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Hydrazine

RTECS #
MU7175000
CAS #
302-01-2
See: NMAM or OSHA Methods
Updated
December 2018
Molecular Weight
32.06
Molecular Formula
H4N2
Synonyms
Hydrazine (ACGIH:OSHA)
Hydrazine fume
Hydrazyna (Polish)
Levoxine
Nitrogen hydride
Oxytreat 35
RCRA waste number U133

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
skin /rabbit 50%/1HTPKVAL 4,65,1962

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA adduct/Escherichia coli10 µmol/LMUREAV 89,95,1981
DNA Damageliver/rat3 mmol/LMUREAV 113,357,1983
DNA Damageintraperitoneal/mouse100 mg/kgMUREAV 415,1,1998
DNA Damageoral/mouse100 mg/kgMUREAV 415,1,1998
DNA Damageoral/hamster15 mg/kgPAACA3 24,59,1983
DNA Damagelymphocyte/mammal (species unspecified)95 pphBBACAQ 174,591,1969
DNA Damagelung/rat0.5 mmol/L/20HMUREAV 605,94,2006
DNA Damagelung/human0.5 mmol/L/20HMUREAV 605,94,2006
DNA Damageoral/rat30 mg/kgMUREAV 605,94,2006
DNA inhibitionoral/rat60 mg/kgCRNGDP 4,953,1983
DNA inhibitionoral/mouse200 mg/kgMUREAV 46,305,1977
DNA inhibitionHeLa cell/human50 µmol/LCNREA8 44,59,1984
morphological transformliver/human80 µg/LBJCAAI 37,873,1978
morphological transformother cell types/human35 mg/LITCSAF 17,719,1981
morphological transformkidney/hamster80 µg/LBJCAAI 37,873,1978
mutation in mammalian somatic cellslymphocyte/mouse1 mmol/LMUREAV 89,321,1981
mutation in microorganisms/Saccharomyes cerevisiae200 mmol/L (-enzymatic activation step)MUREAV 93,339,1982
mutation in microorganisms/Haemophilus influenzae2 mmol/L (-enzymatic activation step)MUREAV 30,9,1975
mutation in microorganisms/Other microorganisms70 µg/L (-enzymatic activation step)MUREAV 173,233,1986
mutation in microorganisms/Salmonella typhimurium120 µg/plate (-enzymatic activation step)BIZNAT 97,137,1978
mutation in microorganisms/Escherichia coli4300 µmol/L (+enzymatic activation step)TOLED5 31,131,1986
other mutation test systems/Escherichia coli80 pmol/tubeMUREAV 147,79,1985
other mutation test systems/Bacillus subtilis10 mmol/LMUREAV 5,343,1968
sex chromosome loss and nondisjunctionoral/Drosophila melanogaster10 mmol/LMUREAV 16,363,1972
Unscheduled DNA Synthesisoral/rat60 mg/kgCRNGDP 4,953,1983
Unscheduled DNA Synthesislung/rat250 µg/LNTIS** AD-A075-605
Unscheduled DNA Synthesisovary/hamster250 µg/LNTIS** AD-A075-605
Unscheduled DNA Synthesislung/hamster250 µg/LNTIS** AD-A075-605

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
inhalation/rat 4 mg/m3/2H (7-20D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)GISAAA 39(10),23,1974
inhalation/rat 1 mg/m3/24H (1-11D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death
GISAAA 39(10),23,1974
inhalation/hamster 1 ppm/6H (1Y male)Reproductive: Paternal effects: Testes, epididymis, sperm ductFAATDF 5,1050,1985
inhalation/rat 1 mg/m3 (1-22D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)VCVN5* -,20,1989
intraperitoneal/mouse 48 mg/kg (6-9D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
NTIS** AD-A084-023
intraperitoneal/mouse 80 mg/kg (6-9D pregnant)Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Urogenital system
NTIS** AD-A084-023
intraperitoneal/rat 100 mg/kg (6-15D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)APTOD9 19,A21,1980
intraperitoneal/rat 50 mg/kg (6-15D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)APTOD9 19,A21,1980
intraperitoneal/rat 30 mg/kg (7-9D pregnant)Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Specific developmental abnormalities: Urogenital system
NTIS** AD-A119-706
intraperitoneal/rat 30 mg/kg (7-9D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
NTIS** AD-A119-706
skin/rat 50 mg/kg (9D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)NTIS** AD-A119-706
subcutaneous/rat 80 mg/kg (11-20D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)
AEHLAU 21,615,1970

