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Acetone

RTECS #
AL3150000
CAS #
67-64-1
See: NMAM or OSHA Methods
Updated
December 2018
Molecular Weight
58.09
Molecular Formula
C3H6O
Synonyms
2-Propanone
Aceton (German, Dutch, Polish)
Acetone (ACGIH:OSHA)
beta-Ketopropane
Chevron acetone
Dimethyl ketone
Dimethylformaldehyde
Dimethylketal
Ketone propane
Ketone, dimethyl
Methyl ketone
Propanone
Pyroacetic acid
Pyroacetic ether
RCRA waste number U002

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /human 500 ppmJIHTAB 25,282,1943
eye /human 186300 ppm mildCRTXB2 32,43,2002
eye /rabbit 20 mg severeENTOX* -,27,2005
eye /rabbit 20 mg/24H moderate85JCAE -,280,1986
eye /rabbit 10 µL mildJTPAE7 29,187,2001
skin /rabbit 395 mg open irritation test mildUCDS** 5/7/1970
skin /rabbit 500 mg/24H mild85JCAE -,280,1986

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisfibroblast/hamster40 gm/LFCTOD7 22,623,1984
sex chromosome loss and nondisjunctioninhalation/mouse12 gm/LVCVGK* -,409,1994
sex chromosome loss and nondisjunction/Saccharomyes cerevisiae47600 ppmANYAA9 407,186,1983

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
inhalation/mammal (species unspecified) 31500 µg/m3/24H (1-13D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)GTPZAB 26(6),24,1982
inhalation/rat 30 mg/m3 (1-13D pregnant)Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetal death
VCVGK* -,409,1994
inhalation/rat 11000 ppm (6-19D pregnant)Reproductive: Other developmental abnormalitiesNTIS** #DE89-005671
inhalation/mouse 6600 ppm (6-17D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)
NTIS** #DE89-005671
oral/rat 273 gm/kg (13W male)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)NTIS** PB91-185975

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, liver tumor Inhibitor Concentration (50 percent kill): 355 mmol/L/24HIn Vitro Toxicity Studies: Cell protein synthesisTIVIEQ 3,189,1989
In Vitro/Human, lung Inhibitor Concentration (50 percent kill): 546 gm/L/3HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 27,174,2013
In Vitro/Human, lung Inhibitor Concentration (50 percent kill): 231 gm/L/24HIn Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.)TIVIEQ 27,174,2013
In Vitro/Human, lung Inhibitor Concentration (50 percent kill): 402 gm/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 27,174,2013
In Vitro/Human, lung Inhibitor Concentration (50 percent kill): 225 gm/L/24HIn Vitro Toxicity Studies: Other assaysTIVIEQ 27,174,2013
In Vitro/Human, lung tumor Inhibitor Concentration (50 percent kill): 59 gm/L/24HIn Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.)TIVIEQ 27,174,2013
In Vitro/Human, lung tumor Inhibitor Concentration (50 percent kill): 54 gm/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 27,174,2013
In Vitro/Human, skin Inhibitor Concentration Low: 60 µL/well/60MIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 27,1476,2013
In Vitro/jdaInhibitor Concentration (50 percent kill): 148597 mg/L/1HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TOLED5 212,198,2012
In Vitro/Mouse, fibroblast Inhibitor Concentration (50 percent kill): 24 gm/L/24HIn Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.)TIVIEQ 27,174,2013
In Vitro/Mouse, fibroblast Inhibitor Concentration (50 percent kill): 23 gm/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 27,174,2013
In Vitro/Non-mammalian species, fibroblast Inhibitor Concentration (50 percent kill): 620 mmol/L/24HIn Vitro Toxicity Studies: Cell countingTIVIEQ 7,537,1993
In Vitro/Rabbit, ocular Inhibitor Concentration Low: 5 pph/5MIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 25,1425,2011
In Vitro/Rabbit, ocular Inhibitor Concentration (50 percent kill): 0.024 gm/L/10MIn Vitro Toxicity Studies: Cell Viability (cell death), unspecified assayTIVIEQ 3,329,1989
In Vitro/Rat, lung Inhibitor Concentration (50 percent kill): 1445.4 mmol/L/1HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 32,347,2016
In Vitro/Rat, lung Inhibitor Concentration (50 percent kill): 3311.3 mmol/L/1HIn Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.)TIVIEQ 32,347,2016
In Vitro/Rat, lung Inhibitor Concentration (50 percent kill): 2818.4 mmol/L/1HIn Vitro Toxicity Studies: Cell protein synthesisTIVIEQ 32,347,2016
In Vitro/Rat, lung Inhibitor Concentration (50 percent kill): 1584.9 mmol/L/1HBiochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammationTIVIEQ 32,347,2016
inhalation/cat lowest published toxic concentration: 8000 mg/m3Eye: Conjunctiva irritation

