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Notice to Readers Revised Dosing Regimen for Malaria Prophylaxis with Mefloquine

A U.S. interagency group on malaria prevention has recently reviewed documented experience on the effectiveness and tolerance of mefloquine (Lariam((R))) for malaria prophylaxis. Based on this review, the group has proposed a change in the dosing regimen for malaria prophylaxis with mefloquine. Consequently, CDC has revised the dosing recommendations for mefloquine use. The new regimen consists of a single dose of mefloquine to be taken weekly, starting 1 week before travel. Prophylaxis should be continued weekly during travel in malarious areas and for 4 weeks after a person leaves such areas.

This notice updates the information in the following publications:

  1. CDC. Recommendations for the prevention of malaria among travelers. MMWR 1990;39(no. RR-3):4.

  2. CDC. Health information for international travel, 1990. Atlanta: US Department of Health and Human Services, Public Health Service, 1990:98; DHHS publication no. (CDC)90-8280. Detailed recommendations for the prevention of malaria may be obtained 24 hours a day by calling the CDC Malaria Hotline at (404) 332-4555.

Information about the availability of mefloquine can be obtained from the manufacturer at (800) 526-6367. Reported by: Malaria Br, Div of Parasitic Diseases, Center for Infectious Diseases, CDC.

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