Tumorigenic Data and References

Route/OrganismDoseEffectReference
inhalation/hamster lowest published toxic concentration: 1 ppm/6H/1Y- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Gastrointestinal: Colon tumors
FAATDF 5,1050,1985
inhalation/hamster toxic concentration: 5 ppm/6H/1Y- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Olfaction: Tumors
PAACA3 21,74,1980
inhalation/mouse lowest published toxic concentration: 1 ppm/6H/1Y- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Olfaction: Tumors
PAACA3 21,74,1980
inhalation/rat lowest published toxic concentration: 5 ppm/6H/1Y- intermittentTumorigenic: Carcinogenic by RTECS criteria

Endocrine: Thyroid tumors
FAATDF 5,1050,1985
inhalation/rat toxic concentration: 5 ppm/6H/1Y- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Olfaction: Tumors
PAACA3 21,74,1980
inhalation/rat toxic concentration: 1 ppm/6H/1Y- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Olfaction: Tumors
PAACA3 21,74,1980
intraperitoneal/mouse lowest published toxic dose: 400 mg/kg/5W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Blood: Tumors

Blood: Leukemia
UICMAI 7,180,1967
oral/mouse lowest published toxic dose: 1951 mg/kg/2Y- continuousTumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Blood: Lymphoma including Hodgkin's disease
IJCNAW 9,109,1972
oral/rat lowest published toxic dose: 900 mg/kg/2Y- continuousTumorigenic: Neoplastic by RTECS criteria

Liver: Tumors
EXPADD 33,133,1988

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lethal concentration (50 percent kill): 252 ppm/4HEye: Other eye effects

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea
AMIHAB 12,609,1955
inhalation/mouse lethal concentration (50 percent kill): 1000 mg/m3/2HVCVN5* -,20,1993
inhalation/mouse lethal concentration (50 percent kill): 320 mg/m3/4HVCVN5* -,20,1993
inhalation/mouse lethal concentration (50 percent kill): 330 gm/m3Lung, Thorax, or Respiration: Acute pulmonary edema

Liver: Fatty liver degeneration

Liver: Other changes
TPKVAL 4,65,1962
inhalation/mouse Lowest published lethal concentration: 1.5 gm/m3/2HKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Hemorrhage

Blood: Changes in spleen
TPKVAL 4,65,1962
inhalation/mouse lowest published toxic concentration: 0.65 gm/m3/2HBrain and Coverings: Other degenerative changes

Lung, Thorax, or Respiration: Changes in pulmonary vascular resistance

Liver: Fatty liver degeneration
TPKVAL 4,65,1962
inhalation/mouse lowest published toxic concentration: 0.02 gm/m3TPKVAL 4,65,1962
inhalation/rat lethal concentration (50 percent kill): 750 gm/m3/4HBrain and Coverings: Increased intracranial pressure

Cardiac: Other changes

Lung, Thorax, or Respiration: Changes in pulmonary vascular resistance
TPKVAL 4,65,1962
inhalation/rat Lowest published lethal concentration: 0.02 gm/m3Kidney, Ureter, and Bladder: Other changes

Blood: Hemorrhage
TPKVAL 4,65,1962
inhalation/rat Lowest published lethal concentration: 1.5 gm/m3/2HBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TPKVAL 4,65,1962
inhalation/rat lowest published toxic concentration: 0.65 gm/m3/2HBehavioral: Alteration of classical conditioningTPKVAL 4,65,1962
inhalation/rat lowest published toxic concentration: 20000 mg/m3/4HLung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Behavioral: Excitement

Behavioral: Tetany
VCVN5* -,20,1993
inhalation/rat lethal concentration (50 percent kill): 130 mg/m3/2HVCVN5* -,20,1993
inhalation/rat lowest published toxic concentration: 23 ppm/10MOlfaction: Deviated nasal septumTOXID9 44,303,2005
inhalation/rat lowest published toxic concentration: 16 ppm/30MOlfaction: Deviated nasal septumTOXID9 44,303,2005
inhalation/rat lowest published toxic concentration: 13 ppm/1HOlfaction: Deviated nasal septumTOXID9 44,303,2005
inhalation/rat lowest published toxic concentration: 3.1 ppm/4HOlfaction: Deviated nasal septumTOXID9 44,303,2005
inhalation/rat lowest published toxic concentration: 1.6 ppm/8HOlfaction: Deviated nasal septumTOXID9 44,303,2005
inhalation/rat Lowest published lethal concentration: 64 ppm/10MTOXID9 44,303,2005
inhalation/rat Lowest published lethal concentration: 45 ppm/30MTOXID9 44,303,2005
inhalation/rat Lowest published lethal concentration: 35 ppm/1HTOXID9 44,303,2005
inhalation/rat Lowest published lethal concentration: 8.9 ppm/4HTOXID9 44,303,2005
inhalation/rat Lowest published lethal concentration: 4.4 ppm/8HTOXID9 44,303,2005
inhalation/rat lethal concentration (50 percent kill): 570 ppm/4HEye: Other eye effects