Behavioral: Sleep
VCVGK* -,408,1984
inhalation/guinea pig lowest published toxic concentration: 72000 mg/m3/2HBehavioral: Alteration of classical conditioningVCVGK* -,408,1984
inhalation/human lowest published toxic concentration: 12000 mg/m3/3MEye: Conjunctiva irritation

Lung, Thorax, or Respiration: Cough
VCVGK* -,408,1984
inhalation/human lowest published toxic concentration: 10 mg/m3/6HBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesteraseVCVGK* -,408,1984
inhalation/human lowest published toxic concentration: 500 ppmOlfaction: Other olfaction effects

Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Other changes
JIHTAB 25,282,1943
inhalation/man lowest published toxic concentration: 12000 ppm/4HGastrointestinal: Nausea or vomiting

Behavioral: Muscle weakness
AOHYA3 16,73,1973
inhalation/man lowest published toxic concentration: 440 µg/m3/6MBrain and Coverings: Recordings from specific areas of CNSGISAAA 42(8),42,1977
inhalation/man lowest published toxic concentration: 10 mg/m3/6HBiochemical: Metabolism (intermediary): Other carbohydratesGISAAA 42(8),42,1977
inhalation/mouse lethal concentration (50 percent kill): 44 gm/m3/4HCUTOEX 1,47,1993
inhalation/mouse Lowest published lethal concentration: 150000 mg/m3VCVGK* -,408,1984
inhalation/mouse lowest published toxic concentration: 10000 ppm/6MLung, Thorax, or Respiration: Respiratory depressionTOLED5 9,137,1981
inhalation/mouse lowest published toxic concentration: 30000 mg/m3/2HBehavioral: Alteration of classical conditioningVCVGK* -,408,1984
inhalation/rabbit lowest published toxic concentration: 1250 mg/m3Behavioral: Alteration of classical conditioningVCVGK* -,408,1984
inhalation/rat lowest published toxic concentration: 30000 mg/m3/2HBehavioral: Alteration of classical conditioningVCVGK* -,408,1984
inhalation/rat lethal concentration (50 percent kill): 50100 mg/m3/8HAIHAAP 20,364,1959
inhalation/rat lethal concentration (50 percent kill): 50100 mg/m3ENTOX* -,27,2005
inhalation/rat lowest published toxic concentration: 20000 ppm/1HBehavioral: Change in motor activity (specific assay)PBBHAU 89,101,2008
intraperitoneal/Dog lowest published lethal dose: 8 gm/kgBehavioral: Coma

Gastrointestinal: Alteration in gastric secretion
AEXPBL 18,218,1884
intraperitoneal/mouse lethal dose (50 percent kill): 1297 mg/kgSCCUR* -,1,1961
intraperitoneal/rat lowest published lethal dose: 500 mg/kgBehavioral: General anesthetic

