Postexposure Prophylaxis of Persons with Discrete Identifiable Exposures
to Hepatitis B Virus (HBV)
This appendix provides recommendations for management of persons who are exposed to HBV through a
discrete, identifiable exposure to blood or body fluids that contain blood. Recommendations for management of infants born
to mothers who test positive for hepatitis B surface antigen (HBsAg) are provided in this report (see
Prevention of Perinatal HBV Transmission and Management of Pregnant Women).
- Unvaccinated persons (Table C-1) or persons known not to have
responded to a complete hepatitis B vaccine series
should receive both hepatitis B immune globulin (HBIG) and hepatitis B vaccine as soon as possible after exposure
(preferably <24 hours). For sexual exposures, HBIG should not be
administered more than 14 days after exposure. Hepatitis
B vaccine may be administered simultaneously with HBIG in a separate injection site. The hepatitis B vaccine series
should be completed using the age-appropriate vaccine dose and schedule (see
Tables 2 and
- Persons who are in the process of being vaccinated but who have not completed the vaccine series should receive
the appropriate dose of HBIG and should complete the vaccine series.
- Children and adolescents who have written documentation of a complete hepatitis B vaccine series and who did
not receive postvaccination testing should receive a single vaccine booster dose.
Source with Unknown HBsAg Status
- Unvaccinated persons (Table C-1) should receive the hepatitis B vaccine series with the first dose initiated as soon
as possible after exposure, preferably <24 hours. The vaccine series should be completed using the age-appropriate dose
and schedule (see Tables 2,
3, and 5).
- Persons who are not fully vaccinated should complete the vaccine series.
- Children and adolescents with written documentation of a complete hepatitis B vaccine series require no
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A Comprehensive Immunization Strategy to
Eliminate Transmission of Hepatitis B Virus Infection in the United
States: Recommendations of the Advisory Committee on Immunization
Practices (ACIP) Part 1: Immunization of Infants, Children, and
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Date last reviewed: 12/15/2005