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea
AMIHAB 12,609,1955
intramuscular/Dog lethal dose (50 percent kill): 16500 µg/kgGISAAA 16(6),53,1972
intramuscular/rabbit lethal dose (50 percent kill): 38500 µg/kgGISAAA 16(6),53,1972
intramuscular/rat lethal dose (50 percent kill): 53500 µg/kgGISAAA 16(6),53,1972
intraperitoneal/cat lowest published toxic dose: 20 mg/kgBehavioral: TetanyVCVN5* -,20,1993
intraperitoneal/mouse lethal dose (50 percent kill): 62 mg/kgMEPAAX 24,71,1973
intraperitoneal/mouse lowest published toxic dose: 100 mg/kgLiver: Other changes

Blood: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport
TOXID9 72,94,2003
intraperitoneal/rat lethal dose (50 percent kill): 59 mg/kgMEPAAX 24,71,1973
intraperitoneal/rat lowest published toxic dose: 20 mg/kgBehavioral: Alteration of classical conditioningVCVN5* -,20,1993
intravenous/Dog lethal dose (50 percent kill): 25 mg/kgMEPAAX 24,71,1973
intravenous/Dog lowest published lethal dose: 25 mg/kgLiver: Other changes

Kidney, Ureter, and Bladder: Other changes

Blood: Hemorrhage
TPKVAL 4,65,1962
intravenous/mouse lowest published lethal dose: 55 mg/kgBrain and Coverings: Other degenerative changes

Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold
TPKVAL 4,65,1962
intravenous/mouse lethal dose (50 percent kill): 57 mg/kgMEPAAX 24,71,1973
intravenous/rabbit lethal dose (50 percent kill): 20 mg/kgAMIHBC 9,199,1954
intravenous/rat lethal dose (50 percent kill): 55 mg/kgMEPAAX 24,71,1973
intravenous/rat lowest published lethal dose: 55 mg/kgBehavioral: Excitement

Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Dyspnea
TPKVAL 4,65,1962
oral/mouse lowest published toxic dose: 250 mg/kgLiver: Fatty liver degeneration

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TXAPA9 204,135,2005
oral/mouse lowest published toxic dose: 100 mg/kgLiver: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport

Biochemical: Metabolism (intermediary): Other proteins
TOXID9 78,353,2004
oral/mouse lowest published toxic dose: 300 mg/kgLiver: Multiple effects

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects

Biochemical: Metabolism (intermediary): Lipids including transport
TOXID9 78,353,2004
oral/mouse lowest published toxic dose: 100 mg/kgLiver: Other changes

Blood: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport
TOXID9 72,94,2003
oral/mouse lethal dose (50 percent kill): 80 mg/kgLiver: Fatty liver degeneration

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Changes in spleen
TPKVAL 4,65,1962
oral/mouse lethal dose (50 percent kill): 59 mg/kgMEPAAX 24,71,1973
oral/mouse lethal dose (50 percent kill): 59 mg/kgLung, Thorax, or Respiration: Acute pulmonary edema

Kidney, Ureter, and Bladder: Changes in kidney weight
VCVN5* -,20,1993
oral/rat lethal dose (50 percent kill): 60 mg/kgLung, Thorax, or Respiration: Acute pulmonary edema

Kidney, Ureter, and Bladder: Changes in kidney weight
VCVN5* -,20,1993
oral/rat lowest published toxic dose: 90 mg/kgLiver: Hepatitis (hepatocellular necrosis), diffuse

Liver: Fatty liver degeneration

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TXAPA9 204,135,2005
oral/rat lethal dose (50 percent kill): 60 mg/kgMEPAAX 24,71,1973
oral/rat lowest published toxic dose: 75 mg/kgNutritional and Gross Metabolic: Weight loss or decreased weight gainCRTOEC 14,975,2001
oral/rat lowest published toxic dose: 90 mg/kgKidney, Ureter, and Bladder: Other changes in urine composition