Behavioral: Muscle weakness

Kidney, Ureter, and Bladder: Renal function tests depressed
JPPMAB 11,150,1959
intraperitoneal/rat lowest published toxic dose: 1452 mg/kgBehavioral: AnticonvulsantBJPCBM 158,872,2009
intravenous/mouse lowest published lethal dose: 4 gm/kgFAONAU 48A,86,1970
intravenous/rabbit lowest published lethal dose: 1576 mg/kgBehavioral: Muscle contraction or spasticity

Lung, Thorax, or Respiration: Respiratory depression
JPETAB 33,175,1928
intravenous/rat lethal dose (50 percent kill): 5500 mg/kgNPIRI* 1,1,1974
oral/Dog lowest published lethal dose: 8 gm/kgBehavioral: Ataxia

Behavioral: Coma

Musculoskeletal: Joints
AEXPBL 18,218,1884
oral/Dog lowest published lethal dose: 8000 mg/kgVCVGK* -,408,1984
oral/human lowest published lethal dose: 714 mg/kgVCVGK* -,409,1984
oral/mammal (species unspecified) lowest published toxic dose: 3.49 gm/kgBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes

Biochemical: Effect on specific coenzyme: NAD, NADP
VCVGK* -,408,1984
oral/man lowest published toxic dose: 2857 mg/kgBehavioral: Coma

Kidney, Ureter, and Bladder: Other changes
34ZIAG -,64,1969
oral/man lowest published toxic dose: 2857 mg/kgBehavioral: Coma

Biochemical: Metabolism (intermediary): Other
DIAEAZ 15,810,1966
oral/mouse lethal dose (50 percent kill): 3 gm/kgPCJOAU 14,162,1980
oral/rabbit lethal dose (50 percent kill): 5340 mg/kgFAONAU 48A,86,1970
oral/rat lowest published toxic dose: 5 mL/kgOlfaction: Other olfaction effects

Lung, Thorax, or Respiration: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)
TOXID9 60,404,2001
oral/rat lethal dose (50 percent kill): 5800 mg/kgENTOX* -,27,2005
oral/rat lethal dose (50 percent kill): 5800 mg/kgBehavioral: Altered sleep time (including change in righting reflex)

Behavioral: Tremor
JTEHD6 15,609,1985
skin/guinea pig lethal dose (50 percent kill): >9400 µL/kgTXAPA9 7,559,1965
skin/rabbit lowest published lethal dose: 20 mL/kgUCDS** 5/7/1970
subcutaneous/Dog lowest published lethal dose: 5 gm/kgAEXPBL 18,218,1884
subcutaneous/guinea pig lowest published lethal dose: 5 gm/kgAGGHAR 5,1,1933
unreported route/man lowest published lethal dose: 1159 mg/kg85DCAI 2,73,1970

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/human lowest published toxic concentration: 100 mg/m3/6H/5D- intermittentCardiac: EKG changes not diagnostic of above

Cardiac: Pulse rate increased without fall in BP

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
VCVGK* -,409,1994
inhalation/human lowest published toxic concentration: 440 mg/m3/3Y- intermittentBlood: Changes in erythrocyte (RBC) count

Blood: Granulocytopenia
VCVGK* -,410,1994
inhalation/mouse lowest published toxic concentration: 11000 ppm/12D- intermittentBehavioral: General anestheticNTIS** #DE89-005671
inhalation/rat lowest published toxic concentration: 206 mg/m3/21D- continuousBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Reproductive: Other effects on female
GISAAA 4,12,1994
inhalation/rat lowest published toxic concentration: 11000 ppm/9D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainNTIS** #DE89-005671
inhalation/rat lowest published toxic concentration: 30 mg/m3/13D- intermittentBiochemical: Metabolism (intermediary): Lipids including transportVCVGK* -,409,1994
inhalation/rat lowest published toxic concentration: 5000 ppm/3D- intermittentBehavioral: Change in motor activity (specific assay)PBBHAU 89,101,2008
inhalation/rat lowest published toxic concentration: 2000 mg/m3/4H/45D- intermittentEndocrine: Change in gonadotropins

