),1,1987
DNA damage mouse lymphocyte 202 Ámol/L MUREAV 203,155,1988
DNA damage mouse other cell types 32 mg/L/24 hour (-enzymatic activation step) MUREAV 541,9,2003
DNA inhibition oral
mouse
200 mg/kg MUREAV 46,305,1977
DNA repair Escherichia coli 39 mmol/L MUREAV 272,145,1992
host-mediated assay mouse
Escherichia coli
780 mg/kg MUREAV 272,161,1992
mutation in microorganisms mouse lymphocyte 196 Ámol/L (+enzymatic activation step) MUTAEX 3,193,1988
mutation in microorganisms Salmonella typhimurium 1 mg/plate (-enzymatic activation step) ENMUDM 5(Suppl 1),3,1983
mutation in mammalian somatic cells mouse lymphocyte 392 Ámol/L MUTAEX 3,193,1988
morphological transform hamster embryo 6.16 mg/L/7 day MUTAEX 20,51,2005
sister chromatid exchange hamster ovary 14 mg/L EMMUEG 10(Suppl 10),1,1987
specific locus test mouse Ascites tumor 32 mg/L/24 hour EMMUEG 42,91,2003


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
mouse
lethal dose (50 percent kill): 806 mg/kg N/R JMCMAR 17,900,1974
intraperitoneal
rat
lethal dose (50 percent kill): 1,400 mg/kg N/R AGGHAR 15,447,1957
ocular
rabbit
lowest published toxic dose: 100 pph Eye: Conjunctiva irritation TPKVAL 4,91,1962
oral
mouse
lethal dose (50 percent kill): 1,410 mg/kg Eye: Other eye effects

Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Ataxia
ATDAEI 1,184,1992
oral
mouse
lowest published lethal dose: 295.6 mg/kg Cardiac: Other changes

Liver: Fatty liver degeneration

Liver: Other changes
TPKVAL 4,91,1962
oral
rat
lethal dose (50 percent kill): 1,320 mg/kg N/R TLSMA6 128,14,1979
oral
rabbit
lethal dose (50 percent kill): 2,900 mg/kg Kidney, Ureter, and Bladder: Other changes

Blood: Normocytic anemia

Blood: Other changes
IMEMDT 27,63,1982
skin
rat
lethal dose (50 percent kill): 3,200 mg/kg N/R AGGHAR 15,447,1957


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lowest published toxic concentration: 10 mg/m3/4 hour/30 day- intermittent Brain and Coverings: Changes in circulation

Peripheral Nerve and Sensation: Recording from peripheral motor nerve

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi
TPKVAL 4,91,1962
inhalation
rat
lowest published toxic concentration: 10 mg/m3/4 hour/244 day- intermittent Blood: Normocytic anemia TPKVAL 4,91,1962
inhalation
rat
lowest published toxic concentration: 10 mg/m3/4 hour/335 day- intermittent Blood: Changes in other cell count (unspecified) TPKVAL 4,91,1962
inhalation
rat
lowest published toxic concentration: 10 mg/m3/4 hour/0.5 year- intermittent Gastrointestinal: Ulceration or bleeding from small intestine

Endocrine: Changes in spleen weight

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TPKVAL 4,91,1962


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.5 mg/m3 (skin) DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not classifiable as human carcinogen DTLVS* TLV/BEI,2007
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 27,63,1982
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMSUDL 7,56,1987


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.1 ppm (0.5 mg/m3) (skin) DTLWS* 3,10,1973
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 0.5 mg/m3 (skin) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.5 mg/m3 (skin) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 0.5 mg/m3 (skin) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 0.5 mg/m3 (skin) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.1 ppm (0.5 mg/m3), JAN1993
Occupational Exposure Limit - BELGIUM time-weighted average 0.1 ppm (0.5 mg/m3), Skin, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 0.1 ppm (0.5 mg/m3), OCT 2002
Occupational Exposure Limit - FINLAND time-weighted average 0.5 mg/m3, short term exposure limit 1.5 mg/m3, Skin, Carcinogen, JAN1993
Occupational Exposure Limit - FRANCE VME 0.1 ppm (0.5 mg/m3), Skin, FEB2006
Occupational Exposure Limit - INDIA time-weighted average 0.1 ppm (0.5 mg/m3), Skin, JAN1993
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 0.1 ppm (0.5 mg/m3), skin, APR2007
Occupational Exposure Limit - MEXICO time-weighted average 0.1 ppm (0.5 mg/m3) (skin), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.5 mg/m3, Skin, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 0.1 ppm (0.5 mg/m3), skin, JAN2002
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.5 mg/m3, Skin, JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0.5 mg/m3, MAC(short term exposure limit) 1 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 1 mg/m3, Skin, JUN2003
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.1 ppm (0.51 mg/m3), 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not classifiable as human carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not classifiable as human carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO p-ANISIDINE-air 10 hour time-weighted average 0.5 mg/m3 (Sk) NIOSH* DHHS #92-100,1992


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used for the production of dyes and pharmaceuticals
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Anisidine, 2514


REFERENCES:

CODEN
REFERENCE

AGGHAR Archiv fuer Gewerbepathologie und Gewerbehygiene. (Berlin, Ger.) V.1-18, 1930-61. For publisher information, see IAEHDW.
ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1- 1990-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
DTLWS* "Documentation of the Threshold Limit Values for Substances in Workroom Air," Supplements. For publisher information, see 85INA8.
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
TLSMA6 Trudy Leningradskogo Sanitarno-Gigienicheskogo Meditsinskogo Instituta. (Leningrad, Russia) V.1-145, 1949-82. Discontinued.
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-

Used for the production of dyes and pharmaceuticals

RTECS Compound Description:
   Tumorigen
   Drug
   Mutagen

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