Blood: Changes in leukocyte (WBC) count

Blood: Changes in other cell count (unspecified)
CRTOEC 14,975,2001
oral/rat lowest published toxic dose: 120 mg/kgLiver: Hepatitis (hepatocellular necrosis), zonal

Liver: Fatty liver degeneration

Liver: Other changes
CRTOEC 14,975,2001
skin/Dog lowest published lethal dose: 96 mg/kgTXAPA9 21,186,1972
skin/Dog lowest published toxic dose: 3 mg/kgBehavioral: Tetany

Behavioral: Alteration of classical conditioning
VCVN5* -,20,1993
skin/guinea pig lethal dose (50 percent kill): 190 mg/kgBehavioral: Convulsions or effect on seizure thresholdXAWPA2 CWL 2-10,1958
skin/rabbit lethal dose (50 percent kill): 91 mg/kgAMIHBC 9,199,1954
subcutaneous/mouse lowest published toxic dose: 30 mg/kgBlood: Changes in leukocyte (WBC) count

Immunological Including Allergic: Increase in cellular immune response
TXCYAC 172,35,2002
unreported route/mouse lethal dose (50 percent kill): 200 mg/kgBJCAAI 6,160,1952

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/Dog lowest published toxic concentration: 14 ppm/6H/26W- intermittentBehavioral: Food intake (animal)

Behavioral: Muscle weakness

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
AMIHBC 10,476,1954
inhalation/guinea pig lowest published toxic concentration: 14 ppm/6H/14W- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldAMIHBC 10,476,1954
inhalation/guinea pig lowest published toxic concentration: 5 mg/m3/24H/59D- continuousLung, Thorax, or Respiration: Other changesVCVN5* -,20,1989
inhalation/hamster lowest published toxic concentration: 1 ppm/6H/1Y- intermittentLiver: Other changes

Kidney, Ureter, and Bladder: Other changes

Endocrine: Other changes
NTIS** AD-A086-341
inhalation/monkey lowest published toxic concentration: 1 ppm/24H/90D- continuousRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldNTIS** AD-A086-341
inhalation/mouse lowest published toxic concentration: 130 mg/m3/1H/17W- intermittentBlood: Normocytic anemia

Blood: Changes in leukocyte (WBC) count
VCVN5* -,20,1989
inhalation/mouse lowest published toxic concentration: 1 ppm/24H/90D- continuousRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldNTIS** AD-A086-341
inhalation/mouse lowest published toxic concentration: 14 ppm/6H/5W- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldAMIHBC 10,476,1954
inhalation/mouse lowest published toxic concentration: 0.003 gm/m3/30D- intermittentLung, Thorax, or Respiration: Changes in pulmonary vascular resistance

Blood: Changes in spleen

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TPKVAL 4,65,1962
inhalation/rat lowest published toxic concentration: 0.003 gm/m3/91D- intermittentLung, Thorax, or Respiration: Changes in pulmonary vascular resistance

Blood: Changes in spleen

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TPKVAL 4,65,1962
inhalation/rat lowest published toxic concentration: 0.0005 gm/m3/30D- intermittentPeripheral Nerve and Sensation: Recording from peripheral motor nerveTPKVAL 4,65,1962
inhalation/rat lowest published toxic concentration: 0.0005 gm/m3/213D- intermittentBehavioral: Alteration of classical conditioning

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Hemorrhage
TPKVAL 4,65,1962
inhalation/rat lowest published toxic concentration: 1 ppm/24H/90D- continuousRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldNTIS** AD-A086-341
inhalation/rat lowest published toxic concentration: 5 ppm/6H/26W- intermittentBehavioral: Muscle weakness

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
AMIHBC 10,476,1954
inhalation/rat lowest published toxic concentration: 10 mg/m3/4H/30D- intermittentLiver: Liver function tests impaired