Endocrine: Evidence of thyroid hyperfunction

Biochemical: Metabolism (intermediary): Effect on Na-K pump
VCVGK* -,409,1994
inhalation/rat lowest published toxic concentration: 199 mg/m3/8H/45D- intermittentBehavioral: Alteration of classical conditioningVCVGK* -,409,1994
inhalation/rat lowest published toxic concentration: 19000 ppm/3H/8W- intermittentBrain and Coverings: Changes in brain weightTXAPA9 61,302,1981
inhalation/rat lowest published toxic concentration: 199 mg/m3/8H/45D- intermittentBehavioral: Muscle contraction or spasticityGISAAA 25(5),3,1960
oral/mouse lowest published toxic dose: 546 gm/kg/13W- continuousLiver: Changes in liver weight

Endocrine: Changes in spleen weight
NTPTR* NIH-91-3122
oral/mouse lowest published toxic dose: 2 mg/kg/5D- continuousLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
LIFSAK 69,923,2001
oral/rat lowest published toxic dose: 273 gm/kg/13W- continuousLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Blood: Normocytic anemia
NTPTR* NIH-91-3122
oral/rat lowest published toxic dose: 5 mg/kg/5D- continuousLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
LIFSAK 69,923,2001
oral/rat lowest published toxic dose: 7 gm/kg/7D- continuousBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)BCPCA6 67,875,2004
oral/rat lowest published toxic dose: 15 mL/kg/3D- intermittentLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)
TOLED5 144,55,2003
oral/rat lowest published toxic dose: 8.75 mL/kg/7D- continuousLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects

Biochemical: Metabolism (intermediary): Lipids including transport
CBCPAI 128,503,2001
oral/rat lowest published toxic dose: 145600 mg/kg/13W- continuousKidney, Ureter, and Bladder: Other changes

Blood: Macrocytosis

Blood: Other hemolysis with or without anemia
TOXID9 60,432,2001
skin/mouse lowest published toxic dose: 31.6 µg/kg/2W- intermittentBiochemical: Metabolism (intermediary): OtherMOCAE8 44,122,2005

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 500 ppm;short term exposure limit 750 ppmDTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWTOLED5 127,111,2002
TOXICOLOGY REVIEWCRTXB2 32,43,2002
TOXICOLOGY REVIEWMUREAV 566,209,2004
TOXICOLOGY REVIEWCHHSA* 9,6,2002
TOXICOLOGY REVIEWENTOX* -,27,2005
TOXICOLOGY REVIEWREPTED 25,192,2008
TOXICOLOGY REVIEWMUREAV 659,93,2008
TOXICOLOGY REVIEWHUTOX* -,577,1996
TOXICOLOGY REVIEWMUREAV 674,62,2009
TOXICOLOGY REVIEWNCLNA* 16,503,1998
TOXICOLOGY REVIEWNTAPM* -,629,1995
TOXICOLOGY REVIEWNTAPM* -,727,1995
TOXICOLOGY REVIEWREPTED 58,252,2015
TOXICOLOGY REVIEWFCTOD7 94,93,2016
TOXICOLOGY REVIEWMUREAV 770,92,2016
TOXICOLOGY REVIEWMUREAV 770,170,2016
TOXICOLOGY REVIEWREPTED 61,120,2016
TOXICOLOGY REVIEWTIVIEQ 36,105,2016
TOXICOLOGY REVIEWRTOPDW 59,364,2011

