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Notice to Readers Unavailability of Streptomycin and Para-Aminosalicylic Acid in the United States

Streptomycin (SM) and para-aminosalicylic acid (PAS), antimicrobial agents used to treat tuberculosis (TB), are currently unavailable in the United States. Because of problems in the supply of bulk SM, which is produced outside the United States, the U.S. manufacturer has ceased production of the finished product. The U.S. manufacturer of PAS has voluntarily discontinued production on a temporary basis. Although CDC and the Food and Drug Administration are attempting to reestablish production of these drugs, health-care providers should be prepared for an interruption in their supply. For guidance in selecting appropriate alternatives to SM and PAS for the treatment of TB, health-care providers should contact their state or local TB control program.

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