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Update: Availability of Streptomycin and Para-Aminosalicylic Acid -- United States

Since April 1992, streptomycin (SM) and para-aminosalicylic acid (PAS) (antimicrobial agents used in the treatment of tuberculosis (TB)) have been available through CDC under an investigational new drug agreement for the treatment of patients with multidrug-resistant TB. SM will now be made available for use in the drug-treatment regimen of any patient with active TB. This announcement updates and supersedes the previous notice (1) on availability of SM. Eligibility criteria for PAS remain unchanged. Clinicians interested in obtaining SM or PAS for their patients should provide an abbreviated medical history and, for SM, a recent creatinine serum level measurement.

These drugs are expected to become commercially available in the United States later this year. Until then, requests should be directed to CDC's Clinical Research Branch, Division of Tuberculosis Elimination, National Center for Prevention Services; telephone (404) 639-2530.


  1. CDC. Availability of streptomycin and para-aminosalicylic acid -- United States. MMWR 1992;41:243

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