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESCancelledRBREV* -,289,1998
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 1000 ppm (2400 mg/m3)DTLVS* 3,3,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 500 ppm (1185 mg/m3), short term exposure limit 1000 ppm (2375 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 500 ppm (1200 mg/m3);KZW 2000 ppm (4800 mg/m3), 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 500 ppm (1210 mg/m3), MAR2002
Occupational Exposure Limit-BELGIUMshort term exposure limit 1000 ppm (2420 mg/m3), MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 250 ppm (600 mg/m3), MAY2011
Occupational Exposure Limit-ECtime-weighted average 1210 mg/m3 (500 ppm), JUN2000
Occupational Exposure Limit-FINLANDtime-weighted average 500 ppm (1200 mg/m3), short term exposure limit 630 ppm (1500 mg/m3), NOV2011
Occupational Exposure Limit-FRANCEVME 500 ppm (1210 mg/m3), FEB2006
Occupational Exposure Limit-GERMANYMAK 500 ppm (1200 mg/m3), 2011
Occupational Exposure Limit-HUNGARYtime-weighted average 1210 mg/m3, short term exposure limit 2420 mg/m3, SEP2000
Occupational Exposure Limit-ICELANDtime-weighted average 250 ppm (600 mg/m3), NOV2011
Occupational Exposure Limit-JAPANOccupational Exposure Limit 200 ppm (470 mg/m3), MAY2012
Occupational Exposure Limit-KOREAtime-weighted average 750 ppm (1780 mg/m3), short term exposure limit 1000 ppm (2375 mg/m3), 2006
Occupational Exposure Limit-MEXICOtime-weighted average 1000 ppm (2400 mg/m3);short term exposure limit 1260 ppm(3000 mg/m3), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 500 ppm (1.185 mg/m3); short term exposure limit 1 ppm (2.375 mg/m3), JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 125 ppm (295 mg/m3), JAN1999
Occupational Exposure Limit-PERUtime-weighted average 500 ppm (1187 mg/m3); short term exposure limit 750 ppm (1781 mg/m3), JUL2005
Occupational Exposure Limit-POLANDMAC(time-weighted average) 600 mg/m3, MAC(short term exposure limit) 1800 mg/m3, JAN1999
Occupational Exposure Limit-RUSSIAtime-weighted average 200 mg/m3, short term exposure limit 800 mg/m3, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 250 ppm (600 mg/m3);short term exposure limit 500 ppm (1200 mg/m3), JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 500 ppm (1200 mg/m3), KZG-week 1000 ppm (2400 mg/m3), JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 1780 mg/m3, 2003
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 1000 ppm (2400 mg/m3), JAN1993
Occupational Exposure Limit-TURKEYtime-weighted average 1000 ppm (2400 mg/m3), JAN1993
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 500 ppm (1210 mg/m3);short term exposure limit 1500 ppm, OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 1000 ppm (2400 mg/m3)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 1000 ppm (2400 mg/m3)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 1000 ppm (2400 mg/m3)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 1000 ppm (2400 mg/m3)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ACETONE-air10H time-weighted average 250 ppmNIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 02820; Number of Industries 358; Total Number of Facilities 97342; Number of Occupations 215; Total Number of Employees Exposed 1740164; Total Number of Female Employees Exposed 540313
National Occupational Hazard Survey 1974Hazard Code 02820; Number of Industries 350; Total Number of Facilities 99713; Number of Occupations 188; Total Number of Employees Exposed 1287794

Status in Federal Agencies

OrganizationReference
ATSDR TOXICOLOGY PROFILE (NTIS** PB/95/100095/AS)
EPA GENETOX PROGRAM 1988, Negative: Cell transform.-RLV F344 rat embryo
EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test; In vitro SCE-nonhuman
EPA GENETOX PROGRAM 1988, Negative: In vitro cytogenetics-nonhuman
EPA GENETOX PROGRAM 1988, Negative: SHE-clonal assay; Cell transform.-mouse embryo
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Ketones I, 1300
NIOSH Analytical Method, 1996: Volatile organic compound, 2549
NTP Toxicity studies, RPT# TOX-03, October 2000
On EPA IRIS database
OSHA ANALYTICAL METHOD #ID-69
Page last reviewed: November 16, 2018