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Acetaldehyde, chloro -

RTECS #: AB2450000

CAS #: 107-20-0


UPDATE: May 2009 MW: 78.50 MF: C2H3ClO


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 2 - Chloro - 1 - ethanal
  2. 2 - Chloroacetaldehyde
  3. 2 - Chloroethanal
  4. Chloroacetaldehyde
  1. Chloroacetaldehyde (ACGIH:OSHA)
  2. Chloroacetaldehyde monomer
  3. Monochloroacetaldehyde
  4. RCRA waste number P023


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
DNA adduct mammal (species unspecified) lymphocyte 200 mmol/L CBINA8 22,211,1978
DNA adduct salmon testis 3 gm CRNGDP 3,663,1982
DNA damage human lymphocyte 100 µmol/L EMMUEG 20,277,1992
DNA damage rat liver 47 mmol/L TOLED5 42,183,1988
DNA damage salmon sperm 20 mmol/L CNREA8 48,4804,1988
DNA inhibition intravenous
rat
5 gm/kg CBINA8 17,239,1977
DNA repair Bacillus subtilis 100 mmol/L 37ATAD -,155,1977
DNA repair Escherichia coli 10 mg/plate EVHPAZ 21,79,1977
mutation in microorganisms Aspergillus nidulans 30 mg/plate (-enzymatic activation step) CBINA8 30,9,1980
mutation in microorganisms Bacillus subtilis 5 mmol/L (-enzymatic activation step) MSERDS 5,131,1981
mutation in microorganisms Escherichia coli 1 mmol/L (-enzymatic activation step) CBINA8 12,265,1976
mutation in microorganisms other microorganisms 250 µg/plate (-enzymatic activation step) CBINA8 30,9,1980
mutation in microorganisms other microorganisms 1 mmol/L (-enzymatic activation step) MUREAV 73,1,1980
mutation in microorganisms Salmonella typhimurium 400 µmol/L (+enzymatic activation step) MUREAV 32,93,1975
mutation in microorganisms Saccharomyes cerevisiae 3,100 µmol/L (+enzymatic activation step) CNREA8 37,253,1977
mutation in microorganisms Schizosaccharomyces pombe 6,250 µmol/L (+enzymatic activation step) CNREA8 37,253,1977
mutation in mammalian somatic cells hamster lung 6,400 nmol/L IJCNAW 16,639,1975
mutation in mammalian somatic cells human lymphocyte 16 µmol/L CRNGDP 18,31,1997
other mutation test systems Bacillus subtilis 1 mole/L 37ATAD -,155,1977


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
guinea pig
lowest published lethal concentration: 400 ppm/30 minute Eye: Other eye effects

Behavioral: Hallucinations, distorted perceptions

Lung, Thorax, or Respiration: Dyspnea
NTIS** OTS0536151
inhalation
rat
lethal concentration (50 percent kill): 650 mg/m3/1 hour Vascular: BP elevation not characterized in autonomic section

Lung, Thorax, or Respiration: Respiratory obstruction

Lung, Thorax, or Respiration: Other changes
EPASR* 8EHQ-0387-0660
intraperitoneal
guinea pig
lethal dose (50 percent kill): 2,523 µg/kg N/R JPMSAE 61,19,1972
intraperitoneal
mouse
lethal dose (50 percent kill): 7 mg/kg N/R JPMSAE 61,19,1972
intraperitoneal
rat
lethal dose (50 percent kill): 7 mg/kg N/R JPMSAE 61,19,1972
intraperitoneal
rabbit
lethal dose (50 percent kill): 5,522 µg/kg N/R JPMSAE 61,19,1972
oral
mouse
lethal dose (50 percent kill): 82 mg/kg N/R JPMSAE 61,19,1972
oral
rat
lethal dose (50 percent kill): 89 mg/kg N/R JPMSAE 61,19,1972
skin
rabbit
lethal dose (50 percent kill): 267 mg/kg N/R JPMSAE 61,19,1972


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
rat
lowest published toxic dose: 113 mg/kg/30 day- intermittent Brain and Coverings: Changes in brain weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
JPMSAE 61,19,1972
parenteral
rat
lowest published toxic dose: 58 mg/kg/12 week- intermittent Lung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis)

Blood: Changes in erythrocyte (RBC) count

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
JPMSAE 61,19,1972


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value ceiling concentration 1 ppm DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
MUREAV 584,1,2005
TOXICOLOGY REVIEW
MUREAV 636,178,2007


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD air-ceiling concentration 1 ppm (3 mg/m3) DTLVS* 3,48,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) ceiling concentration 1 ppm (3 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) ceiling concentration 1 ppm (3 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) ceiling concentration 1 ppm (3 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) ceiling concentration 1 ppm (3 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 1 ppm (3 mg/m3), JAN1993
Occupational Exposure Limit - AUSTRALIA ceiling concentration 1 ppm (3.2 mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM short term exposure limit 1 ppm (3.2 mg/m3), MAR2002
Occupational Exposure Limit - DENMARK ceiling concentration 1 ppm (3 mg/m3), OCT 2002
Occupational Exposure Limit - FINLAND short term exposure limit 1 ppm (3 mg/m3), JAN1993
Occupational Exposure Limit - FRANCE VLE 1 ppm (3 mg/m3), continuous3 Carcinogen, FEB2006
Occupational Exposure Limit - KOREA ceiling concentration 1 ppm (3 mg/m3), 2006
Occupational Exposure Limit - MEXICO peak 1 ppm (3 mg/m3), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC- continuous 3 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND ceiling concentration 1 ppm (3.2 mg/m3), JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 1 ppm (3 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 1 ppm (3 mg/m3), JAN1993
Occupational Exposure Limit - SWITZERLAND MAK- week 1 ppm (3 mg/m3);
KZG- week 1 ppm (3 mg/m3), DEC2006
Occupational Exposure Limit - THAILAND time-weighted average 1 ppm (3 mg/m3), JAN1993
Occupational Exposure Limit - TURKEY time-weighted average 1 ppm (3 mg/m3), JAN1993
Occupational Exposure Limit - UNITED KINGDOM short term exposure limit 1 ppm (3.3 mg/m3), 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

ceiling concentration 1 ppm
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
ceiling concentration 1 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CHLOROACETALDEHYDE-air ceiling concentration 1 ppm NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 18065;
Number of Industries 1;
Total Number of Facilities 21;
Number of Occupations 3;
Total Number of Employees Exposed 788


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Positive: E coli polA without S9; Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Positive: V79 cell culture-gene mutation
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae gene conversion
EPA GENETOX PROGRAM 1988, Negative: S pombe-forward mutation
EPA GENETOX PROGRAM 1988, Inconclusive: Carcinogenicity-mouse/rat
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as an industrial chemical and chemical intermediate
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Chloroacetaldehyde, 2015
OSHA ANALYTICAL METHOD #76


REFERENCES:

CODEN
REFERENCE

37ATAD "Prevention and Detection of Cancer, Proceedings of the 3rd International Symposium on Detection and Prevention of Cancer," New York, Marcel Dekker, 1977
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown.
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
IJCNAW International Journal of Cancer. (International Union Against Cancer, 3 rue du Conseil- General, 1205 Geneva, Switzerland) V.1- 1966-
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961-
MSERDS Microbiology Series. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1973-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-

Used as an industrial chemical and chemical intermediate

RTECS Compound Description:
   Mutagen
   Human Data

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