Kidney, Ureter, and Bladder: Other changes in urine composition

Blood: Changes in bone marrow not included in above
GISAAA 40(3),29,1975

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.01 ppm (skin)DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Confirmed animal carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 4,127,1974
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 71,991,1999
International Agency for Research on Cancer (IARC)Cancer Review:Human Inadequate EvidenceIMSUDL 7,223,1987
International Agency for Research on Cancer (IARC)Cancer Review:Human Inadequate EvidenceIMEMDT 71,991,1999
International Agency for Research on Cancer (IARC)Cancer Review:Group 2BIMEMDT 71,991,1999
TOXICOLOGY REVIEWAMIHBC 9,199,1954
TOXICOLOGY REVIEWATXKA8 28,135,1971
TOXICOLOGY REVIEWMUREAV 627,10,2007
TOXICOLOGY REVIEWENTOX* -,536,2005
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWHUTOX* -,719,1996
TOXICOLOGY REVIEWISMEA* 10,302,2008
TOXICOLOGY REVIEWMUTAEX 25,335,2010
TOXICOLOGY REVIEWMUREAV 762,76,2014
TOXICOLOGY REVIEWMUREAV 743,10,2012
TOXICOLOGY REVIEWFCTOD7 55,596,2013
TOXICOLOGY REVIEWMUREAV 771,85,2017
TOXICOLOGY REVIEWFCTOD7 107,502,2017
TOXICOLOGY REVIEWRTOPDW 54,247,2009
TOXICOLOGY REVIEWRTOPDW 55,43,2009

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 1 ppm (1.3 mg/m3) (skin)DTLVS* 3,127,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.01 ppm (0.013 mg/m3), Carcinogen, JUL2008
Occupational Exposure Limit-AUSTRIATRK-TMW 0.1 ppm (0.13 mg/m3);KZW 0.4 ppm (0.52 mg/m3), skin, sen, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 0.01 ppm (0.013 mg/m3), Skin, Carcinogen, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.01 ppm (0.013 mg/m3), skin, carc, MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 0.1 ppm (0.13 mg/m3), short term exposure limit 0.3 ppm (0.4 mg/m3), skin, NOV2011
Occupational Exposure Limit-FRANCEVME 0.1 ppm (0.1 mg/m3), FEB2006
Occupational Exposure Limit-HUNGARYceiling concentration 0.13 mg/m3, Carcinogen, SEP2000
Occupational Exposure Limit-ICELANDtime-weighted average 0.1 ppm (0.13 mg/m3), carc, skin, sen, NOV2011
Occupational Exposure Limit-JAPANOccupational Exposure Limit 0.1 ppm (0.13 mg/m3), skin, 2B carc, s1 sen, MAY2012
Occupational Exposure Limit-KOREAtime-weighted average 0.1 ppm (0.13 mg/m3), skin, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 0.1 ppm (0.1 mg/m3), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.01 ppm (0.013 mg/m3), skin, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 0.1 ppm (0.13 mg/m3), JAN1999
Occupational Exposure Limit-PERUtime-weighted average 0.01 ppm (0.013 mg/m3), JUL2005
Occupational Exposure Limit-POLANDMAC(time-weighted average) 0.05 mg/m3, MAC(short term exposure limit) 0.1 mg/m3, JAN1999
Occupational Exposure Limit-RUSSIAshort term exposure limit 0.1 mg/m3, Skin, JUN2003
Occupational Exposure Limit-SWEDENGroup B Carcinogen, JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 0.1 ppm (0.13 mg/m3), carc 2, skin, sen, JAN2011
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 1 ppm (1.3 mg/m3), Skin, JAN1993
Occupational Exposure Limit-TURKEYtime-weighted average 1 ppm (1.3 mg/m3), Skin, JAN1993
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 0.02 ppm (0.03 mg/m3);short term exposure limit 0.1 ppm (0.13 mg/m3), carc, skin, OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 1 ppm (1.3 mg/m3) (skin)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 1 ppm (1.3 mg/m3) (skin)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 1 ppm (1.3 mg/m3) (skin)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 1 ppm (1.3 mg/m3) (skin)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO HYDRAZINES-airCarcinogen ceiling concentration 0.03 ppm/120MNIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 38110; Number of Industries 44; Total Number of Facilities 2515; Number of Occupations 46; Total Number of Employees Exposed 60490; Total Number of Female Employees Exposed 2841
National Occupational Hazard Survey 1974Hazard Code 38110; Number of Industries 37; Total Number of Facilities 2134; Number of Occupations 27; Total Number of Employees Exposed 11185

Status in Federal Agencies

OrganizationReference
ATSDR TOXICOLOGY PROFILE (NTIS** PB/98/101025/AS)
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-1292-8619;8EHQ-0593-9056
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Hydrazine, 3503
NTP 14th Report on Carcinogens,2016:Reasonably anticipated to be human carcinogen
On EPA IRIS database
OSHA ANALYTICAL METHOD #108
OSHA ANALYTICAL METHOD #20
Page last reviewed: November 16, 2018